Drs DeStefano and Offit are authors.
Principal Controversies in Vaccine Safety in the United States
Frank DeStefano, MD, MPH Heather Monk Bodenstab, PharmD Paul A Offit, MD
Clinical Infectious Diseases, ciz135, https://doi.org/10.1093/cid/ciz135
Concerns about vaccine safety can lead to decreased acceptance of vaccines and resurgence of vaccine-preventable diseases. We summarize the key evidence on some of the main current vaccine safety controversies in the United States, including:
1) MMR vaccine and autism;
2) thimerosal, a mercury-based vaccine preservative, and the risk of neurodevelopmental disorders;
3) vaccine-induced Guillain-Barré Syndrome (GBS);
4) vaccine-induced autoimmune diseases;
5) safety of HPV vaccine;
6) aluminum adjuvant-induced autoimmune diseases and other disorders; and
7) too many vaccines given early in life predisposing children to health and developmental problems.
A possible small increased risk of GBS following influenza vaccination has been identified, but the magnitude of the increase is less than the risk of GBS following influenza infection. Otherwise, the biological and epidemiologic evidence does not support any of the reviewed vaccine safety concerns.
You can comment on this article at the site. Please feel free to add your own interpretation of the statements made in this manuscript in our comments. Some immediate content questions:
Autism is a neurodevelopmental condition that has a strong genetic component and whose genesis begins in utero. WORD SALAD: Where is the citation and/or incontrovertible proof? Here is a recent article on regressive autism. No genetics mentioned.
The authors found no sudden change in the incidence of autism after introduction of MMR vaccine and no association between receipt of the vaccine and development of autism. WORD SALAD: "sudden" and "receipt". Autistic regression takes place over time.
Ethylmercury is broken down and excreted much more rapidly than methylmercuryand is thereforemuch less likely to accumulate in the body and cause harm WORD SALAD: "less likely" is hardly scientific nor reassuring. WORD SALAD: Thimerosal is the "safe" mercury... read The Comparable Dangers of Ethylmercury and Methylmercury