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WHO "Solidarity" and UK "Recovery" Clinical Trials of Hydroxychloroquine using Potentially Fatal Doses

HDCQBy Meryl Nass, MD

[Editor’s note: It should be noted that Dr Nass’s first objective has been achieved as following the publication of this article the WHO have halted these lethal trials.]


Updates can be found here.

The Solidarity Trial is a WHO-led conglomeration of many national trials of treatments for Covid-19. Per the WHO:

As of 3 June 2020, more than 3500 patients have been recruited in 35 countries, with over 400 hospitals actively recruiting patients. Overall, over 100 countries have joined or expressed an interest in joining the trial, and WHO is actively supporting 60 of them...

The hydroxychloroquine arm of the Solidarity trials restarted enrolling patients June 3, after being halted May 25 by WHO Director-General Dr. Tedros Adhanom Ghebreyesus and the Executive Group of the Solidarity Trial. The hydroxychloroquine (HCQ) arm of the trials had been stopped after publication of the Lancet Surgisphere study, which claimed that patients who received hydroxychloroquine had 35% higher death rates, but the Lancet study was retracted 13 days after publication, as its data turned out to be fabricated.

Below are the drugs being tested in Solidarity:

  • Remdesivir
  • Hydroxychloroquine
  • Lopinavir with Ritonavir
  • Lopinavir with Ritonavir plus Interferon beta-1a.

However, the doses were not specified on WHO's list of the drugs to be trialed, nor were they specified, surprisingly, in WHO's 4 person consultation on chloroquine (CQ) dosing, dated April 8. Instead, the Introduction of the Report of that meeting notes, 

"The chloroquine or hydroxychloroquine schedule selected for the trial includes two oral loading doses (250 mg per tablet CQ or 200 mg per tablet HCQ), then oral twice-daily maintenance doses for ten days. This meeting convened to discuss the appropriateness of the selected doses for the trial."

Last week, I was alerted to the fact that India's ICMR, its official medical research agency, had written to the WHO, telling WHO that the hydroxychloroquine doses being used in the Solidarity trial were 4 times higher than the doses being used in India.  Then I learned that Singapore had been hesitant to participate in the WHO trial due to the hydroxychloroquine dose.  

The UK "Recovery" trial was very similar to, but not part of, the international Solidarity conglomeration of clinical trials.  The Recovery trial ended its HCQ arm on June 4, reporting no benefit. In-hospital mortality of the 1542 patients receiving hydroxychloroquine was 25.7%, or 396 deaths, about 10% higher than those receiving standard care, a non-significant difference.


The Recovery trial Study Protocol notes it is funded in part by the Wellcome Trust and the Bill and Melinda Gates Foundation, and by UK government agencies.  The Protocol provides the doses of hydroxychloroquine used, on page 22.  Twitter users began to notice a dosing problem, with hashtag #Recoverygate. 

The HCQ dosing regimen used in the Recovery trial was 12 tablets during the first 24 hours (800mg initial dose, 800 mg six hours later, 400 mg 6 hrs later, 400 mg 6 hours later), then 400 mg every 12 hours for 9 more days.  This is 2.4 grams during the first 24 hours, and a cumulative dose of 9.2 grams over 10 days.

Even more disturbing than this, babies weighing 5 kg could be given a dose of 300 mg HCQ in the first 24 hours in the Recovery trial, which is 233 mg of the base, nearly 4 times the recommended maximum.

The quote from the WHO report on dosing, provided 4 paragraphs ago, seems to be deliberately vague regarding the dose used in the Solidarity trial, stating the number of milligrams per tablet, but not the number of tablets to be used.  The trial is registered but the registration fails to specify dosages.

The registration of the Canadian portion of the Solidarity trial informs us of its HCQ dose: ten 200 mg tablets during the first 24 hours (800 mg initial dose, 800 mg 12 hours later then 400 mg every 12 hours for 9 more days).  This is 2.0 grams during the first 24 hours, and a cumulative dose of 8.8 grams over 10 days, or only 0.4 grams less than what Recovery used. The Norwegian Solidarity trial uses dosing identical to Canada.

Co-Principal Investigators of the Recovery trial, Drs. Peter Horby and Martin Landray, said they followed the WHO dosing. This is what their trial document says as well, on page 23. Landray also claimed in an interview with Paris Soir that the maximum allowed HCQ dose was "6 or 10 times" the dose used in Recovery, and that he was using the hydroxychloroquine dose that is used for amebic dysentery.  However, the accepted use for HCQ in amebiasis is only for a liver abscess and only then in pregnancy, when other drugs cannot be used.  That dose is 600 mg per day for 2 days, then 300 mg per day, considerably less than half the Recovery dose.  Co-Principal Investigator Peter Horby said that Paris Soir misinterpreted Landray's comments, but Paris Soir said Landray had confirmed what he told them in an email prior to publication.  Landray is a very busy man, too busy, apparently, to look up the proper dose of a drug he gave to over 1500 subjects, who were randomized to the treatment and had no say in the matter.

We know that in Brazil, both a high HCQ dose and a low HCQ dose were trialed, and by April 17 the high dose arm was stopped prematurely due to an excess of deaths.  The high dose arm used 600 mg HCQ twice daily for ten days, with cumulative dose of 12 grams. EKG changes typical of toxicity were seen in 25% of high dose subjects. The low dose trial continues in Brazil.

How is the drug hydroxychloroquine normally used?  For chronic daily use in systemic lupus erythematosus or rheumatoid arthritis, patients receive between 200 and 400 mg daily, or a maximum of 5 mg/kg.  In acute Q fever, 600 mg daily may be given at the start of treatment. For acute attacks of malaria, 2,000 mg may be given over 3 days.  Professor Didier Raoult's group in Marseille used 600 mg daily for up to ten days in 1061 Covid-19 patients, and reported 8 deaths, a mortality rate of 0.75%, all over 74 years of age.  The mortality rate reported by Landray and Horby in the Recovery trial is 34 times higher.

We know from WHO's March 13 Informal consultation on the potential role of chloroquine that the Gates Foundation had been studying the drug's complex pharmacokinetics, and of the 25 participants at this meeting, 5 were from the Gates Foundation.  

The only treatment dose mentioned in the March 13 Informal consultation report was in a paragraph about preventive doses.  It said, "Higher doses would be considered for treatment, i.e., 10mg/kg base, followed by 5mg/kg twice daily for seven days." 

What is the "base"?  A 200 mg dose of hydroxychloroquine contains 155 mg "base" drug.

The typical 70 kg person would, if this suggestion were followed, receive 700 mg base, or 900 mg total of hydroxychloroquine as a loading dose, then 450 mg twice daily. Generally, a loading dose refers only to a high first dose, not to several high additional doses.

What is a toxic dose?  All experts agree. "... chloroquine has a small toxic to therapeutic margin," according to Goldfrank's Toxicologic Emergencies.  The drug is very safe when used correctly, but not a lot more can potentially kill.  Prof. Nicholas White, a Wellcome Trust Principal Research Fellow and expert in malaria treatment, who attended both WHO consultations on the chloroquines, has confirmed this.  Careful monitoring of electrolyte levels and an EKG can prevent most problems.

The WHO hired a consultant to explore the toxicity of hydroxychloroquine in 1979. The consultant, H. Weniger, looked at 335 episodes of adult poisoning by chloroquine drugs.  Weniger on page 5 notes that a single dose of 1.5-2 grams of hydroxychloroquine base "may be fatal.

The Recovery trial used 1.86 grams hydroxychloroquine base (equal to 2400 mg of hydroxychloroquine) in the first 24 hours for treatment of already very ill, hospitalized Covid-19 patients, a potentially lethal dose.  The Canadian and Norwegian trials used 2,000 mg of HCQ, or 1.55 grams of HCQ base in the first 24 hours. Each trial gave patients a cumulative dose during the first 24 hours that, when given as a single dose, has been documented to be lethal. (The drug's half-life is about a month, so the cumulative amount is important.)  

The doses used in these trials are not recommended for therapy of any medical condition, which I confirmed with Goodman and Gilman's Pharmacology textbook, the drug's US label, and the online subscription medical encyclopedia UptoDate

Excessive, dangerous HCQ dosing continues to be used in WHO's Solidarity trials. These trials are not, in fact, testing the benefits of HCQ on Covid-19, but rather are testing whether patients survive toxic, non-therapeutic doses.

The WHO Solidarity trials, in order to rapidly enroll patients and spare clinicians a lot of paperwork, collect only limited information on side effects.  No information has yet been provided regarding causes of death in the completed hydroxychloroquine arm of the Recovery trial, in which 396 patients died, and may never be.  

The Solidarity trial design being employed by WHO obscures whether mortality is due to drug toxicity (in which case, one would expect cause of death to be due to an arrhythmia, neuropsychiatric effects, or hypoglycemia) as opposed to death due to Covid-19.

In fact, the lack of safety data being collected is downright scary.  Here is a description of the data obtained on patients enrolled in Solidarity, as reported in Science magazine:

The participant has to sign an informed consent form that is scanned and sent to WHO electronically. After the physician states which drugs are available at his or her hospital, the website will randomize the patient to one of the drugs available or to the local standard care for COVID-19. 

“After that, no more measurements or documentation are required,” says Ana Maria Henao Restrepo, a medical officer at WHO’s Emergencies Programme. Physicians will record the day the patient left the hospital or died, the duration of the hospital stay, and whether the patient required oxygen or ventilation, she says. “That’s all.”

The WHO report of its meeting on chloroquine dosing states,

"Although the preponderance of opinion tilted towards a reasonable benefit risk profile for the intervention, there was some scepticism about what was considered a ‘minimalistic safety data collection’ currently included in the protocol." 

The high dose regimen being used in these trials has no medical justification.  The trial design, with its limited collection of safety data, makes it difficult or impossible to identify toxic drug effects, compared to a standard drug trial.  This is completely unethical.

Excessive dosing makes it impossible to assess therapeutic benefit, if any, of HCQ.

Giving the drug only to hospitalized patients means that the window of time during which HCQ would be expected to provide the most benefit, early in the illness when viral titers are rising, has passed.

Didier Raoult's group has recently published on the major differences in treatment and outcomes patients receive when placed in "big data" studies vs. receiving individualized care for Covid-19.

As I was completing this article, the FDA announced it was withdrawing its Emergency Use Authorization for hydroxychloroquine in Covid-19, because the "known and potential benefits" no longer outweigh the risks of the drug. The FDA cited data from the Recovery trial in its announcement.

To sum up:

  1. In the UK Recovery trial, and in WHO Solidarity trials, HCQ is used in a non-therapeutic, toxic and potentially lethal dose.
  2. HCQ is furthermore being given, in clinical trials, too late in the disease course to determine its value against SARS-CoV-2.
  3. Collection of limited safety data in the Solidarity trials serves to protect trial investigators and sponsors from disclosures of expected adverse drug effects, including death.
  4. It appears that WHO has tried to hide information on the hydroxychloroquine doses used in its Solidarity trial.  Fortunately, the information is discoverable from registries of its national trials.
  5. The conclusions to be drawn are frightening:

  6.  a)  WHO and other national health agencies, universities and charities have conducted large clinical trials that were designed so hydroxychloroquine would fail to show benefit in the treatment of Covid-19, perhaps to advantage much more expensive competitors and vaccines in development.

  7.  b)  In so doing, these agencies and charities have de facto conspired to increase the number of deaths in these trials.

  8.  c)   In so doing, they have conspired to deprive billions of people from potentially benefiting from a safe and inexpensive drug, when used properly, during a major pandemic.  This might contribute to prolongation of the pandemic, massive economic losses and many increased cases and deaths. 

Comments

Flea

Nice work. Note that despite the excessive doses in the RECOVERY trial, the authors reported:

"The primary concern with short-term high dose 4-aminoquinoline regimens is cardiovascular toxicity. Hydroxychloroquine causes predictable prolongation of the electrocardiograph QT interval that is exacerbated by co-administration with azithromycin, as widely prescribed in COVID-19 treatment. Although torsade de pointes has been described, serious cardiovascular toxicity has been reported very rarely despite the high prevalence of cardiovascular disease in hospitalized patients, the common occurrence of myocarditis in COVID-19, and the extensive use of hydroxychloroquine and azithromycin together."

[...]

"We did not observe excess mortality in the first 2 days of treatment with hydroxychloroquine, the time when early effects of dose-dependent toxicity might be expected. Furthermore, the preliminary data presented here did not show any excess in ventricular tachycardia (including torsade de pointes) or ventricular fibrillation in the hydroxychloroquine arm."

So either it is CYA or the fears for cardio problems with HCL are exaggerated as a result of the usual internal political animus in the sheople press.

kat sheetz RN BSN

Many years ago...Canadian rats were fed the sweetener saccharine which had been used by diabetics for many years (without reports of Adverse Events). Equivalent Dosing of the Saccharine given to the rats was WAY ABOVE what humans were already consuming on a regular basis...The rats developed cancer in statistically significant amounts....interesting to notice that shortly thereafter Aspartame came on the market.

It sounds good to use higher doses possibly to find the maximum harm level but then should it not be tittered down from there to find the most efficacious AND safe dose.

FTM ALWAYS... [Follow The Money]

Jonathan Rose

And here's the latest on hydroxychloroquine, which does work when administered properly:

https://sharylattkisson.com/2020/07/breaking-hydroxychloroquine-lowers-covid-19-death-rate-study-finds/

Angus Files


Pharma using political science to take out non vaccine treatments..

Dr. Nesheiwat on WHO shutting doing hydroxychloroquine trials

https://www.youtube.com/watch?v=P1ZGcs0cBvY&ab_channel=FoxNews

Pharma For Prison

MMR RIP

Arun Kumar Laha

COVID19 and Ivermectin
High population density plus unlocking lead to community transmission, resulting in fast increase in the number of COVID19 cases in India. Good news is that, large number of infected persons would be cured of the disease without much symptoms; these asymptomatic persons would not subject themselves to any form of testing or treatment; they would roam freely in society and would infect more persons – and this would usher in HERD IMMUNITY in India.

Patients with mild-to-moderate symptoms do not require costly indoor treatment; and such patients should be treated by doctors at the periphery; and the doctors should treat these patients based on clinical assessments of the patients – elaborate testing, to exclude COVID19, for each and every persons suffering from fever with mild-to-moderate Flu-like symptoms is a very costly proposition. There would be severe forms of chaos if we try to cater indoor treatment to all symptomatic patients presenting with mild-to-moderate Flu-like features. However, severely ill patients, aged patients with comorbidities should be admitted in well-equipped institutions.

ICMR should allow doctors, not attached to any state-run hospital or private institution, to treat patients with mild-to-moderate Flu-like symptoms with a cocktail of drugs – Vitamin D, Vitamin C, Zinc, Azithromycin and Ivermectin. Doctors attached to state-run or private institutions are, I think, already instructed by ICMR about management of such patients at indoor and outdoor.

COVID19 is a Global emergency; we do not have much time for elaborate clinical trials (multi-centric, double-blind, placebo-controlled, above all, reports should be acceptable to peer-group-reviewed international Journals) to prove or disprove efficacy of Ivermectin in treating COVID19. Doctors of many nations have published reports proving excellent efficacy of Ivermectin; no doubt, these studies have been conducted with a small number of patients; but still, we cannot discard the inferences of these reports out right, because these findings are collected by senior physicians with long experiences in clinical medicine.

Arun Kumar Laha 09 06 2020

< laha.a53@gmail.com >

IVERMECTIN

Times Of India published two reports on 21st and 22th May praising Rendesivir and Favipiravir, two antivirals. Mainstream media worldwide are promoting these drugs of big pharma companies; however, most, if not all, antivirals are of questionable efficacy. No one is promoting IVERMECTIN, a cheap oral drug, prescribing which against COVID19 doctors from many nations, including Bangladesh, got EXCELLENT results. No one is interested in promoting this off patented molecule. Scientists could not fabricate vaccines against all and every pathogenic Virus; most probably, COVID19 is one of such type. Monoclonal antibody against viral proteins, however, is a good treatment plan.


NO MASK, NO SOCIAL DISTANCING, NO LOCKDOWN, WILL BE ABLE TO SAVE HUMANITY FROM COVID19. IVERMECTIN, HCQ AND HERD IMMUNITY DUE TO SUBCLINICAL INFECTION IN COMMUNITY AT LARGE WOULD SAVE US.

Fight against COVID19

To fight against COVID19 India has to chalk out her own plan; we should not ape other nations. There would be serious socio-economic disaster in India if we continue total or partial lockdown. Most of the COVID19 infected patients in India are asymptomatic; and this might be due to the presence of Curcumin in our daily food. So, it is very difficult to determine patient- load in India; we can not test for COVID19 in all persons under the Sun.

Asymptomatic persons would refuse testing and any form of treatment - they would roam freely in society; and would infect the population at large; and this will in near future usher in HERD IMMUNITY in India. Most of the symptomatic patients present with mild to moderate illness; we should treat them as OPD patients. We have to treat these patients with mild-to-moderate Flu-like symptoms as quickly as possible; so that they do not become severely ill to overwhelm the scarce indoor facilities in our country. Here is a safe outdoor treatment plan that will show quick and effective response in symptomatic patients (for adults): - Vitamin D & C and Zinc daily in usual recommended doses + Virostatic drug Ivermectin 12mg daily for 3 to 5 days + Senolytic antibiotic Azithromycin 250mg to 500mg daily for 5 days to 10 days. This treatment plan ushers in prompt response. Serious indoor patients would get these medicines + necessary supportive measures + Hydroxychloroquine (HCQS). - Arun Kumar Laha 29, Abinash Banerjee Lane. Howrah 711104. (laha.a53@gmail.com)

Disclaimer: -

This is not a prescription for the general public to self- medicate themselves. It is for the medical fraternity to think about my humble suggestion.

To solve the problems of COVID 19, lockdown is not the only way out; we have to rely on development of HERD IMMUNITY by exposing people to low grade infection with COVID19 and we have to treat the symptomatic patients as fast as possible, to cut short the number of serious patients requiring indoor treatment.

Many health- care personnel and other fighters against COVID19 are losing their lives to save humanity at large; ICMR should think about prescribing IVERMECTIN (12mg in empty stomach once in a week instead of Hydroxychloroquine) to these persons. Ivermectin is safer than Hydroxychloroquine.

Grant Church

Sharyl Attkisson in her show Full Measure reveals Gilead's complicity in pushing their drug Remdesivir and discrediting Hydroxychloroquine. https://www.youtube.com/watch?v=zB-_SV-y11Y

Pogo

Even worse than 'Recovery,' potentially lethal hydroxychloroquine study in patients near death.
Ah! You speak too soon John. Meryl Nass now reports that the new REMAP-Covid study is using the same HCQ dose as the Recovery trial. How do these people sleep at night? Or maybe I’m dreaming all this and will soon wake up. http://anthraxvaccine.blogspot.com/2020/06/even-worse-than-recovery-potentially.html

John Stone

But most importantly, well done Meryl Nass because they have stopped these lethal trials.

susan welch

I know I won't be the only one to report that this article received excellent coverage on Highwire tonight. Jim Meehan was great and this sordid, corrupt 'research' had the spotlight firmly shone on it. It was wonderful reporting.

Well done AoA and Highwire.

Computer Girl

Designing a clinical trial to purposefully kill people, knowing the medication dosage is over 8 times the usual dose for Hydroxychloroquine treatment is tantamount to murder!!! These trial using knowingly toxic doses of Hydroxychloroquine, supported by the World Health Organization and its biggest funders should be stopped immediately!

Betty

I can't believe the testing is accurate. A naturopathic clinic that I use has not produced a single positive test for Covid 19 despite several of the patients having classic symptoms. I have heard that false positives sometimes occur in people who have recently had the flu shot. The clinic I frequent probably has very few people who get the flu shot regularly. I would love to see data on how many people who tested positive (especially those with minimal symptoms) had the flu shot in the last few years. Is there some miscellaneous coronavirus in the flu shot that might give a false positive?

Betty

Azithromycin is one of several antibiotics used in Chronic Lyme. I wonder how many people who have a severe case of Covid 19 also have a smoldering Lyme infection that is not recognized and not being treated.

Cia

Thank you, Michael and Benedetta!

I just learned that the Red Cross is doing free antibody tests on donated blood, because they want to use it for plasma therapy for seriously ill, hospitalized Covid patients. I’m sure they use a reliable test. I just made an appointment to donate blood for that reason. Others may want to do the same. They think they will offer the testing through this summer and see how their funding holds out.

michael

Thanks Cia!!

I appreciate how clear your explanations are. Forwarded them on to others.

Benedetta

Well explained Cia!
That is how I understood it too.

Cia

Benedetta,

Thank you. I cannot believe the utter lack of concern for human life on full display here. It is hard to believe that anyone would tell such transparent, evil lies, but that has been just about all that has been coming out of the medical and Pharma industries. I knew close to nothing about virology and bioengineering a few months ago, but the lies comprising every single g-ddamned WORD of the Surgisphere non-study were SO obvious that I’d REALLY like to know what Fauci and his hundreds of colleagues around the world said to their intimates in confidence about it, when they were deciding what their public stance on it was going to be. Did anyone even bring up that there was a GOOD chance that SOME honest person somewhere would call them out on it? As it turned out, there were hundreds.

Azithromycin is an interesting therapeutic discovery. It DOES treat secondary bacterial infections, but it ALSO has antiviral properties of its own, and also interrupts the autoimmune cytokine storm which is often the cause of death in Covid. And it’s a mild drug, with few side effects.

This is such an interesting issue, all aspects of it. The autoimmune cytokine storm is one problem. (I have them from MS very often, initiated by the vaccine reaction, but so far they have not been fatal. I treat with selenium, quercetin, NAC, Cytokine Suppress, and Steven Buhner herbal formulas I made myself, specific to quelling overproduction of cytokines.) But there are a lot of other problems too, I’ll just say they can affect any system of the body severely, even fatally. It looks like the lung problem, more than being classic pneumonia, is a hypercoagulatory problem, with tiny microclots of blood forming really anywhere. They can quickly destroy the lungs. In a limb it can lead to amputation. But one interesting thing is that CV attacks the heme, the iron-containing structure of hemoglobin. The virus gnaws open this structure and releases the iron uncontained into the bloodstream. So the human host often died without the hemoglobin providing oxygen to every cell, and may also die from the damage done by the released iron. The INTERESTING thing is that the malaria parasite does much the same thing. The malaria drug HCQ PREVENTS this attack on the hemoglobin. And it does this exactly as well when used to protect the hemoglobin in Covid as in malaria.

Benedetta

Cia;
Some times you are just above even the exceptional genius.

Good post

Benedetta

Will;
Hydroxy is a chemical term that means it has an OH group on it. Oxygen and hydrogen
Like Methyl mean it has a CH3 group on it. That is carbon, and three hydrogens.

Hydroxyl is often put on other molecules to get them to dissolve in water more easily. That is all it means.

azithromycin is an antibiotic, because often it is not one illness that gets you like the flu, but your immune system has run up against a virus and a bacteria and needs help.

So chloroquine apparently helps with a virus and the azithromycin helps with a bacteria infection.
That is why they are using them together.

Benedetta

And Dr. Hatfill: Please look at Hera's post, for I too had those same questions in mind?

Benedettal

Thee Hatfill? The Hatfill that worked for Derick and got blamed for the anthrax letter mailing? That Hatfill?
The Hatfill that was on Sharyl Attkinson's show recently. That Hatfill?

Did you know Bruce Edwards Ivins?
Do you think he went crazy, dementia, inflammation of the brain after taking his own anthrax vaccine, but just did not know it cause well how often does a sick brain recognize that it is sick?

How come while the FBI was blaming you, and you worked at Fort Derrick with him, that you didn't even have a clue that it was him?

Morag

A sneaky,clever, viral, oxygen depleting, walking pneumonitis?
More evidence of commercialised scientific decay ,with clinical leadership that couldnae sit it's own hin- end, the right way round on a circular bed pan ?
Chanty Wrastlers ,Criteria and Guidelines in the criminal clinical negligence zone ?
Do they really need to think too long and hard why public respect for the state of their clinical standards and leadership are haemorrhaging into gusset and suspenders rupturing laughter!

Frontline/The Vaccine War /PBS America YouTube
The Risk Assessments are totally stuffed ! Apparently [WHO] World Health Organisation states
Re efficacy of vaccines . It dosen't matter whether a vaccine shows a high efficacy or a low efficacy ,as long as it shows "an" efficacy ?

Sweet -Love is like oxygen. YouTube

Hera

Dr Hatfield; thank you for commenting. What do you consider a toxic dosage of Hydroxychloroquine to be?
it does seem after checking several different sites, that the highest dosage suggested online for hydroxychloroquine was short term use for acute malaria.
https://www.medicalnewstoday.com/articles/hydroxychloroquine-oral-tablet#dosage
from the site
Acute attack:
Typical starting dose is 800 mg. This is followed by 400 mg three times: 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose.
And this site
https://reference.medscape.com/drug/plaquenil-hydroxychloroquine-sulfate-343205
which also states
800 mg (620 mg base) PO, then 400 mg (310 mg base) PO at 6 hr, 24 hr, and 48 hr after initial dose, and then there is this site
https://www.mayoclinic.org/drugs-supplements/hydroxychloroquine-oral-route/proper-use/drg-20064216
Standard dosing: At first, 800 milligrams (mg) (4 tablets) taken as a single dose. Then, 400 mg taken 6 hours, 24 hours, and 48 hours after the first dose.
Weight-based dosing: Dose is based on body weight and must be determined by your doctor. At first, 13 milligram (mg) per kilogram (kg) of body weight taken as a single dose. Then, 6.5 mg per kg of body weight taken 6 hours, 24 hours, and 48 hours after the first dose. However, dose is usually not more than 800 mg for the first dose and not more than 400 mg for the next doses.

All of these dose regimes on these websites, which appear to be describing the highest dosages being used for short term acute malaria treatment, are less than the dosage that is being quoted in this article.
As a physician, what is your opinion on why an apparently extremely high dose regime was chosen , ( when compared with the maximum typical dosages listed on these three independent medical sites) , and then used to rule out the use of the medicine at any dosage, as causing too many side effects?

Again , it would also be useful if you could link to the data about what level of hydroxchloroquine dosage you consider to be toxic or unsafe, as this data seems to be hard to find online.
Thank you again for your comment.

Pft

Kind of missing the point. HCQ needs to be used early in disease before a patient required hospitalization. Dr Raoult emphasized that last February. It also should be used with zinc supplements as HCQ helps zinc transport into cells which reduces viral replication.

They continue to design these studies to fail. HCQ was available OTC IN France up to January. The pulled it because if everyone took HCQ at first sign of a cold there would br no problem, and no need of a vaccine. They new it was effective based on SARS studies. Fauci himself said as much in 2005

Also given the low cost of HCQ vs SIC drugs, it doesn't need to be better

Trials for crimes against humanity need to start. Make sure there is enough rope

Cia

I looked up the NHS recommended dosage in March. It was 500 mg chloroquine once daily for ten days, or 400 mg hydroxychloroquine, same. Azithromycin 500 mg, same. I got HCQ and Z-pac. While HCQ is considered less toxic than the older chloroquine, both drugs are considered very safe. Hundreds of millions of doses have been taken since the ‘30s, with very few negative reactions. In a few cases, retinal damage has occurred after taking it for over ten years. Not a single case of sudden cardiac arrest or any other heart problem was reported for the ninety years chloroquine has been in existence. If you read the articles claiming that it does, notice that all they do is say “it has been reported that,” but there is not a single verified case in which it has ever really happened. The fraudulent Surgisphere non-study just cooked the fraudulent non-figures to yield the predetermined desired outcome: 35% excess mortality from cardiac events (not) caused by hydroxychloroquine. The dosage SAID to have been used in American hospitals (never named) was TWICE the FDA-recommended dosage. So what American hospitals are going to do that? I think that was just a slip-up on the part of the ONE Surgicel employee responsible for CAREFULLY going through 96,000 patient records in a few weeks. Did Anthony Fauci and the hundreds of other Pharma-funded authorities not notice obvious problems like this before they praised it to the high heavens and cut off HCQ from several studies? Didn’t notice how convenient it was that they just happened to come up with almost exactly the same number of patients for every category and variable. 500 in the HCQ group with diabetes, 502 in the control group. 800 in the HCQ group with hypertension, 804 in the control group. Fauci is intelligent. I don’t understand how he thought he could praise obvious lies and not be caught out. Also don’t understand how he could pour millions of American dollars into gain-of-function studies in Wuhan DESIGNED to make the bat coronavirus more transmissible and more pathogenic to other species, inserting gene sequences from other viruses, when dozens of scientists have always warned of the tremendous danger involved if (when) it escaped the lab. Fauci has a lot to answer for and I see no alternative to life in prison for him and dozens others.

Richard Horton actually said that Pharma companies hold the power and always call the tune. Over 200 scientists wrote an open letter to The Lancet with a list of their concerns. The Lancet was forced to retract it. But never say die, the industry immediately published results of three studies on HCQ. While there is reason to believe that sometimes HCQ saves Covid patients even when the disease is late-stage and can help even when taken after infection has occurred, it is at its best when taken in the first five days of symptoms. It does work to prevent infection if taken before infection occurs: one Chinese study found that lupus patients, who had been taking it anyway, never got coronavirus. So what three studies did they publish, still hoping to tank HCQ and route everyone to remdesivir (a thousand bucks a dose daily for ten days), as opposed to a dollar a dose for HCQ. No, that’s right, this is the US. At least fifty dollars a dose. But still much less than remdesivir, which does not reduce mortality and just reduces length of hospitalization from fifteen to eleven days.

So one of the studies was on late-stage Covid patients given HCQ, when in most cases it needs to be early and it needs to be given with zinc. Among other things, HCQ is a zinc ionophore and forces zinc into the infected cells, and the zinc kills the virus. So did they give zinc as well as HCQ? Not a chance! The other two misleading studies were on HCQ given to people ALREADY exposed to CV. And it didn’t magically avert the disease. Once you’re infected, your immune system has to deal with the disease. However, none of the patients in these two studies had a severe case and all recovered. Another win for HCQ, but the articles purported to be trashing it.

I hope that these shenanigans will wake the world up to the venality and dishonesty of the Pharma industry and maybe make people realize that vaccines are the other side of the same coin.

michael


Here is a link to H. Weniger's "Review of Side Effects and Toxicity of Chloroquine" that he performed for WHO. https://apps.who.int/iris/bitstream/handle/10665/65773/WHO_MAL_79.906.pdf?sequence=1&isAllowed=y

It does confirm S.J. Hatfield's comment that Weniger's review was for chloroquine and not HCQ.


Will

Hydroxychloroquine should not be combined with azithromycine because both contain hydroxy in the prefix. Most formulas of azithromycine have a hydroxy type pharmaceutical preperations and the two together can cause heart problems. The very few doctors that used hydroxychloroquine to treat SARS COVID 19 patients did not use it to treat COVID 19 directly they used it to reduce a cytokine storm a type of deadly autoimmune reaction to the virus. They also did not add azithromycine to the drug cocktail because of a drug interactions mentioned above. Both pro Trump and anti Trump people need to look at the research and drug interactions first before commenting.

Laura Hayes

John Stone,

Thanks for posting the previous AoA link documenting the science-eliminating, completely fraudulent, should be deserving of prison time and large fines, both corporate and personal, fact that, once again, placebos are never used as controls in vaccine trials. As such, not even one vaccine should be on the market, as not one has been tested or approved properly or ethically.

As Michael noted below, AoA is one of a few, but growing, places where citizens seeking truth can come to learn, then point others to the truth.

To that end, in addition to my 2018 presentation whose link I posted in my previous comment, here is the link to my 2016 presentation, which is different than, but complementary to, my 2018 presentation.

“Vaccines: What Is There to Be ‘Pro’ About?” by Laura Hayes

https://www.ageofautism.com/2016/12/vaccines-what-is-there-to-be-pro-about-laura-hayes-to-weston-a-price-foundation-conference.html

greyone

another possibility for adjunctive therapy
https://www.sciencedirect.com/science/article/pii/S0306987720308276?via%3Dihub

Johnathan Stein

The link for "page 5 notes that a single dose of 1.5-2 grams of hydroxychloroquine base "may be fatal."" is blank.

Could you please fix?

S.J. Hatfill MD, MSc MSc, M.Med

In her article Meryl Nass incorrectly lumps hydroxychloroquine together with Chloroquine. These are two different drugs with much different safety profiles. This carelessness extends to her references. In this respect, she is incorrect with stating" - The WHO hired a consultant to explore the toxicity of hydroxychloroquine in 1979. The consultant, H. Weniger, looked at episodes of adult poisoning by chloroquine.

Nass states that Weniger on page 5 notes that a single dose of 1.5-2 grams of hydroxychloroquine base "may be fatal." On examination this the WHO document says nothing of the sort. It refers to Chloroquine, not hydroxychloroquine which has an acknowledged much lower low toxicity.

Meryl Nass has again demonstrated her usual carelessness with the facts. The failure to recognize the toxicity differences between Hydroxychloroquine and Chloroquine shows the lack of even a basic knowledge of the situation she purports to describe.

Karen Walker

This Tweet from Dr. James Todaro suggests they may have based the high doses on THE WRONG DRUG--which is inexcusable and suggests these doctors are, in fact, trying to rig the numbers against hydroxychloroquine.

https://twitter.com/JamesTodaroMD/status/1272542546758074369

michael

Once again I have to go to Age of Autism to become informed about the state of scientific affairs when it comes to the clinical accurate information on HCQ trials. Searching google I could not find an article that comes close to this one my Meryl Nass.

I am just so sick and tired of the inexcusable gross failure of the "scientific" media and main-stream-media to write the kind of articles I seem to be able only to find at AOA. This should be in the NYT or WAPO, PBS or NPR, but it is not.................................................................................................yet. WHY?

WHO is steering this ship?

Karen Walker

I think this clarifies the June 15 Emergency Use Authorization withdrawal by the FDA. It is a Twitter post by Dr Vladimir (Zev) Zelenko, an avid proponent of hydroxychloroquine, of a press conference. From this, it seems the FDA did the right thing to make hydroxychloroquine more available, But this whole mess is certainly confusing, and frightening. Thank you Dr. Meryl Nass for the information.
https://mobile.twitter.com/zev_dr/status/1272658607730053125

Benedetta

They don't mind killing people!

Surely Dear God in Heaven there should be some kind of police, justice department, judge that says this is a crime? And end this insanity.

This has to be the beast in Revelations? Has to be, it is so evil!

I would love Fauci to get the coronavirus. Then how he treats his illness put on a bright shining, biggest magnifying glass of all time!

And how come the likes of Fauci never gets such stuff like these viruses? After all they are "Heroes" suppose to be working with all this stuff. .

John Stone

Laura

Just to say we reported the use of the meningitis placebo by the OVG in April.

https://www.ageofautism.com/2020/04/british-government-plays-with-fire-over-covid-19-enter-prof-pollard.html

Of course, the trials on children for whom there could be little benefit is a most unethical and undesirable development.

greyone

Ivermectin as possible therapeutic.
https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2.article-metrics

Bob Moffit

When this PANDEMIC man-made nightmare is finally over …. "if the truth is ever known or revealed .. the reputation of the CDC, WHO and most public health EXPERTS will be destroyed .. hopefully .. MANY WILL GO TO JAIL FOR WHAT THEY DID TO OUR WORLD.

Laura Hayes

Thank you, Dr. Meryl Nass, for this important information. I have shared what you have written with my email group, accompanied by the message: Beware and be warned.

And thank you, Kim, for running Dr. Nass's expose here on AoA.

For yet another example of purposeful and inexcusable unscientific trials, which make them flat-out criminal, as people, including children, will be harmed and killed, note in this article that the "placebo" for one of the Covid vaccines in development to be tested on children is a meningococcal vaccine.

https://articles.mercola.com/sites/articles/archive/2020/06/16/coronavirus-cover-up.aspx

That vaccine in and of itself has pages' worth of risks to children, including death:

http://www.vaccinesafety.edu/package_inserts.htm (includes links to 3 meningitis vaccines)

Furthermore, participants are asked to record symptoms for only one week following vaccination.

For those who are not aware, there are no placebos used in any vaccine trials, and post-vaccination follow-up is as short as 4 days.

For those wanting to learn more about the dangers, inefficacies, and lack of need for vaccines, and about the vast corruption that underlies vaccines from manufacture to mandate and beyond, please read or watch my "Why Is This Legal?" presentation from 2018:

https://www.ageofautism.com/2018/11/why-is-this-legal-presentation-on-vaccines-by-laura-hayes.html

greyone

if you have a loved one in a nursing home facility, this interview is worth a listen.
the audio loads slowly, at the top of the article.
https://971talk.radio.com/blogs/the-marc-cox-morning-show/dr-steve-crawford-of-festus-manor-on-hydroxychloroquine

Angus Files

Never let the public know that high dosing got in the way of failing an alternative to vaccines..

India being threatened by China maybe it’s the threat that never worked.. tow the line or else I`ll send the boys round..

https://www.express.co.uk/news/world/1296478/World-war-3-China-vs-India-border-china-soldiers-dead-injured-Ladakh

Pharma For Prison

MMR RIP

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