What Can Be Done For Those With Autism and Antibiotic Resistance?
Here are some treatment ideas but more are needed for so many ill children and adults. These are based on research so I need to do the usual disclaimer:
What I also want to say as this is usually cutting edge information that I report so you may need to go to your doctors/practitioners and give them this information. As always, this may be years before it becomes common knowledge in any medical school or practice.
From the researchers:The gut is the epicentre of antibiotic resistance
“Techniques are available to prevent, detect, and treat the carriage of resistant organisms in the gut. However, evidence on these techniques is scant,...”
1) Oral digestive decontamination for preventing nosocomial infections and antibiotic resistance...SDD relies on non-absorbable antibiotics (aminoglycosides, polymyxin E, and amphotericin B) applied to the oro-pharyngeal cavity and administered into the stomach, usually in combination with an intravenous antibiotic (third-generation cephalosporin) for three days. The use of SDD was highly controversial at first, chiefly because early studies found no significant decrease in mortality  and many physicians were deeply concerned about the risk of selecting organisms resistant to the drugs used for SDD [54-56],. Recent studies, however, documented a significant decrease in mortality [55,57,58] and a paradoxical decrease in resistance to the antibiotics used locally or systemically [55,58].
2) Probiotics have been suggested to maintain or restore gut homeostasis. Probiotics are defined by the World Health Organisation as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’. Lactic acid bacteria and bifidobacteria are the most common micro-organism types used as probiotics, although certain yeasts and bacilli may also be helpful. Saccharomyces boulardii is a tropical yeast which has been shown to maintain and restore the natural flora in the large and small intestine  and is classified as a probiotic. Non-pathogenic E. coli strains such as Nissle 1917 (EcN) are also classified as probiotics and have been studied in animals, normal volunteers, and elderly patients [60-64].
3) Antibiotics with local effects for managing outbreaks. Targeting resistant bacteria with non-absorbable antibiotics is an extremely appealing strategy that has been investigated in patients carrying multi-resistant strains, as well as during outbreaks. ..Oro-pharyngeal chlorhexidine baths combined with oral paromomycin (plus an oral antibiotic in patients with urinary tract colonisation/infection) was effective in 76% of patients carrying ESBL-producing E. coli or K. pneumoniae.
4) Faecal microbiome transplantation. Faecal microbiome transplantation consists in administering faecal flora from a normal individual into the gut of a patient with the goal of achieving colonisation with a well-balanced community of organisms. Faecal microbiome transplantation has produced excellent results in patients with C. difficile relapses [75-77]. In two recent systematic reviews, faecal microbiome transplantation via the oral route or colonoscopy was effective in 83% and 92% of cases of C. difficile disease, respectively [75,76].
5) Beta-lactamase treatment. Oral treatment with enteric-coated beta-lactamases has been used in dogs and in humans [79,80] in an attempt to prevent the appearance of antibiotic resistance in the gut during intravenous ampicillin administration. The desired effect is destruction by the beta-lactamase of residual antibiotic in the distal gut, to prevent the acquisition of resistance without affecting systemic drug levels. Both studies were encouraging, in particular the study in human patients, which included a control group [79,80]. However, the development of this compound has been stopped due to a lack of resources. This topic deserves further attention, since the concept is appealing.
6) The search, destroy, and restore concept. The ‘search and destroy’ concept was used initially in The Netherlands to prevent and treat MRSA colonisation and infection. Patients at risk for MRSA carriage were screened, and cultures of the pharynx and sometimes of the skin were performed . The patients were isolated until the results became negative. Patients with MRSA colonisation were treated with nasal mupirocin, often combined with chlorhexidine baths. This strategy may be among the reasons explaining the very low prevalence of MRSA in The Netherlands . The search and destroy strategy has also produced favourable outcomes in Ireland, Denmark, and other Scandinavian countries [82,83].
This too- important for doctors, researchers, and families to know:
“Diet, Prebiotics, Probiotics/Synbiotics, Postbiotics, Antibiotics, and Fecal Microbiota Transplantation (FMT).”
I also like this mention of Charcoal: Toxins produced by gut microbiota may also lead to injurious effects in the brain. Consequently, activated charcoal may be useful in microbe-induced neurobehavioral disorders, including ASD. A few studies suggest activated charcoal suppresses the growth of antibiotic-resistant intestinal bacteria.
This sounds like a study that expectant and new parents would love:
Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria Colonization of the gut of breastfed infants by a single strain of B. longum subsp. infantis had a profound impact on the fecal metagenome, including a reduction in ARGs. This highlights the importance of developing novel approaches to limit the spread of these genes among clinically relevant bacteria. Future studies are needed to determine whether colonization with B. infantis EVC001 decreases the incidence of AR infections in breastfed infants.
This may sound like sci-fi but it’s real and what may end up being very important in autism treatments:
In the battle against antibiotic resistance, many scientists have been trying to deploy naturally occurring viruses called bacteriophages that can infect and kill bacteria.
Bacteriophages kill bacteria through different mechanisms than antibiotics, and they can target specific strains, making them an appealing option for potentially overcoming multidrug resistance. However, quickly finding and optimizing well-defined bacteriophages to use against a bacterial target is challenging.
Yes, challenging but not impossible. Here is an actual conference coming up that is looking exactly at antibiotic resistance which could help many affected.
The only industry-focused forum dedicated to facilitating the discovery, translation & acceleration of bacteriophage research into targeted therapeutics with clinically significant results.
As phage therapy offers an opportunity to tackle the ever-growing problem of antibiotic resistant infections, the 2nd Bacteriophage Therapy Summit returns to not only drive forward the translation of phage pharmacology into the clinic but also generate discussion around the direction that phage therapy is heading and how this can be commercialized and delivered into the hands of physicians and patients in need.
This hot off the press study is hugely important and promising as it uses “in vitro cultured gut microbiota as transplants.” -
Therapeutic Effects of the In Vitro Cultured Human Gut Microbiota as Transplants on Altering Gut Microbiota and Improving Symptoms Associated With Autism Spectrum Disorder The present study demonstrated that GMT with in vitro cultured microbiota also improved behavioral abnormalities and chemokine disorders in an ASD mouse model compared with GMT with original donor gut microbiota.
To summarize - Those who have an autism diagnosis have more antibiotic resistant genes in their gut. There is evidence that it can develop from prenatal exposure to antibiotics, exposure to mercury, exposure to their environment, and we may need to include an increase of antibiotic resistance among non-vaccine serotypes. This line of research shows we need to be concerned , - “Rapid replacement of vaccine with non-vaccine serotype pneumococci is likely to have important implications for invasive disease. Population-based surveillance in the Upper River Region of The Gambia conducted between May 2008 and December 2014 showed a 47% increase in non-vaccine-type invasive pneumococcal disease,....It was also striking that 19A invasive pneumococcal disease persisted between 2013 and 2014 among children less than 5 years old despite widespread use of PCV13 in the country..”
Of course, I must go back to Megan, my catalyst on this long autism journey. She turned 27 and I wanted to share her birthday night.
She loved the gluten-free broccoli and pasta with the awesome cast iron steak I made. Of all her gifts, she loved the Mama Mia CD from her sister and also the DVD of Frankie Valli and the Four Seasons Live in Concert, that I gave her. I made a gluten free, dairy free cake and it was pretty good. Her sister and I were both so happy that she had so much joy. Meg is sick with infections and PANS often yet much better with immune help. We love to see her happy and not in pain.
Thoughts and questions we may need to consider and please add yours in the Comments section. All of these factors - antibiotics, mercury, and vaccines have a part in this dangerous recipe of changing the gut, tilting it to the tipping point. Information is not always honest as industry and profits cloud the true message of health -- For example -- here we have multiple studies showing injury and lifelong health disease from mercury in fish yet here is the NYT with an article saying “no adverse effects.”:
2- Why is there not more research on both prenatal antibiotic and vaccine consequences in infants later diagnosed with autism?
4- Since “gut bug communities are likely passed down from generation to generation” is it also possible that each generation’s gut microbes are becoming more toxic and less resistant to antibiotics?
6- Why are some of these topics taboo to investigate?
7- Our children and future generation look to be at risk. Isn’t human health more important than the goliath Industries out to make a buck?
Our good friend and founder here at AoA, Dan Olmsted, wrote an entire series over 15 years ago on the premise of autism being an environmental illness of the body, affecting the brain and not some sole psychiatric diagnosis. He and Mark Blaxill then went on to write a ground-breaking book on the historical links to mercury, in their amazing The Age of Autism book , published in 2010. Dan was so correct fifteen years ago with this article: The Age of Autism: A whole-body illness . We will never give up on helping Megan and thousands more.