The Microbiome - New Research On Inflammatory Bowel Disease May Foreshadow Autism?
I continue to be mesmerized on the constant research coming out on the MICROBIOME. My daughter’s gastroesophageal reflux disease, autoimmune disease, seizures and chronic infections seem to resonate in this research. There are thousands like her and their AUTISM diagnosis is part of that connection.
A recent study caught my interest as it encompasses some of these very issues:
“Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease”
Some facts from that study:
• Inflammatory bowel diseases are associated with a decrease in the diversity of bacteria in the gut, but a new study led by researchers at Washington University School of Medicine in St. Louis has linked the same illnesses to an increase in the diversity of viruses.
• The scientists found that patients with inflammatory bowel diseases had a greater variety of viruses in their digestive systems than healthy volunteers, suggesting viruses likely play a role in the diseases.
• Scientists only recently started recognizing the role of the microbiome—the bacteria in and on the body, and the bacteria's genes—in illness. For example, changes in the gut microbiome have been linked to obesity, diabetes, metabolic syndrome and inflammatory bowel diseases.
• The new research is the first to associate disease with changes in the virome, or the viruses in the human body and their genes. According to the researchers, the results raise the possibility that viruses may have unrecognized roles in obesity and diabetes and the two most common inflammatory bowel diseases, Crohn's disease and ulcerative colitis.
• "Much of the increased viral diversity in participants with inflammatory bowel diseases was in the form of bacteriophages, which are viruses that infect bacteria and can incorporate themselves into the bacteria's genetic material……
Nowhere in that research is autism mentioned yet the connections are there. Consider these facts:
• it is becoming increasingly clear that the composition of the human gut microbiome plays a major role in the development of many human diseases including obesity, type 1 diabetes, inflammatory bowel disease, and autism [1-7] .
• “Fifty years ago, IBD was almost exclusively diagnosed in adults. These days, treating children with IBD is business as usual in our clinics.” The two main forms of IBD are Crohn’s disease (CD) and ulcerative colitis (UC). For unknown reasons, Crohn’s disease seems to be rising more rapidly in children than ulcerative colitis …..
• Gastrointestinal (GI) disorders are among the most common medical conditions associated with autism. These issues range from chronic constipation or diarrhea to irritable and inflammatory bowel conditions.
• … the microbiome can influence the brain: by stimulating and over-stimulating the immune system, producing neurotoxic agents, releasing hormones or neurotransmitters identical to those made by the human body, or through direct neuronal stimulation that sends signals to the brain. http://www.sleepreviewmag.com/2015/01/gut-bacteria-affect-brain-health/
So it appears that the MICROBIOME, in addition to being influenced by BACTERIA, is also influenced by VIRUSES and BACTERIOPHAGES. Here is information regarding BACTERIOPHAGES:
• bacteriophage, also called phage, or bacterial virus, any of a group of viruses that infect bacteria ….During infection a phage attaches to a bacterium and inserts its genetic material into the cell. After this a phage follows one of two life cycles, lytic (virulent) or lysogenic (temperate). Lytic phages take over the machinery of the cell to make phage components. They then destroy, or lyse, the cell, releasing new phage particles.
• In recent years, work has shown that whole phage particles can be used to deliver vaccines in the form of immunogenic peptides attached to modified phage coat proteins or as delivery vehicles for DNA vaccines, by incorporating a eukaryotic promoter-driven vaccine gene within their genome.
• Ratajczak also looks at a factor that hasn't been widely discussed: human DNA contained in vaccines. That's right, human DNA. Ratajczak reports that about the same time vaccine makers took most thimerosal out of most vaccines (with the exception of flu shots which still widely contain thimerosal), they began making some vaccines using human tissue. Ratajczak says human tissue is currently used in 23 vaccines. She discusses the increase in autism incidences corresponding with the introduction of human DNA to MMR vaccine, and suggests the two could be linked. Ratajczak also says an additional increased spike in autism occurred in 1995 when chicken pox vaccine was grown in human fetal tissue.
• Bacteriophages, as well as their recombinant derivatives, are now used in a multitude of applications in the biotechnology and medical fields (e.g., as an alternative to antibiotics; tools for screening libraries of proteins, peptides or antibodies; vectors for protein and DNA vaccines; or as gene therapy delivery vehicles). Although most bacteriophages do not represent a threat to human health (unless they are carrying virulence factors), the use of recombinant viral particles in some instances might raise some biosafety concerns by bringing and potentially disseminating new genetic traits among bacterial populations. A thorough risk assessment evaluating the properties of the manipulated bacteriophages may be required to implement adequate containment and control measures to protect human health and the environment.
It is doubtful that there has been much “risk assessment” done on the MICROBIOME as the decades have passed. We now are seeing the damage that can be done with AUTISM, being the heartbreaking tip of that iceberg. Brave researchers dare to identify the risks but they are either ignored or instead, banished from research and worse, cast as liars and evil perpetrators. Dr. Andrew Wakefield is the best example of this immoral bullying. His research identified a novel bowel disease with persistent measles virus in the intestinal tissue of children with developmental disorder. That truth still cannot be ignored:
The data confirm an association between the presence of measles virus and gut pathology in children with developmental disorder.
Teresa Conrick is Contributing Editor for Age of Autism.
Also, emulsifiers (polysorbate 80) are now shown to contribute to contribute to an inflamatory response and shift in the microbiome of the gut.
Headline:
"Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome"
http://www.nature.com/nature/journal/v519/n7541/full/nature14232.html
Wow, if polysorbate 80 can do that in the stomach, what does it do when you shoot in into veins?
Posted by: Jenny | March 08, 2015 at 11:52 AM
Headline reads "Researchers find link between microbiome, type 1 diabetes"
Mentions shift in microbiome a year before onset of problem, including a shift toward bacteria families known to cause inflammation.
http://www.broadinstitute.org/news/6451
Posted by: Jenny | February 06, 2015 at 09:51 AM
Sounds like the gut bacteria as a viral infection.
Posted by: Benedetta | January 27, 2015 at 08:00 PM
Oh and speaking of MSGs - the mitochondria website says to avoid them in the diet seems to help. And it does.
Posted by: Benedetta | January 27, 2015 at 06:51 PM
Flummoxed
http://en.wikipedia.org/wiki/Cellular_respiration
Good question of yeah why do they name these microbes what they name them. I guess they have a reason, and most of the time I don't know.
But lacto is probably named that because they don't use oxygen to help them burn energy but instead use a form of fermentation whose end point produces lactic acid.
That is for them and them alone.
As for the lactic acid build up in our blood - it has to do with what is happening in our own cells.
Our own body cells prefers oxygen but they can switch over and burn the other way - for a brief time.
Our cells burns oxygen until the oxygen is all used up and then the cell changes over to a fermentation type of energy.
When running we might use up more oxygen in the cells that the body - our lungs and our body and blood is able to carry to the cells.
My husband with a mitochondria disease caused by a vaccine does have high lactic acid in his blood and his blood levels for oxygen is a bit low. A gluten free/ low carb diet helped that for some reason. This is not coming from the bacteria in the gut though, but from his own cells.
Dr. Moulden points to aluminum piggy backing on the iron transport system, or the mercury's effect on the heme (iron) or how white blood cells if too many slow the blood and we can have little strokes on any organ or part of the body that does not get enough oxygen because of clumping blood.
I was in a room full of nurses the other day and we got into a discussion about diets. . One of them said that MSGs gives her an arrthymia --
And now we are right back to a virus in the vaccine - or worse -- viruses.
It is looking like there is as many answers to what caused a vaccine reaction as there are ingredients in the vaccine and that seems to be a lot.
Posted by: Benedetta | January 27, 2015 at 06:50 PM
Found these links which might be useful
Paul 1999
http://www.horizonpress.com/backlist/jmmb/v/v1/v1n1/07.pdf
-towards the end of the article, a paragraph about how antibody developed which I found interesting.
Pray et al 2013
http://books.google.co.uk/books?hl=en&lr=&id=GD5eAgAAQBAJ&oi=fnd&pg=PA1&dq=immunity%22bacteriophage+diversity%22&ots=d27t-tpkYa&sig=V26DO4W6Z8ZyyXUTrG-TF5ct8Xo&redir_esc=y#v=onepage&q=viriome&f=false
-gut microbiome overview
Proel 2011
http://www.nature.com/cmi/journal/v8/n3/full/cmi201077a.html
Casado et al 2013
https://hal.archives-ouvertes.fr/hal-00932236/
-mercury response and resistance--- sorry Jeanette, best I could do.
Wonder if these strengthen the epigenetic angle(s) of chronic illness.
Posted by: flahute | January 27, 2015 at 06:12 PM
Human DNA injected into babies and adults against their will or knowledge? I thought that was the definition of rape.
Posted by: Argh | January 27, 2015 at 05:29 PM
Questions about probiotics.
Why would someone feel joint pain the day after taking a dose of VSL #3?
It contains:
Bifidobacterium breve
Bifidobacterium longum
Bifidobacterium infantis
Lactobacillus acidophilus
Lactobacillus plantarum
Lactobacillus paracasei
Lactobacillus bulgaricus
Streptococcus thermophilus
And does the "lacto" root prefix have anything to do with lactic acid production?
Which, I'm told, if high could be one biomarker of mitochondrial dysfunction.
Posted by: Flummoxed | January 27, 2015 at 04:02 PM
OK, maybe a more specific question regarding
"Much of the increased viral diversity in participants with inflammatory bowel diseases was in the form of bacteriophages, which are viruses that infect bacteria and can incorporate themselves into the bacteria's genetic material…"
if thimerosal, whatever effect it has on viral components, only really acts as a bacteriostatic substance (i.e. it deters growth, but not necessarily kills bacteria), would that make contamination of vaccines with bacteriophages a greater possibility when thimerosal is relied upon in manufacture?
Posted by: Jeannette Bishop | January 27, 2015 at 03:25 PM
Thanks as always, Teresa.
I want to add positively to a helpful discussion, coming to a better understanding than I see our "healthcare" trying to achieve of what is going wrong, but all I can think of are possibly pointless, questions:
Is it the skewing of immune function that affects the microbiome balance of the gut, and then affecting other systems? Or is it the skewing of the microbiome balance that disrupts healthy immune function, as well as other systems? Or is the answer, at least sometimes, yes to both?
(And mostly today I just feel like screaming "enough with the blinkered use of anti-biotic--anti-life?--poisons and calling it 'healthcare,' 'technological advancement," and all that!")
But it does feel like understanding this is key to prevention of much trouble and to restoring the health of many.
Posted by: Jeannette Bishop | January 27, 2015 at 12:45 PM