Autism and Housing Dangerous Logic an Article by Amy Lutz in Psychology Today
The Grooming of Children By the Vacciphilia Public Health and Pediatric Machine

Journal Of Alzheimer's Disease: Aluminum and Amyloid-β in Familial Alzheimer’s Disease

Alzheimers generations
Note: One wonders why this isn't front page news, instead of a new virus in China (for which is a vaccine is in the works) and rare Ebola (for which a vaccine is coming out.) Alzheimer's affects at least three generations at a pop.  When a grandparent succumbs, Mom and Dad (the sandwich generation) may race through savings and certainly face exhaustion finding care.  Their children pay a price. The parallels in care and behavior to an autism diagnosis are heart breaking. Yet aluminum is prevalent in day to day living and in bolus presence in many vaccines. Deodorants and antacids tout being aluminum free as a selling point.  Still, the topic is verboten when an adjuvant in vaccines.  Vaping and e-Cigs were ripped in headlines quickly for safety concerns. Just last week, I got 3 fliers in the mail from my daughters CT Medicaid talking about the dangers of vaping.  Imagine the expense, and vaping isn't mandated or pushed by doctors, stores, the media. It's a legal product one chooses.   Doctors tell women to have genetic tests for breast cancer, and many women choose preventive mastectomy to prevent the disease. With aluminum and Alzheimers, the aluminum is foisted upon us and we're ridiculed if we say, NO.

Here is a study  that includes Professor Chris Exley that should chill every reader, if the media would only publish it.

###

Article type: Research Article

Authors: Mold, Matthewa | Linhart, Carolineb | Gómez-Ramírez, Johanac | Villegas-Lanau, Andrésc | Exley, Christophera; *

Affiliations: [a] The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, United Kingdom | [b] Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innsbruck, Austria | [c] Grupo de Neurociencias de Antioquia, Sede de Investigación Universitaria SIU, Medellín, Colombia

Correspondence: [*] Correspondence to: Professor Christopher Exley, The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, United Kingdom. E-mail: c.exley@keele.ac.uk.

Keywords: Aluminum in human brain tissue, amyloid-β, familial Alzheimer’s disease, human exposure to aluminum

DOI: 10.3233/JAD-191140

Journal: Journal of Alzheimer's Disease, vol. Pre-press, no. Pre-press, pp. 1-9, 2019
Accepted 16 December 2019
| Published: 13 January 2020

Abstract

Genetic predispositions associated with metabolism of the amyloid-β protein precursor underlie familial Alzheimer’s disease; a form of dementia characterized by early disease onset and elevated levels of cortical amyloid-β. Human exposure to aluminum is linked to the etiology of Alzheimer’s disease and recent research measured a high content of aluminum in brain tissue in familial Alzheimer’s disease. To elaborate upon this finding, we have obtained brain tissues from a Colombian cohort of donors with familial Alzheimer’s disease. We have used established methods to measure the aluminum content of these tissues and we have compared the data with a recently measured dataset for control brain tissues. We report significantly higher levels of aluminum in brain tissues in donors with familial Alzheimer’s disease than in control tissues from donors without neurological impairment or neurodegeneration. We have used aluminum-specific fluorescence microscopy along with complementary imaging for amyloid-β to demonstrate a very high degree of co-localization of these two risk factors in brain tissue in familial Alzheimer’s disease. Aluminum and amyloid-β were co-located in senile plaques as well as vasculature, the latter resembling cerebral amyloid angiopathy. Aluminum was also found separately from amyloid-β in intracellular compartments including glia and neuronal axons. The research has identified an arguably unique association between high brain aluminum content and amyloid-β and allows postulation that genetic predispositions defining familial Alzheimer’s disease underlie this relationship.



INTRODUCTION

An association between aluminum and amyloid-β in Alzheimer’s disease has been postulated for 40 years [1]. It has not been without controversy [2] though a consensus does now support the co-localization if not co-deposition of these two major risk factors in Alzheimer’s disease [3]. Familial Alzheimer’s disease, fAD, is characterized by genetic mutations affecting the expression and metabolism of the amyloid-β protein precursor (AβPP), leading to early onset of disease [4, 5]. One fAD mutation is PS1-E280A (Glu280Ala), a mutation that occurs in a significant cohort of individuals in Colombia. The mutation results in elevated cortical levels of amyloid-β, early disease onset (<50 years of age) and an aggressive disease etiology [6].

Previous research on brain tissue from 12 donors diagnosed as fAD [7] demonstrated significant accumulations of aluminum with 11 of the 12 brains having at least one tissue sample where the concentration of aluminum was defined as pathologically concerning (≥3.00 μg/g dry wt.). Aluminum-specific fluorescence microscopy [8] confirmed the presence of aluminum in these tissues and suggested that the majority of deposits of aluminum were extracellular associated with neuronal and cellular debris. A tentative suggestion was made that aluminum and amyloid-β were co-located in a senile plaque-like structure. Herein we have measured aluminum in brain tissue in Colombian donors carrying the fAD mutation PS1-E280A and compared the data with data for control brains. We have also used aluminum-specific fluorescence microscopy to investigate interrelationships between aluminum and amyloid-β in fAD.

Continue Reading HERE.

Comments

Benedetta

That is spelled Gherardi of France. Romain Kroum Gherardi,

Benedetta F Stilwell

Well, well, well;
Here is a study right on pubmed.
metal ions are indeed a factor in the forming of those alpha synuclein in the Lewy bodies of Parkinson disease.

They even went through a bunch of different metals like Magnesium, Cobalt, Nickel, copper and such.

On the very end it mentions that it is aluminum that is the worse in creating alpha synuclein.

Now, let my pharmacist friend from high school tell me that it is just life; the way things go when my elderly father had a heart attack and then started scooting his feet from Parkinson soon after his series of yearly flu shots.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739322/


At high concentration of metal ions, K+, Na+, Li+, Cs+, and Ca2+ has no effect on the unfolded structure of αS, but Mn2+, Cd2+, Mg2+ and Zn2+ induce a small increase in α-helix contents, and Cu2+, Co2+, Fe3+ and Al3+ induce more α-helix contents

So Cesium and Cadmium has not effect! Surprised me.
As for Mn, Mg, Zn, iron, copper there are regulators for them in the body, starting at the lining of the stomach. Most over load of iron starts there.

There is only one type of transporter of iron, ferroportin, and it is suppose to transport iron from around in the cells, and body, as well as help in the recycling of iron. It surprised me to learn that ferroportin find excess iron, and takes the iron found in the spleen, carried there by macrophages.

Carried by the macrophages to the spleen. Just like Ghrardi of France says aluminum is carried to the spleen from the tonsils to the brain. By macrophages just like Professor Exley finding.

Copper also has body regulators too.

Recently, studies have shown that lanthanide ions might affect the neuronal systems, but the toxicological behaviours were very complicated and the effects depended on a variety of factors [34–36]. With the increasing applications of lanthanides in industry, agriculture and medicine [37–41], particularly for the people who has long-term exposure in the electronics components industry or mining, public concern pays more and more attention on the toxicity of the lanthanides. In this study, we characterized the interaction between lanthanide metal ions (Ln3+) with recombinant human αS and the binding sites (region) were determined using NMR spectroscopy. We found that lanthanide metal ions accelerated αS fibrillation much faster than divalent cations in vitro. Based on the interaction information, we proposed the mechanism by which lanthanide metal ions accelerated αS fibrillation in vitro.

Now, let my pharmacist friend from high school tell me that it is just life; the way things go when my elderly father had a heart attack and then started scooting his feet from Parkinson soon after his series of yearly flu shots


Benedetta

I have read this study four times now.
I am coming away with more questions than answers.

Do the elderly with Alziehemers here in the U.S.A, and not in Columbia have this mutation?
Do the elderly that died of Alziehemers here in the U.S.A also have aluminum in their brains?
The poor, pitiful people of Columbia; that died of Alziehemers; what does this mutation really cause? I means does it cause them to form these tangle, these amyloid-β, or does it mean that they are not able to get rid of aluminum easily. Which one?

What else does aluminum do to the body? Buddy Epsom when he was sprayed and painted with aluminum for the scare crow part in "The Wizard of Oz" ended up in the hospital deathly ill. According to him he never had good health since. He did not get Alziehemers though.

Could aluminum cause Parkinson disease in people that have perhaps another kind of mutation somewhere? Now there too is a disease with some kind of tangle mass, some kind of alpha--- alpha-synuclein (a-synuclein). It's found in all Lewy bodies in a clumped form that cells can't break down similar to amyloid-β. Yeah, maybe in the brain stem it would be good to look?

The aluminum that is in the Columbia donor'r brains; big question here!!!! Did they obtain their aluminum from vaccines, or did it come from breathing dust from mining (going through the lungs is the same as injecting it) or are they so delicate to aluminum that it came through their the GI track?

Benedetta

I was made to think we were rare. For years; we were alone, and the odd ducks. Then I looked around me, as well as at the rising numbers of those with autism. We were not rare, we were common. So which is it? Are we some thing that just needs to die out and go away; let the human race squeeze through some bottle neck and then explode in great numbers on the other side of age that we injected aluminum in our bodies, and drank it from pop cans? or does it finally get everybody?

Benedetta

Am I understanding this study correctly?
The people in the area of Columbia that are developing Alziehemers at an early age, it is both a problem with their genetics (getting rid of aluminum) and the presents of aluminum in the environment ?

And so it is the same for those living outside of Columbia and developed Alziehemers at a later age, that they too have a genetic problem of getting rid of aluminum?

Pogo

How about voting for Professor Chris Exley to be awarded a Nobel Prize. The USA have tested more nuclear bombs (well only 1,054 nuclear tests by the official count) than he’s got votes for so far.
https://www.change.org/p/karolinska-institutet-professor-chris-exley-to-be-awarded-a-nobel-prize

Benedetta

I wondered about such things a decade or more ago.
Now we know.
Dan Olmsted and Mark Blaxill said when we finally figured out the problems with vaccines that it would really be a simple answer.

Not so simple of how to get aluminum out of our brains?

Bob Moffit

Sharyl Attkisson column on censoring of news .. worth reading .. especially part on vaccines:

https://sharylattkisson.com/2020/01/on-the-70th-anniversary-of-orwells-death-the-danger-of-third-parties-curating-and-fact-checking-our-info/?

Apparently … "curating" is now being used instead of good old fashioned "censoring" .. which is exactly Sharyl's point on Orwellian abuse of language.

greyone

https://www.medicalnewstoday.com/articles/323797.php#1
wish that Judy Mikovits were funded for this research.

John Stone

Bob

It will, of course, have been Kim who wrote that.

John

Julie

I imagine this isn't front page news for the same reasons that the information contained in this podcast has not hit the news.

https://podcasts.apple.com/us/podcast/19-bret-weinstein-the-prediction-and-the-disc/id1469999563?i=1000462975502

If the information on this podcast is reliable, the implications for the validity of drug (and/including vaccine) testing results is astonishing. The podcast is slow to start but stick with it.

Bob Moffit

John writes:

"Yet aluminum is prevalent in day to day living and in bolus presence in many vaccines. Deodorants and antacids tout being aluminum free as a selling point. Still, the topic is verboten when an adjuvant in vaccines. Vaping and e-Cigs were ripped in headlines quickly for safety concerns. Just last week, I got 3 fliers in the mail from my daughters CT Medicaid talking about the dangers of vaping"

Just yesterday a warning about the dangers of SUNSCREEN …

https://www.health.com/condition/skin-cancer/fda-sunscreen-warning

"We know you’ve been told all your life to slather on the sunscreen before a day spent outside. We’re not disputing that advice, but a new report in the Journal of the American Medical Association has given us some food for thought: There’s a chance that sunscreen could potentially be dangerous.

Here’s how: Sunscreen ingredients can travel through the skin and build up in the bloodstream, the new report suggests. This finding has raised concerns about how sunscreen might affect reproductive and developmental health and whether it can cause cancer, according to an editorial accompanying the new report.

For the new study, scientists from the U.S. Food and Drug Administration (FDA) studied the effects of sunscreen on 24 healthy people. They tested four different sunscreens—two sprays, one lotion, and one cream—each applied four times a day, to 75% of the body surface, for four days.

Blood samples were then taken from the participants to determine how much of four specific sunscreen ingredients—avobenzone, oxybenzone, ecamsule, and octocrylene—ended up in their bloodstreams. And it turns out, it was a significant amount."

Duh … who'ed thunk it … sunscreen ingredients (CHEMICALS .. AVOBENZONE, OXYBENZONE, ECAMSULE, OCTOCRYLENE) cam travel through the skin and build up in the bloodstream. Are these people stupid or what … market a product that can be INJECTED DIRECTLY INTO THE BLOODSTREAM .. CALL IT A VACCINE … AND … VIOLA … YOU GET FDA APPROVAL AND FULL PRODUCT LIABILITY PROTECTION.

Hans Scholl

Professor Excellent Strikes again ! Bish Bash Bosh Easy

Meanwhile elsewhere And in other news :

https://www.forbes.com/sites/gerganakoleva/2012/06/27/merck-whistleblower-suit-a-boon-to-anti-vaccination-advocates-though-it-stresses-importance-of-vaccines/#1e3527419678

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335060/

https://patents.justia.com/patent/10130701

https://globalnews.ca/news/6442231/dominic-cardy-death-threats-vaccine-legislation/


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