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New Paper: Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms.

Science post image 2018 Mar 20. pii: S0889-1591(18)30078-3. doi: 10.1016/j.bbi.2018.03.025. [Epub ahead of print]

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms.

Abstract

OBJECTIVES:

Many studies have reported the increased presence of gastrointestinal (GI) symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles, pro-inflammatory responses and impaired intestinal permeability have been observed in children with ASD and co-morbid GI symptoms, yet few studies have compared these findings to ASD children without GI issues or similarly aged typical developing children. The aim of this study was to determine whether there are biological signatures in terms of immunedysfunction and microbiota composition in children with ASD with GI symptoms.

METHODS:

Children were enrolled in one of four groups: ASD and GI symptoms of irregular bowel habits (ASDGI), children with ASD but without current or previous GI symptoms (ASDNoGI), typically developing children with GI symptoms (TDGI) and typically developing childrenwithout current or previous GI symptoms (TDNoGI). Peripheral blood mononuclear cells (PBMC) were isolated from the blood, stimulated and assessed for cytokine production, while stool samples were analyzed for microbial composition.

RESULTS:

Following Toll-Like receptor (TLR)-4 stimulation, the ASDGI group produced increased levels of mucosa-relevant cytokines including IL-5, IL-15 and IL-17 compared to ASDNoGI. The production of the regulatory cytokine TGFβ1 was decreased in the ASDGI group compared with both the ASDNoGI and TDNoGI groups. Analysis of the microbiome at the family level revealed differences in microbiome composition between ASD and TD children with GI symptoms; furthermore, a predictive metagenome functional content analysis revealed that pathways were differentially represented between ASD and TD subjects, independently of the presence of GI symptoms. The ASDGIalso showed an over-representation of the gene encoding zonulin, a molecule regulating gut permeability, compared to the other groups.

CONCLUSIONS:

Overall our findings suggest that children with ASD who experience GI symptoms have an imbalance in their immuneresponse, possibly influenced by or influencing metagenomic changes, and may have a propensity to impaired gut barrier function which may contribute to their symptoms and clinical outcome.

KEYWORDS:

ASD; Autism; Cytokines; Gastrointestinal; ImmuneMicrobiota; Mucosal Immunity; Zonulin

Comments

John Stone

I gather Del Bigtree is covering this today on Highwire, 11am Pacific time.

Hans Litten

We are killing them at the moment.
Tough times to be a ProVaxxer (long may it continue)
The Mumps court case is due very soon
And those latest cdc Autism figures cant be postponed forever.

These papers

1. Kenya HCG - Oller
http://www.thehealthconsciousness.com/bombshell-science-paper-documents-the-depopulation-chemical-covertly-spiked-into-vaccines/

2. Dtap Mortality in Africa - Abay
https://www.frontiersin.org/articles/10.3389/fpubh.2018.00079/full (thanks JP)

3. Gardasil's future hangs by a thread in the US courts right now
https://www.healthnutnews.com/merck-accused-of-fraud-deceit-and-negligence-in-u-s-gardasil-case/
“Initially, qGardasil (Quadrivalent Gardasil) is not a treatment process and does not prevent cancer as marketed by Merck. Gardasil is a vaccine designed to increase the response of the Human Immune system to pathogens namely HPV viruses 6, 11, 16 & 18.”

4. The Gatti raid seems to have been explained : (Beatrice you damn criminal)
Mrs. Gatti, was about to testify in parliament about vaccine damage.
https://www.healthnutnews.com/world-renowned-scientists-have-their-lab-shut-down-after-troublesome-vaccine-discovery/

JP Sand

Another new paper:

"Evidence of Increase in Mortality After the Introduction of Diphtheria–Tetanus–Pertussis Vaccine to Children Aged 6–35 Months in Guinea-Bissau: A Time for Reflection?".

By Peter Aaby et al, Front Public Health. 2018; 6: 79.
Published online 2018 Mar 19. doi: 10.3389/fpubh.2018.00079
PMCID: PMC5868131
PMID: 29616207

John Stone

Hans

It certainly supports it.

Hans Litten

Doesn't this validate what Wakefield said like 20ish years ago ?

Copyright © 2018 Elsevier Inc. All rights reserved.

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