Thinking Inside the Box
Possible Explanations Behind The Autistic Struggle to Understand Social Skills

Report: Insel Should be Fired from Autism Research Panel

Thomas inselThe following is from The Bloomington Alternative's Steven Higgs and explains how Dr. Tom Insel has had nothing but "Great job Brownie" moments as head of the IACC.

Interagency Autism Coordinating Committee biased against environmental studies

by Steven Higgs
August 11, 2012

IACC head Dr. Thomas Insel has failed in his duty to effectively and responsibly allocate federal research money for autism, according to the Elizabeth Birt Center for Autism Law and Advocacy. A July 2012 report says Insel has been transparently biased against studies of environmental causes of autism, especially mercury-containing childhood vaccines.

The federal panel charged with allocating funds for autism research has squandered hundreds of millions in taxpayer money on ideological, nonscientific priorities. Its decisions have been financially irresponsible and practically ineffective. Its chairman should be fired and many board members replaced.

So says the Brooklyn-based Elizabeth Birt Center for Autism Law and Advocacy (EBCALA) in a stinging critique of autism policy under the Bush and Obama administrations titled "A Critical Review of the Performance of the Interagency Autism Coordinating Committee" (IACC).

"From the controversial appointment or retention of committee representatives, to the troublesome history of committee members themselves, to the lack of accountability for the few advances made in autism research, to the questionable direction of the Strategic Plan, it is fair to state that the IACC is not living up to Congress’ and the public’s expectations," the July 10, 2012, report says.

Read the full post at The Bloomington Alternative.

Comments

Garbo

Bless your little white cotton socks, now I think you are just trying to push my buttons. By all means, have your friend waste time and money on a study to replicate a study that accomplishes nothing. Garbo predicts the future news story:
"A young epidemiologist has conducted a study funded by the NIH and Autism Speaks that confirms a previous study funded by the UK's National Health Services that found that there's no autism epidemic and there are the same number of adults with autism as there are children. They did this by interviewing a non-randomly selected population of people who have gone their whole lives without any sort of diagnosis and services and who were able to complete the questionnaires and interviews on their own. Indications that the younger one is, the greater risk of autism were explained away with dodgy p values. Everyone in government and insurance were greatly relieved to know they need not worry about the tidal wave of hand-flapping, head-banging, non-verbal, diaper-wearing former school children now aging out of the overburdened special education services and into the public sector, because those children will just go where they have always gone. Researchers and public officials had no explanation for why those imaginary places don't actually seem to exist. Pharma was especially pleased by the results, which get them off the hook for causing the problem in the first place and as a bonus suggest a means of creating a much bigger market for the drugs that mask the symptoms as well as the underlying cause of autism."

SIGH.

Alain

Furthermore, I have a good friends who's doing a PhD in epidemiology and I'm looking to see if she could replicate the English study.

Alain

Alain

I'm not part of the revolution yet and I take account of the english publication[1] saying 9.8 out of 1000 adult 16+ years old are autistics (which is covered in my blog in a French post) but if there is indeed damage to the brain in ALL the population of autistics, I want to know about it.

So far, the numbers of fMRI studies in the visual modality of autistics (meta-analysis[2] here: http://www.ncbi.nlm.nih.gov/pubmed/21465627) shows that perceptual region display an enhanced perceptual functioning (also evidenced by the entire body of knowledge of that research group: http://www.lnc-autisme.umontreal.ca/n45/) and my job is to determine if subtle brain damage will be compatible with that body of knowledge.

Is it possible to measure if brain damage result in higher functioning of brain area?

Alain

[1] == Epidemiology of autism spectrum disorders in adults in the community in England
Traolach S. Brugha, MD(NUI), FRCPsych; Sally McManus, MSc; John Bankart, MSc, PhD; Fiona Scott, PhD, CPsychol; Susan Purdon, MSc, PhD; Jane Smith, BSc; Paul Bebbington, PhD, FRCPsych; Rachel Jenkins, MD, FRCPsych; Howard Meltzer, PhD


[2] == Samson F, Mottron L, Soulières I, Zeffiro TA. Enhanced visual functioning in autism: an ALE meta-analysis.
Hum Brain Mapp. 2012 Jul;33(7):1553-81. doi: 10.1002/hbm.21307. Epub 2011 Apr 4. PubMed PMID: 21465627.

Garbo

Viruses can also selectively destroy brain cells. You might be interested in the early work of Dr. Anthony Van den Pol at Yale:

"A Yale researcher tracing a recombinant virus as it entered the brains of laboratory animals found it damaged selective areas and then vanished without a trace, raising questions about possible mental problems caused by undetected viruses.

"The virus went to areas of the brain that play an important role in functions related to attention," said Anthony Van den Pol, professor of neurosurgery at Yale School of Medicine and lead author of the study published as the cover story in the February 2002 issue of the Journal of Virology. "After a few days the virus was eliminated by the immune system, leaving no trace of the virus in the brain, but nerve cells in very specific areas of the brain were lost. This is a potential model for viruses that can cause psychiatric and neurological dysfunction, yet leave no evidence of their presence at later times."

http://jvi.asm.org/content/76/3/1309.abstract?sid=5c252f2d-aeb2-4746-a57b-44265bedfe9f

A second study found that cytomegalovirus had an affinity for developing (as opposed to adult) brain cells, and "CMV-infected cells were more prevalent in the postmitotic Purkinje cell layer than in the mitotic granule cell layer, suggesting a selective infection of some cell types not dependent on cell division. Together, these data support the view that CMV has an intrinsic preference for infection of developing brain cells, independent, but not mutually exclusive, of the developmental status of the systemic immune system in controlling CMV infection."

http://jvi.asm.org/content/76/17/8842.abstract?sid=5c252f2d-aeb2-4746-a57b-44265bedfe9f

PS Welcome to the Revolution...

Alain

Ok, I'll see if I can get the book on hand and start to do research on that (it must have a reference list). Furthermore, I'll do some research to see if there's similar research to Sajdel-Sulkowska et al and I'll report back on my blog.

Alain

Garbo

From the medical textbook "Mineral and Metal Neurotoxicology" 1996, Excerpts from Chapter 12 by Dr. Walter Lukiw (LSU Neuroscience Center): "More so than any other organ, the brain and central nervous system (CNS) are remarkably heterogeneous in cellular composition with a wide variety of cell types, each with their own distinct structures and physiologic function. This cellular heterogeneity within the CNS may also be the basis for the selective vulnerability of certain brain cell types to neurotoxic injury because of each cell's unique anatomical, neurobiochemical, or physiological signature.... Franz Nissl (1869-1919) was first to demonstrate and acknowledge the exposure of certain toxic compounds to the brain consistently resulted in a strictly defined and often characteristic interaction with certain types of brain cells.... Since these original ideas were proposed by Franz Nissl, pathoclisis, or this neuronal selectivity towards neurotoxic insult, has been clearly and repeatedly demonstrated, for example by the selective vulnerability of cerebellar granule cells to mercury, or by the destruction of the hippocampal mossy fiber system by lead.... As discussed more fully below, there are many reports that one preferred target of aluminum deposition in the CNS is these same pyramidal cells so prominently affected by AD (Alzheimer's Disease) neuropathology."

You're welcome.

Benedetta

Alain

I think you are real, I am not for sure though.

My adult son has problems communicating so I do have a softness for someone that may have this same affliction.

But it can also make me blind to people that are really just being evasive too.

Don't worry about it. If you have autism, even higher functioning there will probably be no kids on the way to get the vaccines.

If you are worried for yourself, hmmm I will warn you that some people react fast and hard and others takes some time so be careful. But you said you don't have any health issues at all?
So go ahead and do what you wish.
However; as for me and mine - I will do my best to stop all vaccines - for there is nothing like eye witnessing (seeing is beleiving) Been Shown by the forces of natural observation -- to make you as Garbo said zzzzzzzzz at Raven test or really any othere study. At this point there is no study under the sun that could be done to prove to me that vaccines did not damage my family - none - because I know they are lying. The only thing that would interest me about these studies is why they are making up stuff and that is were

Jake Crosby

Is a genius.

Alain

Given the number of studies you have, let's make a deal:

if you can show me an environmental pollutant or insult (thimerosal, aluminum, etc...anything) which can selectively damage some neurons (as evidenced by the Sajdel-Sulkowska et al article) and not ALL of them, I'll reconsider my position.

you know where my blog is.

Alain

Garbo

Thanks Benedetta. Not commenting because I got bored. Alain asked how vaccines could be responsible for the results but doesn't seem to like the answer. You are right, there are plenty of other studies if he cares to look. The P values of the study Alain keeps banging on about, insisting 40% better, appear to be very weak and they show the results to be non-significant wrt the the scoring. The article he links to specifically states that there was no difference in scores between the two groups. The only part of the experiment that has significance according to P-value is response time, but response time is not a factor used in scoring the Raven. If 3 people take the Raven, and one finishes with 25 correct answers in 20 minutes, one with 25 correct answers in 40 minutes, and one doesn't finish the test before time is up but still gets 25 right, they all get the same score.

I'm all for making sure that people with autism have their intelligence evaluated in the best way possible, and if this study helps families get their kids' intelligence tested using a Raven instead of a WISC, more power to them if that's what's best for their child. But it would be a sin for these researchers to skip off happily touting 40% faster, without every stopping to consider the physical reasons why their autistic subjects' brains aren't functioning properly.

Wake me up when these researchers test for oxidative stress markers, viral loads, toxicity, mito disorders, and give their autism subjects SPECT scans & FMRIS before and after a series of 40 HBOT sessions with supplements. Until then...zzzzzzzzz....

Benedetta

Alain:
Well I might come over and read it for sure.
I will see about the blogging;
I have found a voice here-- and I really did need to get all that I have blogged here out of my soul, heart and mind for my heart burns with how my family and I have been treated.

I also have been rather TRAMATIZED by how I was treated at other blogs sites- specifically Joe's Kawasakis.

I am not sure I could be as strong as Jake - esp at these meetings - I would lose control - with no thought processes an either rage or cry or weep.

But I will come over and look at your site at least Alain.

Alain

How about commenting on my blog then? I only output one or two articles a week.

Alain

Benedetta

Hi Alain.
It is a fast pace site. They have articles every day and then pretty much move on. This one is getting rather old.
They only reason they will come back is if some one gets in and makes a really crude comment - like -
You people are going to cause the vaccination rates to go down and it will be your fault that zillions die. Or

Before vaccines children died of measles. THat sets them off and me too mostly because kids are still dying with vaccine reactions are being harmed and it is just not right to say that to a parent that has watched their child damaged neurological by a vaccine.

Okay - about your most recent comment
Garbo had a lot of studies and the one you commented about you are right but then so is she - and the truth it is only one out of a lot more stuff put together in combination that makes us all think Garbo is right.

Alain

Is it me or no one is commenting anymore here?

Alain

Alain

@Garbo

The study you cite by Sajdel-Sulkowska et al, the text says that NT-3 proliferate cell growth in normal range (1 to 10) but decreases it in higher range. This is consistent with some brain region being bigger than other (visual cortex, auditory cortex, in fact, the brain regions involved with perception).

It can simply mean that the brain is pruning some of the cells to make place for other. It doesn't say where the oxydative stress come from.

Alain

Alain

[quote]
Alain, in the study you cite, the group with autism didn't do "better" on the test (which is to be expected because the test groups were matched by IQ in the first place). As a group, they finished faster, but they did not score any higher (more correctly) than the neurotypical group. They are not rats in a maze; finishing the test faster doesn't mean they did "better", unless they answered more questions correctly in the allotted time.
[/quote]

They did better on the test; first, they were matched on WAIS-III score, not the Raven, the Raven test is different and the autistic group had better performance than the neurotypical in the Raven as well as the pattern matching setting (which I don't discuss). The only part where the neurotypical had more correct answers was in the analytic 2 test. Read the data again (3rd picture in the test).

As for the scanner environment, I've did it twice (not in that study) and I'd do it again anytime, it's a smooth experience. Likewise for a few autistics I know who took part of the test but I'll ask the author about users' experience in the scanner since I worked with her sometime ago.

Alain

Garbo

Alain, in the study you cite, the group with autism didn't do "better" on the test (which is to be expected because the test groups were matched by IQ in the first place). As a group, they finished faster, but they did not score any higher (more correctly) than the neurotypical group. They are not rats in a maze; finishing the test faster doesn't mean they did "better", unless they answered more questions correctly in the allotted time. Maybe it means the ASD subjects had sensory issues and wanted to get out of that MRI machine as quickly as possible, while the neurotypical subjects were more comfortable and therefore took their time. Maybe as the test got progressively harder (it does) the ASD group were inclined to just randomly guess to get it over with, and these particular 15 subjects got lucky in their guesses. Or maybe the neurotypical group had a better sense of time management, and if the ASD group had slowed down they would have had more correct answers (i.e. by going faster perhaps they did worse than they otherwise could have).

While it is interesting to see how brain functioning affects performance on IQ tests (for instance, a high IQ child with a visual processing disorder could be expected to do poorly on a Raven test, while one with speech/language deficits would be expected to do more poorly on a Stanford-Binet or oral test, and one with CP or fine motor coordination problems might have a hard time on an SAT filling in all those little circles), it does little to elucidate the underlying cause of their learning differences.

What is interesting is that the MRI showed that the ASD group used different, visually oriented parts of their brain when answering the questions, and that the researchers found the typically-used brain areas to be less-functioning in the ASD group. As the studies I cited below demonstrate and corroborate this finding, those same parts of their brains that are typically used for these tests have been shown to be damaged in lab rats and in ASD brains by neurotoxins such as thimerosal and aluminum, which damage astrocytes, causing glutamate toxicity, glutathione depletion and oxidative stress. Perhaps the "ASD" (damaged) brain then compensates by using different, undamaged parts of the brain for problem solving.

While we may want to celebrate the ability of the brain to rewire itself and the ability of brain damaged-people to persevere and function, let us not do so at the expense of actually addressing the brain damage. There are far too many ASD children on the low end of the spectrum who are not as lucky as those 15 test subjects, whose brains were perhaps even more decimated and whose IQs and behavioral issues would have excluded them from such a study in the first place. What about them?

If the numbers of ASD and other impaired children continue to rise at current rates, there is no amount of money or specialized schooling or jobs programs or residential facilities that will be able to handle the load. Are we as a society really ready to say that brain damage is the new black, let's celebrate it kumbaya? Wouldn't it be better if we could study and address the root cause of this impaired brain functioning? Wouldn't it be more useful to find the relative levels of oxidative stress markers in ASD vs. neurotypical groups? To track levels of oxidative stress in a prospective study and see what changes occur in infants and children over time, relate it to environmental exposures, genetics, and epigenetics, and be able to put in place protocols for limiting exposures and mitigating biochemical changes before they are able to cause brain damage? To find out if these 15 ASD subjects would score even better on tests -- and function better in their daily lives -- after they underwent biomedical treatments to address oxidative stress and brain damage; to see if those under-performing parts of their brain could be re-awakened so that they might reach their true potential? To fund a proper study of SPECT/FMRI/HBOT? In short, to scientifically validate the very treatments that parents and physicians are already using to make children better?

The IACC has decided to be a roadblock to the kind of cutting edge research that can make a difference in the lives of millions of children; the research that builds on existing toxicology, neurology, and immunology studies and takes them to the next level. Under Tom Insel's insolent leadership they have become a joke, only a not very funny one.

Visitor

Edit:

Wrote:
"There is not normally a much lesser need for bias discernment in visual processing save optical illusions,..."

Meant:
There is normally a much lesser need for bias discernment in visual processing save optical illusions,...

Visitor

Alain

As an opener I am for a delineation of HFA and the rest.
This resposne is simply theoretical and specific to the concept of how a stress oriented brain fucntion may orient in such a way explaining the speed differences you highlight.

The premise of my response is based partially upon the concept that those with Autism have an intrinsic stress respoinse in general, and in certain ways, that neurotypicals do not.

Could it be you are ascribing too much to the outcome of one test that caters to one pattern of thinking? There are plausible explanations for the increased speed. Habitual pattern conditioning and lack of integration are two that jump out. A lack of inhibitory affects in neurons too could, in a certain focus, increase processing speed, when the parameters of testing match a certain type of information presentation more narrowly matched to one’s ability. I can say, and mentally acquire, my ABC's very fast compared to when I first encountered them, but if other parts of my brain are considering other tangential ideas at the time I recite them I am slower. Extreme focus has a blinder affect even while it may help under certain conditions. The "neurotypical baggage" may have some drag in some ways, but consider the mean of function. My computer is faster in many tasks without my anti-viral program running as well.

Are there scans of brain activity comparing the groups to see how much global activity is occurring during the test? The performance in an isolated test setting is also different than operating in the human environment of application of facts. Even removing the notion of bias from one’s thinking could increase processing speed and many with Autism seem to not be able to consider bias as a factor. In other words if I could and did accept all information at face value and be no worse in understanding for it, I would not be dealing with people in a realistic way and would be more gullible to boot. There is not normally a much lesser need for bias discernment in visual processing save optical illusions, but there is in much other information presentation discrimination including social behavior flowing from a consideration of possible feeling or intent in those observed.

I don't know about the groups tested or the procedure of testing so I won't comment as to its value in total. There is some small amount of savants, but I am inclined to believe generally, at least in most with Autism, this reflects more of a reduction to survival processing. Anyone can see an obvious threat like a Doberman running at you with viciousness, but when other ways of contemplating danger are lacking the heightened attention to visual detail predominates. In Autism there is usually an almost certain dysfunctional perception of threat and attendant responses that are reflected in the social deficits.

When one does not acclimate to social norms every venue carries a higher priority to visual detail, and other sensory information, as a safety/stress mechanism. Yet, in a select group an atypical division of function may impart some advantage in an age where threats are much lesser. A large number of those with Autism have many more issues including biomedical ones and any speedier processing in a limited area does not appear to usually confer an advantage in most ways. Also, a blind man does quite well in an obstacle course race at night. I have nothing against blind people.

To be clear these are general comments and those you know with Autism may be somewhat different in these regards, but if those you know don't have some degree of this difference I don't see how they would be considered as having Autism. It remains that if there were no neurotypicals there would be no Autism. By this I am declaring that neurotypicals have noticed Autism, but those with Autism who can understand the difference have had to be informed about the condition of neurotypicals and those with severe Autism don’t seem to ever realize the ideas of the reality of either state.

Finally, how many with Autism would have any clue about the concepts we are discussing. If you cannot get to the pool it does not matter how fast you may swim. One thing that I think is a major problem for some with Autism is extrapolation. A massive pattern for a neurotypical arises from the ability to extrapolate from all sorts of cues into a intuitive understanding of social and other behavior that those with Autism apparently don't recognize and therefore this neither informs nor taxes their being and mental faculties.

The notion that those with Autism are very often stress prone, or even intrinsically dealing with stressed neurobiology, is buttressed by observation and by a lot of literature and admittedly the reality of this factor being a part of this Autism performance view relies on this being a part of Autism. The following report is faster processing of emotional pictures, but it is reasoanble to ask where does this begin and end for those with Autism, and does it extend to general visual processing given the idea that a test setting may be a stress condition itself for any of those with Autism in such settings?

Stress Sensitizes the Brain: Increased Processing of Unpleasant Pictures after Exposure to Acute Stress

"A key component of acute stress is a surge in vigilance that enables a prioritized processing of highly salient information to promote the organism's survival. In this study, we investigated the neural effects of acute stress on emotional picture processing. ERPs were measured during a deep encoding task, in which 40 male participants categorized 50 unpleasant and 50 neutral pictures according to arousal and valence. Before picture encoding, participants were subjected either to the Socially Evaluated Cold Pressor Test (SECPT) or to a warm water control procedure. The exposure to the SECPT resulted in increased subjective and autonomic (heart rate and blood pressure) stress responses relative to the control condition. Viewing of unpleasant relative to neutral pictures evoked enhanced late positive potentials (LPPs) over centro-parietal scalp sites around 400 msec after picture onset. Prior exposure to acute stress selectively increased the LPPs for unpleasant pictures. Moreover, the LPP magnitude for unpleasant pictures following the SECPT was positively associated with incidental free recall performance 24 hr later. The present results suggest that acute stress sensitizes the brain for increased processing of cues in the environment, particularly priming the processing of unpleasant cues. This increased processing is related to later long-term memory performance."

http://www.mitpressjournals.org/doi/abs/10.1162/jocn_a_00174

Alain

[quote]

It appears that the autistic participants (who must have been high functioning), had decreased activity in the lateral prefrontal cortex compared to controls; a logical hypothesis would be that the greater activity in other brain areas may be because the brain has rewired itself to compensate for injury.

[/quote]

That's a very simple explanation for 40% better performance on the Raven test. Your explanation may suffice if there was no difference between group or lesser performance for the autistics group but how come we get an increase in performance?

Alain

Garbo

"I also discuss about the neurology involved in solving that test; now please, take a look and tell me that this research shouldn't be financed? Furthermore, tell me how does vaccines causes that?"

Alain, it looks like that study was done in 2009. Though there was a difference in speed on one of the two tests, there was no difference in accuracy between the groups. The researchers concluded that those with autism learn differently and different teaching methods should be developed for them. I think any parent of an autistic child would shrug and say "duh".

It appears that the autistic participants (who must have been high functioning), had decreased activity in the lateral prefrontal cortex compared to controls; a logical hypothesis would be that the greater activity in other brain areas may be because the brain has rewired itself to compensate for injury.

The question isn't should this study be funded, obviously AS and NIH thought it should and this study has been done. The question is what studies should be funded going forward and what the goal of that research should be. Is it more important to "discover" the learning differences of autism so that different teaching can be developed, or to find the underlying cause of those differences so that autism can be remediated and prevented in future generations, eventually obviating the need for these different teaching methods?

To answer your question as to what could possibly be causing damage to the prefrontal cortex and thereby explain the structural results found in your 2009 study, perhaps this newer study can shed some light.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264864/
Neurochem Res. 2012 February; 37(2): 436–447.
Published online 2011 October 21. doi: 10.1007/s11064-011-0630-z
PMCID: PMC3264864
Administration of Thimerosal to Infant Rats Increases Overflow of Glutamate and Aspartate in the Prefrontal Cortex: Protective Role of Dehydroepiandrosterone Sulfate
"Since excessive accumulation of extracellular glutamate is linked with excitotoxicity, our data imply that neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEAS may partially protect against mercurials-induced neurotoxicity."

Or this one, older but along the same lines:
http://www.ncbi.nlm.nih.gov/pubmed/14698570
Toxicology. 2004 Jan 15;195(1):77-84.
Effect of thimerosal, a preservative in vaccines, on intracellular Ca2+ concentration of rat cerebellar neurons.
"The potency of thimerosal was similar to that of methylmercury in the presence of L-cysteine. Both agents at 1 microM or more similarly decreased the cellular content of glutathione in a concentration-dependent manner, suggesting an increase in oxidative stress. Results indicate that thimerosal exerts some cytotoxic actions on cerebellar granule neurons dissociated from 2-week-old rats and its potency is almost similar to that of methylmercury."

Or this one:
http://www.springerlink.com/content/44584u7t832482k5/
The Cerebellum
Volume 10, Number 1 (2011), 43-48, DOI: 10.1007/s12311-010-0223-4
Brain Region-Specific Changes in Oxidative Stress and Neurotrophin Levels in Autism Spectrum Disorders (ASD)
Abstract
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by social and language deficits, stereotypic behavior, and abnormalities in motor functions. The particular set of behavioral impairments expressed in any given individual is variable across the spectrum. These behavioral abnormalities are consistent with our current understanding of the neuropathology of ASD which suggests abnormalities in the amygdala, temporal and frontal cortexes, hippocampus, and cerebellum. However, regions unrelated to these behavioral deficits appear largely intact. Both genetic predisposition and environmental toxins and toxicants have been implicated in the etiology of autism; the impact of these environmental triggers is associated with increases in oxidative stress, and is further exacerbated when combined with genetic susceptibility. We have previously reported increased levels of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in ASD cerebella. We have also shown that this increase was associated with an elevation in neurotrophin-3 (NT-3) levels. The objectives of the current study were to determine whether the increase in oxidative stress in ASD is brain region-specific, to identify the specific brain regions affected by oxidative stress, and to compare brain region-specific NT-3 expression between ASD and control cases. The levels of 3-NT and NT-3 were measured with specific ELISAs in individual brain regions of two autistic and age- and postmortem interval (PMI)--matched control donors. In the control brain, the levels of 3-NT were uniformly low in all brain regions examined ranging from 1.6 to 12.0 pmol/g. On the other hand, there was a great variation in 3-NT levels between individual brain regions of the autistic brains ranging from 1.7 to 281.2 pmol/g. The particular brain regions with the increased 3-NT and the magnitude of the increase were both different in the two autistic cases. In the older autistic case, the brain regions with highest levels of 3-NT included the orbitofrontal cortex (214.5 pmol/g), Wernicke’s area (171.7 pmol/g), cerebellar vermis (81.2 pmol/g), cerebellar hemisphere (37.2 pmol/g), and pons (13.6 pmol/g); these brain areas are associated with the speech processing, sensory and motor coordination, emotional and social behavior, and memory. Brain regions that showed 3-NT increase in both autistic cases included the cerebellar hemispheres and putamen. Consistent with our earlier report, we found an increase in NT-3 levels in the cerebellar hemisphere in both autistic cases. We also detected an increase in NT-3 level in the dorsolateral prefrontal cortex (BA46) in the older autistic case and in the Wernicke’s area and cingulate gyrus in the younger case. These preliminary results reveal, for the first time, brain region-specific changes in oxidative stress marker 3-NT and neurotrophin-3 levels in ASD."

alain

Benedetta, I'm out of town for the rest of the week and using public computers so I can't provide answers for the moment but
I'll comment back soon

Benedetta

Alain;
My son is a human being with deep thoughts, feelings, and he knows things - really smart - it is communication that is the problem; that and there is some immaturity - that perhaps all people have.

He is who he is and I like him a lot. I do however; try to finally jump in and try to figure out what he means and interject - just as I did with you some few post ago.
Sorry - habit.

But is this who he was meant to be?
Well, yes he is - but he is hampered by injuries.

You are still like you are after you have a leg amputated but darn - you have a handicap

I find communcation problems a handicap.
I find seizures and not being allowed to drive - a handicap
I find that even after seizures are very well controlled and he can drive - he is not ever -ever allowed to drive big transfer trucks across state lines - or even smaller commercial vehicles.

Neuro diverse is that what you are trying to say, and down in there they are smart,and human. OF COURSE
My son is my rock! He helps me in the fencing - now that his father is too ill - he is strong as a ox, and he is smart - he can get an piece of machinery started.

But it woul have been better if we could have stopped his injury in the first place.

Is this what you mean?
or
Have I interjected my own feelings on to yours again?
Which is what I have to be careful of about my own son -- and to get it straightened out - it takes a long, very patient and persistent time to do it?

Autistic Lurker

@Hera

Thanks for reminding me, I'll blog about the few Raven studies I have on hands which include non-verbal subjects.

Alain

hera

Hi Benedetta; wanted to thank you for your kind words about my son on another thread; he does have speech,but with his speech apraxia,what he can say is so much less than what he understands, and of course it makes it hard for him to make friends,which is painful for both of us at times, as he comes across via his speech as many years younger than he actually is.( He is going into fourth grade now) We are still luckier than many though
Alian, this study only looks at some higher functioning people with autism. Anyone who is non verbal and unable to complete an IQ test was automatically excluded.Non verbal, self injuring people who do not cooperate on long tests are automatically excluded from this type of study.
And it seems ( anecdotally)that many of those children who were vaccine injured,tend to have more of these severe types of symptoms.
Given that autism appears as brain inflammation, it makes sense to me that over active immune systems,stimulated by multiple vaccines and adjunctants could cause autoimmune problems and inflammation in the brain.
It also makes sense that for those who did suffer from encephalitis following a vaccine, that this could also cause brain damage .
Re the actual results of the study; the fact that those who have brains that process words or social situations much slower than average, also have parts of the brain that they use more,or that compensate for other parts that don't work, and that these parts work more quickly than average, is not that surprising.
And again, high functioning aspergers may be different in some cases from "vaccine damage" autism.
Wishing you all the best, Hera

Barry

You nailed it Benedetta

Thomas Insel is doing EXACTLY what he was put in place to do... which is to derail all pursuits that would EASILY point to vaccines as the cause for the autism epidemic.

The medical mafia was conceived a long time ago, by a decrepit old psychopath names James D Rockefeller.... a guy who Satan himself would identify as how HE defines evil.

Rockefeller didn't give a second thought to poisoning men women and children for money .. yet even HE was amazed at how easily the so-called intellectuals could be bought ( .. near the end of article http://www.whale.to/b/ruesch.html).

While I struggle with concept of calling Thomas Insel an "intellectual", I guess he must have been the best of those who actually chose to get in line, for the opportunity to throw yet more children under the bus.

Congratulations Tom, that's a hell of a way to leave your mark on the world.

Benedetta

Insel is doing a fine job!
Yes, he is doing the job he has been hired to do, and that is to stall, stall, stall.

Alain
I looked at it briefly, but I had not a clue what any of it meant.

I would look at it more deeply but I am off to see the video of why Thyroid is connected to all of this.


I spent last night listening to Dr. Richard Frye, on mitro problems, epilepsy, diets -

The questions and answer session would have been better if Richard had restated question before he answered because I could not hear the question.
But I think someone asked what would be good fats -- and his answer - was not good fats that mattered as much as reduction of carbs.

My mother had mild pancreatis this past Friday - I took her to the emergency room and a bladder infection. I asked the doc which is better diet for her untill she got over it and he said neither.

My dog some years ago had pancreatis (after a booster of a rabies of course) She only got better when we starved her -- There comes a time perhaps both energy pathways must rest.

Oh these links are under the news articles up at the right hand side under: Video - Age of Autism - year review.

Eileen Nicole Simon

cmo, the best IACC meeting was held October 23, 2009. Several parents with their autistic children were there, and spoke as part of a panel. See the transcript at
http://iacc.hhs.gov/events/2009/transcript_102309.pdf

Also read Dr. Insel's opening remarks, pp 7-22, preceding the presentations of parents and their children. We do need more meetings of this kind.

Brian Warner

It is about time you Americans got rid of the corrupt dealings of all those at the top who are in effective and in bed with big pharma and the medicos..
More drugs,more profits and to hell with the damage done to children...

Carol

Insel appears to be all about drug development and partnering with drug companies. There isn't any money in eliminating environmental causes of autism.

The 1 Boring Old Man blog ( http://1boringoldman.com/ ) rakes Insel over the coals on a regular basis. Search there for "Insel" if you want more.

Autistic Lurker

I have a post up at http://www.securivm.ca/2012/08/bonjour-lecteurs-pour-ce-blogue-je-vais.html where I discuss the results of a study finding out that autistics are 40% faster than neurotypical on the Raven Standard Progressive Matrix IQ test.

I also discuss about the neurology involved in solving that test; now please, take a look and tell me that this research shouldn't be financed? Furthermore, tell me how does vaccines causes that?

Alain

Bob Moffitt

Apparently .. "ineffectiveness" within the powerful lobby that fronts for the vaccine industry is never considered reason for "change" .. whether it is the almost daily acknowledgements the whooping cough vaccine no longer protects our children .. or .. those in positions of power and influence who have squandered millions of critical financial reasources accomplishing nothing without shame or fear for their jobs.

The time for Congress to call Insel before a committee to explain his failure to provide ANY meaningful contribution to stop the dramatic increase in autism during his reign as head of the IACC is ... LONG OVERDUE.

cmo

Dr. Insel could at least disclose how much money he made from stock sales / options on his brother's mercury vaccine.

Perhaps to enhance future IACC meeting, 10 to 20 Autistic children could be present during the proceedings. This might begin to help steer the committee in the correct direction.

The IACC also needs to developed a "question / answer period" rather than the present, "Let's listen to questions, and then discuss them at a later time...".

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