What Was That B?
Dear Tough Nuts and Old Timers, below is a Vitamin B study summary from the Safeminds site. ...due to the risk of peripheral neuropathy at high doses, medical supervision is essential... That sentence made me laugh. Can you imagine asking your (non-organic) garden variety pediatrician about vitamin doses and getting anything other than, a blank stare followed by "buy a multivitamin?"
Vitamin B was a rock star back in the prehistoric autism treatment days (early 2000s.) My daughter used Dr. Derrick Lonsdale's TTFD - high dose Vitamin B1 Thiamine - in his first clinical trials. It came in a suppository and made my beautiful 6 year old daughter smell like a skunk. There was a multi-B supplement we all used from a company whose name I can not recall. Anyone remember? I can't. Guess I too need vitamins. It smelled and tasted.... like B vitamins. Awful. I'm sure I have the brand in a notebook buried in my autism "Save this forever in case someday..." but I just don't have it in me to go look.
Vitamin B is back in the news for autism. Much like gut issues. And we roll our eyes knowing that the Defeat Autism Now! structure had all of this in its sights for so many years. Until.... defeating autism became a sin. I will always be pissed about this. Feel free to join me.
From Safeminds.
A new British study has found that high-dose Vitamin B6 supplementation may improve sensory hyperreactivity and motor control issues in individuals with sensory over-responsivity by altering the brain’s excitation-inhibition (E-I) balance. This improvement is achieved by increasing the inhibitory GABA levels and reducing excitatory glutamate levels, as demonstrated in both animal models and human participants. In contrast, the study discovered that Vitamin B12 showed no such benefits, suggesting that the effects are specific to Vitamin B6. This research also highlighted potential improvements in postural control and coordination, indicating that Vitamin B6 could be particularly beneficial for addressing motor issues often accompanying sensory hyperreactivity. Given that sensory over-responsivity is common in conditions such as autism, ADHD, and anxiety, these findings suggest a wide potential application. However, due to the risk of peripheral neuropathy at high doses, medical supervision is essential, and further studies are necessary to determine the optimal dose and ensure long-term safety.
Okay; I don't think vitamin B 6, and magnesium can over come certain foods.
He has been depressed today. He doesn't come across as sad, but mad, and mad cause I dared talk to him,. Then just to aggravate him I went in and out of the house, making noise opening and closing the door.
Two days ago he went to Hardees instead of coming home to eat. So, I don't think the vitamins can over come the big fluffy gluten bun.
Histamines? Immune system?
Gluten? Riimland was sure right about that one.
Posted by: Benedetta | September 26, 2024 at 08:52 PM
Yeah, too soon.
Banging in the kitchen, closing the doors, some woman on the TV has him covering his ears, and chit chat for the rest of the family we get to hear complaints it is bothering his peace and attention to something.
But they gave it a month, so will we.
Posted by: Benedetta | September 23, 2024 at 07:49 PM
It might be too soon to say; two days on B6 P5P type 100mg, and magnesium.
He seemed to me for a change not mad and wanting silence. Give me prayers cause he is driving us all nuts.
Posted by: Benedetta | September 21, 2024 at 12:24 PM
Ohhhh, I did not know that . Thanks Kathy Sincere that is very useful. What ever Bernard Rimeland thought was/is gold!
I was looking on line last night for one of the seizure meds that both of my kids were taking. I could not remember the name, but as I looked down the list to my surprise one of the seizure med is B6. Did you know that? I sure did not!
Posted by: Benedetta | September 20, 2024 at 11:39 AM
Dr. Bernard Rimland thought B6 and magnesium was the bees knees:)
https://www.ariconference.com/ari/newsletter/014/page3.pdf
https://www.organicbakerymiami.com/single-post/2017/03/24/dr-bernard-rimland-and-vitamin-b-6-for-autism
Kirkman makes a wonderful P-5-P with Magnesium.
Posted by: Kathy Sincere | September 19, 2024 at 10:12 PM
Nonnymouse; So should magnesium, do you think needs to not be taken with B6, or added when taking B6?
Posted by: Benedetta | September 19, 2024 at 12:08 PM
Thank you Visitor., and Nonnymouse; I think I have lost my edge on reading. I could not find it anywhere. above . I have become like a lot of us when we read Kennedy Jr's book - I need audio.
PD I was thinking surely not Parkinson disease. Well that is my son, big, strong and no endurance.
I also thank you Nonnymouse, and Emma on your thoughts about B6
I ordered some P5P, I have a good vitamin B complex. Maybe I will give him extra B6 for just a week? Look it all over at the end of the week and decide what to do.
And if anyone thinks you will get help with the medical doctors in monitoring B 6 , well it ain't going to happen for at least. I am not the only one in this boat.
Posted by: Benedetta | September 19, 2024 at 11:32 AM
B6 deficiency causes peripheral neuropathy. So does excess B6. How can too much of something cause same problem as too little? Because standard B6 is synthetic, has to be activated in body to P5P. Too much of it will block its own activation pathway, creating in effect, a B6 deficiency. Supplements using the P5P form (as found in food) are not known to cause this, so are arguably much safer to use at high doses / long term. Situation is not unlike the folic acid / folate problem, or the vitamin D2 / D3 problem, or the beta-carotene / vitamin A, or the cyanocobalamin / active B12 problem… the chemical forms really do matter!
Posted by: Emma | September 19, 2024 at 04:03 AM
Benedetta,
PD = Postural Disorder
Children with Postural Disorder (PD) demonstrate poor core strength and decreased endurance. Thus they are weak, have low endurance, and often exhibit poor balance. They tend to move inefficiently and have poor body awareness.
Posted by: visitor IH | September 18, 2024 at 09:11 AM
The initials PD in the study stand for Postural Disorder.
Posted by: Nonnymouse | September 18, 2024 at 02:50 AM
* Taking large doses of Vitamin B-6 can cause nerve damage. Serious deficiency of same can cause nerve damage. (Good example of "moderation in all things: -- in this case, B-6.)
* Taking only one of the B vitamins is not a very good idea. They all work together in a variety of ways. Taking a modest amount of all them -- as a multi-B supplement -- with a meal of some sort should demonstrate a benefit after a week or so. If no clear benefit, at least the B vitamins are water-soluble and should wash out of the system.
* To some extent, Vitamin B-6 can act as a "stand in" or "trade" for magnesium. One of its many functions. Not a good idea to count of this very much, of course.
* Store them in the proverbial cool dark place. At least one of them is sensitive to light, and one is sensitive to heat.
* Some of the B vitamins as co-enzymes -- just some examples:
Thiamine pyrophosphate --
pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase (also called α-ketoglutarate dehydrogenase)
branched-chain α-keto acid dehydrogenase
2-hydroxyphytanoyl-CoA lyase
Riboflavin, two major coenzymes --
flavin mononucleotide (FMN; also known as riboflavin-5'-phosphate)
flavin adenine dinucleotide (FAD)
. . . and so on
Posted by: Nonnymouse | September 18, 2024 at 02:45 AM
Pyridoxine 5′-phosphate oxidase is the active form of B6.
Some people need the active form.
Study had three different dosages, high middle, and low.
The middle dose had the best results.
What was the middle dosage?
They mentioned 100 mg. Is that the dosage?
They said one of the SOR -- sensory - over load response is what I am calling it, and one of the sensory over load was noise bothers them.
Posted by: Benedetta | September 17, 2024 at 11:26 AM
I also wished they had said the entire total of their study.
IT says 300, but they have greater numbers in the studies - and it was studies than this, when it came to controls.
They used test to decide who had sensory problems.
They used different dosages of B6.
They discussed how it increases the calming GABA .
Posted by: Benedetta | September 17, 2024 at 11:15 AM
Help?
I can't find what (PD) stands for in this study.
I wish that up at the top under right under the title that science papers would list the word they are going to use as acronyms then I don't have to search around.
Posted by: Benedetta | September 17, 2024 at 11:10 AM
ATE into Pharma profits Darn it!
Posted by: Karalyn Kylesmom | September 16, 2024 at 06:46 PM
We used these wonderful liquid vitamins and fish oil and later vitamin B lollipops.
I miss DAN drs so much ! It made such a difference .
It was like this golden time where people ignored us so we could get the care we needed. I went to the green our vaccines rally. No one hated on us. John Kerry was open to this. John Edwards , by the same rally, listened to me and seemed to actually care. There was a study in Marin that showed the lower vax happening there led to lower autism. So someone empowered Pan to cause 100% compliance before that proof are into Pharma profits and Pharma hubris.
Posted by: Karalyn Kykesmom | September 16, 2024 at 06:44 PM
We really have no choice on who to vote for if you reason it out at all. Thank God for RFK Jr. Thank God for Peggy too.
.
These things need to be pointed out to those wanting our votes NOW, cause right now they are listening. Later it is harder to get our points across.
So, now is the time to speak our concerns.
JFK Jr is going to push the point that AUTISM is NOT GENETIC. That is a big point cause Americans as a whole thinks it is genetic, and not the environmental.
There is a danger though in this too. There is plenty of things the NIH can blame in the environment while slipping out of the vaccine noose for another 20 years. I don't think we have 20 years as a human race.
JFK Jr. is an environmentalist, and it makes him open to lies that evil people can throw out, as well as the truths. We all have faced this. He is an environmentalist for people, not like some Earth/nature worshipper, like the average American. He is also like a lot of us, he can be easily lead away from the problem of vaccines by looking at so many other things. The lies are good, and it all makes it rather hard to discern the truth.
Example of what I mean would be back in the 70s and 80s when environmentalists inside the government made war on very safe, heavy, noble gases used in air conditioning (really they were against the production of plastics). They did this by falsely claiming it was getting to the very outer limits of the earth's atmosphere, and causing the two holes in the ozone at the poles to enlarge - during the winter. It takes sunlight to make ozone. They made us think holes - all over the sky too.
Then it was carbon dioxide for heaven sakes. What a fake scare there, and they were able to lead even some one as smart as J.B. Handley down that path, along with so many others. It was all so the tyrants could set a trap for the control of the whole human race. Never mind that plants need carbon-- I will stop on my rant there.
The production of something that makes frogs turn from male to female is out there, but like the noble gases being too heavy to get into the upper regions of space, are these chemical really that widespread? It has been claimed they are. Lots gets claimed as we can see.
It is kind of like polar bears, there was a claim that polar bears were becoming an endangered species in the North Pole, but really the populations of polar bears were doing great. How are the masses of humans to really know the truth since most of us are not living in the upper north to observe this ourselves.
If we are not careful those in the NIH will get away with causing inflammation through vaccines , through mass vaccination than what can spread much further than the waters out of West Virginia, or out of a train wreck in Ohio . Yes, we locally need protection from such evil, but wide spread, NO.
Meanwhile those that makes vaccines will keep their secret that Inflammation that causes damage to the hypothalamus which can cascade into a million problems of over eating, under eating, all that is involved in messing up hormones that the hypothalamus is responsible for, right on till autism is 1 out of 2 . Game is then over for the human race. Aluminum added to water is also widespread. Most people don't know that food dyes have aluminum, and that is wide spread.
Posted by: Benedetta | September 16, 2024 at 09:47 AM
Back 20 years ago and on going from 10 years ago; I did not get blank stares from the neurologists,; but down right warnings that I could cause great harm to my son by giving him vitamin B6. Even though he was taking Keppra which was known, and even in the packet insert that it just sucks the B6 right up from the body.
Did they test for that? Why no! Not interested at all. Sure let me know and worry me.
Thanks for the study.
He is on to his father and I for talking to loud or banging dishes too much. He says we scared him. Every since the bout with Strep at the end of 2019 just on-going anxiety. I wonder if I should start back with extra B 6.
Posted by: Benedetta | September 16, 2024 at 08:56 AM