Best of: What’s In Your Flu Shot?
The BBC Files: Incompetent British Government Science

Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism

Journal ERPHRubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism Read the full pdf here

Anthony R. Mawson 1,* and Ashley M. Croft 2

1 Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences,
Jackson State University, Jackson, MS 39213, USA

2 School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK;
ashley.croft@myport.ac.uk

* Correspondence: amawsn@gmail.com

Received: 15 August 2019; Accepted: 15 September 2019; Published: 22 September 2019

Abstract: Rubella is a systemic virus infection that is usually mild. It can, however, cause severe birth defects known as the congenital rubella syndrome (CRS) when infection occurs early in pregnancy. As many as 8%–13% of children with CRS developed autism during the rubella epidemic of the 1960s compared to the background rate of about 1 new case per 5000 children. Rubella infection and CRS are now rare in the U.S. and in Europe due to widespread vaccination. However, autism rates have risen dramatically in recent decades to about 3% of children today, with many cases appearing after a period of normal development (‘regressive autism’). Evidence is reviewed here suggesting that the signs and symptoms of rubella may be due to alterations in the hepatic metabolism of vitamin A (retinoids), precipitated by the acute phase of the infection. The infection causes mild liver dysfunction and the spillage of stored vitamin A compounds into the circulation, resulting in an endogenous form of hypervitaminosis A. Given that vitamin A is a known teratogen, it is suggested that rubella infection occurring in the early weeks of pregnancy causes CRS through maternal liver dysfunction and exposure of the developing fetus to excessive vitamin A. On this view, the multiple manifestations of CRS and associated autism represent endogenous forms of hypervitaminosis A. It is further proposed that regressive autism results primarily from post-natal influences of a liver-damaging nature and exposure to excess vitamin A, inducing CRS-like features as a function of vitamin A toxicity, but without the associated dysmorphogenesis. A number of environmental factors are discussed that may plausibly be candidates for this role, and suggestions are ordered for testing the model. The model also suggests a number of measures that may be effective both in reducing the risk of fetal CRS in women who acquire rubella in their first trimester and in reversing or minimizing regressive autism among children in whom the diagnosis is suspected or confirmed.

Comments

greyone

Incredible diligence.
Thanks, Age of Autism.

Benedetta

Can too much vitamin A being dumped by the mother be treated to protect the her unborn baby?

Bob Moffit

"A number of environmental factors are discussed that may plausibly be candidates for this role, and suggestions are ordered for testing the model. The model also suggests a number of measures that may be elective both in reducing the risk of fetal CRS in women who acquire rubella in their first trimester and in reversing or minimizing regressive autism among children in whom the diagnosis is suspected or confirmed."

Would one of those "environmental factors" be "rabbit's blood" that Merck whistleblowers are awaiting their day in court to expose? It is amazing how much of our justice system can be BOUGHT by those with unlimited financial resources like Merck. Both .. sad and infuriating at the same time.

Verify your Comment

Previewing your Comment

This is only a preview. Your comment has not yet been posted.

Working...
Your comment could not be posted. Error type:
Your comment has been saved. Comments are moderated and will not appear until approved by the author. Post another comment

The letters and numbers you entered did not match the image. Please try again.

As a final step before posting your comment, enter the letters and numbers you see in the image below. This prevents automated programs from posting comments.

Having trouble reading this image? View an alternate.

Working...

Post a comment

Comments are moderated, and will not appear until the author has approved them.

Your Information

(Name and email address are required. Email address will not be displayed with the comment.)