From Apgar to ADOS
Greatest Threat to Kids

Baby Teeth and Autism Prediction

Copper zincSince the number of children being diagnosed with autism continues to increase, the research and studies continue to grow as well.  Many overlap or years later, they are taken to the next level as our understanding of the science increases.  This is such a study. 

From the adapted version on Medpage - Baby Teeth May Predict Autism - Zinc and copper metabolism biomarker may lead to new diagnostic tools

Zinc and copper metabolism cycles in the layers of baby teeth may be able to predict which children will develop autism spectrum disorder, a longitudinal analysis suggests.

This is the first study to generate a 90% accurate fetal and early childhood biomarker of autism by tracking metabolic pathways over time and could lead to new diagnostic tools...the researchers found that children who later developed autism had disrupted zinc-copper rhythmicity in utero or in their earliest months of life...We looked at the naturally shed teeth of children and explored them much as you would explore the growth rings of a tree, using them as a sort of retrospective biomarker to see what children were exposed to in the womb and in early life...Prenatal and newborn children form a new tooth layer daily, which captures an imprint of chemicals circulating in the body and produces a chronological exposure record. Zinc and copper pathways are central regulators of multiple metals; disruption of the pathways may have downstream effects that may affect the metabolism of other essential elements and toxic metals.

TOXIC METALS.  We don’t see those words enough but there are dozens and dozens of studies showing that environmental toxins are connected to the spectrum of autism.

Here is some very good research on the issues of copper/zinc in the human body .

Important theme from the above new, autism study.  Mercury has become a dirty word in autism research. Also that study seems pretty much targeted as a diagnostic tool.   There are thousands of children and young adults who would benefit from research dealing with helping them feel and function better.  Let’s hope there will be more about that. But here we can see that the issue of copper and zinc is not new in autism.  The idea of “disrupted zinc-copper rhythmicity” is new and helpful but let’s look backwards as well:

The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders, May 2009  

The frequency of zinc deficiency, copper toxicity and low zinc/copper in children with autism spectrum disorders (ASDs) may indicate decrement in metallothionein system functioning....The plasma zinc/serum copper ratio may be a biomarker of heavy metal, particularly mercury, toxicity in children with ASDs.

The role of zinc and copper in autism spectrum disorders, 2013

Several studies have suggested a disturbance in the copper (Cu) and zinc (Zn) metabolism in ASDs....Zinc deficiency, excess Cu levels, and low Zn/Cu ratio are common in children diagnosed with an ASD. The literature also suggests that mercury accumulation may occur as a cause or consequence of metallothionein (MT) dysfunction in children diagnosed with an ASD, which may be one of the causes of Zn deficiency.

Zn/Cu Levels in the Field of Autism Disorders: A Systematic Review and Meta-analysis, 2015 Autumn

Low Zn/Cu ratios can be associated with total body Zn deficiency or accumulation of toxic metals, which can act as Zn-antagonists. Hg toxicity may be a major cause of MT dysfunction in children diagnosed with ASD, which may be reflected in the Zn/Cu ratio...The plasma zinc/serum copper ratio may be a biomarker of heavy metal, particularly mercury, toxicity in children with ASDs....

Evaluation of whole blood zinc and copper levels in children with autism spectrum disorder, Aug, 2016

The results indicate that the ASD children were characterized by ~10 % (p = 0.005) and ~12 % (p = 0.015) lower levels of whole blood Zn and Zn/Cu ratio, respectively, in comparison to controls.

As researchers continue their search to both identify and help those with autism, especially the severe type with pain and suffering, we must look at the patterns and connections.  There is a large connection of autism with the immune system, and this too is a part of the copper, zinc relationship .  The environment is also connected and the microbiome and yes, copper and zinc are important biomarkers


Hans Litten

The wonderful brilliant Judy XMRV Mikovits

turn off that TV


----- and all this environmental stuff will lead to --- vaccines


Med page better be careful; because as one doctor told an intern right "right" in front of me; there is no faster career killer than to discuss vaccines in any way with your patients except when is the next one scheduled.

Hans Litten

You are what you eat. Or so the saying goes. Science now tells us that we are what the bacteria living in our intestinal tract eat and this could have an influence on how well we age. Building on this, McGill University scientists fed fruit flies with a combination of probiotics and an herbal supplement called Triphala that was able to prolong the flies’ longevity by 60 % and protect them against chronic diseases associated with aging.

The study, published in Scientific Reports, adds to a growing body of evidence of the influence that gut bacteria can have on health. The researchers incorporated a symbiotic – made of probiotics with a polyphenol-rich supplement – into the diet of fruit flies.

The flies fed with the synbiotic lived up to 66 days old – 26 days more than the ones without the supplement. They also showed reduced traits of aging, such as mounting insulin resistance, inflammation and oxidative stress.

“Probiotics dramatically change the architecture of the gut microbiota, not only in its composition but also in respect to how the foods that we eat are metabolized,” says Satya Prakash, professor of biomedical engineering in McGill’s Faculty of Medicine and senior author of the study. “This allows a single probiotic formulation to simultaneously act on several biochemical signaling pathways to elicit broad beneficial physiological effects, and explains why the single formulation we present in this paper has such a dramatic effect on so many different markers”.

The fruit fly is remarkably similar to mammals with about 70 % similarity in terms of their biochemical pathways, making it a good indicator of what would happen in humans, adds Prakash.
“The effects in humans would likely not be as dramatic, but our results definitely suggest that a diet specifically incorporating Triphala along with these probiotics will promote a long and healthy life.”

The authors also say that the findings can be explained by the “gut-brain axis,” a bidirectional communication system between microorganisms residing in the gastrointestinal tract – the microbiota – and the brain. In the past few years, studies have shown the gut-brain axis to be involved in neuropathological changes and a variety of conditions such as irritable bowel syndrome, neurodegeneration and even depression. Few studies, however, have successfully designed gut microbiota-modulating therapeutics having effects as potent or broad as the formulation presented in the new study.

The herbal supplement used in the study, Triphala, is a formulation made from amalaki, bibhitaki and haritaki, fruits used as medicinal plants in Ayurveda, a form of traditional Indian medicine.
Susan Westfall, a former PhD student at McGill and lead author of the study, says the idea of combining Triphala and probiotics comes from her long-standing interest in studying natural products derived from traditional Indian medicine and their impact on neurodegenerative diseases.

“At the onset of this study, we were hopeful that combining Triphala with probiotics would be at least a little better than their individual components in terms of physiological benefit, but we did not imagine how successful this formulation would be,” says Westfall, who is now a postdoctoral fellow at the Icahn School of Medicine at Mount Sinai in New York, USA.
The new study, which includes data filed in a US provisional patent through a company cofounded by the authors, has the potential to impact the field of the microbiome, probiotics and human health.

Considering the broad physiological effects of this formulation shown in the fruit fly, Prakash hopes their formulation could have interesting applications in a number of human disorders such as diabetes, obesity, neurodegeneration, chronic inflammation, depression, irritable bowel syndrome and even cancer.
This research was funded by the Natural Science and Engineering Research Council of Canada and the Canadian Institutes of Health Research.

Gary Ogden

Very important work. Multiple replication shows that this is a real biochemical phenomenon which plays a central role in the etiology of ASD. Yet nothing is done to address the root causes, which are clearly identified in the 2009, 2013, and 2015 papers. Good quality science strikes terror in the wallets of greedy pharma execs and their facilitators, the quislings in government regulatory agencies. Thank you very much for this post. Knowledge is power.

Hans Litten

We are ALL waiting ...... Scott Pruitt, Nancy Beck, Richard Yamada, Molly Block

Pressured by industry, U.S. EPA slows formaldehyde study release: documents

WASHINGTON (Reuters) - The U.S. Environmental Protection Agency, under pressure from the chemical (vaccination) industry, has delayed release of a study detailing cancer risks from formaldehyde, according to internal communications seen by Reuters, potentially keeping important health information from the public.

Democratic senators Ed Markey, Sheldon Whitehouse and Tom Carper last week wrote to EPA chief Scott Pruitt to ask about delays to the report and request communications between the EPA and ACC related to the formaldehyde assessment, saying they were concerned the agency was bowing to industry pressure.

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