AofA Science Summary: Prenatal Exposure to Organomercury & Association with Developmental Disorders
Prenatal exposure to organomercury, thimerosal, persistently impairs the serotonergic and dopaminergic systems in the rat brain: Implications for association with developmental disorders
(See study at Prenatal thimerosal and neurotransmitter imbalances in rats)
Michiru Ida-Eto a,*, Akiko Oyabu a, Takeshi Ohkawara a, Yasura Tashiro a, Naoko Narita b, Masaaki Narita a
a Department of Anatomy II, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
b Department of Education, Bunkyo University, Koshigaya, Saitama 343-8511, Japan
Received 8 November 2011; received in revised form 2 May 2012; accepted 3 May 2012
* Corresponding author. Address: Department of Anatomy II, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. Tel.: +81 59 232 1111x6326; fax: +81 59 232 8031.
E-mail address: [email protected] (M. Ida-Eto).
Brain & Development xxx (2012) xxx–xxx
Ida-Eto M et al. Prenatal exposure to organomercury, thimerosal, persistently impairs the serotonergic and dopaminergic systems in the rat brain: Implications for association with developmental disorders. Brain Dev (2012), http://dx.doi.org/10.1016/j.braindev.2012.05.004
Thimerosal, an organomercury compound, has been widely used as a preservative. Therefore, concerns have been raised about its neurotoxicity. We recently demonstrated perturbation of early serotonergic development by prenatal exposure to thimerosal (Ida-Eto et al. (2011) ). Here, we investigated whether prenatal thimerosal exposure causes persistent impairment after birth. Analysis on postnatal day 50 showed significant increase in hippocampal serotonin following thimerosal administration on embryonic day 9.
Furthermore, not only serotonin, striatal dopamine was significantly increased. These results indicate that embryonic exposure to thimerosal produces lasting impairment of brain monoaminergic system, and thus every effort should be made to avoid the use of thimerosal.
Keywords: Thimerosal; Serotonin; Dopamine; Embryonic exposure; Developmental disorders; Rat" that closes with (emphasis added):
"These results indicate that embryonic exposure to thimerosal produces lasting impairment of brain monoaminergic system, and thus every effort should be made to avoid the use of thimerosal."
Dosing help needed: are these numbers, .1 mg/kg and .01 mg/kg, dosed according to maternal weight or fetal weight?
Posted by: Jeannette Bishop | June 04, 2012 at 12:59 PM
Wow - Holy staggering implications, Batman, maybe we should not "just get the damn shot."
Posted by: Ask just one question | June 04, 2012 at 10:10 AM
Too bad the American Academy of Pediatrics thinks otherwise. Our own AAP feels it is just too cost prohibitive for other countries to have vaccines without thimerosal, so neurotoxic thimerosal should remain in all of our vaccines in the USA, too! What a load of crap! The question I have for the AAP is this: Whose interests are you protecting here? You are the AMERICAN Academy of Pediatrics, and you should, therefore, be most concerned about AMERICAN babies and children, right? Why is the AAP so concerned about what goes on in other countries? That should not be their concern. Some of the other countries of the world actually do pay extra for thimerosal-free, single dose vaccines for their citizens. Hey AAP, how about caring about the serious neurological harm you are causing to American babies on American soil for once? Isn't it about time you did?
Posted by: Not an MD | June 04, 2012 at 09:43 AM