In case you don't have enough worries just yet..... Is there any limit to the lengths "public health" will go to make sure everyone is vaccinated? Has informed consent ever really existed? Could scientific advances in medicine delivery equate to vaccine delivery? Some "speculation" and science on theragrippers below. Not sure if one swallows or snorts a theragripper to land it in the belly. (That is the most bizarre sentence I have ever typed.) Over the teeth and through the gums! Theragrippers are real and there ain't no Tums!
Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged duration are very challenging. Here, we report that GI parasite–inspired active mechanochemical therapeutic grippers, or theragrippers, can reside within the GI tract of live animals for 24 hours by autonomously latching onto the mucosal tissue. We also observe a notable sixfold increase in the elimination half-life using theragripper-mediated delivery of a model analgesic ketorolac tromethamine. These results provide first-in-class evidence that shape-changing and self-latching microdevices enhance the efficacy of extended drug delivery.
Are PCR Tests Secret Vaccines?
Concern is growing that an innovative nanotech device developed at Johns Hopkins University may be used to secretly deliver the COVID19 vaccine to those people who are “vaccine hesitant.” Certainly, the technology is real, but is their any merit to such a claim?
Patrick Smith (November 25, 2020) writing for hub.jhu.edu explains:
“Inspired by a parasitic worm that digs its sharp teeth into its host’s intestines, Johns Hopkins researchers have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body. David Gracias, a professor in the Whiting School of Engineering, and gastroenterologist Florin M. Selaru, director of the Johns Hopkins Inflammatory Bowel Disease Center, led a team of researchers and biomedical engineers that designed and tested shape-changing microdevices that mimic the way the parasitic hookworm affixes itself to an organism’s intestines.”
Johns Hopkins researchers take inspiration from parasitic work for medicine delivery "Theragrippers" are tiny, shape-changing machines that deliver medicine efficiently to the GI tract
...Thousands of theragrippers can be deployed in the GI tract. When the paraffin wax coating on the grippers reaches the temperature inside the body, the devices close autonomously and clamp onto the colonic wall. The closing action causes the tiny, six-pointed devices to dig into the mucosa and remain attached to the colon, where they are retained and release their medicine payloads gradually into the body. Eventually, the theragrippers lose their hold on the tissue and are cleared from the intestine via normal gastrointestinal muscular function.
A theragripper is about the size of a speck of dust. This swab contains dozens of the tiny devices.
Image caption: A theragripper is about the size of a speck of dust. This swab contains dozens of the tiny devices.
Gracias notes advances in the field of biomedical engineering in recent years.
"We have seen the introduction of dynamic, microfabricated smart devices that can be controlled by electrical or chemical signals," he says. "But these grippers are so small that batteries, antennas and other components will not fit on them."
Theragrippers, says Gracias, don't rely on electricity, wireless signals or external controls. "Instead, they operate like small, compressed springs with a temperature-triggered coating on the devices that releases the stored energy autonomously at body temperature."