Autoepitopes (22 of 27) in rheumatoid arthritis differ from vaccine antigens by a single amino acid residue, ideal for low affinity self reactive T cell mediated autoimmunity and aluminum adjuvant promotes citrullination of vaccine antigens thus the synthesis of ACPA
Rheumatoid arthritis (RA) is an autoimmune disorder. Rheumatoid factor (RF) and anti-
citrullinated protein antibodies (ACPA) are known to play a role in RA. RF and ACPA origin is
Vaccines contain numerous residual proteins of food, animal, plant, fungal and bacterial origin,
from the manufacturing process. Protein sequence analysis shows that 14 of 14 known RF
autoepitopes differ from vaccine antigens by just one amino acid residue. The immune system’s cancer surveillance system looks for exactly such antigens. Cancer begins with a single DNA mutation where one base-pair is modified. Proteins encoded by this DNA segment will therefore also exhibit a single amino acid change. So such peptides with a single amino acid change (neoantigens) are strong markers for cancer and result in an anti-cancer immune
response, when accompanied by innate immune system co-stimulation. With thousands of such proteins in vaccines, there is an overwhelming anti-cancer immune response following vaccine administration. The adjuvant or live virus in the vaccine provides the requisite innate immune system co-stimulation. Since cancer cells/proteins are very similar to normal cells/proteins, attacking cancer always carries the risk of autoimmunity (collateral damage). Therefore vaccines cause numerous autoimmune diseases by triggering unnecessary anti-cancer immune responses.
In the specific case of RF, the target is the immune system’s IgG antibody itself. The immune system produces IgM antibodies (RF) that bind to the IgG antibody. Since this is a case of the immune system attacking its own “soldiers” (friendly fire), it weakens the immune system’s ability to fight cancer or infections.
Aluminum adjuvant in vaccines promotes citrullination of the antigens. Therefore the immune system produces antibodies against the regular and citrullinated versions of the antigen. The antibodies synthesized against citrullinated antigens (anti citrullinated protein antibodies (ACPA)) play a major role in RA.
The solution is to immediately remove all non-target antigens from all vaccines and injections.
Vaccination with bovine, chick, yeast antigens synthesizes cross-reactive antibodies targeting human acetylcholine receptor and MuSK protein to cause Myasthenia Gravis: Confirmed by natural experiment (VAERS data), bioinformatics, case reports, animal experiments and titer study
Myasthenia Gravis (MG) is a neuromuscular junction disorder. It is caused by antibodies directed against the acetylcholine receptor (AchR) or Muscle-Specific Kinase (MuSK) protein. 45 years ago, researchers discovered that immunizing rabbits with AchR from an electric eel, resulted in an MG like disease. Immunizing with the AchR protein is now the usual method used to induce experimental autoimmune MG (EAMG).
Development of MG is reported following the administration of many vaccines. Most cases occur following administration of the influenza vaccines per the Vaccine Adverse Event Reporting System (VAERS). A study found 20-81.2% AchR antibody level increase in 2 out of 31 patients following egg derived influenza vaccine administration and most of whom were on immunosuppressive treatment.
Most influenza vaccines are manufactured using embryonated chicken eggs and contain residual egg proteins. Embryonated chicken eggs contain the chick AchR protein. We show that the chick AchR protein sequence differ from human AchR by just one or two amino acid residues. Thus they are ideally suited to activate human low affinity self reactive (LASR) T cells. These human LASR T cells that recognize human AchR with low affinity can escape the thymus due to positive selection. Such T cells with T cell receptors (TCR) that bind with high affinity to chick AchR can be activated by injected chick AchR proteins. These activated T cells interact with B cells and initiate antibody production directed against chick AchR. These antibodies cross react with human AchR to cause MG.
Vaccines contain numerous animal proteins. Many of those AchR proteins are also similar to human AchR. So as above, many of these vaccines cause MG.
Similar mechanism is involved in Graves’ disease (GD). Yeast (Saccharomyces cerevisiae) is used to produce recombinant Hepatitis B vaccine (HBV), Human Papillomavirus vaccine (HPV) and injectable insulin products. We show significant protein sequence homology between GD autoepitopes, animal proteins and S. cerevisiae proteins. Humoral immune response directed against S. cerevisiae occurs following HBV, HPV administration and prolonged injectable insulin usage as in type 1 diabetes. Thus leading to the development of GD and numerous other autoimmune disorders.
Important findings: Animal protein containing vaccines cause autoimmune diseases even when the vaccine does not contain an adjuvant. Adjuvanted vaccines only make the problem worse.
Vaccines interact to cause autoimmune diseases. Post-marketing vaccine safety surveillance systems are an abject failure.