By Teresa Conrick
It was last year that I reported on Anti-NMDA-Receptor Encephalitis and a connection to Autism. My daughter had some prominent symptoms and I was looking into the dynamics of this increasing medical condition. Meg tested negative and subsequent labs showed that her positive antinuclear antibodies [autoimmunity] to be associated with Gad65 [ glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2.] It is no coincidence that Megan's symptoms seemed to mirror some of those in Anti-NMDA-Receptor Encephalitis as the two, GAD65 and N-methyl-D-aspartate receptor, are connected.
Below is a study now showing that Anti-NMDA-Receptor Encephalitis has been added into the current Diagnostic and Statistical Manual of Mental Disorders as a true, medical causation to an Autism diagnosis. In other words, an antibody causing autoimmunity can cause regression of behaviors and skills, and then appear to present as a primary psychiatric disorder . Immediate and proper medical care must be given to prevent further damage and permanent disability -- "Patients with early immunotherapy performed significantly better. The most severe deficits were observed with inefficient or delayed initial treatment. " --
Researchers must not be afraid to admit that vaccinations can cause this increasing and horrific medical phenomenon:
Anti-NMDA receptor encephalitis after TdaP-IPV booster vaccination: cause or coincidence?
Researchers must not deny its connection to other childhood immune disorders with cute names:
"In about 50% of the patients Mycoplasma pneumonia serum IgM is positive. Although the significance of this is unknown, infections may trigger an autoimmune encephalitic process akin to PANDAS (pediatric autoimmune neuropsychiatric illness associated with streptococcal infections) mediated by antistreptococcal-antineuronal antibodies."
Researchers must not avoid the Anti-N-methyl-D-aspartate receptor encephalitis connection to research involved in Autism and autoimmunity:
"NR1 and NR2b glutamate receptor immunoreactivity patterns are abnormal in the hippocampi of thimerosal treated SJL mice."
Tijdschr Psychiaty 2012;54(5):475-9.
[Anti-NMDA-receptor encephalitis: a new axis-III disorder in the differential diagnosis of childhood disintegrative disorder, early onset schizophrenia and late onset autism].
[Article in Dutch]
Psychiatrie & Psychologie, Masstricht.
Childhood disintegrative disorder (CDD), early onset schizophrenia (EOS), and late onset autism (LOA) often follow a similar course: initially, development is normal, then there is a sudden neuropsychiatric deterioration of social interaction and communication skills, which is combined with a decline in intelligence and reduction in daily activities. A 9-year-old boy was admitted to the paediatric ward with acute onset of secondary epileptic seizures. It was not long until the boy's symptoms resembled that of patients with cdd, eos and loa. Intensive tests led to the diagnosis of anti-NMDA-receptor encephalitis. Anti-NMDA-receptor encephalitis should be regarded as a possible organic cause underlying the syndromal presentation of CDD, EOS and LOA.
Teresa Conrick is Contributing Editor for Age of Autism.