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Will Flu Shots Exacerbate COVID?

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Note: Below is a Rapid Response from March, 2020 in BMJ (British Medical Journal) that asks a very important question.  Have you seen any official concern, let alone answers, as to whether flu vaccination could increase COVID?

In a world where EVERY move we make is judged upon its possible (no matter  how small) affect on COVID transmissions, should we be seeing the standard flu shot campaigns that are already popping up all over the USA? 

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Rapid Response: Flu shots and the risk of coronavirus infections

John Watkins is right; we need to think beyond containment, but he overlooks the possibility that seasonal flu shots are potential contributors to the current outbreak. (BMJ 2020;398:m810—February 28)….A randomized placebo-controlled trial in children showed that flu shots increased fivefold the risk of acute respiratory infections caused by a group of noninfluenza viruses, including coronaviruses. (Cowling et al, Clin Infect Dis 2012;54:1778) From Table 3, vaccine recipients had 20 noninfluenza virus-positive ARIs and 19 virus-negative ARIs; non-recipients had 3 noninfluenza virus-positive ARIs and 14 virus-negative ARIs. These figures yield an odds ratio of 4.91 (CI 1.04 to8.14).

Such an observation may seem counterintuitive, but it is possible that influenza vaccines alter our immune systems non-specifically to increase susceptibility to other infections; this has been observed with DTP and other vaccines. (Benn et al, Trends in Immunology, May 2013) There are other immune mechanisms that might also explain the observation.

To investigate this possibility, a case-control study is in order as we study and care for the victims of covid-19. Influenza vaccines have become sacred cows in some quarters, but they shouldn’t be.

ALLAN S. CUNNINGHAM 2 March 2020

Comments

David L

Getting sick with the mosquito-borne Zika virus makes people more vulnerable to developing dengue disease later on, and to suffering from more severe symptoms when they do get sick from dengue, finds a new study published online today (Thursday, Aug. 27) in the journal Science.
Its findings confirm earlier suspicions that some antibodies to the Zika virus, which usually serve to protect the body from infection, may actually interact with dengue viruses in ways that can make dengue infection worse. This interaction, known as antibody-dependent enhancement, could make it harder for researchers to design a safe and effective vaccine that protects against Zika without also increasing the risk of dengue. https://www.sciencedaily.com/releases/2020/08/200827141250.htm Immune Enhancement has also been a concern with coronavirus vaccines, explained here by Dr Peter Hotez https://www.c-span.org/video/?c4860972/user-clip-immune-enhancement

@ Ronald - My post contained additional information on whether flu vaccination could increase COVID-19 and 'that influenza vaccines alter our immune systems non-specifically to increase susceptibility to other infections' as mentioned in the article. I also included a new papers finding that brings to light a new safety concern over anti-spike SARS-CoV-2 IgG antibodies discussed in my post and the linked study which needs to be investigated prior to widespread usage of spike-targeting vaccines and convalescent serum, especially with certain groups of the population. The different concern you bring up: Given the possibility of latency, or lag, periods between vaccination and its potential adverse impacts... is a known issue with vaccines and since its a potential problem for a covid-19 vaccine that may be mandatory or even possibly forced https://www.lewrockwell.com/2020/08/no_author/764696-2/ is already being worked on by ICAN (Del Bigtree's nonprofit).

Here is the first part: The NIH and Moderna have rigged the clinical trial of their COVID-19 vaccine, mRNA-1273, to avoid capturing adverse reactions that occur more than 28 days after injecting this experimental vaccine. ICAN’s legal team has filed an emergency petition to stop this unethical conduct. ICAN previously filed a petition to the FDA demanding that this clinical trial include a placebo. The clinical trial for this vaccine was then delayed and when its design was finally issued, it included a placebo. But it appears that NIH and Moderna have decided to play a different game to avoid capturing safety issues that could prevent licensure of their mRNA-1273 vaccine.

Their trick is to only capture adverse reactions that occur more than 28 days after injection if the participant withdraws from the clinical trial. This is nonsensical, since there is little for a participant to withdraw from after getting two doses during the first 28 days of the clinical trial. Once a participant has received both doses, if anything, a participant would have an incentive to remain part of the follow-up check-ups to address any adverse effects. There could be many autoimmune, neurological and chronic health disorders which have a major impact on the quality of life that this experimental vaccine could cause. All of which may only arise more than 28 days after the injection. But yet, as long as the participant does not withdraw from the clinical trial, these will nonsensically be ignored as if they did not occur. This is unethical and renders vacuous any claim of safety for this product based on this trial. Given that efficiency in this trial will be tracked for two years, the only reason to not track safety for this same duration is to avoid detecting safety issues that would prevent licensure. ICAN’s legal team, headed by Aaron Siri, has therefore filed a citizen petition and an emergency stay petition demanding that the clinical trial design for this vaccine be updated to require that all adverse reactions for the entire period of the clinical trial be tracked. These petitions also demand that the number of participants in this trial be increased and that they be tested before and after injection for any T-cells to SARS-CoV-2. ICAN intends to take further legal action if its rational and sensible requests are not met.
https://www.icandecide.org/wp-content/uploads/2020/07/2020_07_20-Final-Filed-Citizen-Petition-and-Cover-Letter.pdf

Grace Green

Benedetta,
Over here in Europe, and your turn is probably just starting in New York, many thousands of people are out on the streets, with placards about the dangers of vaccines, corruption, etc. At last I find I'm not alone, I had no idea so many people had the same views as me. So you're right, there are many fighting our cause.

Benedettal

I forgot but should not have, Dr. William Thompson whistle blower, Zimmerman changing his mind and upset that the vaccine court lawyers are still trying to use his out dated science, Jon Poling; I must not forget his brave stance, and pointing to the mitochondria,
Senator Posey all alone taking Dr. William's papers to Congress and presenting them.

They are all giants, And they stood on other giants; like Senator Dan Burton, Dan Olmsted, Mark Blaxill, Barabara Loe Fisher, Dr. Wakefield, Jenny McCarthy, JB Handley as he handled some doctor on TV. Katie Wright as she sat behind all the liars in these meetings, and rolled her eyes, Kim the Stag Rossi Oh, must not forget Harris Coulter and his book warning us from the very beginning and he co- authored with Barabara Loe Fisher.

It has been a wild, wild, crazy, teeth grinding, finger gripping till they are white kind of ride, and I think it is coming to an end.

Guys; Who have I left out? I am sure that I did?

Recent and wonderful: Del Bigtre,

Colleen Boyle, I probably won't get to see what you look like in orange? But then again I just might.

Benedetta

Carolyn Cassandra
I was thinking maybe, he might be, still holding out hope it was some three D chess?
Then I saw some video clips, and read some article on what Gates had to say.

Warmed my heart. Gates don't like Trump and Trump don't trust vaccines - says Gates. Gates said that and more.

So, I am back to thinking it is a 3 D chess game.

For the last few years, I have had some mighty ups and that is after some really long decades of despair, and being down!

But the last few years I have had: The SPIDERS letter, Nine hours of video tapes with squirming Plotkins (what a lawyer) , Trump's interview on Fox and Friends saying before running for president that vaccines cause autism, and while running for president during the debates what he, Rand Paul, and Ben Carson said about vaccines. Trump going to Florida and sitting down and talking with our vaccine injury/autism leaders, and then him inviting them all to Trump's inauguration ball, The over exposure to the public of Fauci.

I am not going back, I am just not. I believe that people the public is starting to wake up and I am meeting more and more people that don't think I am a crack pot. My friends and family are coming around. That has been so very hard -- alone --- to have your family think of you as that nut.

Mayhem Global

Latest from Paul Offit

“What keeps me up at night is that the first vaccines are going to roll off the assembly line, or gonna roll off first, because they were the easiest to construct and the fastest to mass-produce,” not the most effective or best ones, Children's Hospital of Philadelphia vaccine expert Paul Offit said at a medical press briefing on Monday.

https://www.buzzfeednews.com/article/danvergano/coronavirus-vaccine-h1n1-biden-trump

Ronald N. Kostoff

David L,

"So every vaccine against SARS--CoV-2 should have to prove that is not able to induce possible harmful immunologic effects before going into larger trials and broad usage."

Given the possibility of latency, or lag, periods between vaccination and its potential adverse impacts, how many years would be required to prove what you want?

Bob Moffit

@ Benedetta

"Did you see yesterday's High wire that had David Martin on it, Bob?"

I try my best not to miss Del's weekly show … and I did see Highwire yesterday .. as usual a very informative show. Eagerly awaiting next week's show of hopefully MASSIVE GLOBAL DEMONSTRATION on subject of Covid and vaccines. I know a rally in Albany NY today is being held and hopefully they will have a huge turnout.

The two best people representing our community … DEL AND RFK …. (Kim of AoA and Laura Hayes are very close #3's)

David L

A 2020 US Pentagon study that found that the flu shot increases the risks from coronavirus by 36%. Examining non-influenza viruses specifically, the odds of coronavirus in vaccinated individuals were significantly higher when compared to unvaccinated individuals with an odds ratio (association between an exposure and an outcome) of 1.36. In other words, the vaccinated were 36% more likely to get coronavirus. (and others...) https://childrenshealthdefense.org/news/vaccine-misinformation-flu-shots-equal-health/

There are several other studies showing that the influenza vaccine causes immune impairment. Immune suppression from the influenza vaccine has been observed in human studies, and is supported by findings of reduced CD8+ T cells in vaccinated humans. And these effects have been confirmed in multiple animal studies, using two different types of animals. CD+ T-cells are specific types of immune cells targeting specific types of pathogens. CD8+ T cells are necessary for proper immune function. In the following study by Bodowes, it was found that annual influenza vaccination was associated with a reduction in the number of CD8+ T-cells. Specifically, lower numbers of CD8+T cells will reduce “heterosubtypic immunity” (HI). “Heterosubtypic immunity” refers to immunity to pathogens different from pathogens the immune system has already been exposed to. http://vaccinepapers.org/influenza-vaccine-immune-suppression/
This study found that a poor T cell response was associated with worse Covid-19 disease outcome in male patients, but not in female patients. https://www.nature.com/articles/s41586-020-2700-3

Vaccine-induced disease enhancement has been described in connection with several viral vaccines in animal models and in humans, some discussed in the vaccinepapers link. Here they vaccinated "naive" piglets (those that had never been exposed to flu viruses) against the H1N2 influenza strain and later exposed them to the rare H1N1 virus, which is the virus responsible for the 2009 swine flu pandemic. When the piglets were vaccinated they produced a wide range of antibodies to block the H1N2 virus, but these "cross-reactive" antibodies not only failed to provide protection against the second virus, H1N1, but appeared to actually help the H1N1 virus infiltrate lung tissue and cause more severe symptoms and respiratory system complications such as pneumonia and lung damage. The unvaccinated controls suffered milder pneumonia and fewer other complications. This effect is called Vaccine-Associated Enhanced Respiratory Disease. The researchers found that the antibodies produced in response to H1N2 could not bind to a key region of the H1N1 virus and could therefore neither kill nor neutralize them and stop them binding to cells in the pigs' lungs, and in fact helped the new virus to fuse to lung cells and multiply more readily, through a process the scientists dubbed "fusion enhancing." https://stm.sciencemag.org/content/5/200/200ra114 and https://medicalxpress.com/news/2013-08-vaccination-flu-worse-exposed-strain.html

In conclusion of this new paper, data show that anti-Spike IgG from serum of severely ill COVID-19 patients strongly amplifies pro-inflammatory responses by human macrophages, and can contribute to subsequent endothelial barrier disruption and thrombosis (blood clotting). This may explain the observation that many COVID-19 patients become critically ill around the time of activation of adaptive immune responses. Dutch researchers are reporting that IGG antibody therapies can backfire badly in patients as these would react with the macrophages in the bodies of the infected and accelerate cytokine storms. Anti-SARS-CoV-2 IgG generated from the serum of severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses, they promoted inflammatory cytokines, endothelial barrier disruption, and microvascular thrombosis (blood clotting), which are key phenomenon in severely ill COVID-19 patients that are thought to underlie the pathology. Data demonstrate that anti-Spike IgG immune complexes generated from the serum of severely ill COVID-19 patients induce a strong pro-inflammatory response by (otherwise immunosuppressive) human M2 macrophages, which is characterized by high production of classical cytokine storm mediators such as IL-1 beta;, IL-6, IL-8, and TNF. Further analysis showed that the enhanced macrophage secretion of these cytokines was associated with anti-spike IgG in a dose-dependent manner. These data indicate that anti-Spike IgG from COVID-19 patients has an aberrant glycosylation pattern that makes these antibodies intrinsically more inflammatory than common IgGs by increasing its capacity to induce high amounts of pro-inflammatory cytokines. These findings may not only be valuable to find new ways to treat the most severely ill COVID-19 patients, but may also have implications for the therapeutic use of convalescent serum, for which it may be wise to omit the de-glycosylated IgGs that are present in severely ill patients. https://www.biorxiv.org/content/10.1101/2020.07.13.190140v1 It has been mentioned that this raises the possibility that spike-targeting vaccines may pose hidden risks in people with already higher pro inflammatory macrophages. The demographic will include older people, smokers, or those with chronic inflammation, obesity, type 2 diabetes, cancer, or autoimmune diseases. Evidence supports that these demographic groups can suffer worse outcomes when infected by covid. Also that the Phase 1 studies being conducted for the vaccines on healthy young volunteers will not accurately portray the real safety or effectiveness information regarding the covid vaccines because pro inflammatory macrophages are less prominent in the group. So every vaccine against SARS--CoV-2 should have to prove that is not able to induce possible harmful immunologic effects before going into larger trials and broad usage.

Angus Files

They have Trump doing exactly what Pharma wants unless Trump is going along with the COVID pantomine script until he gets then reverses his position on a vaccine for COVID.l hope.


Pharma For Prison

MMR RIP

Carolyn Cassandra

Bob Moffit you are a gem. But you need to know that Trunp did a bait and switch on us. He pretended to care about vax injury but sold out his first week. His affected person is okay. They have tons of money. Apparently the treatments work. So he doesn’t GAF about us and betrayed all the Dems who switched on this one issue his first week in office.
It is awful because the dem leadership is just as bad except at least they don’t lie and pretend to court us.

Benedetta

I don't think Trump has to do anything, but the hardest thing and that is to make sure our wonderful system is working.

Did you see yesterday's High wire that had David Martin on it, Bob? Did you see the ending?

Bob Moffit

About 400 various vaccine experts … including Hotez and Offit .. have signed a petition WARNING exactly of the possibility any potential COVID vaccine may induce what they say is a KNOWN AS IMMUNE ENHANCEMENT that causes the vaccinated to be at much higher RISK of suffering deadly consequences if after vaccinated they contract COVID.

PLEASE … PRESIDENT TRUMP … STOP ANY AND ALL CONTINUING EFFORTS TO CREATE A COVID VACCINE AT WARP SPEED. THAT COULD BE DIASTEROUS FOR MILLIONS OF PEOPLE SHOULD THE VACCINE ACTUALLY INCREASE THE SERVERITY OF COVID.

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