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Risperidone and Weight Gain: New Microbiome Research

American fat kidBy Teresa Conrick

The research on the Microbiome is rapidly developing.  As it does, we are finding out how the Microbiome can be damaged and the negative outcomes as a result. Here is a recent study that now explains how and why so many children have been gaining enormous weight on the prescription drug, Risperidone (Risperdal).  Many children with an AUTISM diagnosis are being prescribed Risperidone. More damage to the already dysfunctional Microbiome in Autism may be a side effect that parents need to know about and doctors question.

Use of the second-generation antipsychotic, risperidone, and secondary weight gain are associated with an altered gut microbiota in children , Published online 6 October 2015

The caveats from this study:

-  Over the last two decades, the prescribing rate of second-generation antipsychotic medications (SGAs) to treat children has increased nearly eightfold...

The atypical antipsychotic risperidone (RSP) is often associated with weight gain and cardiometabolic side effects.

    -  Significant alterations in the microbiome were seen at the phyla level following both acute and chronic exposure to RSP.

-  Chronic treatment with RSP was associated with an increase in body mass index (BMI) and a significantly lower ratio of Bacteroidetes:Firmicutes as compared with antipsychotic-naïve psychiatric controls.

-  Furthermore, a longitudinal observation, beginning shortly after onset of RSP treatment, revealed a gradual decrease in the Bacteroidetes:Firmicutes ratio over the ensuing months of treatment, in association with BMI [ body mass index] gain.

-   ...gut bacteria utilize neurotransmitter signaling pathways targeted by antipsychotic medications..

-  participants in the chronic RSP group were significantly different from psychiatric controls (analysis of similarity (ANOSIM) R=0.516, P<0.05). This indicates that a robust difference exists between the overall gut microbial profiles of the two groups...

-  Importantly, significant differences in bacterial composition also differentiated RSP-treated participants who exhibited significant BMI gain from those who did not...

-  Importantly, Clostridium sp., Lactobacillus sp., Ralstonia sp. and Erysipelotrichaceae family members were more abundant in participants in the chronic RSP group who also displayed a significant BMI gain.

    -  In our study, higher levels of KEGG-associated pathways for butyrate and propionate metabolism were found within the RSP treatment group compared with psychiatric controls (Figure 4), suggesting that the gut microbiome of these individuals may have higher levels of short-chain fatty acids production, potentially leading to weight gain. 

    -   These results suggest that specific Firmicutes and Burkholderiales species may have a role in RSP-induced weight gain while Coriobacteriales may be  protective.

The cardiac issues here also cannot be denied. Stay tuned.

 

Comments

Christine MacVicar

Risperidal, as with all antipsychotics, damages complex1 of the mitochondria. A subgroup of ASD are known to have MTD, indeed the term " autism secondary to mitochondrial disorder" or AMD has been used.
The knowledge of the harm these drugs cause has been known of since 2008 when James Dykens and Yvonne Will co- edited a collection of research publications. It is called " Drug induced mitochondrial dysfunction". I made enquires of our Health Board's librarian and they do not have this book.
In Scotland we have a Patient Safety Programme which states that no treatment should be given which causes harm, but this drug is still being forcibly given to people.
We are suing.

Linda1

Not about Risperdal specifically, but about the Microbiome and available testing:

https://www.youtube.com/watch?v=UjdivDJ9cho&feature=youtu.be

http://ubiome.com/

Denise Anderstrom Douglass

Thank you, Teresa, and thank you, AOA. Yes, Benedetta, you are 100% correct: Seroquel is a second generation anti-psychotic drug. The way they prescribe it and the way it is viewed (on the street, in the jails, etc) is not as an anti-psychotic, but as some kind of "relax you so you can get a good night's sleep" and/or "it helps the videos in your head quiet down, helps the repetitive thoughts go away so you can sleep" -- BS folks! It is classed as an anti-psychotic by the FDA just like risperdal/risperidal.

I cannot stand to even start on risperidol: it was the new Haldol/Haloperidol, and was used on the elderly, back, starting in the 90's. Never mind tardive dyskenesia, I cannot tell you how many dementia patients I personally saw die from that drug. Later, they quietly declared it not for the elderly. And ... started giving it to children on the autism spectrum! Weight gain is the least of it; gynomastia (boys developing breasts) is the least of it. I saw that drug suddenly cause the inability to swallow. More than once or twice! Upon discontinuing the drug, sometimes the ability to swallow came back. Sometimes it didn't -- and you die pretty fast.

The research into the microbiome is so heartening. I'm mainly saying: if you personally know anyone who has a child on Risperidol, please, please help them understand this!

david m burd

Thanks Teresa, for your ceaseless effort to educate about our interactive physical chemistry, and further warn about Pharma's out-of-control drugs,

Such drugs further abetted by the FDA, a major accomplice in poisoning our children.

cia parker

My uncle had schizophrenia from vaccine mercury poisoning, and took Thorazine for decades. He had been a slender, handsome young man, but the Thorazine caused him to become extremely obese, close to 400 pounds. It also dampened his personality, making him indolent and excessively calm. He died nearly thirty years ago, at 59, found one morning slumped over his dining room table. Another one whose life was ruined by vaccine mercury.

Jeannette Bishop

Thank you, Teresa, for this investigation.

Another somewhat fluffy (possibly insubstantial) rant...Does the medical literature establish that being overweight causes heart problems (and other health problems) or is this a blaming of a co-morbid symptom? I see such strong fat phobias (as strident as some vaccine dogma) in some working in the medical field, it raises suspicions (in me) that there is a concerted effort (I don't know whether conscious or not) to prevent questioning of weight gain dogma(?).

I'm suspicious in part because I watched an active family member experience a huge gain (as far as I know unreversed despite maintaining a high level of activity) with just a few weeks on an "anti-psychotic," and

I gained some weight (and horrible headaches) taking birth control. I think I became prediabetic on them. My ob/gyn said that she had trouble finding ways to avoid weight gain for some of her patients on any of the pills. I still have occasional freaky (changes you can feel overnight) weight gains when I dust off some musical training and try to practice singing (especially when I'm allowing myself to eat complex carbs). I think the type of breathing involved with singing might have something to do with that too, but that's just a feeling.

Also, I see active children/youth (mostly born in the 90s) who are just pudgier than my generation was at their age (and as far as I can tell many of their parents try to provide good diets, etc) so I'm pretty suspicious of the universally administered pharmaceuticals (mainly vaccines, particularly my favorite tag-team, aluminum/thimerosal).

For now my opinion is, while diet and exercise are important (possibly mainly for detox), pharma makes one fat (and generally unhealthy)...and if they stop being so modest and start taking full credit where credit seems to be due (perhaps if the rest of society bands together and puts some positive social pressure in that direction) we might get some real healthcare for our microbial friends (and ourselves).

Benedetta

Is seroquel on of those drugs? I think so - It is impossible for anyone to take that stuff and not become obese.

It really causes them to crave sugar and carbohydrates too.

Zonnagram an anti-seizure med though makes patients to lose their appetites.

They have known for 60 years or more that all these drugs side effects are weight gain or lose.

Linda1

Thank you Teresa for another excellent article.
Would like to see them write that "no actual children were harmed in the production of this research". But, of course, they are not able to say that and even worse, they are not expected to, despite the Art Caplans of the world giving them green lights to drug children. The control group was on other types of drugs. I was most interested in what happened to these poor kids. Did they get them off the drugs? Did their microbiomes recover and their weight normalize? They don't say and those are the most important questions. I guess getting them off the drugs is not the goal.

Lisa

It is simply horrifying to me that they are giving children -- any children with any diagnosis -- reward-hormone blockers. There is no logical reason whatsoever to block the reward hormone (dopamine) in a child who is not actively hallucinating or otherwise exhibiting an extreme form of psychosis. That reward hormone is why we are still living on this planet. It is largely responsible for our survival as a species. As much as we need to actively campaign against the vaccine mandates, we just as desperately need a campaign against dopamine blockers. They are not just bad medicine. There is something inherently evil about what is happening with this class of drugs now. They are being used to sedate people -- adults and children -- often to the point of becoming non-functioning. This class of drugs has no value beyond that for the vast majority of patients to whom it is being prescribed.

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