Above All, Autism, When It Comes to the Microbiome and the Immune System
The ever-increasing word -- AUTISM -- is seen as a disorder and also a disease:
DISORDER: Autism is a complex spectrum of disorders that share three classic features - impaired communication, poor social engagement and repetitive behaviors. On one end of the spectrum are people who are socially awkward but, in many cases, incredibly bright. At the other extreme are individuals with severe mental disabilities and behavioral problems. Among autistic children's most common health complaints? Gastrointestinal problems. Although estimates vary widely, some studies have concluded that up to 90 percent of autistic children suffer from tummy troubles.
Tummy troubles is putting it mildly.
DISEASE: Autism spectrum disorders (ASDs) are considered a heterogenous set of neurobehavioral diseases, with the rates of diagnosis dramatically increasing in the past few decades. As genetics alone does not explain the underlying cause in many cases, attention has turned to environmental factors as potential etiological agents. Gastrointestinal disorders are a common comorbidity in ASD patients.
Far too many children and young adults who have a diagnosis of AUTISM suffer GI issues and that has turned out to be a big clue. ENVIRONMENTAL FACTORS would then be the culprit. Here is a recent study that ties these issue together but never, ever mentions AUTISM -- WHY?
The gut microbiota: a major player in the toxicity of environmental pollutants?
...There is clear evidence that bacteria-dependent metabolism of pollutants modulates the toxicity for the host. Conversely, environmental contaminants from various chemical families have been shown to alter the composition and/or the metabolic activity of the gastrointestinal bacteria, which may be an important factor contributing to shape an individual’s microbiotype. The physiological consequences of these alterations have not been studied in details but pollutant-induced alterations of the gut bacteria are likely to contribute to their toxicity. In conclusion, there is a body of evidence suggesting that gut microbiota are a major, yet underestimated element that must be considered to fully evaluate the toxicity of environmental contaminants....Environmental chemicals can also interfere with the composition of the GI microbiota, which may lead to detrimental consequences for the host...the GI bacteria may have a significant, but underestimated, capacity to metabolise environmental chemicals.
.....there has been a tremendous increase in the prevalence of allergic diseases such as asthma and food allergies in the last few decades. Recent evidence suggests that both alterations of microbial colonisation during the perinatal period and early-life exposure to environmental chemicals may promote dysregulated immune responses. 86,87,88 It therefore seems plausible that exposure to chemicals may affect the normal colonisation of the gut by bacteria, with effects on host physiology later in life. Therefore, chemical-induced perturbations of the composition of the GI microbiota may constitute an underestimated mechanism by which they interfere with human health.
From the study:
Pesticide Exposure - Glyphosate is the active component of Roundup (Montsanto, St Louis, MO, USA), the most widely used herbicide worldwide. It has been shown that the growth of Enterococcus faecalis bacteria isolated from cattle and horse faeces is inhibited by the lowest concentrations of glyphosate and the herbicide formulation tested.90 Further studies demonstrated that sensitivity to glyphosate is dependent on the bacterial strain.
Mercury Exposure - In vivo, the importance of bacterial demethylation for the elimination of mercury has been confirmed in studies where the suppression or absence of the GI microbiota was associated with lower faecal excretion of total mercury 60,61,62 and with increased accumulation of mercury in most tissues, including the brain.......
Three types of "chemicals" often cited in Autism research and by parents are 1- Vaccines , 2- Pesticides and 3- Mercury
YES, But What About AUTISM?
So we have ENVIRONMENTAL EXPOSURE, ENVIRONMENTAL POLLUTANTS, EXPOSURE TO CHEMICALS, CHEMICAL-INDUCED PERTURBATIONS OF THE GI MICROBIOTA, yet not one mention of Autism?
There is much information that should make the alarm LOUDER on the MICROBIOME and AUTISM:
- changes in gut bacteria composition are reflected in changes in behaviors, highlighting a strong and interconnected way of communication between the gut microbiota and the brain.
- dysfunctions of the gut bacteria-brain axis are correlated with several disorders: anxiety, depression, irritable bowel syndrome and, ABOVE ALL, AUTISM.
- GI microorganisms have been known for decades to be involved in the biotransformation of xenobiotics (a foreign chemical substance found within an organism that is not normally naturally produced by or expected to be present within that organism.)
- About 50% of Desulfovibrio strains tested to date have the ability to produce MeHg.
- pyrosequencing analysis showed that gram-negative bacteria, Desulfovibrio and Bacteroides vulgatus, were detected at higher levels in autistic children
And from the very recent International Meeting for Autism Research (IMFAR):
- All of the daily stool samples from the child with autism contained four organisms that earlier research had associated with autism. These included Sarcina ventriculi, Barnesiella intestihominis, Clostridium bartlettii, and Clostridium bolteae. By contrast, none of these bacteria appeared in the stool of the unaffected sibling.
- The bacterium Haemophilus parainfluenzae appeared in the stool of the child with autism during a three-day period when the child experienced GI pain, diarrhea and a spike in challenging behaviors including self-injury.
- On a separate two-day period, another spike in H. parainfluenzae correlated with another increase in self-injurious behavior – but this time without any change in stool consistency or obvious signs of GI pain.
- The appearance of H. parainfluenzae in the child’s stool came as a surprise to the researchers. This bacterium normally resides in the respiratory tract, where its overgrowth can cause ear, throat and lung infections. None of those sicknesses were present in the child or family members during the study period....
The Immune System and Microbiome are Connected
- Other researchers have suggested a link between the gut–brain axis and neuropsychiatric disorders such as autism, depression, and eating disorders. The gut contains microorganisms that share a structural similarity with the neuropeptides involved in regulating behavior, mood, and emotion—a phenomenon known as molecular mimicry. The body can’t tell the difference between the structure of these mimics and its own cells, so antibodies could end up attacking both, potentially altering the physiology of the gut–brain axis.
- Microbiota interact with host cells in particular by modulating the mitochondrial activities. This mitochondria – microbiota cross-talk is intriguing because mitochondria and bacteria share a lot of common structural and functional features. Several studies reported strong association between microbiota quality and diversity and mitochondrial function. The mitochondrial production of Reactive Oxygen Species plays an important role during the innate immune response and inflammation and is often target by pathogenic bacteria.
- Children with AU have significantly reduced levels of plasma IgG and IgM compared to both DD and TD controls, suggesting an underlying defect in immune function. This reduction in specific Ig levels correlates with behavioral severity, where those patients with the highest scores in the behavioral battery have the most reduced levels of IgG and IgM.
- When the body doesn't produce enough IgG, the condition is known as an IgG deficiency. People with IgG deficiency are more likely to get infections.
- Patients are often referred to immunologists for the evaluation of reduced serum IgG levels. Because antibody deficiencies are the most common of the primary immune defects, examination of humoral immunity in these patients is valuable.
- Patients with profoundly reduced (<100 mg/dL) or significantly reduced (100–299 mg/dL) IgG levels with clearly impaired antibody response are generally treated with replacement immunoglobulin starting at 100 mg/kg per week given either intravenously or subcutaneously.
- Prophylactic antibiotics may also be required in some individuals.
It's important to remember that Dan Olmsted reported on the profound recovery of a young child after receiving IVIG (replacement immunoglobulin):
"Absent, too, is the fact that Child 11 is now in college in California after graduating from high school with a 3.75 academic average.
The treatment the father cited, and the rationale for it, has been described in detail by the U.S. doctor who administered it. “A number of immunological abnormalities have been observed in patients with autism,” according to the text of comments he subsequently made at a meeting of an autism group. He said all the children he treated, which included child 11, had regressed after the MMR shot.
“Natural killer cells … that appear to play an important role in defense against virus infected cells and tumor cells are decreased both in numbers and functions in patients with autism. This deficiency may play a role in increased susceptibility to various infections that may in turn play a role in the pathogenesis of autism.”
He goes on to describe the use of IVIG in this context, at the 400 mg/kg dose the father cited. “IVIG has been used in a number of primiary immunodeficiency syndromes, and autoimmune and immunoinflammatory disorders including demyelinating polyneuropathy, multiple sclerosis, Guillain-Barre syndrome."
Many children with an Autism diagnosis need immune therapies and families are not aware of this important fact. A big reason we are seeing so many children with both AUTISM and PANDAS, PANS, and Lyme diagnoses may be that something has happened to alter their Microbiome, thus their immune system. More must be done to help our very sick and affected children. In that theme, stay tuned next time for an update on Fecal Transplants.
Teresa Conrick is Contributing Editor to Age of Autism.
Teresa: the part of the IgG and IgM levels being shown low in autism caught my attention. I know bacteria can produce hormones and vitamins. Is there evidence that they produce antibodies themselves, also? Thereby could using probiotics eventually could serve a similar purpose as getting IgG treatment?
Are those with autism with low IgG and IgM the same groups lacking certain bacterial groups vs healthy control groups?
Also: re: mitochondrial disfunction, just for the heck of it I wanted to post this:
"Cinnamon polyphenols attenuate cell swelling and mitochondrial dysfunction following oxygen-glucose deprivation in glial cells." even when vitamin E, reseveratrol couldn't.
Posted by: Jenny | May 17, 2016 at 02:06 PM
Giardia; Is a good clue isn't it Teresa. An intestinal parasite. I bet every one has a bit of it in their intestines.
Right now I have a good friend from my high school days trying to raise her granddaughter. The girl's mother is in jail for drugs and her own son is a drug addict and no help to her at all. The granddaughter is being treated for depression - and it is severe. She is now in the 8th grade - in special behavior class and she came down with C diff last month.
And strep - there are tons of strep out there and not all are pathogenic. If some of these niche filling good strep is missing - do you get Kawasakis?
Next article - fecal transplants. Hmmmmm; I took some walnuts over to the Amish last Fall and sold them some - they looked healthy How to I approach that subject. LOL!
Posted by: Benedetta | May 17, 2016 at 11:04 AM
Bacteriodes fragilis very common in the gut - but outside the gut there is no part of the body that it will not cause problems -- like abscesses in the brain, - well no where except the gut is it a great bacteria. When you have a GI wound it is this bacteria that gives you the most trouble.
So, leaky gut - hmmmmm just how big are the holes and what does it leak.
And that brings me to the wonderment of how many different types of zonnulin (not sure that is spelled right - but Dr. Fassano named this immune cell located in the GI track that reacts with the protein gluten and open up the gut lining and makes it leaky)
I am pretty sure there is a zonnulin in my Mother and Daughter for onion and peppers.
Can the immune system be reset? The answer is yes, possibly - by a low carb diet/ ketogenic diet - steroids (maybe long term if used right), and of course marrow transplants - like a cancer patient.
But Gary and Vaccine Papers -- am I understanding this right - if we can get the right kind of bacteria growing - they too will control these - for the lack of a better name for me - these multiple zonnulins, stomach immune cells.
Posted by: Benedetta | May 17, 2016 at 10:55 AM
Hi and thanks for the comments (Susan- HI!)
I thought this might fit here--
"That’s increased drugmakers’ interest in the human microbiome -- the universe of roughly 100 trillion good and bad bacteria, fungi and viruses that live on and inside the body. Roche is already undertaking basic research in the field and plans to investigate the microbiome’s potential for cancer treatment....."We are in active discussions with the usual suspects in the immunotherapy space," .......Efforts are under way to turn bacteria into regulated pharmaceutical products to treat illnesses of the gut, where the microbes reside. http://www.bloomberg.com/news/articles/2016-03-14/how-gut-bacteria-are-shaking-up-cancer-research
Meg had Giardia. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933943/
Posted by: Teresa Conrick | May 16, 2016 at 10:50 PM
Vaccine papers: This is extraordinarily important work. In the mouse model “the human commensal Bacteriodes fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensimotor behaviors.” Someone must be doing similar work in the human model. Has pharma submitted patent applications for human commensal gut bacteria?
Posted by: Gary Ogden | May 16, 2016 at 08:14 PM
The rest of the story - that a doctor found a moving mole, got out the magnifying glass and found it was a bird/deer tick and it carried - in Lyme, named after a town in New Hampshire - or was it Vermont - or Mass. ?
Oh, well; the rest of the story is that the little cork screw bacteria found in bird/deer tick had always been around - what was really going on was a whole country suddenly could not fight it off because of sick immune systems.
That sounds like how it is going to play out.
Which reminds me of 1983 - that year - my Mother and I took an elevator ride down to the first floor of the University of Kentucky while listening to two young doctors talk in hush tones about another one died today - that makes five this week. They were talking about the newly emerging immune eating AIDs virus.
Meanwhile: Up on the fourth floor we had just left my two year old daughter; just for a few minutes with a strange disease of the immune system called Kawasaki's disease.
Teresa what did your daughter have that was unusual, was it a protozoa - starts with a G - often found in water and most people have no problem with it.
Posted by: Benedetta | May 16, 2016 at 07:45 PM
AOA is still missing the story about immune activation. Immune activation per se damages the microbiome. See this study by the patterson group.
Posted by: Vaccine papers | May 16, 2016 at 04:45 PM
As always Teresa, another outstanding article from you! Thank you so much for your ongoing commitment to our children.
Posted by: Susan O. | May 16, 2016 at 03:16 PM
Mercury in vaccines never surprises me,and the mantra,that you are crazy when you try to remove it...but what about the clown puppets sorry doctors that put the mercury where it is, in the first place they were seemingly not crazy...Andy Cutler slow oral dosage seems a sensible way to achieve mercury removal if followed in the slow safe methods described.
Posted by: Angus Files | May 16, 2016 at 02:07 PM
I don't think you are alone wondering that. Thank you.
Posted by: Teresa Conrick | May 16, 2016 at 01:38 PM
Like those with MCS, toxin avoidance should be managed.
New carpeting, pesticides and fragrance likely affect any damaged CNS system.
Posted by: Tom Knight | May 16, 2016 at 01:19 PM
Rebecca Lee--- or aluminum.
Posted by: Benedetta | May 16, 2016 at 11:12 AM
"The appearance of H. parainfluenzae in the child’s stool came as a surprise to the researchers. This bacterium normally resides in the respiratory tract, where its overgrowth can cause ear, throat and lung infections. None of those sicknesses were present in the child or family members during the study period...."
The Hib vaccine couldn't have anything to do with finding the above type of bacteria where it's not expected, could it?
Posted by: Jeannette Bishop | May 16, 2016 at 10:55 AM
So, you inject the fetus, and then the baby with driblets of mercury here and there with all those vaccines. This totally hammers their immune system. Then, at 18 months you inject them with three live viruses. What could go wrong?
Posted by: Rebecca Lee | May 16, 2016 at 08:46 AM