What Could Possibly Go Wrong? British Government & World Economic Forum plan to replace clinical trials with AI projections
Project led by the Medicines and Healthcare products Regulatory Agency (MHRA)
Project name: Using High-fidelity Synthetic Data as synthetic control arms and to boost sample sizes in clinical trials
Project grant: £750,387
Clinical trials are a critical part of how new medicines are tested before use in the NHS to improve patient care and wellbeing. In standard clinical trials, patients are either given a treatment or not by random selection. This can be challenging in some health conditions, as random assignment to a control group could deny patients access to treatments that could extend their life or improve symptoms. Many clinical trials also find it difficult to recruit enough patients, particularly those investigating rare diseases.
Recent improvements in computing power have allowed researchers to create artificial patients, with similar health information to real patients in clinical trials. This artificial data could help to ‘boost’ smaller clinical trials, lessening the number of patients needed to be successful. Artificially generated information could also be used to better reflect groups in society that are less well represented in clinical trials, including different age groups and ethnicities.
This project will focus on the use of computer-generated data to help boost small clinical trials, and to see if this can improve the value of these trials. Following this, we will create an entirely artificial control group for a clinical trial. In the future, these approaches could be combined with, or even replace, real patient information. Success in this project could help to change the way clinical trials are performed in common and rare diseases, lowering their cost and improving how new treatments are tested before they are applied in the NHS.
Against a background where the WEF, WHO and the British government propose to have a new “vaccine” ready within 100 days of their expected new pandemic this is presumably how they would model the safety and effectiveness of a product with few or no trial participants. Weep.
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