Gut Problems In Autism May Originate In Genes.... SERIOUSLY?
NOTE: Of interest to our readers, CHOP, home of vaccine apologist Dr. Paul Offit, just received millions for their autism research.... in genetics. Another nauseating wave of busy work while our children grow older and families drown. Biz Journals: CHOP Joins Larger Ever Autism Genetics Study
By Teresa Conrick
It takes a strong stomach - no pun intended - to stomach some of the research on AUTISM. I do appreciate research on the GUT but trying to link GENES again (!!) to AUTISM and then to hook that premise on to the many GASTROINTESTINAL issues in Autism (!!) is seemingly odd. The rapid release of study after study showing that kids and young adults with an AUTISM diagnosis having abnormal bacteria, paints a strong picture of the MICROBIOME being a top contender in the cascade of issues involved in Autism.
From the GENE research:
GI Problems In Autism May Originate In Genes, Study Suggests NEW YORK, NY (April 25, 2016) study :
"Gastrointestinal issues have been recognized as a common occurrence in people with autism since the condition was first described in the 1940s, but there was no indication that they were directly related," says the study's lead author, Kara Gross Margolis, MD, associate professor of pediatrics at Columbia.......
That's interesting as we have highlighted that for YEARS here at Age of Autism :
Leo Kanner wrote these descriptions of those first-ever, diagnosed children but he did not see the obvious:
- "Eating," the report said, "has always been a problem with him.”
- large and ragged tonsils.
- Following smallpox vaccination at 12 months, he had an attack of diarrhea and fever
- Large tonsils and adenoids
- He vomited a great deal during his first year,
- She quit taking any kind of nourishment at 3 months. She was tube-fed five times daily up to 1 year of age.
- He vomited all food from birth through the third month.
- His tonsils were removed when he was 3 years old.
- He vomited all food from birth through the third month.
- He suffered from repeated colds and otitis media, which necessitated bilateral myringotomy
- Because of a febrile illness at 13 months, her increasing difficulties were interpreted as possible postencephalitic behavior disorder.
- He had been kept in bed often because of colds, bronchitis, chickenpox, streptococcus infection, impetigo
Kanner missed the pattern of GI issues and INFECTION. These two medical problems have continued to be prevalent in many if not most of the children being diagnosed today.
And then more from that Gene research above-
Recent research by Jeremy Veenstra-VanderWeele, MD, the Mortimer D. Sackler, MD Associate Professor of Psychiatry at Columbia, and Randy Blakely, PhD, professor of psychiatry at Vanderbilt University School of Medicine, had linked some cases of autism to genetic mutations that inhibit serotonin activity. Serotonin is a chemical that transmits signals from one neuron to another in the brain. The brain, however, contains only 5 percent of the body's serotonin; most of the rest is at work in the GI system. Genetic mutations that affect serotonin's activity will thus have ramifications in the gut as well as in the brain.
Yes, serotonin has been around for YEARS as being important in research on Autism, but let's see how the puzzle pieces have been connecting as the Microbiome studies show that BACTERIA and not GENES, as the driving force :
A study published last year in the Journal of Abnormal Child Psychology linked the GI issues with behavior, showing that autistic children who have GI issues often experience extreme anxiety as well as regressions in behavior and communication skills. What's worse, the side effects of the psychotropic drugs that are prescribed to many autistic children may be intensifying the digestive issues. Once the GI issues are treated, aggressive and problematic behaviors sometimes subside....Serotonin is best known for its role in the central nervous system. It regulates mood, appetite, and sleep -- yet more than 90 percent of the body's serotonin is actually in the gut......A 2009 study found that about 30 percent of autistic children have too much serotonin.
Add this to the puzzle picture:
Scientists have found that gut bacteria produce neurotransmitters such as serotonin .........
And this:
Recent studies also demonstrate that gut microbes directly alter neurotransmitter levels, which may enable them to communicate with neurons. For example, Elaine Hsiao, a biologist now at the University of California, Los Angeles, published research5 this year examining how certain metabolites from gut microbes promote serotonin production in the cells lining the colon — an intriguing finding given that some antidepressant drugs work by promoting serotonin at the junctions between neurons. These cells account for 60% of peripheral serotonin in mice and more than 90% in humans.
Plus this:
Gut bacteria help regulate serotonin levels
The researchers then investigated the effects that specific bacteria had on increasing serotonin levels in germ free mice and discovered that spore forming bacteria, especially those belonging to Clostridia, were able to increase the levels of serotonin in the mice.
Convincing evidence connecting the gut bacteria to SEROTONIN. Interestingly, Children and young adults with an Autism diagnosis show significant abnormal counts and species of Clostridia ------
....Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridiumnot found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found......
What this shows up is that research on GENES is doing little in showing, explaining, treating, or preventing the pain and suffering of thousands with a diagnosis of AUTISM and the GI issues that are prevalent:
For example, the Centers for Disease Control and Prevention (CDC) recently found that children with autism are more than 3.5 times more likely to suffer chronic diarrhea or constipation than are their normally developing peers. Other researchers have found a strong link between GI symptoms and autism severity in children. Some experts have even proposed that toxins produced by abnormal gut bacteria may trigger or worsen autism in some children.
And there you have it. Please donate to valid and responsible research that will help our children. Gene research does not seem to be part of that at all.
Teresa Conrick is Contributing Editor to Age of Autism.
Changing the Course of Autism - Autism Treatment Trust - Scotland
https://vimeo.com/76566995
Dr Martha Herbert - Taking a Fresh Look at Autism: Chronic Dynamic State, not Fixed Trait
Martha starts her lecture at 6:46
Posted by: Citizen Scientist Xileen | May 03, 2016 at 01:45 PM
Gut problems are like the rocket science of this whole epidemic. I think it says a lot about what happens when you get out of balance and how hard it is to get it back. My father got C-dif in the hospital. They brought in the big gun medicines with one pill (anti-biotic, not sure) that cost like $500.00 a pill. This was years ago but everyone was practically washing the skin off her hands to not catch it, and wiping down the seat of the toilet. We were terrified. It's one of those examples about what happens in infancy that can change a life longterm---turning those born to sweet delight, into those born to endless night.
Posted by: kapoore | May 02, 2016 at 10:43 PM
In the wonderful world of CHOPS ... Children's Hospital for Profit ... if you give a vaccine to 100 children and 3 of them die, you have saved 97 lives.
The other big money maker at CHOPS, is securing Washington funding for something that does not exist, such as the Autism gene, making endless progress with markers and variants, and bullshitting Congress for new funds.
CHOPS is also working on a new MMR ... More Money Regardless ... vaccine due out in a few months.
This will have a new patent, it will be said to be safer than the the old MMR vaccine, and take another 20 years to show that they are still lying about it all.
Posted by: go Trump | May 02, 2016 at 07:26 PM
Last Week in Vaccinated America
https://jameslyonsweiler.com/last-week-in-vaccinated-america/
A worthwhile read.
Posted by: Danchi | May 02, 2016 at 07:02 PM
Thank you, Teresa. This discussion of the issues of Clostridium, MMR vaccine, the symptoms of regressive autism, antibiotic use, and bowel disease is one of the most important avenues to continue to research. I've been reading everything I can for years about this, because it closely fits what I know of my grandson's story. Thank you.
Posted by: Denise Anderstrom Douglass | May 02, 2016 at 07:00 PM
Genes? Sheesh! Just idly twiddling their thumbs and taking home their salaries. Seems to me a group at the Royal Free Hospital raised alarm bells about this very issue a mere eighteen years ago. God bless the BHARE Foundation. I’m certain now that the gut microbiome plays a critical role in our health in every way, and particularly in autism. This is the most important research we can possibly be doing, and supporting. I would make a contribution if I had an address to send it. I can no longer safely use my credit card on line.
Posted by: Gary Ogden | May 02, 2016 at 06:07 PM
In case You're not familiar with Mike Adams:
http://www.naturalnews.com/053867_vaccine_scandal_parent_protests_China.html
NaturalNews is his website and he's great!
Posted by: Sun~Rose | May 02, 2016 at 05:50 PM
Are they trying to latch on to serotonin because its such a recognizable word and keeps the patient within the psychiatric meds false paradigm?
Let's not forget what good bacteria do for GABA also.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769009/
"Major GABA producing microorganisms are lactic acid bacteria (LAB), which make food spoilage pathogens unable to grow and act as probiotics in the gastrointestinal tract. The major factors affecting the production of GABA by microbial fermentation are temperature, pH, fermentation time and different media additives, therefore, these factors are summarized to provide the most up-dated information for effective GABA synthesis. There has been a huge accumulation of knowledge on GABA application for human health accompanying with a demand on natural GABA supply. Only the GABA production by microorganisms can fulfill the demand with GABA-enriched health beneficial foods."
God only knows what other hormones might benefit from probiotics. Isn't insulin a hormone?
Check this out: http://insulinnation.com/treatment/medicine-drugs/probiotics-combat-insulin-resistance/
and
http://www.nutraingredients-usa.com/Research/Probiotics-may-counter-obesity-and-diabetes-NIH-study
Posted by: Jenny | May 02, 2016 at 05:22 PM
My 26 year old son has had many years of sleeping difficulties. We did the whole sleep clinic thing and tried out different medications, which basically did nothing. A few months ago I started giving him glutamine for his gut. Bingo. After a month he started sleeping very well and not surprisingly, his mood improved. It's amazing how little pragmatic research is done, when it could do so much.
Posted by: Margaret | May 02, 2016 at 01:29 PM
Hey so if you go down to my next post, there's an article about the BHARE Foundation and how they are doing important research for our kids. Please donate !
Posted by: Teresa Conrick | May 02, 2016 at 11:27 AM
"Gastrointestinal issues have been recognized as a common occurrence in people with autism since the condition was first described in the 1940s..."
Isn't that what Dr. Wakefield was supposedly "disgraced" and "discredited" for pointing out?
Posted by: Rae | May 02, 2016 at 10:27 AM
Ha ha, the pharmcos are *desperate* to make vaccine injuries nature's fault. But we know the truth.
"124 Research Papers Supporting the Vaccine/Autism Link"
http://www.scribd.com/doc/220807175/124-Research-Papers-Supporting-the-Vaccine-Autism-Link
Autism symptoms mirror (are synonymous with) heavy metal poisoning. If you live downwind from an old (unfiltered) coal power plant, you're getting mercury. This means that autism can be gotten from many sources other than vaccines, but vaccines given to children before their blood-brain barrier is formed are the primary cause.
"Merck used animal antibodies to artificially inflate appearance of immune system antibodies."
http://www.naturalnews.com/048402_measles_vaccine_scientific_fraud_court_documents.html
"MMR measles vaccine clinical trial results FAKED by Big Pharma - shocking U.S. court documents reveal all"
Merck spiked the blood test with animal antibodies to artificially inflate the appearance of immune system antibodies.
http://www.naturalnews.com/048402_measles_vaccine_scientific_fraud_court_documents.html
Merck's vaccine fraud has actually contributed to the continuation of mumps across America, causing more children to become infected with mumps. Yes, the MMR vaccine spreads disease.
http://www.naturalnews.com/048402_measles_vaccine_scientific_fraud_court_documents.html
Current National Vaccine Schedule: In the first 6 years, each child receives the following vaccine ingredients:
https://www.facebook.com/photo.php?fbid=140735242963542&set=gm.1008404395864684&type=3&theater
Major wake-up call for the sheeple. Vaccinate their kids with poisons? No problem. Vaccinate THEM? We'll see.
"Now, legislators in California want to pass the “first US adult vaccine mandate with NO personal exemptions and CRIMINAL penalties for failure to comply.” SB 792, would eliminate adults right to exempt themselves."
"California Now Wants to be First State to Mandate Adult Vaccines – Criminal Penalties for those Who Refuse"
https://www.facebook.com/jockdoubleday.writer/posts/984443884944247
Posted by: Jock Doubleday | May 02, 2016 at 09:30 AM
Hi Jenny,
Thanks! I thought that's what you meant-- BHARE and not CHOP. I can't change it but I think anyone reading the comments will know your heart and money is going to BHARE.
All best-
Teresa
Posted by: Teresa Conrick- to Jenny | May 02, 2016 at 09:26 AM
I think the too little and too much serotonin transmitters in the gut and too little is confusing to me. I suppose it shows that a happy medium is necessary. Wonder if the autism behaviors would be the same with too much as with too little. Thanks Teresa for this, as always.
Posted by: Maurine Meleck | May 02, 2016 at 08:52 AM
Hi Teresa I think I might have accidently commented on the wrong thread! Across the Atlantic we have very different (and secretive) medical research arrangements.
But worry not - my paypal donation went correctly to BHARE!
AoA Moderators PLEASE edit and reassign my comment changing CHOP to BHARE.
As for Offit and his $millions to prove GI problems in autism are genetic - POOF!! If that was the case the human race would have died out pre Neandertal. What a waste of taxpayer's cash.
Posted by: Jenny Allan | May 02, 2016 at 08:35 AM
Hi Jenny,
Thanks for your comment but I am not sure what research (or why) you are referring to when you mention CHOP? I hope instead you meant BHARE as they are doing important research related to the Microbiome and that has included Clostridium and Autism. And yes, the paypal on their site is great for donating.
Posted by: Teresa Conrick- to Jenny | May 02, 2016 at 07:37 AM
As a hospital acquired Clostridium difficile survivor, I was left with gut issues very similar to those of my autistic grandson, including pain and food intolerances.
My Grandson received the MMR vaccine when he was a year old. At the time he was still recovering from a respiritory infection and had been on antibiotics. I've often wondered what part those antibiotics played in his regression into autism.
Most newborn babies are known to be infected with Clostridium difficile bacteria. No one knows why, but these apparently do no harm to newborns' developing gut linings. Any C diff bacteria persisting would be kept in check by a diverse gut 'flora'. However, antibiotics wipe out most of these 'friendly' bacteria. C diff bacterial spores survive the wipe out and without competition proliferate, producing toxins which attack the gut lining.
The CHOP research is both valuable and urgent. It's simple to donate via Paypal from anywhere in the world.
Posted by: Jenny Allan | May 02, 2016 at 06:58 AM