Here's an interesting Covid twist. There are reports of successful COVID prevention in ferrets via a nasal spray that blocks absorption of the virus. It is a form of a cholesterol called a lipopeptide. Lipo means fat. Like all of us are getting during Covid. To date, and according to reports, the product appears to be inexpensive to manufacture, does not require refrigeration like the vaccines, and has proven successful. In ferrets. With further study and knowledge, could the demonized cholesterol lead us out of COVID? Would you take it?
Inexpensive Nasal Spray Prevents COVID-19 Infection in Ferrets, Shows Promise for Human Trials
A multi-institutional research team has developed a nasal spray that effectively blocks absorption of the SARS-CoV-2 virus in ferrets with direct contact to infected animals, indicating the product could potentially protect against coronavirus disease 2019 (COVID-19) infection. While promising, the researchers say the nasal spray still needs to be tested in humans.
The intranasal spray consists of a lipopeptide, or a cholesterol particle that is linked to a chain of amino acids. This lipopeptide matches the stretch of amino acids in the spike protein of SARS-CoV-2 exactly. The pathogen uses the spike protein to attach to a human airway or lung cell, fusing into the cell wall and injecting its RNA. The lipopeptide in the spray intervenes in this process by attaching itself onto one of the spike’s amino acid chains, thereby preventing viral attachment.
Testing of the intranasal fusion inhibitor lipopeptide spray was conducted by researchers from the Columbia University Medical Center in New York, Erasmus Medical Center in the Netherlands and Cornell University in Ithaca, N.Y.