Science

Institutional Confirmation Bias and the United Kingdom Department of Health: Letter to Dame Sally Davies

image from pbs.twimg.comBy John Stone

Below is the text of my recent letter to Dame Sally Davies (pictured), Chief Medical Officer since 2010 to the British government. Davies has now replied twice to my original challenge to substantiate her comment on the BBC regarding the MMR: ""It's a safe vaccination - we know that". My original reply was published last November. It is evident that if she had a strong reply to make she ought to have made it the first time around, and the second reply was only an amplification of the first, to which I have in turn responded in more comprehensive detail. I believe it demonstrates how a government department had come to justify its choices made originally on weak evidence, and how as the decades went by the resulting decisions got worse and more desperate: and as the problems got more drastic the denial - even if believed - got more implausible.

It is interesting and likely significant that when I asked about MMR safety it was Davies who brought up the issue of autism (which I had not mentioned). This mirrors the situation two decades ago when I tried to raise the subject with the department of the rising autism numbers and they brought up Andrew Wakefield (though I had mentioned neither Wakefield or vaccines). The message is that they make the connection as a reflex, the safety of MMR and the claimed stability of the autism figures are inextricably entwined and in both instances the department are making a “leap of faith”.

My title refers to “the Department of Health", but to clarify at the beginning of this period when the original decisions were being made it was part of the Department of Health and Social Security (DHSS), and since January last year it has been called the Department of Health and Social Care (DHSC), but for the three decades during which most of this happened it was the DoH or DH.

Dear Dame Sally,

Re: MMR Safety and Autism Numbers

Thank you for your further courteous reply (20 December), however I must point to a host of anomalies (apologies for the length and detail of my reply). The MMR programme was introduced to the UK in 1988 but the earliest of the autism safety studies included in the Cochrane review 2005 [1] was published only 11 years after this (and apparently based on illegally obtained children’s records, which cannot be cross checked [2]), while the first listed in the review by Luke Taylor (2014), which you cited, comes from 14 years after the introduction of the products [3]. Indeed, in 1988 the DH recklessly favoured SKB’s Pluserix MMR vaccine although it was already withdrawn in Canada [4] and contrary to your first letter it never made an attempt to withdraw the product until the decision was made to do so unilaterally by the manufacturers in 1992 [5].

The safety of the products had not been established at the time of introduction (quite the reverse as the main one in use was known to be hazardous), and the featured studies only began when, following the intervention of Andrew Wakefield, health officials came under pressure to justify the policy. The picture became further complicated in 1999 when the problem of mercury in other vaccine products, previously unacknowledged, came to light in the US. The problem of the Cochrane paper of 2005 is that the bland reassurance it gave regarding MMR and autism is in stark contrast to the cool to scathing comments about the six autism related studies it reviewed (three of which overlap with the Luke Taylor review of 2014 which you previously gave as your evidence for MMR safety and MMR not causing autism) [6]. The manifest contradiction in the review should in itself raise red flags.

Continue reading "Institutional Confirmation Bias and the United Kingdom Department of Health: Letter to Dame Sally Davies" »


Vaccingate: Two Articles from Il Tempo

Corvelva vaccingateBelow are two articles translated into English from Il Tempo regarding vaccine purity and reliability in manufacturing.  Please refer to our article last week CORVELVA VACCINEGATE: GSK's Infanrix Hexa Exposed.

It is an interesting development that Dr Bolgan, a graduate of Harvard Medical School has associated herself with project. Meanwhile, Drs Montanari and Gatti make the important point that without hands-on, independent regulation - which is patently absent - there is no basis for trust in the products. It would be problematic enough if they were what was said on the packet, but if they are they are not the we are into another territory altogether.

About Corvelva: The CORVELVA association - Veneto Regional Coordination for the Freedom of Vaccinations - was founded in 1993 and its principle is the free choice of vaccinations. In recent years Corvelva has actively managed the vaccination objection regarding the scholastic aspect, the Juvenile Court and sanctions obtaining excellent results. These three areas, thanks to constant and continuous work, have been overcome by reaching the regional law that determines the suspension of the compulsory vaccination for all those born from 1 January 2008. Since then the Association's activity has focused on assisting those who have been injured due to mandatory and non-mandatory vaccines and on research related to the issue of vaccine damage. Today, there is a new battle for the right of therapeutic choice. We continue our work of supporting families in every aspect of freedom of choice and care.

From IlTempo.it:
The pharmacologist versus Aifa: "The vaccine investigation is correct". The validated methods required for a certifying body that deals with the release of batches

by Loretta Bolgan (pharmacologist and vaccine expert)
 
"I have to underline one important thing once and for all: Corvelva is not doing a batch release check and has not required the use of validated methods for batch analysis, as manufacturers, accredited laboratories and the ISS have to do. What you are conducting is a simple investigation that is done in the initial phase of the development of a vaccine, ie screening". Loretta Bolgan, pharmacologist expert in vaccines responds to Aifa, the Medicines Agency that, after the shocking revelations of IL Tempo on vaccines (where there is no rubella antigen in the product which should eradicate it, and there are human DNA and herbicides in the other) [READ THE ARTICLE] claimed that the "incriminated" lots were all in place after testing them [READ THE ARTICLE]. 
 
Dr. Bolgan, a graduate in Chemistry and Pharmaceutical Technology, reports to the Medicines Agency, which - after reporting the two lots indicted on the market - has replied that it has tested them. Bolgan obtained a PhD in Pharmaceutical Sciences, is currently scientific consultant lg 210, ONB and Corvelva for the analysis of vaccines. She was also a consultant in the last parliamentary committee of inquiry on the military.

Continue reading "Vaccingate: Two Articles from Il Tempo" »


Three New Papers from Vinu Arumugham

Science post imageBelow are the three recent papers from independent vaccine safety and autism researcher Vinu Arumugham et al. You can see more at ResearchGate.net.

Autism pathogenesis: Piecing it all together, from end to beginning …

Vinu ArumughamMaxim V Trushin

Increased extra-axial cerebrospinal fluid (EA-CSF) have been observed in imaging studies of infant brains, who go on to develop autism. Folate deficiency can cause defects in neural development that can affect CSF production and drainage. Folate receptor alpha antibodies (FRAA) are observed in 75% of autism patients. Maternal FRAA have also been observed in the case of neural tube defects.

Folate deficiency can cause aluminum accumulation in the brain. Autistic brains have been shown to accumulate aluminum. FRAA in the child or mother can therefore explain all the observations.

Further, autism patients have a higher genetic risk for cancer but have lower cancer rates. Many cancer cells express folate receptor alpha to transport folate required for rapid growth. Once again FRAA in autism can thus explain lower rates of cancer occurrence as FRAA block FRA expressed on cancer cells, affecting folate transport.

A majority of FRAA are of the IgG4 subclass and bind with higher affinity to the bovine folate receptor than the human folate receptor. The human and bovine FR have 90% protein sequence homology.

From allergies and parasite infections we know that IgG4 is the second stage of the immune response. The first stage is IgE against FRA. The US Institute of Medicine concluded that antigens in vaccines do cause IgE mediated sensitization. Many vaccines contain cow’s milk proteins, one of which is the bovine folate receptor protein. Bovine casein and casamino acids used as growth media for vaccine manufacture are derived from cow’s milk.

The solution for vaccine-induced IgE against FRA, is to immediately remove all non-target proteins from all vaccines by using processes such as affinity chromatography.

Correlation of type 1 diabetes trends in European countries to the number of bovine insulin and GAD65 contaminated chick embryo cell culture containing vaccines in the schedule, as predicted by the autoimmunity mechanism involving immunization with homologous xenogeneic antigens and EPIT as a potential treatment

Arumugham, Vinu

Type 1 diabetes (T1D) affects millions and is a growing problem worldwide. The etiology of T1D is considered to be unknown.
Many vaccines are manufactured using bovine milk derived proteins such as bovine casein and casamino acids as growth media to grow bacteria. These vaccines contain trace quantities of all bovine milk proteins.

Continue reading "Three New Papers from Vinu Arumugham" »


CORVELVA VACCINEGATE: GSK's Infanrix Hexa Exposed

Corvelva vaccingateThe latest press release below from Italian organization that campaigns on vaccine rights,  which has just received a grant from the Italian National Order of Biologists to the fury of GSK funded scientists from Padua University.  Now read why.


###

When we started these analysis, from the metagenomics to the chemical ones, we had a lot of questions and we were only looking for answers… After these first results, more questions have arisen and so did the concerns!

The quali-quantitative analysis of organic compound is of great importance in the pharmacological field, as potential safety problems arise from the new production processes of biological drugs and from the complex structural and biological characteristics of these products.

In Infanrix Hexa we found

  • chemical contamination from the manufacturing process or cross-contamination with other manufacturing lines;
  • chemical toxins;
  • bacterial peptide toxins;
  • insoluble and indigestible macromolecule that reacts to the protein assay, but cannot be recognized by any protein databases.

We have not found:

  • Protein antigens of diphtheria toxoids, tetanus, pertussis, hepatitis B, haemophylus influenzae B, Poliomyelitis 1-2-3;
  • Formaldehyde and glutaraldehyde, phenoxyethanol, antibiotic residues indicated in the composition;

In Infanrix Hexa there are six antigens

Tetanus, diphtheria and pertussis toxoids, D antigens of Poliomyelitis 1-2-3, hepatitis B proteins obtained with genetic engineering and Haemophylus polysaccharides chemically linked to tetanus toxoid as carrier. Toxoids are created by treatments with formaldehyde and glutaraldehyde that should remove toxicity keeping intact their ability to stimulate protective antibodies against original toxins.

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Flu data: more FAKE NEWS from the BBC and the British Government

image from upload.wikimedia.orgby John Stone

The BBC was at it again on Friday running a report hinting that 50,000 people had died from flu in the England and Wales during the the 2017-18 season based on newly published data from the Office for National Statistics:

"There were around 50,100 excess winter deaths in England and Wales in 2017-18 - the highest since the winter of 1975-76, figures from the Office for National Statistics show...The increase is thought to be down to the flu, the ineffectiveness of the flu vaccine in older people and spells of very cold weather last winter."

One fundamental problem with this is that the government had already published the influenza death toll for the season in May - it was indeed an exceptionally  bad year but it still only meant 320 deaths in England and 372 in the United Kingdom as a whole (which includes Scotland, Wales and Northern Ireland):

"Through the USISS mandatory scheme, a total of 3,454 ICU/HDU admissions of
confirmed influenza were reported across the UK from week 40 2017 to week 15 2018,
including 372 deaths, based on combined data from England, Scotland and Northern
Ireland. In England, the total number of influenza confirmed admissions to ICU/HDU
was 3,175 (rate of 0.22 per 100, 000 population) and 320 deaths during the same
period...

"The cumulative number of cases and deaths were higher compared to the 2016 to 2017
season (992 cases (rate of 0.06) and 112 deaths) and to the 2015 to 2016 season
(2,173 cases (rate of 0.14 per 100, 000) and 166 deaths) in England. This season
represents the highest number and rate observed since the beginning of the scheme
..."

Public Health England, 'Surveillance of influenza and other respiratory viruses in the UK:Winter 2017 to 2018' p. 21

It is also interesting to note that the issue of high mortality for the period came to light early on and was even reported in some national newspapers. In the British Medical Journal Hiam and Dorling wrote in March:

"Within the first seven weeks of 2018, some 93 990 people died in England and Wales.1 Over the same weeks in the previous five years, an average of 83 615 people died..This rise of 12.4%, or 10 375 additional deaths, was not due to the ageing of the population. Ageing is a slow process and leads to slow, not sudden, rises in mortality...An additional person died every seven minutes during the first 49 days of 2018 compared with what had been usual in the previous five years. Why?

"Not the weather or flu

"The weather was unusually mild during the initial weeks of this year—very cold weather did not arrive until late February. The mean temperature was 4.1°C across the UK in January 2018, almost half a degree above the average for this time of year."

Continue reading "Flu data: more FAKE NEWS from the BBC and the British Government" »


More Junk Autism Data From The British Government

image from www.nhs.ukBy John Stone

In my letter to the British government's leading medical adviser, Dame Sally Davies, published in these columns two days ago I commented:

"When the DHSC last surveyed this problem in 2004-5 the overall ASD rate among school children was ~1% which was 5 times higher than the rate for those young people born between 1984-8 mostly before MMR was introduced, as reported in the equivalent 1999 survey. Since then your department has neglected to look at the issue (apart from a couple of failed adult autism surveys) as everything manifestly got worse, year on year."

By a strange coincidence the government published its first survey of child and adolescent mental health (including autism) in 13 years the day after my letter to Davies was dispatched, placing the overall prevalence of autism in English schools at 1.2%, completely out of line with the situation engulfing our schools. My criticisms of the new data have now been published in British Medical Journal Rapid Responses:-

Scepticism regarding the NHS survey 'Mental Health of Children and Young People, 2017' and ASD/PDD

I note the recent comment of Prof Philip Graham in Guardian letters [1] regarding the publication of these figures:

" In addition, the rate of autism spectrum disorder was stable between 2004 and 2017, providing no support for the commonly held view that rates of this disorder are rising."

I doubt even using the figures for the 2017 survey [2] against the 2004 survey [3] that Prof Graham is justified since the overall figure for 2004 is 0.9% and the figure for 2017 is 1.2% and my rudimentary maths makes this an un-negligible 33% rise, while the the level for boys was 250% higher between the 17-19 year-olds and the 5-10 year-olds (1% against 2.5%). I also note that these figures are discrepant from the 2004 survey. For instance the 2017 survey measures the level of autism for boys in the 17 to 19 group at 1% when it was 1.9% 5-10 years in 2004, and this suggests inconsistency. In fact, the survey admits [4]:

"ASD was not associated with age. Rates appeared higher in younger age groups than
older ones (1.5% of 5 to 10 year olds; 1.2% of 11 to 16 year olds; 0.5% of 17 to 19
year olds). However, due to the small number of cases identified in the sample, the
survey was underpowered to detect variation."

Continue reading "More Junk Autism Data From The British Government" »


The Junk Safety Science Which Underpins UK Government MMR Vaccine Policy

image from religion.ua.eduBy John Stone

I recently wrote to Dame Sally Davies, Chief Medical Officer of England and to the British government, asking her for the basis of her statement to the BBC regarding MMR: "It's a safe vaccination - we know that", and was a lucky enough to receive a reply (letter of 12 November, from which I extract):

Specifically in relation to whether MMR vaccines may be a cause of autism, a substantial body of population-based research has found no evidence to suggest a causal association. This evidence (not just for MMR, but other types of vaccine) is available for review in the published medical literature, and was summarised in a meta-analysis in 2014 which is free to download (https://www.sciencedirect.com/science/article/pii/S0264410X14006367?via%3Dihub).

In relation to vaccine safety monitoring more generally, I can assure you that systems are in place to keep safety under review. This includes continual review of suspected adverse reaction reports (such as those submitted through the Yellow Card Scheme), evaluation of GP and hospital-based health records linked to immunisations, review of worldwide data and close collaboration with international health authorities.

It is noteworthy that the "meta-analysis" by Luke E Taylor is identical to the one cited by Thomas Insel to a US Congressional committee in 2014, but it constitutes no more than a bureaucratic fig-leaf. Dame Sally - who is the UK's leading government adviser on medical matters - ought to be able to do a lot better than this if every child is to be subjected to these products. It is, if anything, a rather naive response citing a shallow collection of studies which were published under political pressure decades after the policy was introduced. I have since attempted a conscientious and detailed reply:

 

21 November 2018

Dear Dame Sally,

Thank you for your letter of 12 November. I would point out that though you are quite right I am concerned about the rise in autism I specifically asked about the evidence base for MMR safety. That said it is reasonable to point out autism for a whole host of reasons is a much more serious problem in modern Britain (and elsewhere) than measles. When the DHSC last surveyed this problem in 2004-5 the overall ASD rate among school children was ~1% which was 5 times higher than the rate for those young people born between 1984-8 mostly before MMR was introduced, as reported in the equivalent 1999 survey. Since then your department has neglected to look at the issue (apart from a couple of failed adult autism surveys) as everything manifestly got worse, year on year [1,2].

As it is, a recent survey carried out by the Department of Health in Northern Ireland showed that the rate had risen from 1.2% in 2009 to 2.9%, while in Belfast it was as high as 4.7%. Moreover, 60% are educational Stage 5 [3], ie the most severe level of disability, so these are not cases that could previously have been missed because somehow subliminal. Educational data from across the nation and reports of collapse in educational services in the media testify that Northern Ireland is not an isolated case, but just better documented [4].

Regarding the meta-review by Taylor 'Vaccines are not associated with autism' [5] which you cited I note that there are just six MMR related studies included all of which have major problems. Three of the studies show apparent protective effect of MMR vaccines against autism (Madsen 8% [6], Smeeth 14% or 22% [7] and Mrozek-Budzyn 83%!!! [8]) which suggests bias. Of the Madsen paper Cochrane 2005 warned [9]:

"The follow up of diagnostic records ends one year (31 Dec 1999) after the last day of admission to the cohort. Because of the length of time from birth to diagnosis, it becomes increasingly unlikely that those born later in the cohort could have a diagnosis"

It remains troubling that as with a number of studies from this Danish group the co-ordinator on behalf of US Centers for Diseases Control, Poul Thorsen, is wanted for financial fraud from the CDC, though not extradited to the US now after nearly 8 years [10].

Of the De Stefano paper Cochrane commented [9]:

“The conclusion, however, implied bias in the enrollment of cases which may not be representative of the rest of the autistic population of the city of Atlanta, USA where the study was set.”

And indeed in 2014 the paper was repudiated by one of the leading authors, William Thompson [11]:

“I regret that my coauthors and I omitted statistically significant information in our 2004 article published in the journal Pediatrics. The omitted data suggested that African American males who received the MMR vaccine before age 36 months were at increased risk for autism. Decisions were made regarding which findings to report after the data were collected, and I believe that the final study protocol was not followed.”

The study by Smeeth [7] is compromised by its patchy data source, the General Practice Research Database where the autism rate represented is perhaps only one tenth of cases diagnosed [12]. Cochrane commented [9]:

“In the GPRD - based studies (Black 2003; Smeeth 2004) the precise nature of controlled unexposed to MMR and their generalisability was impossible to determine…”

It remains problematic whether the unvaccinated in this study were genuinely unvaccinated.

Of the Uchiyama study [13] Cochrane commented [14]:

“The cohort study of Uchiyama 2007 was potentially affected by a different type of bias, considering that the participants were from a private clinic and that definitions of applied Autistic Spectrum Disorders (ASD) diagnosis and of methods used for ASD regression ascertainment were not clearly reported.”

And the Uno study [15] will suffer from similar issues since the cases came from the same clinic. Moreover, in both instances the studies were far too small (904 persons and 413) to necessarily provide any clear result even if they had been better controlled.

Nor can the Taylor meta-analysis [5] cover up the entire absence of pre-marketing studies. In 1988-9 when the British government was persuaded to introduce Pluserix, MMR2 and Imravax there were no safety studies at all, and successive governments have been forced into the defence of a policy which they had embarked on without safety evidence.

As to the robustness of the yellow card reporting system I note the recent correspondence in the columns of BMJ On-Line regarding monitoring of Pandemrix vaccine from Wendy E Stephen and Clifford G Miller [16], which has serious implications for how the MHRA monitor all products. The MHRA has, of course, the ultimate conflict of being entirely funded by the manufacturers. It may be mentioned that in 1992 the Pluserix and Imravax vaccines were withdrawn not apparently by the British Government concerned about patient safety but by the manufacturers catching the government on the hop [17].

We are confronting a catastrophic situation among our young people with chronic illness replacing infectious illness as the main issue and cost to the state, and laying the emphasis on infectious diseases (with endless hate campaigns in the media against critics labelled “anti-vaxxers”) is a distraction, and a distortion of policy. It would be unfortunate if ministers were being advised about the safety of the programme on such a threadbare and inadequate basis. Re-examining the policy is both essential and urgent.

[1] John Stone,  ‘Response to David Oliver I (The Indisputable Rise in Autism)’, BMJ Rapid Responses 28 August 2018, https://www.bmj.com/content/362/bmj.k3596/rr-12

[2] John Stone, ‘What about autism?’ BMJ Rapid Responses, 21 August 2018, https://www.bmj.com/content/362/bmj.k3596/rr-0

[3] Information Analysis Directorate 'The Prevalence of Autism (including Asperger Syndrome) in School Age Children in Northern Ireland 2018', published 10 May 2018, https://www.health-ni.gov.uk/sites/default/files/publications/health/asd-children-ni-2018.pdf

[4] Responses to Viner RM, 'NHS must prioritise health of children and young people', https://www.bmj.com/content/360/bmj.k1116/rapid-responses

[5] Luke E Taylor et al, ‘Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies’, Vaccine 2014, https://autismoevaccini.files.wordpress.com/2014/05/vaccines-are-not-associated-with-autism.pdf

[6] Madsen et al, ‘A Population-Based Study of Measles, Mumps, and Rubella Vaccination and Autism’, NEMJ 2002, https://www.nejm.org/doi/full/10.1056/NEJMoa021134

[7] Smeeth et al, ‘MMR vaccination and pervasive developmental disorders: a case-control study.’ Lance 2004, https://www.ncbi.nlm.nih.gov/pubmed/15364187

[8] Mrozek-Budzyn et al, ‘Lack of association between measles-mumps-rubella vaccination and autism in children: a case-control study.’ Pediatric Infectious Diseases Journal 2010, https://www.ncbi.nlm.nih.gov/pubmed/19952979

[9] Demicheli et al, ‘Vaccines for measles, mumps and rubella in children.’, Cochrane Database Syst Rev. 2005 Oct 19;(4):CD004407.

[10]  Office of Inspector General, US Department of Health and Human Services, Fugitive Profiles, https://oig.hhs.gov/fraud/fugitives/profiles.asp

[11] https://legislature.vermont.gov/assets/Documents/2016/WorkGroups/House%20Health%20Care/Bills/H.98/Witness%20Testimony/H.98~Jennifer%20Stella~William%20Thompson%20Statement~5-6-2015.pdf

[12] John Stone, ‘An old story: the GPRD does not provide credible autism data’ 11 February 2014 https://bmjopen.bmj.com/content/3/10/e003219.responses

[13] Uchiyama et al, ‘MMR-vaccine and regression in autism spectrum disorders: negative results presented from Japan.’ J Autism Dev Disord. 2007 Feb;37(2):210-7.

[14] Demicheli et al, ‘Vaccines for measles, mumps and rubella in children.’, Cochrane Systematic Review - Intervention Version published: 15 February 2012, https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD004407.pub3/full

[15] Uno et al, ‘The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: the first case-control study in Asia’, Vaccine. 2012 Jun 13;30(28):4292-8. doi: 10.1016/j.vaccine.2012.01.093. Epub 2012 Apr 20.

[16] Responses to Godlee, ‘A tale of two vaccines’ BMJ 2018, https://www.bmj.com/content/363/bmj.k4152/rapid-responses

[17] Report, BMJ 26 September 1992, https://www.bmj.com/content/305/6856/777

When your government, the BBC or the mainstream media tell you that MMR is safe,  this the best that the British government can do. After three decades of pure bluster they need to go back to the drawing board.

 

 


Role of NMDA receptor autoimmunity induced by food protein containing vaccines, in the etiology of autism, type 1 diabetes, neuropsychiatric and neurodegenerative disorders

NmdaNote: Despite tomorrow being America's super food consumption day.....

Vinu Arumugham. (2018, October 16). Role of NMDA receptor autoimmunity induced by food protein containing vaccines, in the etiology of autism, type 1 diabetes, neuropsychiatric and neurodegenerative disorders. Zenodo. http://doi.org/10.5281/zenodo.1463601

Role of NMDA receptor autoimmunity induced by food protein containing vaccines, in the etiology of autism, type 1 diabetes, neuropsychiatric and neurodegenerative disorders

By Vinu Arumugham

Vaccines contain numerous animal and plant proteins (soy, peanut, sesame, maize, wheat, etc.). Vaccine excipients are derived from plant or animal sources. The mechanism of animal protein induced autoimmunity was previously described. Following a report associating maternal gluten intake to type 1 diabetes in the offspring, plant proteins were investigated.

The Pandemrix vaccine induced narcolepsy due to molecular mimicry between a H1N1 nucleoprotein peptide in the vaccine and the human hypocretin receptor 2. The BLASTP match score for this peptide was used as a baseline. BLASTP showed strong sequence alignment between gliadin, a wheat protein, and the human ionotropic N-methyl-D-aspartate receptor (NMDAR).

Analyzing further, strong sequence alignment was found between soy, peanut, sesame, maize, wheat and human glutamate receptors (GR), both ionotropic and metabotropic. There are reports of boosted wheat allergy and de novo synthesis of NMDAR antibodies following immunization. Once immunized with plant derived antigens, antibody levels will be increased by dietary exposure to these antigens.

Continue reading "Role of NMDA receptor autoimmunity induced by food protein containing vaccines, in the etiology of autism, type 1 diabetes, neuropsychiatric and neurodegenerative disorders" »


The Role of Toxic Stimuli Combinations in Determining Safe Exposure Limits

Toxic hazardThank you to author Ronald Kostoff for this link.

An Editorial in the journal Toxicology Reports entitled "The role of toxic stimuli combinations in determining safe exposure limits" has been published recently.  The article asserts that lack of adequate testing of toxic stimuli for safety purposes in combinations reflective of real-world exposures results in regulatory Exposure Limits not fully protective.  While the Editorial applies to all toxic stimuli exposures, RFR is mentioned specifically at the end of Section 2.  The Editorial is Open Access, and can be accessed at https://doi.org/10.1016/j.toxrep.2018.10.010

The role of toxic stimuli combinations in determining safe exposure limits

1. Introduction

Since the dawn of the Industrial Age, and especially over the past century, many thousands of technologies and their products have been introduced to our society. There has been continual concern about the safety of these products, as reflected in their potential adverse impacts on human health. As a result, a number of regulatory agencies have been established for the purpose of ensuring these technology products are safe.

There are three main obstacles these agencies face in determining the degree to which Exposure Limits are protective:

Sufficiency of existing data for setting safe exposure limits (Has adequate research been done and reported on the toxic stimulus in question and does the research that has been conducted and reported reflect real-world exposures?)

Sufficiency of incorporating relevant existing data from the biomedical literature

Trustworthiness of existing data in the biomedical literature [1].

This editorial focuses on the issue of how well real-world exposure effects are reflected by the published literature. The other issues are addressed in part in a recent monograph on occupational exposure permissible limits [2].  Read the full editorial here.

 


Meet The Authors of HPV Vaccine on Trial in Rye, NY November 8

Hpv presentation Rye NY


You're invited to meet the authors of this important book from Skyhorse Publishing called HPV Vaccine on Trial this Thursday, in Rye New York.

A Groundbreaking Exposé to the HPV Vaccine and the Science, Safety, and Business Behind It

Cancer strikes fear in people’s hearts around globe. So the appearance of a vaccine to prevent cancer–as we are assured the human papillomavirus (HPV) vaccine will–seemed like a game-changer. Since 2006, over eighty countries have approved the vaccine, with glowing endorsements from the world’s foremost medical authorities. Bringing in over $2.5 billion in annual sales, the HPV vaccine is a pharmaceutical juggernaut. Yet scandal now engulfs it worldwide.

The HPV Vaccine on Trial is a shocking tale, chronicling the global efforts to sell and compel this alleged miracle. The book opens with the vaccine’s invention, winds through its regulatory labyrinths, details the crushing denial and dismissal of reported harms and deaths, and uncovers the enormous profits pharma and inventors have reaped. Authors Holland, Mack Rosenberg, and Iorio drill down into the clinical trial data, government approvals, advertising, and personal accounts of egregious injuries that have followed in countries as far-flung as Japan, Australia, Colombia, India, Ireland, the U.K. and Denmark. The authors have written an unprecedented exposé about this vaunted vaccine.

Written in plain language, the book is for everyone concerned – parents, patients, doctors, nurses, scientists, healthcare organizations, government officials, and schools. Ultimately, this book is not just about the HPV vaccine, but about how industry, government, and medical authorities may be putting the world’s children in harm’s way.


Harassment and silencing of vaccine and GM critics by the University of Exeter

image from ngw.nlBy John Stone

I am publishing this brief correspondence to highlight how our higher educational institutions are becoming the enemies of freedom of speech and intellectual curiosity, not to mention purveyors of falsehood. I am not suggesting that Exeter University is particularly unusual: there are lots of publications of this kind from many academic sources, arguing how to limit and close down debate while using ad hominem tactics posing as hard science. It is interesting to note how the university dealt with this matter. The vice-chancellor and CEO, Sir Steve Smith - who is an expert in the politics of globalisation - handed the matter on to the provost, Prof Janice Kay, a cognitive neuropsychologist, who does not really tell us what she thinks, but passes the buck to the politics department, the publishers and the peer reviewers. She must however know that our schools are by now drowning in unprecedented and unexplained neurological impairment. It seems that the university's coat of arms with the motto  lucem sequimur 'we follow the light' has fallen into disuse, and frankly the spirit of enlightenment is dead as GSK and the Bill and Melinda Gates Foundation take over the world.

From: John Stone .....
Sent: 24 October 2018 16:20
To: Vice Chancellor.....
Subject: Harassment and silencing of vaccine and GM critics

To Prof Sir Steve Smith, Vice-Chancellor and CEO University of Exeter

Dear Sir Steve,

I would like to express grave disquiet regarding the paper by Lyons et al and the additional publicity given to it by your university. It really will do no good to target people while not addressing their arguments - it is to say the least an open question who is indulging in "innuendo" as your publicity department put it.

A case in point would be the paper's attack on the competence and integrity of Robert F Kennedy Jnr. The article does not address any specifics of Kennedy's argument in his article while labelling him as "a conspiracy theorist". In this regard it is worth noting that by 2004 the British government, without of course admitting any error, had removed mercury from vaccines - the subject of Kennedy's article - and it was only to make a return to doing so in the highly unfortunate and still unaccounted Pandemrix episode. The safety of using the mercury salt preservative thimerosal/thiomersal has been criticised in many scientific publications.

A further problem is that if people are not allowed to express their concerns - or even their unpleasant experiences - a class of product becomes protected and the hazards to the public increase. There can be no automatic assumption that products are safe, and what is proposed is the intellectual and social suppression of views, experience and knowledge inconvenient to global interests and governments. This does not mean that all opinions are equally valid but it does mean that public debate should be tolerated. The very failure to tolerate debate places a question mark of the motives of the people trying to deny it, and it leaves the public in a dangerous position. It is always possible that this or that product has been slandered, but it does not mean that all products or all public bodies meet the standard, and we cannot proceed on this basis.

I believe by promoting "research" of this kind the University of Exeter is placing itself in an invidious historical position, and I look forward to your views.

Yours sincerely,

John Stone, UK and European Editor, AgeofAutism.com

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On 26 Oct 2018, at 15:18,

Dear Mr Stone, (if I may?)

Continue reading "Harassment and silencing of vaccine and GM critics by the University of Exeter" »


Mystery Polio-like Paralytic Disease in Children Related to Vaccination?

TractionChairSongNote: One of the straw man arguments used against anyone who discusses vaccine injury, exemptions and refusal goes like this: "Do you want polio back?" Of course, the answer is "No." Below is an article from IPAK on the frightening outbreaks of "polio-like" paralysis in children across the nation.  No child should be injured by a vaccine, or thrust into another illness because of the vaccine's intended role within the body. If a vaccine stops one disease but causes another even more harmful disease or situation, the risk far outweighs the benefit. These are the conversations parents should be able to have with their doctors. And on social media, without being called anti-vaccine and shut down. Harm is harm. And when your child is worse off after vaccination, that can hardly be called a medical miracle.

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Mysterious Paralysis Affecting Children: Are Vaccines to Blame?

IPAK Modern Medicine and Health News Views from the Open-Minded News and views on modern medicine, health, the future of health, public health, immunity, our environment and medical law,

Eli Kammerman - October 28, 2018

[IPAK Editor's comment: The two-hit hypothesis presented addresses a cellular, but not a molecular, mechanisms of pathophysiology involving vaccination concurrent with enterovirus infection. Whether molecular mimicry or other known molecular mechanisms of vaccine induced autoimmunity also play a role remains to be tested.]

A mysterious disease is paralyzing kids in 22 states. A three-year-old who could barely hold up his own head was featured on the news after contracting a polio-like illness that started with a runny nose and turned into something much more serious. Doctors diagnosed him with Acute Flaccid Myelitis (AFM), a disease that causes sudden arm or leg weakness, and in some cases can lead to permanent paralysis. The CDC reports that so far in 2018, there have been 72 confirmed cases of AFM among a total of 191 cases currently under investigation.

But what’s causing it? And more importantly, how can we prevent it from happening to our children?

Here’s what parents need to know: AFM Peaks During Back-to-School Periods During the past five years, surveillance data reported by the CDC shows a seasonal peak in juvenile cases of acute flaccid myelitis (AFM) in three of the years (2014, 2016, 2018), with the peak occurring in the month of September and the next higher levels of cases seen in the immediately adjacent months. Read on to learn about the relationship between these seasonal peaks and the back-to-school period.

Polio


Continue reading "Mystery Polio-like Paralytic Disease in Children Related to Vaccination?" »


UK Parliamentary Committee Jettisons Vaccines As Strategy To Combat Antimicrobial Resistance

British flagAge of Autism re-posts its submission authored by its UK editor, John Stone, to the House of Commons Health and Social Care Committee inquiry into antimicrobial resistance. The resulting committee report only mentions vaccines once,  and not as a major strategy against antimicrobial resistance. This is in contrast to a British government report of 2016 in which the lead author Jim (Lord) O'Neill saw vaccines as the major tool in combatting the problem, which had occasioned the AoA evidence to the parliamentary committee. Whatever the prospect for creating new antibiotic products the committee - perhaps in a new spirit of realism - appear to have abandoned expanding the vaccine program as a substitute.

Written evidence from John Stone (Age of Autism)

[1] Vaccines are mentioned as one strategy against antimicrobial resistance (1) and this submission seeks to caution against the idea of substituting one kind of over-medication with another (Age of Autism is an on-line newspaper concerned with the publicly unaccounted adverse effects of vaccination).

[2] In the United Kingdom, an infant already receives by 12 months on the routine schedule (2):-

DTaP, Polio, HiB, HepB+Rotavirus+13 Strain Pneumococcal+MenB (8 weeks)

DTaP, Polio, HiB, HepB+Rotavirus (12 weeks)

DTaP, Polio, HiB,HepB+13 Strain Preumococcal+MenB (16 weeks)

13 Strain Pneumococcal+MMR+HiB, MenC

[3] In 2011 Miller and Goldman reported (3):

“The infant mortality rate (IMR) is one of the most important indicators of the socio-economic well-being and public health conditions of a country. The US childhood immunization schedule specifies 26 vaccine doses for infants aged less than 1 year—the most in the world—yet 33 nations have lower IMRs. Using linear regression, the immunization schedules of these 34 nations were examined and a correlation coefficient of r = 0.70 (p < 0.0001) was found between IMRs and the number of vaccine doses routinely given to infants. Nations were also grouped into five different vaccine dose ranges: 12–14, 15–17, 18–20, 21–23, and 24–26. The mean IMRs of all nations within each group were then calculated. Linear regression analysis of unweighted mean IMRs showed a high statistically significant correlation between increasing number of vaccine doses and increasing infant mortality rates, with r = 0.992 (p = 0.0009). Using the Tukey-Kramer test, statistically significant differences in mean IMRs were found between nations giving 12–14 vaccine doses and those giving 21–23, and 24–26 doses. A closer inspection of correlations between vaccine doses, biochemical or synergistic toxicity, and IMRs is essential.”

Continue reading "UK Parliamentary Committee Jettisons Vaccines As Strategy To Combat Antimicrobial Resistance" »


British Medical Journal Finally Goes Over The Top On HPV Vaccine Safety

image from upload.wikimedia.orgby John Stone

After months of infighting and latterly outright war in the scientific community - and particularly within the Cochrane Group, formerly Collaboration - British Medical Journal have finally published  a paper questioning the safety of HPV vaccines. This represents a major step forward, because they had previously backed away from publishing a review by the same authors of European Medical Agency data, preferring in May to report the official Cochrane whitewash of the products by Aubyn et al, and only reluctantly reported the paper in July by three of the present authors in its cadet journal BMJ Evidence Based Medicine criticising their Cochrane colleagues - also now defended. All the present authors are historically associated with Cochrane but matters came to a head the weekend before last when the Group sacked one of the co-authors, a founder member board member of Cochrane - Peter  Gøtzsche -  on the basis of  vague and unsubstantiated allegations of bad behaviour, followed by the resignation of four other board members.

While the Cochrane Group is now widely considered to be a sinking ship, it has been frustrating to see weeks of politics overshadowing the incredibly serious criticisms of HPV vaccine safety made in BMJ EBM in July, and this is now somewhat rectified by the new paper which documents the painful and unsatisfactory process of extracting vaccine data from the European Medicines Agency: -

Challenges of independent assessment of potential harms of HPV vaccines

After three years of trying to access trial data for HPV vaccines, Lars Jørgensen and colleagues find current transparency policies unfit for their purpose

Lars Jørgensen, Peter Doshi, Peter Gøtzsche, Tom Jefferson 

Continue reading "British Medical Journal Finally Goes Over The Top On HPV Vaccine Safety" »


Depression and Autism: More Evidence Points to Physiological Not Psychological

Cause-of-depression-gutBy Teresa Conrick

Many people think depression is feeling bad about a situation. It can be that, but many times, it is a biological happening.  A recent study hitting the news noted this about autism:

Nearly 1 in 5 autistic young adults have history of depression: study

The study seemed to have many participants but seemed to have a bit of a slant in they asked specifically -- “ particularly in the context of bullying.

And young adults with autism who were relatively high-functioning -- meaning they did not have intellectual disabilities -- were actually at higher risk of depression than people with more severe forms of autism, British researchers found…...People with autism without intellectual disabilities "may be particularly prone to depression because of greater awareness of their difficulties," the researchers theorized……

….Not all of the increase in risk for depression was caused by genetics, Rai's group added, because people with autism still had double the odds for depression compared to a full sibling who did not have the disorder. That suggests that something other than DNA -- perhaps the stress of living with autism -- may play a role in depression risk…

"Individuals receiving a diagnosis of autism spectrum disorder later in life often report long-standing stress in relation to social isolation, bullying, exclusion, and the knowledge they are different ….Peng also believes more research is needed to tease out the experiences and stigmas that may contribute to depression in young people with autism.

Continue reading "Depression and Autism: More Evidence Points to Physiological Not Psychological" »


Aluminium and multiple sclerosis

image from i.ytimg.comby Chris Exley 

(From the Hippocratic Post)

In a recent post – A role for aluminium in multiple sclerosis, we highlighted that individuals with multiple sclerosis excrete high amounts of aluminium in their urine.

It was also demonstrated that regular drinking of a silicon-rich mineral water (Why-everyone-should-drink-silicon-rich-mineral-water) facilitated the urinary excretion of aluminium. Elevated urinary excretion of aluminium exacerbated in the short term by drinking a silicon-rich mineral water is indicative of a high body burden of aluminium (http://pubs.rsc.org/en/content/articlelanding/2013/em/c3em00374d#!divAbstract).

However, the systemic origin of excreted aluminium in multiple sclerosis remained unknown though we speculated that it might be brain tissue, reflecting known intimate associations between aluminium and myelin. The latter being the primary target biomolecule in the aetiology of multiple sclerosis. .. (continue reading at the Hippocratic Post)


Dr. Chris Exley: Aluminium in Brain Tissue in Multiple Sclerosis

AnnetteNote: I remember bumping into Annette Funicello at Disney World in 1992. MS had started to ravage her body. She had a cane that was clear and full of glitter. Annette Funicello was a famous, original Mouskateer. MS did not care....  Thank you to Dr. Exley et al for their work exposing the dangers of aluminum - in all its sources, including as a vaccine adjuvant.

MDPI and ACS Style

Mold, M.; Chmielecka, A.; Rodriguez, M.R.R.; Thom, F.; Linhart, C.; King, A.; Exley, C. Aluminium in Brain Tissue in Multiple Sclerosis. Int. J. Environ. Res. Public Health 2018, 15, 1777.


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Ijerph-logo



ABSTRACT

Multiple sclerosis (MS) is a devastating and debilitating neurodegenerative disease of unknown cause. A consensus suggests the involvement of both genetic and environmental factors of which the latter may involve human exposure to aluminium. There are no data on the content and distribution of aluminium in human brain tissue in MS. The aluminium content of brain tissue from 14 donors with a diagnosis of MS was determined by transversely heated graphite furnace atomic absorption spectrometry. The location of aluminium in the brain tissue of two donors was investigated by aluminium-specific fluorescence microscopy. The aluminium content of brain tissue in MS was universally high with many tissues bearing concentrations in excess of 10 μg/g dry wt. (10 ppm) and some exceeding 50 ppm. There were no statistically significant relationships between brain lobes, donor age or donor gender. Aluminium-specific fluorescence successfully identified aluminium in brain tissue in both intracellular and extracellular locations. The association of aluminium with corpora amylacea suggests a role for aluminium in neurodegeneration in MS. View Full-Text


New Study: Aluminium in Brain Tissue in Multiple Sclerosis

image from www.rescuepost.comInt. J. Environ. Res. Public Health 201815(8), 1777; https://doi.org/10.3390/ijerph15081777 (registering DOI)

Aluminium in Brain Tissue in Multiple Sclerosis

Mold M, Chmielecka A, Rodriguez MRR, Thom F, Linhart C., King A, Exley C.

 
 

Abstract

Multiple sclerosis (MS) is a devastating and debilitating neurodegenerative disease of unknown cause. A consensus suggests the involvement of both genetic and environmental factors of which the latter may involve human exposure to aluminium. There are no data on the content and distribution of aluminium in human brain tissue in MS. The aluminium content of brain tissue from 14 donors with a diagnosis of MS was determined by transversely heated graphite furnace atomic absorption spectrometry. The location of aluminium in the brain tissue of two donors was investigated by aluminium-specific fluorescence microscopy. The aluminium content of brain tissue in MS was universally high with many tissues bearing concentrations in excess of 10 μg/g dry wt. (10 ppm) and some exceeding 50 ppm. There were no statistically significant relationships between brain lobes, donor age or donor gender. Aluminium-specific fluorescence successfully identified aluminium in brain tissue in both intracellular and extracellular locations. The association of aluminium with corpora amylacea suggests a role for aluminium in neurodegeneration in MS. View Full-Text
 

British Medical Journal Fails On “First Do No Harm” Over HPV Vaccines

image from encrypted-tbn0.gstatic.comby  John Stone

"If the contents of either of the papers became widely known it would surely have sounded the global death knell for the products and also called twelve years of government policy into question. When balancing the welfare of British children against the interests of industry and state it seems in the end the children barely weighed."

Serious ethical questions arise over the role of British Medical Journal and the promotion of Human Papillomavirus vaccines. Back in May BMJ published a news report of the Cochrane Review of HPV vaccines by former London Times journalist Nigel Hawkes “HPV vaccines are effective and safe and work best in young women, review finds”. It has come to light in the blog of Prof David Healy (author Pharmageddon and Let Them Eat Prozac ) that the BMJ knew the reasons for this confidence were at best extremely controversial, and that the journal itself had turned down an earlier paper by members of Nordic Cochrane (including leading scientists Peter Gøtzsche and Tom Jefferson) highlighting major flaws in the science surrounding the products. Healy states:

“ Some months back, the Nordic Cochrane Center, one of the centres in the Cochrane Collaboration, sent a review of studies done on the HPV vaccine to the BMJ.  Much to their surprise, BMJ turned down this article which contained all studies done on HPV and a serious attempt to flag up the limitations of the trials and accordingly the limitations of what we could confidently say.”

This paper is still unpublished but two weeks ago BMJ Evidenced Based Medicine published a second paper by the Nordic Cochrane group, Lars Jørgensen, Peter Gøtzsche and Tom Jefferson attacking the foundations of the Cochrane Review, as reported on Age of Autism last week and now available in full from Prof Healy’s site. Despite the BMJ Group publication the main journal chose not to publicise this extraordinarily newsworthy event. (It might be said that news is not what it was and this is one of the most blatant suppressions of  the news in modern medicine - the "Fake" comes in not reporting.)

While there is no doubt that the BMJ Group is commercially conflicted, not only accepting advertising from all the manufacturers – GSK, Merck and Sanofi - but also being in historic partnership with Merck, perhaps the real reasons are even more disturbing and relate BMJ’s peculiar relationship as the journal of the British Medical Association (the doctors’ trade union) with the British medical profession. If the contents of either of the papers became widely known it would surely have sounded the global death knell for the products and also called twelve years of government policy into question. When balancing the welfare of British children against the interests of industry and state it seems in the end the children barely weighed.

Last week the present writer tried to challenge a senior BMA member - Dr Peter English, Chair of its Public Health Medicines Committee - in the on-line columns of BMJ:

“As a “Public Health Physician” Peter English seems to express a breath-taking disdain for the public, while also apparently eliding any critical view of vaccines at all with being “anti-science”… I wonder what he thinks the public, particularly prospective vaccinees and their families, should be allowed to know about the recent paper by Jørgensen regarding the inadequacies in the trialing of HPV vaccines?”.

Naturally, it was not published.

 PostScript: In a 2008 letter to BMJ regarding HPV vaccine, co-signed by Prof Keith Neal, Peter English discloses:

"Competing interests: Between them the authors have given occasional lectures for, received expenses for professional conferences from, and participated in advisory boards for various pharmaceutical companies, including GlaxoSmithKline, Sanofi Pasteur MSD, and others."

 

John Stone is UK and European editor of Age of Autism

 

 


Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder

Science post imageMolecular Diagnosis & Therapy ISSN: 1177-1062 (Print) 1179-2000 (Online)

  • Shannon Rose
  • Dmitriy M. Niyazov
  • Daniel A. Rossignol
  • Michael Goldenthal
  • Stephen G. Kahler
  • Richard E. Frye

ABSTRACT: Autism spectrum disorder (ASD) affects ~ 2% of children in the United States. The etiology of ASD likely involves environmental factors triggering physiological abnormalities in genetically sensitive individuals. One of these major physiological abnormalities is mitochondrial dysfunction, which may affect a significant subset of children with ASD. Here we systematically review the literature on human studies of mitochondrial dysfunction related to ASD. Clinical aspects of mitochondrial dysfunction in ASD include unusual neurodevelopmental regression, especially if triggered by an inflammatory event, gastrointestinal symptoms, seizures, motor delays, fatigue and lethargy. Traditional biomarkers of mitochondrial disease are widely reported to be abnormal in ASD, but appear non-specific. Newer biomarkers include buccal cell enzymology, biomarkers of fatty acid metabolism, non-mitochondrial enzyme function, apoptosis markers and mitochondrial antibodies. Many genetic abnormalities are associated with mitochondrial dysfunction in ASD, including chromosomal abnormalities, mitochondrial DNA mutations and large-scale deletions, and mutations in both mitochondrial and non-mitochondrial nuclear genes. Mitochondrial dysfunction has been described in immune and buccal cells, fibroblasts, muscle and gastrointestinal tissue and the brains of individuals with ASD. Several environmental factors, including toxicants, microbiome metabolites and an oxidized microenvironment are shown to modulate mitochondrial function in ASD tissues. Investigations of treatments for mitochondrial dysfunction in ASD are promising but preliminary. The etiology of mitochondrial dysfunction and how to define it in ASD is currently unclear. However, preliminary evidence suggests that the mitochondria may be a fruitful target for treatment and prevention of ASD. Further research is needed to better understand the role of mitochondrial dysfunction in the pathophysiology of ASD.


Bad Bacteria in Mom's Gut as Autism Trigger

Open refrigeratorThe latest study being blasted around the internet has a focus on pregnant mom’s gut, or her diet, and how it could cause her child to “get autism”, as the different articles seem to imply.  

Mom’s Gut Microbiome May Impact Kids’ Autism Risk 

….An unhealthy microbiome in the mother can make her unborn offspring susceptible to neurodevelopmental disorders. The researchers found that the IL-17a molecule was a key contributor to the development of autism-like symptoms in lab mice.

The good news is that the microbiome can be easily changed, either through diet, probiotic supplements or fecal transplant. All of these approaches seek to restore a healthy equilibrium among the different microorganisms that live in the gut.

“In terms of translating our work to humans, I think the next big step would be to identify features of the microbiome in pregnant mothers that correlate with autism risk,” Lukens said. “I think the really important thing is to figure out what kind of things can be used to modulate the microbiome in the mother as effectively and safely as we can.”

Blocking IL-17a also might offer a way to prevent autism, but it carries much more risk.

“If you think about pregnancy, the body is basically accepting foreign tissue, which is a baby,” said Lukens. “As a result, maintenance of embryonic health demands a complex balance of immune regulation, so people tend to shy away from manipulating the immune system during pregnancy.”.....

But, isn’t vaccinating, manipulating the immune system?  We will discuss that more.

Now some may say, when will researchers finally stop blaming mothers for autism?  Since the days of Refrigerator Mothers,  mothers have had blame thrust upon them when it comes to a diagnosis of autism.  Now, it is important to look at the ways a child’s microbiome may become dysfunctional and spiral into autism but is this idea of mom’s gut a true contributor?  Some may say it’s a way to distract from the “environmental” sources of immune dysfunction we seem to be catapulted into these days.  Let’s take a look.

Continue reading "Bad Bacteria in Mom's Gut as Autism Trigger" »


The Thoughts of Chairman Aaronovitch

AaronovitchBy John Stone

David Aaronovitch, recent chair of Index on Censorship, Orwell prize winner and Murdoch poodle (or possibly running dog) writing in the London Times wants to stop people saying things he does not like - so perhaps he will not like this article.

The problem with vaccines, is the more you are not allowed to talk about them the more dangerous they will certainly get. You can be fed lots of reassuring information by the surrogates of the people who manufacture them (the health agencies and mainstream journalists) but until ordinary citizens are listened to you will simply be engaged in an ugly strategy of social repression. It is not good enough to tell people when they have been hurt - or worse when their beloved children have been - that the agencies who did the hurting deny it. But for Aaronovitch the products are not mere fallible industrial products, they are simply beyond public criticism. 

If anybody is expressing unreasonable faith it is he. If he thinks they are safe, what body of science is he citing, and where are the independent agencies? In the UK the licensing agencies are funded by the industry (the MHRA 100%, the EMA 89%), the chair of the vaccine recommendation committee (the JCVI) is director Oxford Vaccine Group which is commercially involved in developing many of the vaccines the committee recommends. These are all perfectly acceptable arrangements to a mainstream media in advanced decline, and no doubt to our lion of free speech.

In his latest article ‘Conspiracy theorists make monkeys of us all’ (The Times 5 July 2018)  Aaronovitch employs all the old bad songs: people who doubt vaccine safety are unscientific and equivalent to those who doubt the theory of evolution; people who doubt vaccine safety are unpleasant right-wing types; people who opposed vaccine mandates in Italy (which incidentally we do not have in the United Kingdom) have caused measles to rise – when he might have focussed on government-pharmaceutical sleaze as the prime cause of their mistrust: the meeting at which Obama put Italian Health Minister Beatrice Lorenzin in charge of global vaccine strategy, the secret deals she signed with GlaxoSmithKline. They probably also knew that she had made up fairy stories about 270 measles deaths among children in London. This was what last year the tens of thousands of people who filled the streets in Italy knew about, unreported by the Italian and global mainstream media, unreported almost certainly in the London Times – just to make them look like idiots. In these circumstances conspiracy was scarcely a theory. Oh yes, and to cap it all they are all “conspiracy theorists”.

Continue reading "The Thoughts of Chairman Aaronovitch" »


Record Cases Of Scarlet Fever In The UK -- Is the Nasal Flu Vaccine Responsible Part IV

Scarlet-fever-quarantine

Part One

Part Two

Part Three

We’ve looked at media reports on SCARLET FEVER in the UK, the use of the nasal influenza vaccine in those locations, and research that shows there are biological mechanisms that could connect the two.  What may need to happen is laboratory research to look specifically at these connections in an honest and scientific manner.

In the United States, there are some considerations to this situation:

Firstly, the CDC does not track SCARLET FEVER:

Image found here  and our thanks.

Scarlet IV

Secondly, the use of FluMist was stopped for two years but is set to resume in Fall, 2018.

ACIP votes down use of LAIV for 2016-2017 flu season, June 22, 2016

CDC panel again advises against FluMist (2017-2018), Wed June 21, 2017

ACIP: LAIV OK to Use During 2018-19 Flu Season, February 26, 2018 03:59 pm

Thirdly, FluMist will NOT be the first and only choice but an option, and it was NEVER administered in schools as it is in the UK.

AAP: Give children IIV flu shot; use LAIV as last resort,  May 21, 2018 : The Academy recommends pediatricians give children inactivated influenza vaccine in the upcoming season and use live attenuated vaccine only as a last resort….Quadrivalent live attenuated influenza vaccine (LAIV4, FluMist), which is given by intranasal spray to healthy patients ages 2 through 49 years, was a popular option for those reluctant to get a shot. While it performed relatively well against influenza B strains, there was modest effectiveness against A/H3N2 strains and no overall effectiveness against A/H1N1 strains. LAIV4 has not been recommended by the AAP and CDC for the past two influenza seasons.

Continue reading "Record Cases Of Scarlet Fever In The UK -- Is the Nasal Flu Vaccine Responsible Part IV" »


Record Cases Of Scarlet Fever In The UK -- Is the Nasal Flu Vaccine Responsible Part III

Scarlet-fever-quarantineIn Part I , we took a look at news articles and data on the increase of scarlet fever in the UK, whilst adding in articles that showed that the LAIV (Live Attenuated Influenza Vaccine) aka the nasal flu shot, has been steadily increased in the UK, in the same time period.

Is it possible that the nasal flu vaccine could somehow result in scarlet fever?  Let’s take a look at research for any connections.

Probably the first fact that needs to be illustrated is -  Influenza infections increase host susceptibility to bacterial infections in a variety of ways

: Viral infections of the upper respiratory tract are associated with a variety of invasive diseases caused by Streptococcus pyogenes, the group A streptococcus…..

With influenza, the one we hear about often is pneumonia.  In 1918, that seems to have been the pattern, that bacteria, not flu, killed millions . Back to scarlet fever.  When penicillin was discovered, the cases and death numbers fell and kept falling. Scarlet fever develops from the organism, S pyogenes, which is classified as a Group A beta-hemolytic streptococcal (GABHS) infection. "Thus, as in the cases of S. pneumoniae and S. aureus, S. pyogenes acts synergistically with influenza viruses and possibly other respiratory viruses in causing secondary bacterial infections. Enhanced adherence and internalization of S. pyogenes to host cells in the presence of influenza virus infection may explain the synergism. 94,95,96

Any form of S. pyogenes infection may potentially lead to systemic manifestations due to release of toxins or superantigens. Scarlet fever typically follows an episode of upper respiratory tract infection,"

Vintage scarlet fever

Vintage illustration online here and our thanks.

Evidence

The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles, December 2015 

Continue reading "Record Cases Of Scarlet Fever In The UK -- Is the Nasal Flu Vaccine Responsible Part III" »


Autism and PANDAS: Parents Knew It and Science Now Shows It

Science post imageBy Theresa Conrick

For years now, parents of children on the autism spectrum have been on the internet and social media sharing their stories.  Many, like me, have had horror stories of their child being sick too often and then abrupt and bizarre behaviors would appear. Strep throat was often a trigger for us.  ---- The strep infection triggers a misdirected immune response causing inflammation within the basal ganglia, a portion of the brain responsible for speech, involuntary movement (tics) and emotion. This inflammation causes an abrupt onset of neurologic and psychiatric symptoms including OCD, tics, anxiety, emotional lability, urinary frequency and sleep disturbances.

While strep is the initial trigger, PANDAS patients can have recurrent symptom exacerbations (flares) later in the disease when exposed to other (non-strep) infections.

We are not crazy.  What we have been living is real and our children are very ill.

Fresh research from my favorite group studying PANS and PANDAS in autism, has their study completed -  and an abstract published - Anti-neuronal and anti-microbial immunity link CaMKII and autism spectrum disorder with pediatric acute-onset neuropsychiatric syndrome .  The full study will be out in late Fall as I had emailed Dr. Cunningham.  She is an awesome researcher and a very compassionate person. She shared that she is involved in similar research, Human anti-dopamine receptor 1 monoclonal autoantibody (mAb) identifies potential mechanisms of neuronal signaling in post-infectious autoimmune-mediated neuropsychiatric disease, and as a result, the full papers are coming out later.  Let’s take a look at the highlights of the asd abstract:

♦  Autism spectrum disorders (ASD) may be associated with neuropsychiatric symptoms such as tics, obsessive-compulsive behaviors, and other symptoms characteristic of pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS).

♦  Functional anti-neuronal autoantibodies which signal CaMKII and induce excess dopamine release were found in ASD/PANDAS serum.

♦  Interestingly, a CamKII mutation has recently been associated with autistic symptoms in animal models and also in ASD in humans. https://www.ncbi.nlm.nih.gov/pubmed/28130356

♦   Children with ASD/PANDAS had significantly elevated anti-neuronal autoantibodies by ELISA, and strong IgG responses against the group A streptococcal epitope GlcNAc were observed in ASD/PANDAS.

Continue reading "Autism and PANDAS: Parents Knew It and Science Now Shows It" »


New Study Links Lowered Probability of Pregnancy in Females 25 - 29 to HPV Vaccination

Empty cribHere is an addendum to this post from the study author, Gayle Delong, PhD:

In connection with my paper, the question has been raised: Given that married women who had the HPV shot were less likely to conceive than those who did not receive the shot, were the former more likely to use birth control than the latter? My result that married women who received the shot were less likely to conceive could be explained if those women were more actively trying to prevent pregnancy than married women who did not receive the shot.

The three questions on NHANES that provide insights into contraception are 1) SXQ251: In the past 12 months, how often had you had sex without a condom? 2) RHD442: Are you taking birth control pills now? 3) RHQ520: Are you now using Depo-Provera or injectables to prevent pregnancy?

I seek to determine whether married women who received the HPV shot are more actively seeking to prevent pregnancy than married women who did not receive the shot. I define “actively seeking to prevent pregnancy” as women who at the time of the interview were using condoms at least half the time or taking the birth control pill or receiving an injectable. I find 51.5% of married women who did not receive the shot and 36.6% of married women who received the shot were actively seeking to prevent pregnancy. The 14.9% difference is statistically significant at the 1% level.

This finding suggests that a greater percentage of married women who received the shot should be conceiving compared with married women who did not receive the shot. However, my original study finds that married women who received the shot are less likely to conceive than married women who did not receive the shot. The finding of my original study is not the result of married women who received the HPV vaccine actively avoiding pregnancy more than women who did not receive the HPV shot. I’m happy to discuss details of my results with researchers who are interested.

A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papilloma vaccine injection

Journal of Toxicology and Environmental Health, Part A, DOI: 10.1080/15287394.2018.1477640

ABSTRACT Birth rates in the United States have recently fallen. Birth rates per 1000 females aged 25–29 fell from 118 in 2007 to 105 in 2015. One factor may involve the vaccination against the human papillomavirus (HPV). Shortly after the vaccine was licensed, several reports of recipients experiencing primary ovarian failure emerged. This study analyzed information gathered in National Health and Nutrition Examination Survey, which represented 8 million 25-to-29-year-old women residing in the United States between 2007 and 2014. Approximately 60% of women who did not receive the HPV vaccine had been pregnant at least once, whereas only 35% of women who were exposed to the vaccine had conceived. For married women, 75% who did not receive the shot were found to conceive, while only 50% who received the vaccine had ever been pregnant. Using logistic regression to analyze the data, the probability of having been pregnant was estimated for females who received an HPV vaccine compared with females who did not receive the shot. Results suggest that females who received the HPV shot were less likely to have ever been pregnant than women in the same age group who did not receive the shot. If 100% of females in this study had received the HPV vaccine, data suggest the number of women having ever conceived would have fallen by 2 million. Further study into the influence of HPV vaccine on fertility is thus warranted.

Gayle DeLong, PhD, is an Associate Professor of Economics and Finance in the Bert W. Wasserman Department of Economics and Finance at Baruch’s Zicklin School of Business. Dr. DeLong has published in leading journals, including Journal of FinanceJournal of Financial EconomicsJournal of International Money and FinanceFinancial Management, and Journal of Financial Research. Research interests include bank acquisitions, regulatory capture, and conflicts of interest. DeLong, the 2013 recipient of the Abraham J. Briloff Prize in Ethics as well as the 2010 recipient of the Zicklin School of Business Teaching Excellence Award, holds a PhD in finance and international business from New York University.

Citation:  Gayle DeLong (2018): A lowered probability of pregnancy in females in the USA aged 25–29 who received a human papillomavirus vaccine injection, Journal of Toxicology and Environmental Health, Part A, DOI: 10.1080/15287394.2018.1477640


Baby Teeth and Autism Prediction

Copper zincSince the number of children being diagnosed with autism continues to increase, the research and studies continue to grow as well.  Many overlap or years later, they are taken to the next level as our understanding of the science increases.  This is such a study. 

From the adapted version on Medpage - Baby Teeth May Predict Autism - Zinc and copper metabolism biomarker may lead to new diagnostic tools

Zinc and copper metabolism cycles in the layers of baby teeth may be able to predict which children will develop autism spectrum disorder, a longitudinal analysis suggests.

This is the first study to generate a 90% accurate fetal and early childhood biomarker of autism by tracking metabolic pathways over time and could lead to new diagnostic tools...the researchers found that children who later developed autism had disrupted zinc-copper rhythmicity in utero or in their earliest months of life...We looked at the naturally shed teeth of children and explored them much as you would explore the growth rings of a tree, using them as a sort of retrospective biomarker to see what children were exposed to in the womb and in early life...Prenatal and newborn children form a new tooth layer daily, which captures an imprint of chemicals circulating in the body and produces a chronological exposure record. Zinc and copper pathways are central regulators of multiple metals; disruption of the pathways may have downstream effects that may affect the metabolism of other essential elements and toxic metals.

TOXIC METALS.  We don’t see those words enough but there are dozens and dozens of studies showing that environmental toxins are connected to the spectrum of autism.

Here is some very good research on the issues of copper/zinc in the human body .

Important theme from the above new, autism study.  Mercury has become a dirty word in autism research. Also that study seems pretty much targeted as a diagnostic tool.   There are thousands of children and young adults who would benefit from research dealing with helping them feel and function better.  Let’s hope there will be more about that. But here we can see that the issue of copper and zinc is not new in autism.  The idea of “disrupted zinc-copper rhythmicity” is new and helpful but let’s look backwards as well:

The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders, May 2009  

The frequency of zinc deficiency, copper toxicity and low zinc/copper in children with autism spectrum disorders (ASDs) may indicate decrement in metallothionein system functioning....The plasma zinc/serum copper ratio may be a biomarker of heavy metal, particularly mercury, toxicity in children with ASDs.

Continue reading "Baby Teeth and Autism Prediction" »


Study: Increased Rates of Cervical Cancer in Sweden Linked to Increase in HPV Vaccinations

HPV-test-alone-OK-cervical-cancer-screening-1440x810(Please see addendum)

Study: Increased Rates of Cervical Cancer in Sweden Linked to Increase in HPV Vaccinations

 

By Brian Shilhavy
Editor, Health Impact News

A new study published in the Indian Journal of Medical Ethics examined cervical cancer rates among women in Sweden and discovered a link between increased cervical cancer rates among women aged 20-49 during a two-year period between 2014 and 2015, corresponding to increased HPV vaccination rates in this population group, years earlier, when mass HPV vaccinations started in Sweden.

Women above the age of 50, during this two-year period, saw no significant cervical cancer increase and were likely too old to have been vaccinated with the HPV vaccine.

Since the study casts doubt on the efficacy of the HPV vaccine, and, in fact, links the vaccine to increased cancer rates, it is highly unlikely you will read about this in the U.S. corporate-sponsored media, where nothing negative about the blockbuster HPV Gardasil vaccine is allowed.

The study was conducted by Lars Andersson, PhD, from the Department of Physiology and Pharmacology at the Karolinska Institute in Solna, Sweden.

Dr. Andersson states that:

…when the Swedish media discussed the increase in the incidence of cervical cancer, the health authorities were unable to explain the increase.

So Dr. Andersson discussed the possibility that mass HPV vaccination rates actually could be the cause of increased rates of cervical cancer:

HPV vaccination could play a role in the increase in the incidence of cervical cancer. About 25% of cervical cancers have a rapid onset of about three years including progression from normal cells to cancer.

Therefore, an increase may be seen within a short period of time.

Gardasil was approved in Sweden in 2006. In 2010, the vaccination of a substantial number of girls started. In 2010, about 80% of the 12-year-old girls were vaccinated.

Combined with 59% of the 13–18-year-old girls vaccinated through the catch-up programme in the same period, one can say that most girls were vaccinated.

Thus, the oldest girls in the programme were 23 years old in 2015; and this is well within the younger age group shown in Fig. 1.

Dr. Andersson points out that even the FDA’s own analysis of Gardasil in 2006 showed a higher risk of “premalignant cell changes” from the vaccine in certain groups that had already been exposed to some HPV strains:

Read more here.

Addendum

Controversy has arisen around the Indian Journal of Medical Ethics article because the author had submitted under a false name to escape professional persecution. After consideration the the journal's editors decided not to retract the article and made the following statement:-

On May 8, the KI informed us that its department of physiology and pharmacology did not have any person of this name and requested us to remove the name of the institution. So, on the same day a correction was carried out and the name of KI was removed and duly intimated to KI.

Since then, we have investigated and learned the identity of the author. The author has said that he used a pseudonym because he believed the use of his real name would have invited personal repercussions from those opposed to any questioning of vaccines.

This deception of the journal’s editors is unacceptable. The author could have asked the editors for confidentiality, giving the reasons. Editors may choose to publish articles without revealing the true name of the author, if it is determined that the circumstances justify it.

However, we considered the matter and decided to keep the article on the site as the issues raised by it are important and discussion on it is in the public interest. The author’s true name is withheld at his request.

 

 


Large Spanish study finds higher rate of pneumonia in vaccinated group (Pfizer's Prevnar 13)

image from www.pharmandorraonline.comThis  study is based on data from middle aged and elderly people echoes the finding of Mawson et al in their pilot study of health outcomes in children (vaccinated vs. unvaccinated) which found "The vaccinated were less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but more likely to have been diagnosed with pneumonia, otitis media, allergies and NDD".

Evaluating clinical effectiveness of 13-valent pneumococcal conjugate vaccination against pneumonia among middle-aged and older adults in Catalonia: results from the EPIVAC cohort study

 
  • Angel Vila-Corcoles
  • Olga Ochoa-Gondar
  • Cinta de Diego,
  • Eva Satue,
  • María Aragón,
  • Angel Vila-Rovira,
  • Frederic Gomez-Bertomeu,
  • Ramon Magarolas,
  • Enric Figuerola-Massana,
  • Xavier Raga,
  • Mar O. Perez and
  • Frederic Ballester
BMC Infectious Diseases201818:196

https://doi.org/10.1186/s12879-018-3096-7

Received: 18 December 2017

Accepted: 16 April 2018

Published: 27 April 2018

Abstract

Background

Benefits using the 13-valent pneumococcal conjugate vaccine (PCV13) in adults are controversial. This study investigated clinical effectiveness of PCV13 vaccination in preventing hospitalisation from pneumonia among middle-aged and older adults.

Methods

Population-based cohort study involving 2,025,730 individuals ≥50 years in Catalonia, Spain, who were prospectively followed from 01/01/2015 to 31/12/2015. Primary outcomes were hospitalisation for pneumococcal or all-cause pneumonia and death from any cause. Cox regression models were used to evaluate the association between PCV13 vaccination and the risk of each outcome, adjusting for age, sex and major comorbidities/underlying risk conditions.

Results

Cohort members were observed for a total of 1,990,701 person-years, of which 6912 person-years were PCV13 vaccinated. Overall, crude incidence rates (per 100,000 person-years) were 82.8 (95% confidence interval [CI]: 77.7–88.1) for pneumococcal pneumonia, 637.9 (95% CI: 599.0–678.7) for all-cause pneumonia and 2367.2 (95% CI: 2222.8–2518.7) for all-cause death. After multivariable adjustments we found that the PCV13 vaccination did not alter significantly the risk of pneumococcal pneumonia (multivariable-adjusted hazard ratio [mHR]: 1.17; 95% CI: 0.75–1.83; p = 0.493) and all-cause death (mHR: 1.07; 95% CI: 0.97–1.18; p = 0.190), although it remained significantly associated with an increased risk of all-cause pneumonia (mHR: 1.69; 95% CI: 1.48–1.94; p < 0.001). In stratified analyses focused on middle-aged or elderly persons and immunocompromised or immunocompetent subjects, PCV13 vaccination did not appear effective either.

Conclusion

Our data does not support clinical benefits of PCV13 vaccination against pneumonia among adults in Catalonia. It must be closely monitored in future studies involving more vaccinated person-time at-observation.

THE FULL STUDY CAN BE READ HERE

 


Autism Risk Increased through Structural Variants Inherited from Dad

Blame-300x300Note: Well, at least it's not blaming Mom.

A scientific team led by University of California San Diego School of Medicine researchers says it has identified the cause that may explain why some people develop autism—rare inherited variants in regions of paternal noncoding DNA. Previous studies have demonstrated that de novo mutations contribute to approximately one-third of cases of the disorder. 

The current findings (“Paternally Inherited Cis-Regulatory Structural Variants Are Associated with Autism”) are published online in Science.

The newly discovered risk factors differ from known genetic causes of autism in two important ways. First, these variants do not alter the genes directly but instead disrupt the neighboring cis-regulatory elements, or CREs. Second, these variants do not occur as new mutations in children with autism, but instead are inherited from their parents.

"For ten years we've known that the genetic causes of autism consist partly of de novo mutations in the protein sequences of genes" said Jonathan Sebat, Ph.D., a professor of psychiatry, cellular and molecular medicine, and pediatrics at UC San Diego School of Medicine and chief of the Beyster Center for Genomics of Psychiatric Genomics. "However, gene sequences represent only 2% of the genome."  Read more here.


Dr. Paul Offit Blames Parents, Not Vaccines, For Immune System & Infection Concerns

DisgracefulBy Teresa Conrick

I would laugh at the irony if it was not so damn sad and wrong.  Paul Offit, a vaccine-maker, profiteer, and head of infectious disease at CHOP, the hub of vaccine industry central, is now asking how is it that children, who have a diagnosis of autism -- and their siblings, are not fully vaccinated?  For years now, the research is showing that autism spectrum disorder is an IMMUNE disorder , with the GUT affecting the brain , the bacteria of the gut abnormal ,  the bacteria types pathogenic , and also that the bacteria is tied to social impairment .  Vaccination has been implicated in changing the microbiome,  so to blame parents as the reason for their child's increased risk of infections, well, that seems pretty ignorant. The children are at risk of infections as they have a microbiome and immune system that have become dysfunctional, many after their first round of vaccines.  Parents did vaccinate but their child's health and well being took a drastic turn. Here is the information that Offit shared with The Inquirer :

"In March, a journal of the American Medical Association published a study defining a new group of children at risk for serious and potentially fatal infections.....Who was this new group? The answer: children with autism spectrum disorder (ASD) and their younger siblings.... Investigators studied 3,729 children with ASD and compared them with 592,907 children without ASD. For vaccines recommended between 4 and 6 years of age (specifically, diphtheria, tetanus, pertussis, polio, influenza, measles, mumps, rubella, and varicella), children with ASD were significantly less likely to be vaccinated than children without ASD. Their younger siblings were also less likely to be vaccinated.  Why were parents of children with ASD making this choice?  In 1998, British researcher Andrew Wakefield published a study...................."

MMR isn’t the only issue. Some parents have also worried that an ethylmercury-containing preservative called thimerosal, which was commonly used in several vaccines given to young children in the United States...Still, the fears persist. Why? Maybe it’s because the cause or causes of autism haven’t been found and because a cure doesn’t exist."

The study examined children with an asd diagnosis "between ages 4 and 6 years,"  and that would reflect the time that a second MMR is scheduled, and parents have reported seeing their children regress often after their first MMR vaccine or a combination with that vaccine.  Thimerosal, a mercury product, may be another player in microbiome dysfunction because - "Increased mercury levels were detected in stools after vaccination, suggesting that the gastrointestinal tract is involved in ethylmercury elimination , - and this -  "As TM (Thimerosal) exposure during the postnatal phase coincided with lactation, some of the TM was delivered through the milk to the GIT [gastrointestinal tract] and may have had an effect on the developing gut microbiome known to be sensitive to heavy metal exposure. "

Continue reading " Dr. Paul Offit Blames Parents, Not Vaccines, For Immune System & Infection Concerns" »


New Paper Challenges HHS on their Vaccine Aluminum Dosing Safety Numbers

AluminumBy Ginger Taylor

Remember a lifetime ago when we figured out that not only did the US Childhood vaccine schedule dramatically exceeded the Federal government's recommended daily limit for mercury, but that the limit that they had set was likely many times what it should have been in the first place? For those of you who are new to the issue, a review of the matter from my chapter in Vaccine Epidemic:

"In July of 1999, the American Academy of Pediatrics (AAP) and the United States Public Health Service (USPHS) issued a joint statement through the Department of Health and Human Services (HHS) on mercury and vaccines. They stated that in the U.S. vaccine program at the time, “some children could be exposed to a cumulative level of mercury over the first six months of life that exceeds one of the federal guidelines.”

The truth was that the amount of mercury in the childhood vaccine schedule grossly exceeded the Environmental Protection Agency’s (EPA) maximum daily adult exposure for methylmercury, the form of mercury most closely related to thimerosal for which the government had established a guideline. The EPA sets the daily limit at 0.1 microgram per kilogram of weight. Based on that guideline, a baby weighing approximately five kilograms (eleven pounds) at two months of age should not receive more than 0.5 micrograms of mercury on the day of a doctor’s visit. At the time the AAP and USPHS joint statement was issued, infants at their two-month visit routinely received 62.5 micrograms of mercury, or 125 times the EPA’s limit. Studies have suggested that, for thimerosal (ethylmercury), “the accepted reference dose should be lowered to between 0.025 and 0.06 micrograms per kilogram per day,” meaning that the exposure at the two-month visit could be as high as 500—rather than 125—times the safe level."

In fact in 1995, Gilbert and Grant-Webster had recommended that the limit be at least cut in half.

Neurobehavioral Effects of Developmental Methylmercury Exposure

Environmental Health Perspectives 103 Suppl 6(Suppl 6):135-42 · October 1995 with 60 Reads

Steven G Gilbert

34.22University of Washington Seattle

Kimberly S. Grant-Webster

Abstract

Methylmercury (MeHg) is a global environmental problem and is listed by the International Program of Chemical Safety as one of the six most dangerous chemicals in the world's environment. Human exposure to MeHg primarily occurs through the consumption of contaminated food such as fish, although catastrophic exposures due to industrial pollution have occurred. The fetus is particularly sensitive to MeHg exposure and adverse effects on infant development have been associated with levels of exposure that result in few, if any, signs of maternal clinical illness or toxicity. High levels of prenatal exposure in humans result in neurobehavioral effects such as cerebral palsy and severe mental retardation. Prenatal exposure to MeHg in communities with chronic low-level exposure is related to decreased birthweight and early sensorimotor dysfunction such as delayed onset of walking. Neurobehavioral alterations have also been documented in studies with nonhuman primates and rodents. Available information on the developmental neurotoxic effects of MeHg, particularly the neurobehavioral effects, indicates that the fetus and infant are more sensitive to adverse effects of MeHg. It is therefore recommended that pregnant women and women of childbearing age be strongly advised to limit their exposure to potential sources of MeHg. Based on results from human and animal studies on the developmental neurotoxic effects of methylmercury, the accepted reference dose should be lowered to 0.025 to 0.06 MeHg microgram/kg/day. Continued research on the neurotoxic effects associated with low level developmental exposure is needed.

HHS never undertook any review, or made any adjustments.

Well everything old is new again. Drs. Lyons-Weiler and Ricketson have reviewed the dosing of aluminum in the US vaccine program, to find that not only is there a lot of it, and not only does it exceed daily limits, but yet again, the daily limits are not based on sound safety data.

Reconsideration of the immunotherapeutic pediatric safe dose levels of aluminum 

Journal of Trace Elements in Medicine and Biology Toxicology

Volume 48, July 2018, Pages 67-73
Authors James Lyons-Weiler, Robert Ricketson


Highlights
• Aluminum levels in vaccine is based on immune efficacy and ignore body weight for safety.

• Several critical mistakes have been made in the consideration of pediatric dosing of aluminum in vaccines.

• Safety inferences of vaccine doses of aluminum have relied solely on dietary exposure studies of adult mice and rats.

• On Day 1 of life, infants receive 17 times more aluminum than would be allowed if doses were adjusted per body weight.

Continue reading "New Paper Challenges HHS on their Vaccine Aluminum Dosing Safety Numbers" »


Evidence of Increase in Mortality After DPT

Front. Public Health, 19 March 2018 | https://doi.org/10.3389/fpubh.2018.00079

Evidence of Increase in Mortality After the Introduction of Diphtheria–Tetanus–Pertussis Vaccine to Children Aged 6–35 Months in Guinea-Bissau: A Time for Reflection?

imagePeter Aaby1,2*, imageSøren Wengel Mogensen1imageAmabelia Rodrigues1 and imageChristine S. Benn2,3
  • 1Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau
  • 2Research Centre for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark
  • 3OPEN, Institute of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark

Background: Whole-cell diphtheria–tetanus–pertussis (DTP) and oral polio vaccine (OPV) were introduced to children in Guinea-Bissau in 1981. We previously reported that DTP in the target age group from 3 to 5 months of age was associated with higher overall mortality. DTP and OPV were also given to older children and in this study we tested the effect on mortality in children aged 6–35 months.

Methods: In the 1980s, the suburb Bandim in the capital of Guinea-Bissau was followed with demographic surveillance and tri-monthly weighing sessions for children under 3 years of age. From June 1981, routine vaccinations were offered at the weighing sessions. We calculated mortality hazard ratio (HR) for DTP-vaccinated and DTP-unvaccinated children aged 6–35 months using Cox proportional hazard models. Including this study, the introduction of DTP vaccine and child mortality has been studied in three studies; we made a meta-estimate of these studies.

Results: At the first weighing session after the introduction of vaccines, 6–35-month-old children who received DTP vaccination had better weight-for-age z-scores (WAZ) than children who did not receive DTP; one unit increase in WAZ was associated with an odds ratio of 1.32 (95% CI = 1.13–1.55) for receiving DTP vaccination. Though lower mortality compared with not being DTP-vaccinated was, therefore, expected, DTP vaccination was associated with a non-significant trend in the opposite direction, the HR being 2.22 (0.82–6.04) adjusted for WAZ. In a sensitivity analysis, including all children weighed at least once before the vaccination program started, DTP (±OPV) as the most recent vaccination compared with live vaccines or no vaccine was associated with a HR of 1.89 (1.00–3.55). In the three studies of the introduction of DTP in rural and urban Guinea-Bissau, DTP-vaccinated children had an HR of 2.14 (1.42–3.23) compared to DTP-unvaccinated children; this effect was separately significant for girls [HR = 2.60 (1.57–4.32)], but not for boys [HR = 1.71 (0.99–2.93)] (test for interaction p = 0.27).

Conclusion: Although having better nutritional status and being protected against three infections, 6–35 months old DTP-vaccinated children tended to have higher mortality than DTP-unvaccinated children. All studies of the introduction of DTP have found increased overall mortality.

The full article can be read here.

 

 


How A Vaccination Can Cause Polio: Mechanism of Injury-Provoked Poliomyelitis

Polioby Bernadette Pajer

Polio is an enterovirus, and it's not the only enterovirus capable of causing paralysis. Enteroviruses are fairly common, most people who become infected have no or few symptoms. If symptoms develop, they are like a cold or mild flu. One enterovirus that has been in the news lately is called "EV-D68" which can cause polio-like paralysis they call "acute flaccid myelitis (AFM)". CDC acknowledges this.

What turns an asymptomatic or low-symptom harmless enterovirus infection into an ER visit and hospitalization? In 1995, researchers figured out that with the polio enterovirus, it was intramuscular injections within 30 days of being given a live polio vaccine. They were studying cases of "provocation" poliomyelitis following receipt of live polio vaccine.

Like other enteroviruses, 95% of polio infections are asymptomatic or very mild. Polio only very rarely leads to paralysis. Researchers in 1998 stated: "Muscle injury due to injection of vaccines or therapeutic agents is common in medical practice. It has been observed that, if concurrent with PV infection, such injury may increase the risk of neurological complications."

PV is polio virus, but as noted above, other commonly circulated enteroviruses can lead to paralysis.

With children today being given so many intramuscular injections so often throughout childhood, odds are a seemingly well child will actually be infected with (and successfully fighting) an enterovirus when given a round of vaccines.

And with the ACIP dangerously telling pediatricians it's OK to vaccinate mildly ill children, those who have earaches or are on antibiotics, the odds increase that a child infected with an enterovirus will be given a round of vaccines, possibly leading to AFM.

How can this be prevented?

Continue reading "How A Vaccination Can Cause Polio: Mechanism of Injury-Provoked Poliomyelitis" »


Correlation, Causation, Antacids and Allergies in Pediatric Population

Stomach painHow many times have we been told that "correlation does not equal causation" regarding autism and vaccine injury?  Except when it does. American children have been lab rats for more than two decades as  medical interventions have taken over infancy and toddlerhood.  How many babies can not  hold down food and are on antacid meds? WHY ARE BABIES ON ANTACIDS?  All roads lead to the GUT and microbiome.  Funny, wasn't "that doctor" from England a gastroenterologist?  Imagine what his research could have done for children had he not been pilloried by Pharma and governments....

Once vaccines are finally "correlated" pharma is going to have a big ache in their tum Tums......

###

Antacids, antibiotics for infants linked to later allergies

Infants who are given antacids like Zantac or Pepcid are more likely to develop childhood allergies, perhaps because these drugs may alter their gut bacteria, a new large study suggests.

Early use of antibiotics also raised the chances of allergies in the study of nearly 800,000 children.

Researchers combed the health records of kids born between 2001 and 2013 and covered by Tricare, an insurance program for active duty and retired military personnel and their families. A surprising 9 percent of the babies received antacids, reflecting the popularity of treating reflux in infancy. 

Over four years, more than half of all the children developed allergies to foods or medications, rashes, asthma, hay fever or other allergic diseases. The study couldn’t prove causes, but the connection with antacids and antibiotics was striking.For children who received an antacid during their first six months, the chances of developing a food allergy doubled; the chances of developing a severe allergic reaction called anaphylaxis or hay fever were about 50 percent higher. For babies who received antibiotics, the chances doubled for asthma and were at least 50 percent higher for hay fever and anaphylaxis.

The results were published Monday in JAMA Pediatrics.  Read more here.


Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder—A Randomized, Controlled 12-Month Trial

FOOD-AS-MEDICINENote: Food has always been the starting point of health since "an apple a day," and all that. Many of us have found some relief from the symptoms of autism via dietary changes. Some have had life altering successes for their kids. Still others, nothing.  I read the local Mom lists on Facebook and am shocked at how many women suffer from migraines. And then ask where is the best take out XYZ food in the next breath. Below is a study may help you talk to your child's doctor about dietary interventions, or perhaps quell your Mother-In-Law's stink eye at the Passover table.

Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder—A Randomized, Controlled 12-Month Trial

Abstract:

This study involved a randomized, controlled, single-blind 12-month treatment study of a comprehensive nutritional and dietary intervention. Participants were 67 children and adults with autism spectrum disorder (ASD) ages 3–58 years from Arizona and 50 non-sibling neurotypical controls of similar age and gender. Treatment began with a special vitamin/mineral supplement, and additional treatments were added sequentially, including essential fatty acids, Epsom salt baths, carnitine, digestive enzymes, and a healthy gluten-free, casein-free, soy-free (HGCSF) diet. There was a significant improvement in nonverbal intellectual ability in the treatment group compared to the non-treatment group (+6.7 ± 11 IQ points vs. −0.6 ± 11 IQ points, p = 0.009) based on a blinded clinical assessment. Based on semi-blinded assessment, the treatment group, compared to the non-treatment group, had significantly greater improvement in autism symptoms and developmental age. The treatment group had significantly greater increases in EPA, DHA, carnitine, and vitamins A, B2, B5, B6, B12, folic acid, and Coenzyme Q10. The positive results of this study suggest that a comprehensive nutritional and dietary intervention is effective at improving nutritional status, non-verbal IQ, autism symptoms, and other symptoms in most individuals with ASD. Parents reported that the vitamin/mineral supplements, essential fatty acids, and HGCSF diet were the most beneficial.

Conclusions:

The study results suggest that the comprehensive nutrition/diet protocol was safe and effective. The nutritional supplements and healthy diet improved nutritional status, and hence presumably increased the brains ability to function and learn. This is supported by the increase in non-verbal IQ, and the substantial 18-month increase in developmental ability in communication, daily living skills, and social skills. Modest improvements in CARS-2 and SAS-Pro suggest some reduction in autism symptoms, consistent with parent reports of improvements on the PDD-BI, ATEC, and SRS. Parent reports also suggest improvements in aberrant behaviors (ABC—Irritability, Lethargy/Social Withdrawal, Stereotypy, and Hyperactivity), sensory processing (SSP), and GI symptoms (6-GSI, PGI-2, ATEC), and Overall (PGI-2). There was not a significant effect on handgrip strength. The treatment efficacy seemed to be similar for both genders and all ages, probably because nutritional requirements are similar for both genders and all ages (after normalizing for caloric intake).

The three unusual case reports, in which three very different long-term problems were greatly improved, shows the power of comprehensive nutritional interventions in addressing complex, puzzling medical conditions which may involve one or more nutritional deficiencies.
There were many significant increases in vitamins, essential fatty acids, and carnitine, and an improvement in homocysteine. The vitamin/mineral supplement and essential fatty acids appeared to have the most clinical benefit, although other treatments appeared to have some benefit for some individuals. So, this comprehensive treatment approach is recommended as a promising therapy for children and adults with ASD, with an emphasis on the vitamin/mineral supplement and essential fatty acids as probably being the most helpful.
The data also suggests some possible improvements could be made to the treatment combination. Specifically, it appears that l-carnitine may be better absorbed than acetyl-l-carnitine. Also, although many vitamins were well-absorbed, larger doses and/or more bioavailable forms of the other vitamins are needed to have a significant effect on blood levels, and larger doses/absorption may in some cases result in greater therapeutic benefit. So, it seems likely that the current treatment protocol could be further improved by making these changes.
 
 

Minocycline and Autism: This Antibiotic Is Not Just For Acne Anymore

MinoclyclineBy Teresa Conrick

Every week, more and more information is coming out that autism is not, just some spectrum of developmental disability.  Here we see in Newsweek a recent announcement: 

COULD AN ANTIBIOTIC TREAT AUTISM? MEDICATION TO REDUCE BRAIN CELL INFLAMMATION COULD TREAT WIDESPREAD DISORDER 

The beginning of it goes into a strange array of gene talk but then the focus of the article is this---

Some signals associated with a cell type called microglia were far higher in the samples from people with autism than from samples of people with other conditions. This signal may be higher because the microglia are more active. If that’s true, an antibiotic that reduces their activity could be one way to treat the condition—which is what UCLA Health psychiatrist and one of the authors of the study, Dr. Michael Gandal, is testing right now....

He and his colleagues are working to recruit about 30 adults for a brain-imaging study to look at their microglia and take an antibiotic called minocycline for 12 weeks.

“Throughout the 12 weeks, we measure a set of cognitive tasks, and we repeat the brain imaging," he said. "The idea is to look at how levels of inflammation in the brain relate to cognitive and behavioral function in individuals with autism.”

Here is that Clinical Trial -

Autism spectrum disorders (ASD) are highly disabling, persistent neurodevelopmental disorders. There are no available treatments for core symptoms of ASD or biologically-based clinical biomarkers. Emerging evidence indicates that levels of brain inflammation are increased in ASD. In particular, recent work implicates hyperactivity of microglial cells, the resident immune cells of the brain. However, the functional consequences of microglial activation remain unknown. This study will measure microglial activation in ASD using positron emission tomography (PET) brain imaging. Adult males with ASD (n=15) and healthy controls (n=15) will be recruited for this study and undergo comprehensive clinical and behavioral baseline assessment. All subjects will then undergo baseline PET imaging using a radiotracer that labels activated microglia. Subjects with ASD will then undergo 12-week open label treatment with minocycline, an FDA-approved antibiotic thought to block microglial activation. PET imaging will be repeated at 12 weeks to confirm target engagement. A subset of control subjects will also undergo repeat PET imaging to determine test-retest reliability. During minocycline treatment, ASD subjects will be evaluated every 2 weeks for safety, clinical impression, behavioral functioning, and measures of cognition. Results will provide important information regarding the relationship between levels of brain inflammation, cognitive and behavioral function in ASD.

I am hoping that more candidates can join as it looks like almost a year since it's been updated.  Let's take a look at Minocycline and see if we can't get more people excited and involved in this type of research.

It's been about six years since I really started putting a focus on autism and bacterial infections. Because I have a daughter who has a diagnosis of autism and also an autoimmune diagnosis, the immune system has become a key player in my research to help her.  The MICROBIOME research has exploded and its connection to the MICROGLIA of the brain may be a big part in autism spectrum disorders.

There are far too many children and young adults who suffer.  The list of painful and debilitating symptoms grows as parents watch in agony.  Patterns tend to emerge:

CHRONIC VIRAL and BACTERIAL INFECTIONS

Continue reading "Minocycline and Autism: This Antibiotic Is Not Just For Acne Anymore" »


The Putative role of Environmental Aluminium in the Development of Chronic Neuropathology in Adults and Children

AlMetabolic Brain Disease, July 2017

Abstract:


The conceptualisation of autistic spectrum disorder and Alzheimer’s disease has undergone something of a paradigm shift in recent years and rather than being viewed as single illnesses with a unitary pathogenesis and pathophysiology they are increasingly considered to be heterogeneous syndromes with a complex multifactorial aetiopathogenesis, involving a highly complex and diverse combination of genetic, epigenetic and environmental factors. One such environmental factor implicated as a potential cause in both syndromes is aluminium, as an element or as part of a salt, received, for example, in oral form or as an adjuvant. Such administration has the potential to induce pathology via several routes such as provoking dysfunction and/or activation of glial cells which play an indispensable role in the regulation of central nervous system homeostasis and neurodevelopment. Other routes include the generation of oxidative stress, depletion of reduced glutathione, direct and indirect reductions in mitochondrial performance and integrity, and increasing the production of proinflammatory cytokines in both the brain and peripherally. The mechanisms whereby environmental aluminium could contribute to the development of the highly specific pattern of neuropathology seen in Alzheimer’s disease are described. Also detailed are several mechanisms whereby significant quantities of aluminium introduced via immunisation could produce chronic neuropathology in genetically susceptible children. Accordingly, it is recommended that the use of aluminium salts in immunisations should be discontinued and that adults should take steps to minimise their exposure to environmental aluminium.

Conclusion:

Evidence of the neurotoxicity of aluminium cations (Al3+) includes: an association between chronic aluminium exposure and the development of AD; the involvement of aluminium adjuvants in the development of ASIA; and epidemiological evidence pointing to an association between the use of aluminium adjuvants and ASD. There is good evidence to suggest that immunisation may accelerate or precipitate the transition between subclinical and overt symptomatic autoimmune conditions within the first 30 days post-immunisation, particularly in those younger than 50 years of age. The immune response to immunisation may be influenced by variations in HLA, TLR and cytokine genes. Moreover, aluminium exposure is associated with the production of pro-inflammatory cytokines and chemokines and with the development of chronic oxidative stress, mitochondrial dysfunction and glial activation or dysfunction; these changes in turn are associated with ASD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596046/

 


LabCorp Patents Test for Autism

LapCorp patent
Note:  LabCorp has received a patent on a method for diagnosing autism spectrum disorders. 

Abstract:
The invention generally relates to methods for diagnosing autism spectrum disorders. In certain embodiments, the invention provides a method for diagnosing presence or increased risk of developing an autism spectrum disorder in a subject.

Type: Grant
Filed: March 17, 2014
Date of Patent: December 5, 2017
Assignee: Laboratory Corporation of America Holdings
Inventors: David Michael Margulies, Mark Firman Bear

Read about the patent here.

The method, invented by David Michael Margulies and Mark Firman Bear of Massachusetts, involves taking a tissue or body sample from a subject and then conducting a test to identify variant sequences in the subject’s genetic code, which may signify “the presence or an increased risk of developing autism spectrum disorders.” Testing can be done on children and fetuses, according to the patent.

The method is stated to aid in the diagnosis of five autism spectrum disorders, all of which fall under the umbrella of pervasive developmental disorders: autistic disorder, Asperger’s disorder, childhood disintegrative disorder, Rett’s disorder, and nonspecific pervasive developmental disorders.

The method claims to have multiple applications, each of which provides insight into the biological basis of autism spectrum disorders through different lenses.

Continue reading "LabCorp Patents Test for Autism" »


Happy New Year! Hopeful Autism Research and Treatments For 2018

Hope dandelionBy Teresa Conrick

2017 had good and bad attached to it.  For many of us, the death of our dear colleague and friend, Dan Olmsted, has saddened many a day since.....  Dan did much innovative research and writing for years to expose the issues that bring us all here daily. Age of Autism has become a refuge for years now, to so many looking for truth and answers. As we enter 2018, I would like to keep with that tradition by sharing my list of what I think is important and innovative in the science area of autism.  It's imperative that families know that there is good research happening but unfortunately, there's a hell of a lot of bad research about autism, and often we hear about that too much.... especially the mulri-million dollars wasted on genes (have you seen the constant SPARK, pop-up infomercials on Facebook,  a nowhere odyssey of genetic, musical chairs?)  We need real research to help so many who suffer with the many symptoms of autism - painful GI disease; seizures;  inability to speak or communicate in a meaningful manner or, at all; extreme sensory disturbance; executive functioning disability; debilitating obsessions, compulsions and tics; acute anxiety; heartbreaking self-injurious behaviors; and the daily struggles with social cues. Much of this originates in the gut.

                                                                                                      Studies on Causation

♦  Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders 

♦  Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study 

♦  Characterization of the Pediatric Acute-Onset Neuropsychiatric Syndrome Phenotype  

♦  The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism  

♦  Systematic Assessment of Research on Autism Spectrum Disorder (ASD) and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research

Continue reading "Happy New Year! Hopeful Autism Research and Treatments For 2018" »


Journal of Trace Elements in Medicine and Biology: Aluminium in brain tissue in autism "Extraordinarily High"

AluminumNOTE: You might recall that a "freezer malfunction" at Harvard University destroyed one third of the world's largest autistic brain collection.   Can you imagine the information lost?

J.B. Handley has written about this paper at his Medium site - STAFFORDSHIRE, England — Professor Chris Exley is a formidable scientist, which is perhaps more important than you think, because a study he published today with his colleagues in the Journal of Trace Elements in Medicine and Biology may just be the “smoking gun” to prove that vaccines are triggering autism that we’ve all been waiting for. Professor Exley is a Professor of Bioinorganic Chemistry at Keele University in Staffordshire, England. He received a Ph.D. in a subject that makes him highly qualified to author this latest paper: “the ecotoxicology of aluminium.”

Journal of Trace Elements in Medicine and Biology

ABSTRACT

Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. Herein we have used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. We have also used an aluminium-selective fluor to identify aluminium in brain tissue using fluorescence microscopy. The aluminium content of brain tissue in autism was consistently high. The mean (standard deviation) aluminium content across all 5 individuals for each lobe were 3.82(5.42), 2.30(2.00), 2.79(4.05) and 3.82(5.17) μg/g dry wt. for the occipital, frontal, temporal and parietal lobes respectively. These are some of the highest values for aluminium in human brain tissue yet recorded and one has to question why, for example, the aluminium content of the occipital lobe of a 15 year old boy would be 8.74 (11.59) μg/g dry wt.? Aluminium-selective fluorescence microscopy was used to identify aluminium in brain tissue in 10 donors. While aluminium was imaged associated with neurones it appeared to be present intracellularly in microglia-like cells and other inflammatory non-neuronal cells in the meninges, vasculature, grey and white matter. The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissue and may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder.

Read the full study http://www.sciencedirect.com/science/article/pii/S0946672X17308763http://www.sciencedirect.com/science/article/pii/S0946672X17308763

or view the pdf below.

https://ac.els-cdn.com/S0946672X17308763/1-s2.0-S0946672X17308763-main.pdf?_tid=9b9b1d32-d4b1-11e7-bd76-00000aab0f6c&acdnat=1511924674_a4c012cd7c025b60b9995a05ecc34f0a


CONCLUSIONS

We have made the first measurements of aluminium in brain tissue in ASD and we have shown that the brain aluminium content is extraordinarily high. We have identified aluminium in brain tissue as both extracellular and intracellular with the latter involving both neurones and non-neuronal cells. The presence of aluminium in inflammatory cells in the meninges, vasculature, grey and white matter is a standout observation and could implicate aluminium in the aetiology of ASD


James Lyons-Weiler PhD on Biological Mechanisms of Vaccine Injury

JLW graphic
NOTE:  James Lyons-Weiler PhD asked Facebook readers to share this piece from his blog,  because Facebook was feeling cranky toward the topic.  Please bookmark James Lyons-Weiler.com.

Please read the original post for copious graphic backup and the full entry.

WHEN DR. CHRIS EXLEY and his research team discovered aluminum co-localized with amyloid plaques in the brains of patients who died from Alzheimer’s, it made big news, even though a study in 1985 discussed the aluminum silicate portion of amyloid. That’s right. We’ve known since 1985 at least that amyloid plaque in the brain is partly aluminum silicate. Now, Exley’s findings completely destroy any hope that aluminum somehow stayed out of the brain,

Aluminum, it turns out, plays a critical role in our understanding of the biological mechanisms of vaccine injury. In this article, I will review the scientific evidence of four major ways that vaccines can cause harm. These are (1) Vaccine-Induced Mitopathy; (2) Vaccine-Induced Persistent Gliosis; (3) Vaccine-Induced Endoplasmic Reticulum Damage, and (4) Vaccine-Induced Autoimmunity (to appear as a separate article). My intent and purpose is not and has never been to discourage anyone from accepting vaccines, nor to provide medical advice of any kind; rather, my intent is to make a clear path toward safer routes to artificial immunization and communicate the state of scientific knowledge about mechanisms of the pathophysiology of disease caused by vaccines, and how such human pain and suffering can be mitigated.
mitopathy(1) Vaccine-Induced Mitopathy

Individuals born with mitochondrial disorders have partially disable cellular energetics. Mutations that alter proteins in the various specific mitochondrial pathways lead to a variety of congenital conditions, including encephalomyopathy and seizures. We need mitochondria to work in all of our tissues. However, our brains consume so much energy, any weakening of mitochondrial ATP flux will almost certainly lead to neurological disorders.

Environmental damage to mitochondria is known to occur from exposure to lead and includes depletion of mitochondrial membrane potential (ΔΨ) and intracellular glutathione (GSH), elevation of caspase-3 activity, intracellular reactive oxygen species, and malondialdehyde levels, and inhibition of GSH peroxidase (GSH-Px) activity (Liu et al., 2014).

Why discuss lead-induced mitochondrial toxicity in an article on vaccine injury? In part because many individuals familiar with brain injuries and conditions that lead to brain injuries will recognize the critical role of GSH, the importance of shutting down ROS, and the potential use of malondialdehyde as a screen for brain injury following vaccination. Another reason is that 25% of the homes in Pittsburgh have higher lead levels in the water coming into the homes than the levels found in the water in Flint, MI, and individuals with mitochondrial damage due to lead are likely to be a higher risk of the toxic effects from vaccines.

The science of the specific actions and mechanisms of mitochondrial injury from vaccines include some of these events, including recognition of aluminum as an intracellular ROS generator (Han et al., 2013). Aluminum is present in vaccines as an adjuvant in a variety of forms, most commonly aluminum hydroxide (a well-known neurotoxin). Vaccine risk denialists spend a lot of time denying the massive literature on the neurotoxicity of aluminum. Nevertheless, studies show that aluminum also disrupts cytoskeletal dynamics (Lemire et al., 2009).

Thimerosal also has damaging influences on mitochondria, including direct damage to the mitochondrial genome. Sharpe et al. (2012) found that thimerosal induced a five-fold increase in the levels of oxidant damaged mitochondrial DNA bases and increases in the levels of mtDNA nicks and blunt-ended breaks.  Read more here.


Psychotropic Medication use in Autism Spectrum Disorders may Affect Functional Brain Connectivity

Brain colors 2017 Sep;2(6):518-527. doi: 10.1016/j.bpsc.2017.06.008.

Linke AC1, Olson L1,2, Gao Y1,2, Fishman I1, Müller RA1.

Abstract

Background:

Prescription of psychotropic medications is common in autism spectrum disorders (ASDs), either off-label or to treat comorbid conditions such as ADHD or depression. Psychotropic medications are intended to alter brain function. Yet, studies investigating the functional brain organization in ASDs rarely take medication usage into account. This could explain some of the inconsistent findings of atypical brain network connectivity reported in the autism literature.

Methods:

The current study tested whether functional connectivity patterns, as assessed with functional magnetic resonance imaging (fMRI), differed in a cohort of 49 children and adolescents with ASDs based on psychotropic medication status, and in comparison with 50 matched typically developing (TD) participants. Twenty-five participants in the ASD group (51%) reported current psychotropic medication usage, including stimulants, antidepressants, antipsychotics, and anxiolytics. Age, IQ, head motion, and ASD symptom severity did not differ between groups. Whole-brain functional connectivity between 132 regions of interest was assessed.

Results:

Different functional connectivity patterns were identified in the ASD group taking psychotropic medications (ASD-on), as compared to the TD group and the ASD subgroup not using psychotropic medications (ASD-none). The ASD-on group showed distinct underconnectivity between the cerebellum and basal ganglia but cortico-cortical overconnectivity compared to the TD group. Cortical underconnectivity relative to the TD pattern, on the other hand, was pronounced in the ASD-none group.

Conclusions:

These results suggest that psychotropic medications may affect functional connectivity, and that medication status should be taken into consideration when studying brain function in autism.


Invitation to Join Study on Microbiome and Autism from Stanford School of Medicine and Second Genome

Stanford medicineBy Teresa Conrick

Autism Parents and Friends of AoA,

We were asked to see if any parents out there might like to join a study on the MICROBIOME and AUTISM :

Researchers at Stanford University School of Medicine and the South San Francisco pharmaceutical company Second Second genomeGenome Inc. have jointly received a $2.1 million grant to recruit subjects for a study exploring potential links between bacteria in the gut — known as the microbiome — and autism, the company announced Tuesday.

Researchers have long suspected, based on anecdotal evidence, that there may be a link between the microbiome and the severity of an autism diagnosis. There is limited data demonstrating the link in humans, but some studies indicate it may exist in lab mice.

Many children with autism have food allergies or gut conditions such as inflammatory bowel diseases, leading researchers to hypothesize that activity in the gut has a relationship to autism, said Dennis Wall, an associate professor of pediatrics at Stanford who is co-leading the study. With the new grant from the National Institutes of Health, the researchers will attempt to test that theory, so doctors can better diagnose and design therapies for people on the autism spectrum.

 Here are the details - (uploading a video is optional)

We are looking for 100 families with two or more children, where:

  1. One child has a medical diagnosis of autism spectrum disorder and is between 2-7 years old,
  2. And another child without an autism diagnosis, who is no more than two years apart in age of the first child.

The study procedures include responding to an online behavioral and dietary survey, uploading a 3-minute home video, and collecting stool and saliva samples at home for each child. Everything is completed either online or in the home. 

Would you be willing to send out this study information to your email listserv and/or post on your social media platforms (Facebook, Twitter, etc)? We only need 40 more families to participate and we are so excited to start analyzing the data! 

Please see our most recent press release on SF Chronicle here, a KQED press release, our recruitment flyer attached, and our study website to sign up now! If you have any questions, please don’t hesitate to ask.

Kindly,

The M3 Team

From Teresa:

I just want to add that Stanford is also making progress on PANDAS and PANS, in fact they do research on that as well  and actually have a team of experts and immune therapies .  But when you look at the AUTISM clinic there , it is dismal and archaic and has very little to do with the immune system, although we know that for many autism patients with moderate to severe symptoms, the immune system is key, as we see in this study, Pediatric autoimmune neuropsychiatric syndrome (PANS), developmental regression and autism.

Continue reading "Invitation to Join Study on Microbiome and Autism from Stanford School of Medicine and Second Genome" »


Win a Copy of Vaccines A Reappraisal By Dr. Richard Moskowitz, MD

Vaccines Richard Moskowitz“This book is a masterpiece and a must-read for anyone with concerns about the safety and efficacy of vaccines.”

—Stephanie Seneff, PhD, senior research scientist, MIT

Leave a comment and enter to win a copy. New from Skyhorse Publishing.  Buy now!

Richard Moskowitz, MD, is a family physician who received his BA from Harvard, Phi Beta Kappa, his MD from New York University, and a US Steel Fellowship in Philosophy at the University of Colorado. He has been in private practice since 1967. After studying herbs, Japanese acupuncture, and other holistic modalities, he has specialized in homeopathic medicine since 1974, and has written four previous books and over a hundred articles on homeopathy, midwifery, natural healing, and the philosophy of medicine. He resides in Boston, Massachusetts.

An experienced family doctor reexamines the risks and benefits of vaccines and our public health policy.

Dr. Richard Moskowitz, a Harvard-educated family doctor with more than forty-five years of clinical experience treating children, examines vaccines and our current policy regarding them. His book Vaccines (Skyhorse Publishing hardcover; September 19, 2017; $27.99) offers an ensemble of observed facts, clinical and basic science research, news reports from the media, and actual cases from his practice, Dr. Moskowitz provides an overview of the subject in a respectful and thoughtfully reasoned manner.

He shows how vaccines, by their very nature, have a major downside that has largely been ignored and is built into their design, and explores how it is reckless to continue mandating them until their dangers are taken seriously, understood in a broader context, and assessed in a more careful and systematic fashion.

He also presents evidence that the risks of vaccination are compounded by the concerted efforts of pharmaceutical companies, the CDC, and the doctors who speak for them to keep them hidden. Writing with a sense of urgency, Dr. Moskowitz advocates for making vaccines optional, while the country seems to be moving in the opposite direction. He believes that parents should be able to exercise their moral and legal right to choose which treatments are appropriate for their children, and which diseases, if any, to vaccinate their children against. Above all, he hopes to promote a healthy debate and to encourage more of the rigorous scientific work that still needs to be done.




CDC Issues a Gag Order on CDC Employees

Gag_Order_WideBy Ginger Taylor

Axios has obtained an internal message from the CDC's public affairs officer, Jeffrey Lancashire, dated August 31, to all CDC employees.  His directive to them was to stop talking to the media, “even for a simple data-related question.”

CDC cracks down on communications with reporters

The memo reads:

"Effective immediately and until further notice, any and all correspondence with any member of the news media, regardless of the nature of the inquiry, must be cleared through CDC's Atlanta Communications Office. This correspondence includes everything from formal interview requests to the most basic of data requests."

Axios tried to contact Mr. Lancashire to find out more about the policy; however, he has not responded.

Why is even basic data being treated like state secrets?

It's almost like the CDC has something to hide.

UPDATE:

BREAKING:

THIS JUST IN:

CDC HAS RELEASED A VIDEO EXPLAINING TO THE PUBLIC WHY THEIR NEW STANCE IS NECESSARY:

 


Risk Of ASD 20% Higher For Child If Mother Has Flu Vaccine In First Trimester

Dice no yes maybeNot even Kaiser Permanente have been able to completely fudge the association between the vaccine and autism in this study, after exchanges with Brian Hooker and Donzelli et al. Here is the abstract:-

JAMA Pediatr. 2017 Jan 2;171(1):e163609. doi: 10.1001/jamapediatrics.2016.3609. Epub 2017 Jan 2.

Association Between Influenza Infection and Vaccination During Pregnancy and Risk of Autism Spectrum Disorder.

Zerbo O1, Qian Y1, Yoshida C1, Fireman BH1, Klein NP1, Croen LA1.

Author information

Abstract

Importance:

Maternal infections and fever during pregnancy are associated with increased risk for autism spectrum disorders (ASDs). To our knowledge, no study has investigated the association between influenza vaccination during pregnancy and ASD.

Objective:

To investigate the association between influenza infection and vaccination during pregnancy and ASD risk.

Design, Setting, and Participants:

This cohort study included 196 929 children born at Kaiser Permanente Northern California from January 1, 2000 to December 31, 2010, at a gestational age of at least 24 weeks.

Exposures:

Data on maternal influenza infection and vaccination from conception date to delivery date, obtained from Kaiser Permanente Northern California inpatient and outpatient databases. Influenza infection was defined by the International Classification of Diseases, Ninth Revision, Clinical Modification codes or positive influenza laboratory test results.

Continue reading "Risk Of ASD 20% Higher For Child If Mother Has Flu Vaccine In First Trimester" »


Autism, Learn To Live With It.

White-flagNOTE: Seems like since Mrs. Wright's death last year, Autism Speaks has changed its mission from "It's time to listen," to "It's time to give up." What a sin. Let's live with autism. Cancer. Alzheimers. Diabetes. MD. Raise money and live with it. Disgusting in the extreme.

By Ginger Taylor, MS

Just saw a new Autism Speaks commercial. The message...

"Learn to live with it."

I kid you not. 

(Let's just skip past the horrid imagery of a child with autism on a boat in the water with no supervision for the sake of time and trauma.)

For the few people who don't see a problem with this or understand why so many of us are so angry, please contrast compare two possible positions here.  The first has been espoused by our community for more than a decade, the second is espoused by Autism Speaks.

1. Autism is preventable and medically treatable.

2. Autism, learn to live with it.

The first is accurate and appropriate, as there are medical treatments for people diagnosed with autism that will alleviate the symptoms of autism (some of which are life threatening...  re: children in a boat in the water with no supervision). This will make their lives better without them having to spend hours and weeks and years combating a terribly debilitating condition. If there is medical treatment available for a debilitating condition, is ethical to tell people that there is medical treatment available for their debilitating condition.

Continue reading "Autism, Learn To Live With It." »


Autism Research Institute Presents Research Updates: Immunological Issues in ASD - Gestational Influences, with Dr. Judy Van de Water

ARI 50Autism Research Institute is presenting a Webinar tomorrow, 4/12 titled:  Immunological Issues in ASD - Gestational Influences. Register here. From ARI:

Join Judy Van de Water, PhD to learn about gestational influences on neurodevelopment.

Dr. Van de Water joined the faculty in the Department of Internal Medicine at the University of California, Davis in 1999. In 2000, she also joined the faculty of the newly formed UC Davis M.I.N.D. Institute when she began her research on the immunobiology of autism. Dr. Van de Water’s laboratory pursues research programs pertaining to autoimmune and clinical immune-based disorders including the biological aspects of autism spectrum disorders. The application of Dr. Van de Water’s immunopathology background has been instrumental in the dissection of the immune anomalies noted in some individuals with autism, and in the differentiation of various autism behavioral phenotypes at a biological level. Most notable of these is the investigation of the maternal immune system as it relates to autism spectrum disorders, with particular emphasis on the presence of highly specific maternal autoantibodies to fetal brain proteins.

Continue reading "Autism Research Institute Presents Research Updates: Immunological Issues in ASD - Gestational Influences, with Dr. Judy Van de Water" »


Safeminds Presents an Interview with Autistic Autism Advocate James Williams

Listen to usNOTE: We're pleased to share this interview from our sponsor Safeminds. While many of our own children can not self-advocate, and the term has become tarnished by many in the Neurodiversity movement, it's important and we welcome those with autism who can help our kids to do so. Thanks, Lisa Wiederlight of Safeminds and James. Please visit the Safeminds site here.

###

An Interview with James Williams, Autistic Advocate, SafeMinds Communications Committee Member

Last year, SafeMinds Executive Director Lisa Wiederlight, had the privilege of interviewing James Williams, a 27 year-old man with autism. James is a bright, highly-intelligent advocate for and representative of the autism community. The text of the interview follows.

Please tell us about yourself, and provide some information on your background.

I am an adult with autism, age 27, who has lived with autism all of my life. Though my official diagnosis of autism was at the age of three, in 1991, I was filmed extensively as an infant as part of a research project to showcase "normal" child development, and this footage has revealed that my autism emerged at birth.

My diagnosis at the age of three was the product of two things--an "explosion" of autism symptoms that increased at 18-months that included a digression of language, and my parent's belief that my digression was a product of the "terrible two's," a belief that had to be discarded when I turned three and the behavior did not change.

I underwent many therapies and interventions growing up--physical therapy, occupational therapy, theraplay, auditory integration training, and speech therapy--you name it, I had it, with two notable exceptions--ABA therapy and psychotropic drugs. My parents did not believe in ABA or drugs, and refused to give me such interventions.

After a highly-successful early intervention where I regained full language, I began my presenting career at the age of 11, answering questions after a presentation by parent advocate Annabel Stehli that was organized by auditory therapist Terrie Silverman. This led to a full-time career as a traveling presenter that I continue today. I am also the author of three books, Out to Get Jack, The H.A.L. Experiment, When Gary Comes to Play. I have served on the leadership team for Camp R.O.C.K.S., a summer camp for individuals with autism, from 2007 to 2012, and also a professional musician who plays the recorder.

Continue reading "Safeminds Presents an Interview with Autistic Autism Advocate James Williams" »