NOTE: Of interest to our readers, CHOP, home of vaccine apologist Dr. Paul Offit, just received millions for their autism research.... in genetics. Another nauseating wave of busy work while our children grow older and families drown. Biz Journals: CHOP Joins Larger Ever Autism Genetics Study
By Teresa Conrick
It takes a strong stomach - no pun intended - to stomach some of the research on AUTISM. I do appreciate research on the GUT but trying to link GENES again (!!) to AUTISM and then to hook that premise on to the many GASTROINTESTINAL issues in Autism (!!) is seemingly odd. The rapid release of study after study showing that kids and young adults with an AUTISM diagnosis having abnormal bacteria, paints a strong picture of the MICROBIOME being a top contender in the cascade of issues involved in Autism.
From the GENE research:
GI Problems In Autism May Originate In Genes, Study Suggests NEW YORK, NY (April 25, 2016) study :
"Gastrointestinal issues have been recognized as a common occurrence in people with autism since the condition was first described in the 1940s, but there was no indication that they were directly related," says the study's lead author, Kara Gross Margolis, MD, associate professor of pediatrics at Columbia.......
That's interesting as we have highlighted that for YEARS here at Age of Autism :
Leo Kanner wrote these descriptions of those first-ever, diagnosed children but he did not see the obvious:
- "Eating," the report said, "has always been a problem with him.”
- large and ragged tonsils.
- Following smallpox vaccination at 12 months, he had an attack of diarrhea and fever
- Large tonsils and adenoids
- He vomited a great deal during his first year,
- She quit taking any kind of nourishment at 3 months. She was tube-fed five times daily up to 1 year of age.
- He vomited all food from birth through the third month.
- His tonsils were removed when he was 3 years old.
- He vomited all food from birth through the third month.
- He suffered from repeated colds and otitis media, which necessitated bilateral myringotomy
- Because of a febrile illness at 13 months, her increasing difficulties were interpreted as possible postencephalitic behavior disorder.
- He had been kept in bed often because of colds, bronchitis, chickenpox, streptococcus infection, impetigo
Kanner missed the pattern of GI issues and INFECTION. These two medical problems have continued to be prevalent in many if not most of the children being diagnosed today.
And then more from that Gene research above-
Recent research by Jeremy Veenstra-VanderWeele, MD, the Mortimer D. Sackler, MD Associate Professor of Psychiatry at Columbia, and Randy Blakely, PhD, professor of psychiatry at Vanderbilt University School of Medicine, had linked some cases of autism to genetic mutations that inhibit serotonin activity. Serotonin is a chemical that transmits signals from one neuron to another in the brain. The brain, however, contains only 5 percent of the body's serotonin; most of the rest is at work in the GI system. Genetic mutations that affect serotonin's activity will thus have ramifications in the gut as well as in the brain.
Yes, serotonin has been around for YEARS as being important in research on Autism, but let's see how the puzzle pieces have been connecting as the Microbiome studies show that BACTERIA and not GENES, as the driving force :
A study published last year in the Journal of Abnormal Child Psychology linked the GI issues with behavior, showing that autistic children who have GI issues often experience extreme anxiety as well as regressions in behavior and communication skills. What's worse, the side effects of the psychotropic drugs that are prescribed to many autistic children may be intensifying the digestive issues. Once the GI issues are treated, aggressive and problematic behaviors sometimes subside....Serotonin is best known for its role in the central nervous system. It regulates mood, appetite, and sleep -- yet more than 90 percent of the body's serotonin is actually in the gut......A 2009 study found that about 30 percent of autistic children have too much serotonin.
Add this to the puzzle picture:
Recent studies also demonstrate that gut microbes directly alter neurotransmitter levels, which may enable them to communicate with neurons. For example, Elaine Hsiao, a biologist now at the University of California, Los Angeles, published research5 this year examining how certain metabolites from gut microbes promote serotonin production in the cells lining the colon — an intriguing finding given that some antidepressant drugs work by promoting serotonin at the junctions between neurons. These cells account for 60% of peripheral serotonin in mice and more than 90% in humans.
The researchers then investigated the effects that specific bacteria had on increasing serotonin levels in germ free mice and discovered that spore forming bacteria, especially those belonging to Clostridia, were able to increase the levels of serotonin in the mice.
Convincing evidence connecting the gut bacteria to SEROTONIN. Interestingly, Children and young adults with an Autism diagnosis show significant abnormal counts and species of Clostridia ------
....Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridiumnot found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found......
What this shows up is that research on GENES is doing little in showing, explaining, treating, or preventing the pain and suffering of thousands with a diagnosis of AUTISM and the GI issues that are prevalent:
For example, the Centers for Disease Control and Prevention (CDC) recently found that children with autism are more than 3.5 times more likely to suffer chronic diarrhea or constipation than are their normally developing peers. Other researchers have found a strong link between GI symptoms and autism severity in children. Some experts have even proposed that toxins produced by abnormal gut bacteria may trigger or worsen autism in some children.
And there you have it. Please donate to valid and responsible research that will help our children. Gene research does not seem to be part of that at all.
Teresa Conrick is Contributing Editor to Age of Autism.