This article from SafeMinds reminded me of my 9th grade biology class.  "The Mitochondria - the powerhouse of the cell." It also reminded me that I was on the mitochondrial trail TWENTY ONE YEARS AGO for my 3 daughters. We saw Dr. Marvin Natowicz (he was wonderful) at The Cleveland Clinic in 2003. I'm looking at my pediatric log as I type.  All three of my daughters tested with abnormalities that couldn't be defined or correlated to any syndrome at the time. Anyone remember the Autism Treatment Network of major teaching hospitals that were going to investigate gut, sleep and mito issues in autism, to come up with treatments?  It fell flatter than cat under a Mack truck. The website still exists - gathering cobwebs since 2005. And get a load of who sponsored it - CAN - ha!  Gobbled up and spit (or pooped) out by Autism Speaks. We can NOT even use the CURE word any longer.  What the hell happened  in 20 years?   And here were all are.... still tired of waiting for treatment.

March 18, 2024

Identifying Vulnerable Children Early to Safeguard Mitochondrial Function Could Reduce the Risk of Regression

A team of researchers, including Dr. Richard Frye, has investigated mitochondrial physiology in children with autism spectrum disorder (ASD) and neurodevelopmental regression (NDR), comparing them to those with ASD but without NDR (ASD-NoNDR) and typically developing (TD) siblings. By utilizing peripheral blood mononuclear cells (PBMCs), mitochondrial respiration was measured under physiological stress conditions by exposing participants to 2,3-dimethoxy-1,4-napthoquinone (DMNQ), which can have the same effects on the body as suffering from an illness or seizure. Results indicate that ASD-NDR children exhibit higher respiratory rates and increased sensitivity to stress compared to TD and ASD-NoNDR children, consistent with a cellular model of NDR. Notably, parents of ASD-NDR children show similar mitochondrial patterns to their offspring, suggesting a potential heritable or environmental influence. The authors believe their findings underscore the importance of early identification of ASD-NDR children and targeted interventions to protect mitochondrial function, potentially mitigating the risk of NDR. Moreover, their study highlights the need for clinical screening of ASD-NDR patients for mitochondrial dysfunction.

Original Study

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