Note: As the C Vax is rolling out across the world, there are reports of serious snags, including this story from San Diego, California below, where the Moderna vaccine was paused. As a site populated by readers affected by vaccine injury, we take no joy in these reports. Shattered trust and lost health is nothing to gloat over.
We took a look at the dosing instructions for the Moderna version. It's complicated. Where does, and will, human error come into play as more and more "civilians" are recruited to get as many doses into as many people as possible in the shortest amount of time? Do any vaccines simply become inert and benign if administered following incorrect storage or mixing? We know that if the multi-dose Thimerosal preserved flu vaccine is not perfectly shaken, the last doses can have far more than the 25 mcg dose of mercury stated on the label. The Moderna product requires a "gentle swirl." No really, that's the exact term used in the Moderna site. Perhaps James Bond could prepare the product consistently well.... Vaccinators are expected to inspect the solution which should be "white to off-white." Benjamin Moore paint offers more than 150 shades of white. My off white might be your ecru. Fugu is a delicacy when prepared by an expert, otherwise, it's a gamble. Are these vaccines too technically detailed to be expertly dosed in a nation where "About one-third of Americans (global literacy rate: 34%) have Level 2 literacy. ... Half of U.S. adults can't read a book written at the 8th-grade level, according to the OECD. The average American reads at the 7th- to 8th-grade level, according to The Literacy Project."
California pauses Covid-19 shots from one lot of vaccine containing more than 330,000 doses By John Bonifield, CNN Health
Health officials in California are telling medical providers across the state not to administer doses from one lot of Moderna's coronavirus vaccine while they investigate possible severe allergic reactions last week in a number of people who got shots at a community vaccination clinic.
More than 330,000 doses from the lot were distributed to 287 providers across the state from January 5-12. Tens of thousands of doses may have already been administered, but the number of unused doses is unknown, according to Darrel Ng, a spokesperson for the California Department of Public Health.
CDPH said Sunday that fewer than 10 people at a clinic in San Diego who received Covid-19 shots from the lot required medical attention over the span of 24 hours. The state said it was not aware of anyone at any of the other 286 sites who had similar allergic reactions after receiving vaccine from the lot.
California's health department said it recommended pausing the entire lot, noting that there are not immediate replacement doses in addition to what had already been ordered.
"Out of an extreme abundance of caution and also recognizing the extremely limited supply of vaccine, we are recommending that providers use other available vaccine inventory," Dr. Erica Pan, California's state epidemiologist, said in the statement.
Moderna told CNN: "The company is fully cooperating with (the California Department of Public Health) in investigating these reported adverse events. Consistent with the statement from CDPH, at this point Moderna is unaware of comparable adverse events from other vaccination centers which may have administered vaccines from the same lot."
Dr. Paul Offit, director of the Vaccine Education Center at Children's Hospital of Philadelphia, said historically there is no such thing as a bad vaccine lot. Read more here.
Consider 5 key points when preparing to administer Moderna COVID-19 Vaccine:
In preparation for administration, remove the required number of vials from frozen storage and thaw each vial before use:
Thaw in refrigerated conditions between 2° to 8°C (36° to 46°F) for 2 hours and 30 minutes. After thawing, let vial stand at room temperature for 15 minutes before administering.
Alternatively, thaw at room temperature between 15° to 25°C (59° to 77°F) for 1 hour.
After thawing, do not refreeze.
Swirl vial gently after thawing and between each withdrawal. Do not shake. Do not dilute the vaccine.
The Moderna COVID‑19 Vaccine is a white to off-white suspension. It may contain white or translucent product‑related particulates. Visually inspect the Moderna COVID‑19 Vaccine vials for other particulate matter and/or discoloration prior to administration. If either of these conditions exists, the vaccine should not be administered.
Each dose is 0.5 mL.
After the first dose has been withdrawn, the vial should be held between 2° to 25°C (36° to 77°F). Record the date and time for first use on the Moderna COVID‑19 Vaccine vial label. Discard vial after 6 hours. Do not refreeze.