For another Iatrogenic condition caused by intravenous Aluminum compounds: search for "dialysis encephalitis". Apparently dialysis patients were commonly given aluminum and suffer from confusion and trouble speaking.

Professor Christopher Exley is crowd funding to do "The first clinical trial testing the link between Alzheimer’s disease and Aluminium."

"Aluminium is now the most commonly and widely used metal on Earth and there are myriad ways in which we are exposed to it in our everyday lives including; our diet (particularly processed drinks and food); medicine (notably antacids, buffered aspirin, vaccinations); cosmetics (examples including antiperspirants and sun blocks); aerosols ( the air that we breathe can be full of particulate materials composed of aluminium).

Human exposure to aluminium is burgeoning and, assuming current projections of its extraction and use will have increased 100 fold between 1950 and 20506. Aluminium has no known benefit in any living organism, from virus to human beings, it is only toxic and it is only the activities of Man which have resulted in our increased exposure over the last 100 years or so.

Aluminium is the most ubiquitous ecological toxicant on Earth being responsible for the death of fish in acid lakes, the decline of forests in areas impacted by acid rain and the decline of food crops on acid sulphate soils. All effects which are attributable to the activities of Man7."

Please see more at link and consider donating: https://www.futsci.com/project/the-aluminium-alzheimer-s-disease-hypothesis-what-is-the-role-of-aluminium-in-alzheimers-disease

I only mentioned the Hep B and Gardasil-both contains aluminum adjuvants.As far as I know-Vitamin K does not contain aluminum adjuvants.

Benedetta,

I had not checked back here till now.

You said:

"Vistor (is it Nick) you write like Nick - excellent research on this one!"

Well, yes it is Nick here again. It seems a little silly to go by "Visitor", but I have thought I would stop researching and posting, and when I quit last fall for a while I had decided I was through pursuing the matter. Later when I felt the desire to post some things I thought it would only be a couple of things and thought posting under the label "Visitor" would be more fleeting as to not divulge my re-engaging the subject{s}. It was silly as well to think my subject posting and typing would not be identified by some. It was either ignore you, lie, or say it is me.

Garbo;
Thanks for sharing about one in your family suffering from elephantitis. When I was so young and reading this is school- who knew it could have anything to do with me. The wonders!
Vistor (is it Nick) you write like Nick - excellent research on this one!

Garbo,

The connections seem quite strong and maybe I should say nearly conclusive. Yet, people like us may reach an overwhelming awareness of the mechanisms and effects and their relationships in these conditions, but if those with the levers and letters behind their names interpreting medical conditions don't pronounce these ideas to be worth a look it is a bit like screaming in a hurricane. It will take more than this appreciated researcher {Chris Shaw, PhD} to tillt the scales, but it is a start. I cannot be sure when I will post my thoughts further on SAP, but SAA is my first focus in this area of studyand I am just getting into this possible SAA/SAP relationship though sometimes making broader connections helps in understanding one much better and has greater explanatory value as to hopefully catch someone's eye that has a position to verify or even clearly dismiss our musings. It seems a lot of these positioned people want to dismiss and quell our ideas because they make some sense and reflect negatively on some current medical apporaches harming many. Others ridicule because it makes them appear in step with "real science" and like riding on the bandwagon as it is much safer there. Thanks for your response.

When I get a better idea of the reason SAP seems to increase Amyloid B fibrils and at other times supposedly disintegrates Amyloid I intend to post more in the "Inflamation Highway" thread were I have been developing thougths bearing on this, but in this report notice the Aluminum SAP connection with Alzheimer.
It may be that Aluminum is involved in the elevation of SAA and SAP at different stages of disease and possibly in a generally age dependent accumulative manner with SAA {Serum amyloid A} able to be found as an early effect of Aluminum exposure esp via injection into the tissues. Other SAA related conditons related to RA and others may occur at various ages.

Amyloid Beta in the Brain of Individuals With Alzheimer’s Disease

"The deposition of amyloid beta in the brain of individuals with Alzheimer’s disease is the focus of much research into both its cause and treatment.

While there may not be a consensus as to whether the deposition contributes to the disease or is a consequence of the disease, there is agreement that it is not favoured thermodynamically, meaning that something else is promoting the process.

Other proteins are often co-deposited in vivo with amyloid beta and one such protein is serum amyloid P component (or SAP). Recent evidence has suggested that SAP is elevated in Alzheimer’s disease and a team of researchers from Keele University in Staffordshire, UK, led by Professor Chris Exley, has shown that physiologically-significant concentrations of SAP promote the deposition of amyloid beta under conditions approaching those found in vivo.

Professor Exley said: “We have shown that SAP is bound by fibrils of amyloid beta and that this interaction stabilises the fibrils over timescales which are physiologically significant. This is the first example of a physiologically significant biomolecule promoting and stabilising the formation of amyloid
fibrils of amyloid beta 42 under near-physiological conditions.”

The group also found that this property of SAP was enhanced in the presence of aluminium, a metal which has also been shown to be co-deposited with amyloid beta in Alzheimer’s disease. There have been recent efforts to reduce the plasma concentration of SAP as a therapy for Alzheimer’s disease and the research provides strong evidence that SAP is involved in the deposition of amyloid beta 42 in Alzheimer’s disease and that by reducing the plasma concentration of SAP it might also reduce the deposition of amyloid beta. Their observations support serum amyloid P component as a therapeutic target in Alzheimer’s disease."

http://www.sciencedaily.com/releases/2012/03/120330123056.htm

This may be a recycle at AoA, but it is relevant. As a precursor thought to the explanation for the expression of the disease meantioned in the articles below I would mention that researchers often cite mutations and SNP’s as though they are natural occurrences that are the problem or a problem in a number of conditions, including Autism, that by themselves would may not causes a disease state without additional factors that are not innately genetic though may involve genes and dna. Sometimes or often it is possible that the nexus of a condition is related to a mutated gene that is found at times in certain conditions, but the greater problems is not a mutation, but effects on gene expression that effects the proteins that alter metabolism and immune function. Certain halotypes may indeed be susceptible to environmental factors in which one factor alone or likely more often together with other environmental factors lead to pathologies in certain types. This seems to be the case in the following and the analogous manifestation of this condition seems to share some aspect of pathology with the effects of Aluminum in Autism.

HLA Class II Locus and Susceptibility to Podoconiosis

“Podoconiosis is a tropical lymphedema resulting from long-term barefoot exposure to red-clay soil derived from volcanic rock. The World Health Organization recently designated it as a neglected tropical disease. Podoconiosis develops in only a subgroup of exposed people, and studies have shown familial clustering with high heritability (63%).”

Results

“We found a genomewide significant association of podoconiosis with the single-nucleotide polymorphism (SNP) rs17612858, located 5.8 kb from the HLA-DQA1 locus (in the allelic model: odds ratio, 2.44; 95% confidence interval [CI], 1.82 to 3.26; P=1.42×10−9; and in the additive model: odds ratio, 2.19; 95% CI, 1.66 to 2.90; P=3.44×10−8), and suggestive associations (P<1.0×10−5) with seven other SNPs in or near HLA-DQB1, HLA-DQA1, and HLA-DRB1. We confirmed these associations using family-based association testing. HLA typing showed the alleles HLA-DRB1*0701 (odds ratio, 2.00), DQA1*0201 (odds ratio, 1.91), and DQB1*0202 (odds ratio, 1.79) and the HLA-DRB1*0701–DQB1*0202 haplotype (odds ratio, 1.92) were risk variants for podoconiosis.”

“Association between variants in HLA class II loci with podoconiosis (a noncommunicable disease) suggests that the condition may be a T-cell–mediated inflammatory disease and is a model for gene–environment interactions that may be relevant to other complex genetic disorders.”

http://www.nejm.org/doi/full/10.1056/NEJMoa1108448?query=featured_home

Study finds immune link to disfiguring leg disease

“Scientists have found a link between genetic variants in an area of the genome that controls immune response and the risk of contracting podoconiosis, a disfiguring and disabling leg disease that affects almost 4 million people, mainly in Africa.
In a study published in the New England Journal of Medicine on Wednesday, researchers compared the genomes of 194 people in southern Ethiopia affected by the disease with 203 people in the same region who were not affected. They found three genetic variants that increase the risk of developing the disease.
Podoconiosis, or "podo" as it is often called, is a type of elephantiasis, or leg swelling, caused by an abnormal reaction to minerals found in soil.
It is found in farming communities in tropical Africa, Central America and northwest India, often among people who cannot afford shoes. It was added to a World Health Organisation (WHO) list of neglected tropical diseases in 2011.
"There are still many places round the world where people cannot afford a pair of shoes," said Gail Davey, a co-researcher on the study. "For some people, this means cold, cut or bruised feet, but for others it can lead to podoconiosis, which can have a significant impact on their quality of life".
Experts say years of walking, ploughing or playing barefoot on soils of volcanic origins which contain irritant mineral particles appears to trigger changes in the lymph system in the legs, which in time can lead to swelling in the feet and legs.
According to the Geneva-based WHO, around a million people in Ethiopia and another 500,000 in Cameroon are estimated to be affected by podoconiosis.
The economic consequences are severe, the WHO says, with productivity losses amounting to 45 percent of working days per year for each patient - suggesting economic losses to a country like Ethiopia of more than $200 million per year.
The disease often runs in families, implying there is likely to be a genetic component to it, but until now no genetic variants had been linked to it.
Melanie Newport from Britain's Brighton & Sussex Medical School, who led the study, said the three variants she and her team found were all in a region of the genome that plays an important role in controlling the immune system.
"Although this is still early days for identifying potential treatments, it suggests that drugs that target immune responses may be useful," she said in a statement about the findings.
Fasil Tekola Ayele of the Armauer Hansen Research Institute in Ethiopia, who also worked on the team, said that this sort of genetic study is still fairly uncommon in African populations but the results of the latest one highlight their importance.
The research team said the next step would be to try to pinpoint exactly which molecules are involved in podoconiosis, and which specific genetic mutations affect the function of those molecules.”

http://in.reuters.com/article/2012/03/28/podoconiosis-genes-idINDEE82R0I920120328

These two reports come across as though this is news, but a search of medical reports shows a report I have linked a little further below is from 1976 and there is at least one other in the mid 2000’s I found about this same thing. The first one is below. Notice the mention of Alumina in the second report from above.

Highlighting this phrase in the second report:

“Experts say years of walking, ploughing or playing barefoot on soils of volcanic origins which contain irritant mineral particles appears to trigger changes in the lymph system in the legs, which in time can lead to swelling in the feet and legs.”

The “irritant mineral particles” sound a lot like adjuvant particularly the Alumina correlating with Aluminum from vaccines injected into the body and contacting adipose cells and small blood vessels. This injected irritant could trigger immune maladies as we find them to in a exposure process able to effect vasculature and brain and other organs and the CNS too.

This is the 1976 report.

The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks.

Abstract
“Endemic elephantiasis of the lower legs in Ethiopia, which reaches a maximum of 86-7 per 1,000 adults in affected areas, is related to the distribution of red clay soil derived from volcanic rocks, particularly basalt. Prevalence falls rapidly on leaving these areas. This observation has been tested in regions of non-filarial elephantiasis reported in Kanya and north-western Tanzania and further investigated in volcanic areas of Rwanda where the disease had not previously been reported. The same relationship is found to occur in these areas. The limitation to the lower legs of the barefooted section of the farming community suggests that the aetiological factor or factors enter by the feet. The occurrence at high altitude (over 1,200 metres) is noted and the predominance of basalt or basalt-like lava in each case is considered significant. The altitude governs rainfall and temperature and thus governs the type of soil produced. The soil produced from these rocks is rich in colloidal iron oxide, alumina and silica, to which a number of metallic ions are adsorbed. This soil is a reddish-brown clay which, when wet, is strongly adherent to the skin. The derived ions are known to be toxic to human tissue and absorption through intact human skin has been shown to occur experimentally. It is suggested that absorption of these irritants through the bare feet is responsible for the irreversible damage to the lymphatic channels. The present studies support the hypothesis that "high-altitude" elephantiasis of the lower legs in East Africa is a geochemical disease.”

http://www.ncbi.nlm.nih.gov/pubmed/1006757

The takeway here is that while these people effected by this mineral exposure may have risk that others don't to the condition arising it is implied that they would not get the condition if not exposed to the mineral irritants. This is like populations more sensitive to adjuvnant like Aluminum.

Mary and oneVoice, thanks for your posts on kidney function and Al in the vitamin K injection.

Anne, Chris Shaw responded to the email I sent him yesterday, and has told me he will add the inferior colliculus to the list of brain sites he plans to look at in his next experiments on the effects of Al on mice. I do look forward to reading all of his publications and trying to get establishment researchers to discuss his findings.

One voice
Yes I read that about plants too. That is why the PH of the soil is so important. AL is not bound as tight to the soil when the soil becomes more acidic.

Anne, I have just sent an email to Professor Shaw suggesting that he look for Al injury in the inferior colliculi in his experiments with mice.

This is a tiny area (even in bigger lab animals) in the roof of the midbrain. Morgan et al. (Toxicol Appl Pharmacol. 2004 Oct 15;200(2):131-45) cited in my previous post noted that damage found in the "posterior colliculi" was fortuitous, because this is not an area of the brain usually looked at in research on toxic substances.

There is good reason to look at this area of the brain, based on a seminal (but long forgotten) paper by Seymour Kety, who discovered (also to his great surprise) that blood flow is higher in the inferior colliculi than anywhere else in the brain. The paper is online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804882/?tool=pubmed. I urge everyone to look at this paper, if even only to look at the picture showing highest amount of the radioactive tracer in the inferior colliculi 60 seconds after injection into the circulation of a cat.

Subsequent research by Louis Sokoloff and others has shown that the inferior colliculi are also the site of highest aerobic metabolism in the brain. What is the significance? In the 5 books I have recently published on Barnes & Noble's Pubit site, I cite audiologists Ladislav Fisch and Richard Angelo who suggested this small area of the midbrain as "the vigilance and information seeking center of the brain." Professor Derek Denny-Brown proposed that this area of the brain might even be the seat of the soul.

I think the inferior colliculi should be investigated as the "final common pathway" in the brain affected by all of the myriad etiological factors associated with autism.

Thanks again, Anne, for pointing out the important research of Professor Shaw.

Let's not forget the synergistic toxicity between Al and Hg. From the Merck MSDS for Thimerosal:
"10.3: "Violent reactions possible with: Strong oxidizing agents, Strong acids, Bases, Aluminum, Reducing agents"

http://www.merck-chemicals.com/united-kingdom/thimerosal/MDA_CHEM-817043/p_uuid?attachments=MSDS

Boyd Haley showed in a 2005 article (Medical Veritas 2 (2005) 535–542) that "Aluminum hydroxide alone (solid triangles [▲])at 500 nM showed no significant death of cells at 6 hours, and only slight toxicity over the 24-hour period. Thimerosal at 50 nM effected only a slight increase in neuron death at 6 hours. However, in the presence of 50 nM thimerosal plus 500 nM aluminum hydroxide(open triangles [Δ]), the neuronal death increases to roughly 60%, an amazing increase and clearly demonstrates the synergistic effects of other metals on mercury toxicity and certainly thimerosal toxicity."

Despite this, mercury-containing vaccines are still injected alongside aluminum-adjuvanted ones.

And in 2008 FDA/CBER held a workshop on Adjuvants (see here for transcripts http://tinyurl.com/fda2008adjuvant). From one presentation, I quote:
"Selected Mechanism of Action; Depends on Adjuvant -- often poorly understood"

"Note: Such mechanisms lead to immune/inflammatory responses that may be localized and/or systemic and antigen specific and/or non-specific Also note: need for and responses to adjuvants may differ with different antigens, in different clinical settings (e.g. priming vs. recall) and in different populations"

"Adjuvant Benefits and Risks:
FDA Perspectives

Enhanced immunity vs. inflammation, AEs, autoimmunity?

Safety expectations very high for preventive vaccines:
–healthy children
–global use
–large numbers
–confidence in immunization, public health, government, industry, and dependent public health outcomes, always at stake"

They clearly are aware of the ability of adjuvants to induce autoimmune conditions:

"Potentially antigen specific or non-specific potent immune and inflammatory stimulation
– Increased reactogenicity, local +/-systemic inflammation
– Unclear which, if any, correlate with risk of rare SAEs – Potential role in autoimmunity, short or long term? – Antigen specific (e.g. neural or cardiac antigens) – Auto-immune/inflamm disease, e.g. SLE, “idiopathic” – Are there plausible risks to developing immune systems?"

And they discussed the possibility (as has been suggested by other research) that there is a protective mechanism behind non-response in young infants, i.e. suppression of cytokines which could harm brain development:

"May there be, in some cases, host (vs. pathogen) protective reasons for poor antigenicity (and a risk to overcoming them)? Or can we select/design better antigens?"

IN SHORT, THEY KNOW. THEY KNOW THAT THEY DON'T ACTUALLY KNOW HOW ADJUVANTS WORK, THEY KNOW THAT THEY INDUCE AUTOIMMUNITY, THEY KNOW THAT USING THEM TO OVERCOME NON-RESPONSE IN INFANTS MIGHT BE DETRIMENTAL. THEY KNOW ENOUGH TO BE CONCERNED ABOUT THE IMPLICATIONS FOR THE VACCINE PROGRAM IF PEOPLE CONNECT THE DOTS!

@Benedetta

Of course, Christopher Shaw also gave an interesting talk on Aluminum and its effects on the nervous system ... amongst all the other distinguished speakers you mentioned and more ...

http://www.vaccinesafetyconference.com/videos.html

... at the Vaccine Safety conference in Jamaica - which was actually in January 2011. The main message from his talk is that the super-Vaccinologists like Paul Offit in the US, and Professor David Salisbury in the UK, simply cannot say that vaccines are safe ... because vaccines have never been properly tested for safety, in any kind of way, let alone on the brain and nervous system.

The mode of exposure, injection versus ingestion, may be a significant factor.

However, the critical factor for the aluminum in vaccines is the nature of the aluminum species present in the vaccine as non-specific adjuvants. The form of the aluminum species used as adjuvants is as a practically insoluble (with in-vivo half-lives of about three [3] years) to very sparingly soluble (with in-vivo half-lives of about one [1] year) polymeric hydrated aluminum salts where the degree of crystallinity and the nature of the counter ions in the aluminum species used to make the adjuvant.

Moreover, the principal mode of action of these aluminum adjuvants involves the macrophagic arm of the human immune system.

Finally, though the increasing load of aluminum adjuvants may certainly be a serious factor in chronic circulating-immune-system-related chronic diseases, mercury in the form of Thimerosal-preserved influenza vaccines given to pregnant women and children from 6 months of age onwards (where more than 50% of the doses are still Thimerosal-preserved doses) as well as in reduced levels of Thimerosal in some other vaccines is still the most significant causal factor in the area of regressive chronic behavioral, developmental, and neurodevelopmental disorders seen in young children.

Unlike aluminum, where the Establishment response continues to be "silence", the response to Thimerosal in vaccines continues to be false assertions of its removal and CDC-influenced articles that knowingly misrepresent the facts concerning the causal reaction between Thimerosal-preserved vaccines and the risk of an "autism" or "other neurodevelopmental disorder" diagnosis.

When, if ever, all of the doses of the Thimerosal-preserved vaccines are finally withdrawn from the US market and only aluminum adjuvants remain, then, perhaps, we will begin to be able to sort out the effects of the various types of aluminum adjuvants on chronic disease.

At present, all should be demanding that all vaccines on the US market should be free of any added mercury compound (e.g., Thimerosal) as well as all adjuvants unless and until toxicological proof of safety with a 100-fold safety margin can be established for Thimerosal and at least a 10-fold safety margin can be established for any adjuvant.

Just my science-based 2 cents.

Excellent interview, Anne. Please do more of these and circulate widely!!

Every answer Dr. Shaw gave is a damning indictment of our reckless vaccine program. HIs discussion of dietary vs. injectable aluminum is so simple, straightforward and obvious, it's amazing that the drug cartel has duped so many physicians into believing injectable toxins are safe. Just amazing. Is there any hope for our species? Sometimes I wonder.

And thank God for a few people like Tom Sandborn who are still appalled that there are people like Offit, and his call for censorship.

Oh; but there are modern crimes againest humananity that I so wish we could perhaps bring back certain punishments from the past.

Anne: What about the argument that children receive more exposure to Al in their diet than from their vaccines?

Shaw: It may be true in terms of amount, but the route of exposure is absolutely critical. This is a key principle of toxicology and it never ceases to amaze me that the argument equating dietary to injected aluminum (or mercury) is made at all. Most dietary aluminum (or mercury) will be excreted. Injected aluminum is not easily removed, hence one reason it is used as an adjuvant in the first place

I must have missed it .. but .. I don't remember any great argument equating dietary to injected aluminum being made by anyone?

In fact .. federal regulatory agencies .. most especially the FDA and EPA .. routinely warn against "eating, touching or breathing" hazzardous chemicals .. such as .. formaldehyde, mercury and aluminum to name just a few.

Yet both the FDA and EPA remain SILENT regarding vaccines containing those very same hazzardous chemicals being routinely INJECTED into children.

Why is that? I suspect because the "common sense" debate regarding dietary exposures and injected exposures never happened.