by Ginger Taylor
Apparently we have had biomarkers for autism for five years.
Remember when Tom Insel, the man tasked by the federal government to coordinate autism research via the Interagency Autism Coordinating Committee, said that what we really needed was biomarkers for autism, and then failed to find us any biomarkers for autism? Then blew town for Google when the Thompson scandal broke in 2014?
Well apparently they were found in 2013, and ignored by Insel. He probably missed it, as they were discovered in a tiny, backwater outfit that no one has ever heard of called the New York State Department of Health.
And prepare to be shocked (or not), but the biggest tell at birth that a child is at risk for autism... wait for it... their levels of Glutathione s-Transferase (GST), the enzyme that links glutathione to toxic substances so they can be escorted out of the body.
Hmmm... if only someone had told us sooner that this was a detox issue from the day of birth... when babies are getting Hep B vaccine.
Apparently Dr. Gerald Mizejewski, God bless his curious heart, was wondering if there were any biomarkers for autism that would be present at birth, and then remembered, “Hey! We are the New York State Department of Health! We have blood spot samples from 12 million children taken at birth!”
So he went and found some kids with autism, and then pulled their blood spot cards to have them tested.
“In collaboration with the Center for Disability Services (NY, USA), 40 families with autistic children between the ages of 3 and 5 years born in New York State who had been diagnosed with autism at the center, were selected from among a group of 200 cases. A single developmental pediatrician made all the diagnoses using the DSMIV-TR criteria , thus assuring that diagnosis was consistent from child to child. These families were contacted by the center, provided with a description of the study and its goals and invited to participate in the study. A brief questionnaire and consent form were included in the mailing (CFDS IRB 07-010) and 20 positive responses were returned. Using the information provided by the parents regarding date of birth, 16 of these infants were identified in the repository of residual frozen newborn screening specimens at the Wadsworth Center (NYS IRB 07-044). “
“The specimens were submitted to Rules-Based Medicine (TX, USA) for analysis in their multiplex immunoassay system.” They tested for 90 biomarkers. They got 15 hits.
“Among the 15 biomarkers, the best set of five ranked in order from the highest BIC score included GST, Lp(a), IL-7, IL-5 and TNFa (Table 2). The second best set included thyroidstimulating hormone (TSH), KLK3, calcitonin (CCT) and IL-4 in addition to ferritin. The third best set included IL-8, TNFa, MUC16, TIMP-1 and AFP.
They kindly provided a list of those biomarkers and their biomedical and biochemical links to autism:
Oh my lands... is that the chemical symbol for mercury in one of those bubbles? It is!
Mizejewski, Lindau-Shepard & Pass end this paper with one of the best closings I have seen in research. It is almost poetry to me.
The pace of autism research and gained knowledge has increased exponentially in the last decade. This is true not only in the clinic, but also at the research bench. In the next 5–10 years, we can expect the autism field to expand and broaden its present base of knowledge in the areas of toxic metals, nutrition, GI biochemistry, genetic loci, medical imaging, autoimmunity and inflammation of the brain. In genetics, increased discoveries of gene clustering and autism susceptability gene loci will be at the forefront. The measurement of heavy metals will lend itself to measurements in the hair of autistic patients, in children and adults, to identify both deficiencies and excessive amounts. The development of new diets and dietary supplements will improve the everyday well-being of those with autism. The suspected linkage of GI peptides to autism will be pursued in light of the discovery that GI peptides have the same gene transcript and mRNA as the neuropeptides of the brain. In the field of medical imaging, disruptions in the motor and sensory areas of the brain will be visualized and defined in regions such as the amygdala and orbital–frontal cortex. The autoimmune association with autism via the human leukocyte HLA system will be clarified especially in the HLA-DRB1*011 and the HLA-DRB1*3 regions. The role of perinatal testosterone exposure in the ‘extreme male brain’ syndrome in autistic patients will be more fully elucidated. Finally, as stated in the present report, procedures to screen newborns at the onset of autism is currently underway and will be further exploited.”
Yet here we are five years later, and no newborn screening panel is being offered by my local docs. What about in your neck of the woods? No phone call from our pediatric practice saying, “Mrs. Taylor, Dr. Headinthesand would like you to bring Chandler in so we can check his glutathione levels.” I keep checking CNN for breaking news, but Gupta got nothin'.
It's a good thing I didn't read this paper five years ago. It might have given me hope that this was really going to happen by now. Because this has not happened. And there is no good reason that this has not happened, except that it continues to indict CDC's vaccine program in causation of autism.
Because CDC is culpable in the causation of autism.
"Autism Spectrum Disorder (ASD)
Screening and Diagnosis
Diagnosing autism spectrum disorder (ASD) can be difficult, since there is no medical test, like a blood test, to diagnose the disorders. Doctors look at the child’s behavior and development to make a diagnosis..."
"Autism Spectrum Disorder (ASD)
Screening and Diagnosis for Healthcare Providers"
........nothing on biomarkers, blood tests, newborn screenings, nothin.......
The phrase, “Glutathione s-Transferase” does not appear anywhere on the IACC web site
The phrase, “Glutathione s-Transferase” does not appear anywhere on the Foundation for the National Institutes of Health Biomarkers Consortium.
The phrase, “Glutathione s-Transferase” does not appear anywhere on the Yale Autism Biomarkers Consortium for Clinical Trials
Please contact CDC and IACC and let them know that they might have missed something important here. And here. Because there are a few other papers that may or may not mention the parts that glutatione and inflammation and blah blah blah from the above tables and bubbles play in autism... or something... who can keep track of these things.
It is not about the science. We won the science argument years ago. It is about corruption and willful ignorance.
Biomark Med. 2013 Apr;7(2):247-60. doi: 10.2217/bmm.12.108.
Mizejewski GJ1, Lindau-Shepard B, Pass KA.
Division of Translational Medicine, Wadsworth Center, NYS Department of Health, PO Box 509, Albany, NY 12201 0509, USA.
Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment.
This retrospective study sought to identify newborns at risk for ASD utilizing bloodspot specimens in an immunoassay.
MATERIALS & METHODS:
The present study utilized stored frozen specimens from ASD children already diagnosed at 15-36 months of age. The newborn specimens and controls were analyzed by immunoassay in a multiplex system that included 90 serum biomarkers and subjected to statisical analysis.
Three sets of five biomarkers associated with ASD were found that differed from control groups. The 15 candidate biomarkers were then discussed regarding their association with ASD.
This study determined that a statistically selected panel of 15 biomarkers successfully discriminated presumptive newborns at risk for ASD from those of nonaffected controls.
"GST [Glutathione S-transferase] is a metabolic biomarker directly associated with ASD. The human gene product for GST constitutes a candidate susceptibility protein due to its tissue distribution and role in oxidative stress and methionine metabolism, which results in neuronal injury and death."