By Teresa Conrick
Stroke Alters Gut Microbiome, Impacting Recovery - What About Vaccine Injury and Autism?
Yes, it just keeps coming. Our good friend Birgit Calhoun, a fellow truth-seeker here at Age of Autism, sent this study to us as she too, is keeping tabs on the Microbiome and Autism. Thank you so much, Birgit. Let's take a look:
A bidirectional link between the brain and the gut can improve or worsen brain injury in mice, researchers report.
Scientists are finding increasing evidence that the stomach and the brain are linked via microbes and the immune system. Researchers from the Ludwig Maximilian University of Munich in Germany have found that inducing strokes in mice altered the animals’ gut microbiota, triggering an immune response that traveled back to the brain and worsened the severity of the lesions. When the researchers transplanted fecal bacteria from healthy mice into germ-free rodents that had suffered strokes, the latter animals made a better recovery than mice that didn’t receive the healthy bacteria, the researchers reported this week (July 12) in The Journal of Neuroscience .
Research has shown that ischemic strokes produce an inflammatory response in the brain, which activates lymphocytes—particularly T cells. Depending on their fate, these T cells can help or worsen the brain’s recovery. Accumulating evidence now suggests that microbes in the gut can influence immune activity in the brain via the so-called “gut-brain axis.” Anrather and colleagues published a study in March [ "antibiotic-induced alterations in the intestinal flora reduce ischemic brain injury in mice, an effect transmissible by fecal transplants." ] showing that antibiotic-induced changes in gut microbiota affected the outcome of stroke, but the opposite effect—how stroke impacts the gut microbiome—had not been investigated until now.
To find out, the researchers transplanted fecal microbiota from mice that had suffered strokes into the guts of germ-free mice, and then induced strokes in the latter group of animals. The animals that received transplanted microbiota from the brain-injured mice had significantly larger stroke infarct volumes compared with mice that received sham transplants, the researchers found. In addition, the mice that received transplants from the post-stroke mice also had higher expression of the inflammatory T cells Th1 and Th17. When the researchers fluorescently labeled immune tissue in the intestines of mice after the animals suffered strokes, they found that T cells in the animals’ guts migrated to the brain two to three days after the stroke, where they exacerbated the brain injury.
To see whether gut microbiota could limit brain damage from stroke, Liesz’s team performed fecal transplants from healthy mice into animals that had just suffered strokes, which resulted in smaller brain lesions, the researchers found. This finding was linked with an increase in the number of regulatory T cells, which help protect the brain from injury.
Stroke (brain injury) traveled negatively to the gut MICROBIOME by altering bacteria >> Then the altered bacteria triggered an adverse immune response back to the brain (worsening the stroke) >> Then healthy fecal bacteria transplanted into the gut gives better recovery (healthy bacteria replacing unhealthy bacteria)>> Mice with no fecal transplant did not have as good of a recovery.
This line of research is so important for AUTISM as so many have suffered vaccine reactions with developmental regression and now it is reported that up to 90 percent of autistic children also suffer gastrointestinal disturbances ( ie. GUT MICROBIOTA).
The conclusion from the researchers -- "These findings highlight the key role of microbiota as a potential therapeutic target to protect brain function after injury."
My conclusion --These MICROBIOME connections are shining a much needed light on the plight of thousands.
Teresa Conrick is Contributing Editor for Age of Autism.