Note: One of the straw man arguments used against anyone who discusses vaccine injury, exemptions and refusal goes like this: "Do you want polio back?" Of course, the answer is "No." Below is an article from IPAK on the frightening outbreaks of "polio-like" paralysis in children across the nation. No child should be injured by a vaccine, or thrust into another illness because of the vaccine's intended role within the body. If a vaccine stops one disease but causes another even more harmful disease or situation, the risk far outweighs the benefit. These are the conversations parents should be able to have with their doctors. And on social media, without being called anti-vaccine and shut down. Harm is harm. And when your child is worse off after vaccination, that can hardly be called a medical miracle.
Mysterious Paralysis Affecting Children: Are Vaccines to Blame?
Eli Kammerman - October 28, 2018
[IPAK Editor's comment: The two-hit hypothesis presented addresses a cellular, but not a molecular, mechanisms of pathophysiology involving vaccination concurrent with enterovirus infection. Whether molecular mimicry or other known molecular mechanisms of vaccine induced autoimmunity also play a role remains to be tested.]
A mysterious disease is paralyzing kids in 22 states. A three-year-old who could barely hold up his own head was featured on the news after contracting a polio-like illness that started with a runny nose and turned into something much more serious. Doctors diagnosed him with Acute Flaccid Myelitis (AFM), a disease that causes sudden arm or leg weakness, and in some cases can lead to permanent paralysis. The CDC reports that so far in 2018, there have been 72 confirmed cases of AFM among a total of 191 cases currently under investigation.
But what’s causing it? And more importantly, how can we prevent it from happening to our children?
Here’s what parents need to know: AFM Peaks During Back-to-School Periods During the past five years, surveillance data reported by the CDC shows a seasonal peak in juvenile cases of acute flaccid myelitis (AFM) in three of the years (2014, 2016, 2018), with the peak occurring in the month of September and the next higher levels of cases seen in the immediately adjacent months. Read on to learn about the relationship between these seasonal peaks and the back-to-school period.
AFM and the Two-Hit Theory
The first hit, as widely acknowledged in case reports, could be an exposure to enterovirus such as EV-D68 and EV-A71, both linked to incidence of AFM by the CDC(1).
Researchers have puzzled over the failure to identify the presence of either of these two virus strains in some AFM cases. A possible explanation for the lack of detection of these viruses is the presence of the virus at undetectable levels or its presence in cells that aren’t adequately sampled for testing. It’s notable that coxsackie viruses CVB3, a close relative of the two enterovirus strains linked to AFM and is also linked to paralysis, is reported to establish infection within cells of the immune system, similar to poliovirus (2,3). Consequently, a low-level enterovirus infection may exist in people believed to have “cleared” their infection.
The second hit could be an intramuscular injection of drugs or vaccines into the arm or the leg that serves as a stimulus for B-cell migration to the injection site.
Intramuscular injections cause mild tissue trauma that naturally attracts immune cells, sometimes producing slight swelling known as an injection site reaction. An enterovirus carrier who has virus residing in B-cells may thereby be susceptible to “provocation paralysis”, a phenomenon that has been observed in recipients of oral polio vaccine (attenuated, live virus) who subsequently received intramuscular injections of penicillin, quinine or DPT vaccine (6,7,8,9). Other modes of sustaining muscle tissue damage could include a mild trauma such as a fall or blunt force hit, which could result in bruised muscle that becomes inflamed, provoking a mild immune response that includes B-cell migration. Muscle tissue damage is significant as a risk factor for enterovirus linked paralysis because damaged muscle has increased numbers of enterovirus (CAR) receptors on cell surfaces as part of the healing response (CAR—coxsackie and adenovirus receptor). Hence, increased presence of CAR would logically increase the probability of enterovirus attachment to damaged muscle. B-cells carrying enterovirus that localize to injection or trauma sites could then release enterovirus into damaged muscle and into nerve tissue via the motor end-plate, providing access to the CNS (spinal cord) for the virus (10,11). Like CAR, the poliovirus receptor PVR is similarly found in muscle and at the motor end-plate(12).
What does this mean for parents?
AFM cases may occur in enterovirus “carriers” who experience a muscle injury from injection, trauma, or blunt force hit. Suspected AFM cases should have statistically meaningful samples of white blood cells that include CD19+ B-cells tested for the presence of enterovirus.
To reduce your child’s risk of contracting AFM, consider avoiding intramuscular injections and muscle trauma during and 1-2 months after a known outbreak of AFM-linked enterovirus strains in the community. Read more and bookmark the IPAK site here.