By Teresa Conrick
The research on the Microbiome continues to be amazing. The newest realization is that the myelin in the brain is affected by the gut microbiota:
UCC scientists uncover a potential role of the microbiome in regulating myelination in the brain.
Over the past decade it is becoming increasing clear that the microbes that reside within and around us play a clear role is our health and well being. Perhaps most surprising of all is the realisation that gut bacteria can even influence brain function and behaviour. Now scientists in the APC Microbiome Institute and Department of Anatomy and Neuroscience, University College Cork Ireland have shown, at least in animal models, that major disturbance in communication between the gut microbiota and brain has resulted in changes in myelination patterns in the prefrontal cortex, a brain region that is key to higher cognitive functions and in the expression of anxiety and social behaviours.....introducing a normal microbiome had the ability to reverse some of the parameters used to measure the changes in myelination.
“It is likely that key signals from the gut to the brain provide a brake on myelination processes” says Prof Cryan. Furthermore, he says that “understanding these may open innovative gut microbiome-based strategies for tackling myelin-related disorders”. Moreover, this data presented by the APC Microbiome team continues to broaden the concept that the microbiome has a remarkable influence over fundamental brain processes and may be harnessed in the future for a wide range of brain disorders.
What disorders or diseases:
Multiple sclerosis --- (MS) is the most common demyelinating disease of the central nervous system. In this disorder, your immune system attacks the myelin sheath or the cells that produce and maintain it.
Optic neuritis — inflammation of the optic nerve in one or both eyes
Neuromyelitis optica (Devic’s disease) — inflammation and demyelination of the central nervous system, especially of the optic nerve and spinal cord
Transverse myelitis — inflammation of the spinal cord
Acute disseminated encephalomyelitis — inflammation of the brain and spinal cord
Adrenoleukodystrophy and adrenomyeloneuropathy — rare, inherited metabolic disorders
...people who got the 2009 H1N1 vaccine may have had a higher risk of getting Guillain-Barre syndrome (GBS). GBS affects the myelin sheath which covers the nerve, damaging it in a process known as demyelination.
Then there's -- Autism:
Autism may involve disordered white matter in the brain
December 5, 2011
Children's Hospital Boston
It's still unclear what's different in the brains of people with autism spectrum disorders, but evidence from genetic and cell studies points to abnormalities in how brain cells, connect to each other. A new study now provides visual evidence associating autism with a disorganized structure of brain connections, as well as defects in myelin -- the fatty, insulating coating that helps nerve fibers conduct signals and that makes up the brain's white matter.
What that means is that the Microbiome is turning out to be a huge and hopeful path to health. More and more research shows that the Microbiome is very damaged in Autism.