Dr. Wakefield Sues Brian Deer and BMJ's Fiona Godlee
That’s My Boy!

The Inflammation Highway: aka Autism

  Tummy-ache-abdominal-pain-t13513By Lisa Goes

"The one thing about my husband and I...we laugh...A lot. We find a way. We really do. Poop filled sleepless nights, injuries, missed appointments, clutter everywhere, missing paperwork...sometimes all you can do is laugh. But today, looking at the dark circles we've seen so many times under our children's eyes, seeing the suffering, the real genuine human suffering that we have worked for three years to alleviate...to see it reach these depths...there is no laughing today. There is sadness. Even the fight is gone. I should be sleeping, but I have to read up on one of our new remedies. Maybe this will be the one that touches his immune damage and regulates him? Maybe. Maybe, it will work for him like it has for THOUSANDS of other children. Maybe. I can't sleep when this could be it and I could be calling the next doctor tomorrow and we could have one less day of this. Plus, I already have an appointment to see a doctor tomorrow and I will need him to know that I know what I'm talking about. If there is one thing you learn as an autism parent it is that YOU MUST KNOW WHAT YOU ARE TALKING ABOUT WITH DOCTORS. You must learn to speak their language. If you don't you will get dismissed. Must read, now.



But, before I go, just need to let everyone know the women who work for us are angels from God. They were hurt today. Two of them. In their sweetest voices they kept repeating, "nice hands." And "time to get down monkey" when he climbed on the counter for the 27th time on their shift. He is 50 lbs now. Very fast and very strong. They get him. They see the real Noah in there, fighting like hell. He is mad. In fact, that's what he said in therapy today, "I'm MAD!" His therapists were thrilled. They were so excited to see him emote appropriately. I agree with them, it's encouraging. It's just that, he's mad he's sick. He's mad his head hurts all the time. He's mad his three year old brother can use the toliet and he cannot. He's mad that his body is rebelling against him and everything hurts. He's mad that in addition to not getting to go where everyone else goes and doing all the fun things other 5 year olds do, he also cannot EAT anything they do. It seems cruel doesn't it? It is.

Autism is the cruelest most malicious, devious, conniving, heinous disease. If you fear the chicken pox or diarrhea more you are in big, big trouble. Because I guarantee with the new schedule autism will come a knocking at your door. And it will get in. It finds a way. Sometimes it looks like OCD, sometimes it looks like ADHD, even arthritis. "That's nuts!", you say. Not really. It should all just be called autism. Because any time pharma causes inflammation they don't want you to find out about, they just make up a word for it. Autism. Asthma. ADD. Just made up words for inflammation. Off to read ABOUT AUTISM . It's a good one, you might want to check it out yourself... Much hope for all our beautiful children. xo lj "

Lisa Goes is Contributing Editor to Age of Autism.

Comments

Visitor

When I said I don't know what I believe I indeed was referring many important things, but I believe in God, the Father, and His son, the Lord Jesus Christ, and the Holy Spirit. I lament my witness is marred and I can't remedy it at this time. I am a peaceful non-violent person, so when I say I was swinging blindly it was a metaphor. I still regret my spiritual affliction. I accept my own responsibility and am attempting to find proper humility in my spirit. Precious people of AoA please forgive my pride. I have asked the Lord for forgiveness. God is good. One day His love will be my ectasy. It should be now, but I am still becoming. Thank you Kim for not banning me.

Visitor

Benedetta,

I did not mean Madness's posts, but M2021's. At that it was only one post by M2021 that stuck in me and it was about being negligent over some treatment measure. I have been at this too long for someone to suddenly pop in a drop such bombs. The mentality is not something I accept. I also, under the influence, mad e a likely wrong association thinking M2021 and Madness were the same person.

I wish I could Roback and not have posted what I did. I have found more recently I am losing it more often. I offer no excuses and I have not lose my appreciation for your posts and insights I was swinging blindly. I don't like what I did. While the medical/biological of those effected may vary I have been meticulous in what I post in trying to paint a picture of the one I have dealt with and what clearly are shared issues with a large number on the spectrum. Just because one with autism does not have a certain aspect of biological dysfunction that another does doesn't mean the one is not effected by it.

Madness if you are not M2021 one I apologize.

Benedetta

Nick did I say something that was wrong? Mandates. Vaccine mandates? I am bad against them. Is that it?

No. That is not what this is about.

Believe you I have always believed you on every thin

I might not have fully understood and maybe asked questions to get a clearer picture.

My husband Mostly sits is what I was thinking of. But not every one does.

Sorry if I said anything to hurt you

madness

According to GAPS and WAPF, it’s important to germinate and ferment grains, beans, and nuts. This gets rid of the phytic acid and anti-nutrients.

Miso, tamari sauce, natto, and tempeh are the healthiest soy products.

But society and the world forgot about properly preparing pulses... now, digestive disorders are exploding worldwide, now also beginning in children.

What the world didn’t forget? How to deny the consequences of injecting aluminum, aborted cell material, and more into the human race.

Visitor

Oh, and I recovered my wife regardless of how you view my behaviors. Maybe what I went through and the type of thinking had something to do with why she is totally functional now after 30 years of subdued being due t her biological state. Benedetta, I have not forgot you didn't believe me to begin with and were not bashful in saying so. I eventually become unbashful myself when I fully determine what I am dealing with. The ,irony of drinking in a mad world would be a suitable book title.

Visitor

Benedetta,

Once you countenanced Madanes battements I lost interest in your views.

benedetta

Maddness there is something abut the GAPS diet though.

I love buttermilk,
I handle it very well.
But I don't drink much.
One day I did and inflammation in my feet and hands.

Same if I eat too much at once of my red cabbage sauerkraut.
Oh, I am fine if I eat a couple of spoonful on a salad.

So histamine over load might be a real thing. And so life goes on.

benedetta

Maddness;
I am still on the fence about beans.

Some times old silly sayings reveal the truth.

Beans, beans, beans are good for the heart, the more you eat, the more you fart.

If beans are good for the heart, and farting is an indication of resistant starch or resistant something; beans might just be great! tofu and all the stuff they process soy into-- I don't know. I can't figure it out.

Visitor Nick
Alcohol speaking the truth or fear? Mostly they just sit and don't speak period. Well there was the time my drunk young uncle kept yelling really loud the name of his cousin,; to come on out of the church meeting. They called the constable and he was arrested.

Visitor

My last song though I may post other things. I will find my way out from his song. Frank is sublime.

https://www.youtube.com/watch?v=hkwdkUXQ1yo

Madness

Nowadays, almost nobody talks about the GAPS diet (very therapeutic dietary regime) let alone WAPF. But many Neurodiversity advocates demonize/want to censor it, or lump it in as “child abuse”.

Autism or not, all the phytic acids in inactivated grains and pulses (otherwise known as “dormant grains”, nuts, beans and seeds) doesn’t do any good for society - especially with an explosion in digestive disorders, intestinal permeability, IBS and IBD now also beginning in children, etc.

What does a diet of 3-6 servings of phytic acid filled, basically asleep grains (both whole and refined), and pulses in defense mode, vaccines, sugar, white starches, highly processed foods, aluminum, drugs, pollution, antibiotics, mercury, etc do to the human individual?

We should know the answer, but many in power don’t want us to.

Visitor

I have followed and what has unfolded may portend what is coming for me. It is pale and seems beyond my control..

In Wine There Is Truth

https://truewestmagazine.com/wine-truth-tombstone/

"There's No Normal Life There's Just Life. Now Get On With It."

"I've Not Yet Begun To Defile Myself."

"My hypocrisy goes only so far."

"I'm Afraid The Strain Was More Than He Could Bear."

"I'm Dying How Are You?"

It may be coincidence that "Tombstone" revolved around alcohol, tuberculosis, standing for something, and death. Not knowing why some things happen and wishing for the visitation of others. Also, facing your other self and finding that destroying the other brings your own demise.

I am dying how are you?

Visitor

I don't agree that drunks' always speak their truth. I find they also often speak what they are afraid may be true or wish was true not knowing what they believe is true and wanting a relief in stating one of these or having the experience of seeing how any of them stated honestly.

One of my favorite cinematic scenes.

TOMBSTONE Clip - Doc Holiday meets Johnny Ringo

https://www.youtube.com/watch?v=MICPyrnGYwg

En vino veritas. [Latin: "In wine is truth".]

Credat Judaeus apella, non ego. [Latin: "The Jew Apella may believe it, not I", loosely meaning "I do not believe drinking is what I do best".]

https://www.moviequotedb.com/movies/tombstone/quote_23889.html

(Rest in peace.) The line "Credat Judaeus Apella, non ego" (Let Apella the Jew believe, not I) was confusing to viewers; scholarly papers showed that Romans used the phrase to show contempt for Judaism's belief that divine power was involved in everyday life.

Credat Judaeus apella, non ego. [Latin: "The Jew Apella may believe it, not I", loosely meaning "I do not believe drinking is what I do best".]

Visitor

This was the theme song of treating and teaching my beautiful wife.
She was not aware of the first part, but was so beautiful in her total ignorance. I still cannot explain it all.

Céline Dion - The Colour of My Love

https://www.youtube.com/watch?v=7UvJUZ_08Uk

Visitor

I do so Love Richard Marx, he should quit that.

Visitor

I don't know where my faith is, I only hope in God to do and be what I am not..

Céline Dion - I Remember L.A.

https://www.youtube.com/watch?v=IVaUx_0KVZo

Visitor

“An abnormal reaction to an abnormal situation is normal behavior.”
― Victor Frankl,

Visitor

Music comes from madness or curiosity.

Visitor

Richard Marxist.

Visitor

Nothings means anything anyway so here's to Richard. Let's just beat the shit out of each other, it doesn't matter.

Richard Marx - Heaven's Waiting

https://www.youtube.com/watch?v=QeWauCykTfw

Richard Marx - The Image

https://www.youtube.com/watch?v=BLORo8bwrm0

Richard Marx - Silent Scream

https://www.youtube.com/watch?v=FO9FdVv0czc

Visitor

"With all hundreds of comments they might be quite hard to find, but do remember that no one actually knows who you are anyway, although your distress is noted."

My previous responses mainly came from degradation of thought{under a bad influence and my fault}. You are likely correct in that no one noted my previous responses and no one cares. The truth I have found has been met with that general attitude. I often post what I post simply to have left a witness. Those who have experienced vaccine injury surly feel their expressions are received or ignored in a similar fashion. I am not unaware that people may have not paid attention to acknowledging any communication from me from one post to the next, but I have posted here hoping some would see a relationship of my testimony and the supporting studies to gain a picture of dysfunction that my be a bit specific to my wife, but shares qualities of damage in others.

I regret calling Mr. Marx an ass as I am one to at times. His statements that I had see caused me great disappointment as I have idealized some artists and his songs had helped so greatly through certain times. He wrote the songs that buoyed me most at the darkest parts of my journey an my disillusionment at his real attitudes was incredibly disheartening. I could not reconcile someone who sang "right here waiting for you" with someone who appalled some one physically assaulting anyone over their views. I have also tired of seeing people pummel the caring in ignorance to indulge their own own uncaring and malicious attitudes. I have 5 of Richard Marx's cd's and have listened to them many, many times. My dismay with him overtook me.

Visitor

This my best response. Jesus is always and above all my best word. My beloved could not see any of these things. But, he gave me to her that in time she could. Praise the Lord. Thank you Jesus.

https://www.youtube.com/watch?v=7iNCiWGVMsU


Visitor

John,
I had thought myself a warrior, but life has made me invalid. At times the indignant feelings rise, but i cannot find my footing. I do care deeply about the vaccine injured.You keep fighting. Maybe things will change for me. I appreciate your invocation.

Visitor

John,
It may suffice that I stated I posted as to make an association and wish I had not. I can produce the posts if someone doubts me.

John Stone

Dear Visitor

With all hundreds of comments they might be quite hard to find, but do remember that no one actually knows who you are anyway, although your distress is noted.

John

Visitor

Please remove any association of me from Richard Marx. I have long appreciated his songs , but he is an ass. ,I regret linking his songs in this thread. he approves of political violence. As low as a human can be. His views are detestable.

benedetta

Nick; you are one of my favorite people too.

Visitor

There is no ethnic enemy. Man is his own enemy. Alone Again Naturally. Johnny Cash, one of the few I would have trusted to lead as he knows himself better..

https://www.youtube.com/watch?v=8AHCfZTRGiI

Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?

Conclusions
In this paper, we have introduced ‘immunoceptive inference’: active inference from the perspective of the immune system. This is in a similar vein to the notion of ‘interoceptive inference’, which frames emotions as emerging from—or perhaps furnishing—predictions about the causes of visceral sensations. In brief, interoceptive inference claims the brain is continuously updating predictions about, and acting upon, the body it inhabits (Seth 2013). In our formulation, the body itself (in this case, the immune system) is seen as furnishing predictions of—and acting upon—sensory input, informing ‘beliefs’ about whether an antigen belongs to the category of ‘self’ or ‘nonself’.

In so doing, we have highlighted three practical contributions (translation, unification and simulation) of the active inference framework to answering and—crucially—redefining the question, “Why are psychiatric disorders and immune responses intertwined?” We suggested that it is inevitable that two systems within the same Markov blanket influence each other: the brain and the body together make predictions about exteroceptive, interoceptive, and immunoceptive input. To this end, we have proposed an example of a common generative model that the brain and immune system jointly optimise, treating molecular components of the immune system as sensory or active states and the resulting cellular response as message passing at lower levels of a ‘sensory’ hierarchy that interfaces with the brain. Our scheme expresses the classical conditioning of the immune system in terms of inference at an immunological level, that may alter the message passing at a psychological level (or vice versa) through an optimal interface between the two systems.

This surrender of mind–body and brain-body dualisms may be of particular importance to psychiatric practice, where it encourages a holistic treatment of patients. For example, with an embodied perspective on the mind, a patient presenting with psychosis may be treated with reference to the mechanisms leading to this syndromic endpoint, whether that be schizophrenia (treated with antipsychotics), or an alternative (e.g., endocrine) diagnosis such as Cushing’s syndrome, which can be effectively treated by normalising cortisol levels (Tang, O'Sullivan et al. 2013, Wu, Chen et al. 2016)—or indeed autoimmune encephalitis (Symmonds et al. 2018). We also advance the possibility of drawing immunological analogues of concepts defined under active inference for neurological phenomena, such as sensory attenuation. Finally, we introduce the novel concept of neuroimmunological diaschisis and the possibility of a diaschisis of threat-avoidance that may contribute to the overlap between psychiatric disorders and immunological hypersensitivities. This kind of overlap leads to clear empirical predictions; for example, an association between psychopathology and (measurable) immunological responses, much in the same way that clinical tools such as the dexamethasone suppression test leverages the link between neuroendocrine function and stress or depression (Naughton et al. 2014)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085803/

I cannot invoke God in these explanations.


"In this paper, we have introduced ‘immunoceptive inference’: active inference from the perspective of the immune system. This is in a similar vein to the notion of ‘interoceptive inference’, which frames emotions as emerging from—or perhaps furnishing—predictions about the causes of visceral sensations. In brief, interoceptive inference claims the brain is continuously updating predictions about, and acting upon, the body it inhabits (Seth 2013). In our formulation, the body itself (in this case, the immune system) is seen as furnishing predictions of—and acting upon—sensory input, informing ‘beliefs’ about whether an antigen belongs to the category of ‘self’ or ‘nonself’.

In so doing, we have highlighted three practical contributions (translation, unification and simulation) of the active inference framework to answering and—crucially—redefining the question, “Why are psychiatric disorders and immune responses intertwined?” We suggested that it is inevitable that two systems within the same Markov blanket influence each other: the brain and the body together make predictions about exteroceptive, interoceptive, and immunoceptive input. To this end, we have proposed an example of a common generative model that the brain and immune system jointly optimise, treating molecular components of the immune system as sensory or active states and the resulting cellular response as message passing at lower levels of a ‘sensory’ hierarchy that interfaces with the brain. Our scheme expresses the classical conditioning of the immune system in terms of inference at an immunological level, that may alter the message passing at a psychological level (or vice versa) through an optimal interface between the two systems.

This surrender of mind–body and brain-body dualisms may be of particular importance to psychiatric practice, where it encourages a holistic treatment of patients. For example, with an embodied perspective on the mind, a patient presenting with psychosis may be treated with reference to the mechanisms leading to this syndromic endpoint, whether that be schizophrenia (treated with antipsychotics), or an alternative (e.g., endocrine) diagnosis such as Cushing’s syndrome, which can be effectively treated by normalising cortisol levels (Tang, O'Sullivan et al. 2013, Wu, Chen et al. 2016)—or indeed autoimmune encephalitis (Symmonds et al. 2018). We also advance the possibility of drawing immunological analogues of concepts defined under active inference for neurological phenomena, such as sensory attenuation. Finally, we introduce the novel concept of neuroimmunological diaschisis and the possibility of a diaschisis of threat-avoidance that may contribute to the overlap between psychiatric disorders and immunological hypersensitivities. This kind of overlap leads to clear empirical predictions; for example, an association between psychopathology and (measurable) immunological responses, much in the same way that clinical tools such as the dexamethasone suppression test leverages the link between neuroendocrine function and stress or depression (Naughton et al. 2014)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085803/

https://www.youtube.com/watch?v=NOa5UOHdwnc

Visitor

All is Said...

https://www.youtube.com/watch?v=xywOYUgOKtA

Best To All

https://www.youtube.com/watch?v=Ku07A-FObLY

Visitor

Benedetta have said things while was drunk that were not meant to hurt or offend you. I hold you in verity high esteem. Please overlook my pain outbursts that are actually in general and not at you.. I like Disturbed's performances. Family is an issue for me and you feel like family so you get some of my vent. I love you.

susan welch

https://www.ageofautism.com/2020/05/autism-up-82-in-northern-ireland-schools-in-5-years.html

M2021 Information about rates of autism in Ireland, thanks to Ann Dachel, AoA

benedetta

M2021
South Korea a few years back said for them it was on in 32? Or was that 23? It was high.

Other than that, not much.

Japan had trouble with vasculitis of all small blood vessels, in children called Kawasakis disease way back in the 70s and 80s.

Even in the United States the CDC whose main job is suppose to track health trends; is hiding it as hard as they can.
Example: What William Thompson said the CDC did with their research material for the MMR.
Utah tried to fudge the statistics and got sued by one of the people working on the stats for their criminal behavior.

M2021

Charcoal soap/certain earth clays/spirulina help eliminate aluminum + toxins in general.

And autism is especially pronounced/most known in the Anglo Saxon world, but it’s also striking areas such as Japan, Korea, China, Malaysia, Ireland, Philippines, etc.

What are the current rates 4 all those countries?

benedetta

M2021:

Oh yeah, I got that covered, probably the best of all.

Dr. Exley - Told us that a bunch of research studies on rats are showing that a special type of silica in the volcanic water of Fiji - Fiji water that is high in it, will take out what you are consuming and will eventually take it on out of your brain.

I go to a special spring that runs out of a rock in the middle of Daniel Boone National Forest.
I come home, and use a special recipe that some wonderful, smart, person on this website told me about and I found in this book: Silica Water the Secret of Healthy Blue Zone Longevity in the Aluminum Age
by Dennis N Crouse PhD.

Crouse also has a video on the internet where he makes it as well.

I don't know if the water I am getting from the spring that rolls through a bunch of ancient limestone - rocks already have a lot of this special silica form - but if I treat every gallon with Crouse's recipe; it has a sulfur taste, and no one is going to drink it. So, I only treat one gallon, and put it in the other water in my three gallon water container.

In addition -- the man that wrote the book "Crooked: Man-Made Disease Explained: The incredible story of metal, microbes, and medicine - hidden within our faces."
by Forrest Maready says to use glycine too.

So since glycine is a some what sweet taste, I put it in the water along with a tsp of concentrated lemon juice. All the urine doctors/kidney stone doctors says a teaspoon of lemon in your water will keep the stones as bay.

Sometimes I get the special magnesium/glycine powder and put it in our lemonade.

.

M2021

The elephant in the room is the countless toxins + high aluminum inside ASD brains thanks to vaccines.

The only green in vaccines is the injection site pus.

Now lots of American + Anglo Saxon children (sadly) are prone to violent rages, criminal behaviors, wandering, extreme social delays etc, thanks to aluminum adjuvants.

Focusing only on gut micro biome (while ignoring brain’s aluminum content) is negligent.

Visitor

https://www.youtube.com/watch?v=9UVjjcOUJLE&list=RD7jVmW41LOMM&index=4ost again it will be from the motivation of this.
https://www.youtube.com/watch?v=9UVjjcOUJLE&list=RD7jVmW41LOMM&index=4

Visitor

"It's just as well for all I've seen" I don't think I have more to say.

Visitor

Benedetta,
You are my kind of people.

Visitor

One that keeps me holding on.. I miss my mother.

https://www.youtube.com/watch?v=8THtJ5T4u_E

I said I miss my mother in reference to this song. I said my mother! That means Disturbed need not apply.

Visitor

https://www.bing.com/videos/search?q=sound+of+silence+by+disturbed&ru=%2fsearch%3fq%3dsound%2bof%2bsilence%2bby%2bdisturbed%26cvid%3d7a2ba59e33384553a948726d7aa68c58%26pglt%3d43%26FORM%3dANNTA1%26PC%3dU531&view=detail&mid=2A9F676FD0105B19A1412A9F676FD0105B19A141&rvsmid=44F600D7B15EC73DAAF344F600D7B15EC73DAAF3&FORM=VDQVAP&ajf=60

benedetta

We are all nobodies, and together our voices will make sure they know us nobodies matters. Some day.

Love the Peterson's and thanks for sharing. Nice to find such musical, talented no bodies. Cause I never heard of them.

Visitor

I thought of speaking of gdf15 morning sickness , mitochondrial dysfunction and autism, but remembered I am a nobody.

https://www.genecards.org/cgi-bin/carddisp.pl?gene=GDF15

https://www.youtube.com/watch?v=OeDiK2uy3DU

https://www.youtube.com/watch?v=y2zeudxXjuU

Visitor

My family is musical and this takes my Kentucky home.

https://www.youtube.com/watch?v=Y3hXYININJw

Visitor

Earlier link does not work.

https://www.youtube.com/watch?v=WLLYpKFW43c

Visitor

Brain-immune interactions in neuropsychiatric disorders: lessons from transcriptome studies for molecular targeting

Abstract
Understanding the pathophysiological mechanisms of neuropsychiatric disorders has been a challenging quest for neurobiologists. Recent years have witnessed enormous technological advances in the field of neuroimmunology, blurring boundaries between the central nervous system and the periphery. Consequently, the discipline has expanded to cover interactions between the nervous and immune systems in health and diseases. The complex interplay between the peripheral and central immune pathways in neuropsychiatric disorders has recently been documented in various studies, but the genetic determinants remain elusive. Recent transcriptome studies have identified dysregulated genes involved in peripheral immune cell activation, blood-brain barrier integrity, glial cell activation, and synaptic plasticity in major depressive disorder, bipolar disorder, autism spectrum disorder, and schizophrenia. Herein, the key transcriptomic techniques applied in investigating differentially expressed genes and pathways responsible for altered brain-immune interactions in neuropsychiatric disorders are discussed. The application of transcriptomics that can aid in identifying molecular targets in various neuropsychiatric disorders is highlighted.

Keywords: brain-immune interactions; immune cells; neuropsychiatric disorders; transcriptomics.

https://pubmed.ncbi.nlm.nih.gov/33773976/

I sit back and watch. It is true, but it is like slow motion watching the dawning of this reality in the community.

Visitor

This proves nothing, but nothing does. It is as good as anything.
I value Matthew, Mark, Luke, and John as much as anyone. The following show sense and faith do go together as do the 10 utterances and our being. Some might quibble with Einstein being a quasi-deist, but he was too smart imo to not believe.

25 Famous Scientists Who Believed in God

https://www.famousscientists.org/25-famous-scientists-who-believed-in-god/

Thank You Lord Jesus.

Visitor

Benedetta,

In a simple response I say while all sorts of evidence have challenged my faith, and to the point of agnostic response, I can't comprehend it all I trust in God and see so much of His glorious hand in life and creation. My A plus B = C sometimes overtakes me in a moment I will not rust in my own understanding. The Lord sometimes is my adversary, but I would have not other. I confess Jesus is Lord and my Savior. I have made stupid statements and decisions and that is why I love grace. Grace makes life worth living. I believe God is infinitely above man and hiss knowledge. We are a strange kind and to this I say to God be the Glory.

benedetta

At first there is constant, often prayers of pleading.
Which some times in exhausting turns into rage and anger toward God.

Then God asked me a question one day when my son was 18.
You are angry with me, are you angry with Jesus Christ.

It surprised me!

I have had intense Holy Spirit relationship with Jesus since I was 12. Many that did not , i am so very sorry.

But No, Jesus is my friend. A deep love I have for him, He loves me. I don't know how this will work for others? But for me it calmed me down.

Jesus is God in another form. How can I be mad, raging anger at Jesus. I can't.

Then whose fault is all of this.
It is man's fault.
It is my fault for being tricked. I had my warnings. I had that class in infectious diseases and I let the professor with his zeal of a preacher on vaccines persuade me, even when the swine flu shot that very year turned out so horrible, even when the young men teased him in class about it. I had my warning, years later; when my husband said he had heard Kawasaki's disease could be caused by vaccines. I had my warnings as I watched soaring temperatures after vaccines. Passing out and on and on.

But it is not all of my fault either.
It is humans the kind that rises up out of the masses that pretend to care but don't. It is Colleen Boyd, it is Plotkin (even before I saw him on a u tube, I knew his kind existed, It is all my friends and neighbors as well as myself that gave such humans power over us.

God does not stop it because we have free will. how will we learn if he is stopping us from ever bad decision.

It is mankind and we best be aware who we choose to worship -- believe --- trust -- those things are a form of worship.

Visitor

I am a pastor who has not come close to coping with what has come to my door. I remain hopefully anonymous as there is something in the way of life I want to vomit about. I met with a young man today who has had such a horrendous life I wanted to melt away. I did not want to know of it all. My life has been effected in like ways and his questions were my own.. His opine is where is God in the middle of all the suffering. He is seeing things, but the pure light still shines. If all there is to hope on is my insight I want to give up too. The afflicted are the pure.

https://www.youtube.com/watch?v=QVVlyWeaMN4

Visitor

I had planned to post other things, but this new report takes precedence. Early in this thread we discussed the New York girls and the media said it was "conversion Disorder". These new findings sure look familiar. An aspect of the same neuroinflammation, cytokines, and vegF.

Assessment of cytokines, microRNA and patient related outcome measures in conversion disorder/functional neurological disorder (CD/FND): The CANDO clinical feasibility study

"Our study sample showed elevated IL-6, IFNγ, IL17A, IL12 and TNFαscores, normal IL1B scores, and VEGF-a scores significantly lower compared to the normal sample. Another study in acute CD/FND patients found elevated IL-6, TNFαand IL1B scores (Tiyekli, 2013), which is different from our
findings as in our study, IL1B was normal. Dysregulated continual synthesis of IL-6 plays a role in pathologic chronic inflammation and autoimmunity (Tanaka, 2014) so our study supports the idea that IL-6 may play a role in CD/FND of longer duration. IFNγisproduced by CD4þT helper 1 cells (Th1 cells). It plays a key role in B cell maturation, as it works to inhibit migration into lymph nodes while the B cells are still immature (Flaishon, 2000) and inhibits proliferation of T cells (Chu, 2000). Tumour Necrosis Factor Alpha (TNFα) is produced by macrophages/monocytes during inflammation and has widespread cellular effects, although still a great deal is unknown about its function and complex interplay with other cytokines (Zelova, 2013)."

3.8.3. microRNAThere is extensive literature linking several miRNAs to inflammationand neuroinflammation as well as pain (Andersen et al., 2014;Mi et al.,2013). We supplemented our analysis of circulating cytokines in thecohort by measuring levels of 5 miRNAs associated with inflammation(miR-146a, miR-223 (Wang et al., 2010) miR-155 (Alivernini et al.,2018;Singh et al., 2019)) and to angiogenesis and vascular inflammatoryresponses (miR-21 (Liu et al., 2011;Sheedy et al., 2010;Du et al., 2019),miR-132 (Kumarswamy et al., 2014) and miR-155 (Singh et al., 2019))and miR-16, a highly abundant miRNA in circulation.We observed a range of miRNA blood plasm levels within the cohortas shown inFig. 2.We also explored if levels of miRNAs correlated with levels of TNF inthe cohort. We found that this was the case for all tested miRNAs."

https://reader.elsevier.com/reader/sd/pii/S2666354621000314?token=E148248E601850A6DA279FB778C5EA6E128A9EF09E887A047FBFDEB5605C58DBF6DB3E1E390BBCEE34F7142CC42F907C

Visitor

https://www.youtube.com/watch?v=m4oZZhpMXP4

Visitor

Sometimes I forget that while God cares for our bodily ills He died for our souls.

Lamb of God, you take away the sin of the world, have mercy on us.
Lamb of God, you take away the sin of the world, have mercy on us.
Lamb of God, you take away the sin of the world, grant us peace.

O Lamb of God, that takest away the sins of the world, have mercy upon us.
O Lamb of God, that takest away the sins of the world, have mercy upon us.
O Lamb of God, that takest away the sins of the world, grant us thy peace.

Jesus, Lamb of God, have mercy on us.
Jesus, bearer of our sins, have mercy on us.
Jesus, redeemer of the world, grant us peace.

Whatever I am errant about I trust in God's mercy though the Lord Jesus Christ.

https://www.youtube.com/watch?v=iAK2UP9SRWU

God Bless AoA. God Bless you Cia. you are my sister.

Visitor

God Bless You Benedetta.

https://www.youtube.com/watch?v=AiuC_CaObbI

benedetta

Damaging the hypothalamus just a bit, messing up the endocrine system and all that implies from thyroid production, to all of the hormones

Or a fever damaging the nerve running from the brain to the gut (damaging or upsetting the Rhythmic undulating intestine' sweeping out food and lowering the numbers of microbes as well.

Changes the environment.

Change the environment, change the type of microbes that can grow.

SO not much hope?

And yet there are the studies that show after a brain injury that leads to a horrible C Diff: That fecal transplants, the transplanted microbes are holding their own.

Visitor

Infections are involved in many, though many appear to not have these issues or have not realized the nature of some infections.

"Allergies/ Immune System: Many individuals with autism also suffer immune system deficiencies or immune dysregulation. Within the autism spectrum population, there are groups that will experience rashes, allergic sensitivities, gastrointestinal, ear and other infections as a result. Immune deficiencies and/or immune dysregulation make a person with autism more vulnerable to infection, chronic inflammation and autoimmune reactions, most frequently in the brain and gastrointestinal tract (Jepson, 2007)."

https://www.autism-society.org/what-is/diagnosis/related-conditions/

and one on the gut bacteria being understood for its effect...

Microbes may hold the key for treating neurological disorders

"In my wildest dreams, I could have never imagined that microbes in the gut could modulate behavior and brain function. To think now that microbial-based strategies may be a viable way to treat neurological dysfunction, is still wild, but very exciting."

https://www.sciencedaily.com/releases/2021/03/210310122535.htm

Visitor

More from rom a past comment I made on this thread with further thoughts on TBI and Autism.

"I said earlier in this thread; "I maybe should have not called it TBI, but an ongoing process in Autism that has similar effects overall." TBI being Traumatic brain injury and this was in reference to the on going inflammatory issues in Alzheimer's disease, Parkinson's disease, multiple sclerosis and known traumatic brain injury and how this was occurring in much Autism.

Now, a new report is out talking about long term chemical changes in the brain strongly suspected to be related to the inflammation found in TBI. Here a couple of snippets from two reports and then a link to the abstract."

The following report was referre4d to then:

Autism: 'different developmental brain chemistry'

"The study authors also note that the pattern of chemical changes within the autism spectrum disorder group aged 3 to 4 years is comparable to brain chemical changes found in other disorders such as multiple sclerosis, epilepsy and traumatic brain injury, where the N-acetylaspartate level is reduced at the time of onset or injury. This level usually then rises again during periods of remission, after successful treatment or through recovery."

https://www.medicalnewstoday.com/articles/264106#1

Another repost to consider the connections.

miR-155 Regulates claudin1 Expression in Humans With Intestinal Mucosa Dysfunction After Brain Injury.

Abstract

"Patients with craniocerebral trauma often have intestinal mucosal dysfunction, and the claudin1 protein plays an important role in intestinal mucosal function. Our previous work has shown that the expression of microRNA-155 (miR-155) in the peripheral blood of patients with craniocerebral trauma is decreased. Animal experiments also suggest that the expression of miR-155 is increased in the intestinal mucosa of mice with brain injury and the expression of claudin1 is decreased. We recruited 56 samples (35 patients with traumatic brain injury [TBI] and 21 patients without history of head trauma) to detect the expression of miR-155 on claudin1 regulation by quantitative polymerase chain reaction, reverse transcriptase polymerase chain reaction, and so on. We also used the receiver operating characteristic curve (ROC) to further evaluate the diagnostic value of the 2 biomarkers. From the results, we found that the expression level of miR-155 and claudin1 in the case group was lower than that in the control group. Human miR-155 (Hsa-miR-155) may positively regulate intestinal mucosal function by inhibiting the expression of claudin1, leading to intestinal mucosal barrier dysfunction. Combining the ROC curve data, the results further prove that miR-155 and claudin1 might be the new clinical diagnostic markers and treatment targets for the intestinal mucosal barrier dysfunction after TBI."

https://www.ncbi.nlm.nih.gov/pubmed/31810510

another repost

Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice.

Abstract

Micro-RNAs (miRs) are short, noncoding RNAs that negatively regulate gene expression at the post-transcriptional level and have been implicated in the pathophysiology of secondary damage after traumatic brain injury (TBI). Among miRs linked to inflammation, miR-155 has been implicated as a pro-inflammatory factor in a variety of organ systems. We examined the expression profile of miR-155, following experimental TBI (controlled cortical impact) in adult male C57Bl/6 mice, as well as the effects of acute or delayed administration of a miR-155 antagomir on post-traumatic neuroinflammatory responses and neurological recovery. Trauma robustly increased miR-155 expression in the injured cortex over 7 days. Similar TBI-induced miR-155 expression changes were also found in microglia/macrophages isolated from the injured cortex at 7 days post-injury. A miR-155 hairpin inhibitor (antagomir; 0.5 nmol), administered intracerebroventricularly (ICV) immediately after injury, attenuated neuroinflammatory markers at both 1 day and 7 days post-injury and reduced impairments in spatial working memory. Delayed ICV infusion of the miR-155 antagomir (0.5 nmol/day), beginning 24 h post-injury and continuing for 6 days, attenuated neuroinflammatory markers at 7 days post-injury and improved motor, but not cognitive, function through 28 days. The latter treatment limited NADPH oxidase 2 expression changes in microglia/macrophages in the injured cortex and reduced cortical lesion volume. In summary, TBI causes a robust and persistent neuroinflammatory response that is associated with increased miR-155 expression in microglia/macrophages, and miR-155 inhibition reduces post-traumatic neuroinflammatory responses and improves neurological recovery. Thus, miR-155 may be a therapeutic target for TBI-related neuroinflammation.


KEYWORDS:

Traumatic brain injury; miR-155; microglial activation; neuroinflammation; neuroprotection

https://www.ncbi.nlm.nih.gov/pubmed/30225790

Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198096/

Halting Excessive Inflammation with New Way to Regulate Lymphocytes

“Mitochondria are important regulators of macrophage polarization. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration. Mechanistically, the catalytic activity and presence of Arg2 at the mitochondria is crucial for oxidative phosphorylation,” write the investigators.


“We further show that Arg2 mediates this process by increasing the activity of complex II (succinate dehydrogenase). Moreover, Arg2 is essential for IL-10-mediated downregulation of the inflammatory mediators succinate, hypoxia inducible factor 1α (HIF-1α), and IL-1β in vitro. Accordingly, HIF-1α and IL-1β are highly expressed in an LPS-induced in vivo model of acute inflammation using Arg2−/− mice.

https://www.genengnews.com/news/halting-excessive-inflammation-with-new-way-to-regulate-lymphocytes/
link to study report: https://www.nature.com/articles/s41467-021-21617-2?error=cookies_not_supported&code=b8131469-0694-4bf8-b1a9-7a20befe255b

Further reading in interested.

Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027314/

Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis

https://pubmed.ncbi.nlm.nih.gov/33691793/

Visitor

I made the following comments on this thread in 2012.

"I maybe should have not called it TBI, but an ongoing process in Autism that has similar effects overall."

"Some of you may recognize the benefit of the drug mentioned in the following report for Autism Cytokine control as TBI quick or slow is involved in the biomed Autism pathology."


How much of those with Autism have this as causation or partially so? It is is clear we have dealt with this as a prominent if not central aspect as it is systemic it has to be central. Here are some new reports that basically say in short form what I have said in this thread. The first with Traumatic Brain Injuries, maybe mild to moderate in some with Autism, pointing to pointing to a more permeable GI tract{leaky gut}. The second with dealing with UTI's and the gut microbiome and bacteria from the gut involved with UTI's. My wife had the elements of TBI and UTI's until of a long term regimen of treatment. She almost never has migraines, I can't recall the last, and has not had a UTI hardly at all since 1997. She had numerous from the years prior to that time.

Traumatic Brain Injuries Affect More than the Brain

Key Points: Although traumatic brain injuries involve brain-related symptoms, other organs including the immune system, GI system, lungs, and heart may also be compromised. These injuries can result in changes throughout the body that can increase morbidity and even mortality.

"Traumatic brain injury (TBI) results from a head injury that damages the brain. Symptoms can include loss of consciousness, post-traumatic amnesia, memory loss, disorientation, and confusion. Symptoms occur immediately following the brain trauma and last for a while afterward. Psychiatric symptoms also may occur and include mood fluctuations, depression, anxiety, irritability, and personality changes. Other CNS (central nervous system) symptoms such as dizziness, headache, tinnitus, light sensitivity, and decreased sense of smell can also occur.

In an interesting paper recently published in Trends in Neurosciences, Alan Faden and colleagues discuss the consequences of TBI that involve organ systems other than the brain. They review evidence demonstrating that TBI can lead to significant changes in the immune, gastrointestinal (GI), pulmonary, and cardiovascular systems. These changes have been observed in humans and are being studied in animal models of TBI.

TBI is associated with a high rate of infections. It causes complex changes in the immune system, both systemically and in the brain. The result of these changes is the suppression of immune responses. These changes can persist over time, become chronic, and contribute to increased mortality.

Changes in the GI tract resulting in it being more permeable to substances and, therefore, less able to block the entry of toxins or bacteria into the circulation. The GI system also becomes more susceptible to infections as well as to relapse from ongoing, chronic GI disorders. Changes in the bacteria inhabiting the GI system (the gut microbiome) also occur. As discussed in an earlier post, the gut microbiome system communicates with the brain and influences brain function.

Lung damage is common following TBI. Individuals are susceptible to respiratory infections that can lead to pneumonia. Inflammatory chemicals are released into the lungs. Some of these changes result from TBI-related changes in the immune system.

Levels of certain chemicals in the blood indicate that cardiac damage may occur following TBI. Animal studies also suggest that TBI can lead to diminished cardiac function.

How do traumatic injuries to the brain lead to dysfunction in other organs? The authors review several possibilities. Following TBI, there are changes in the hypothalamic-pituitary-adrenal (HPA) system that lead to alterations in cortisol production. Such changes can interfere with the body’s ability to respond to stressors. TBI also can lead to a surge in activity of the sympathetic nervous system, which involves catecholamines such as norepinephrine. Such a surge can influence the function of various organs. As already mentioned, TBI results in changes in the immune system throughout the body, which can contribute to chronic neuroinflammation and neurodegeneration.

The take-home message is that TBI can result in changes throughout the body that can increase morbidity and even mortality. Increased understanding of these changes will hopefully lead to better treatments to prevent these deleterious consequences of TBI.

This review article by Faden and colleagues reminds all of us of the intimate relationships between brain function and the function of other organs in the body, and that successful treatment of brain diseases can have widespread positive impact on human physiology."

https://www.psychologytoday.com/us/blog/demystifying-psychiatry/202102/traumatic-brain-injuries-affect-more-the-brain

Study: Infectious gut bacteria may predict UTI risk

Urinary tract infections (UTIs) in kidney transplant patients may be caused by bacteria that originate in the digestive tract, according to investigators at Weill Cornell Medicine, Cornell University and NewYork-Presbyterian.

The study, published Dec. 4 in Nature Communications, was led by Dr. John Lee, assistant professor of medicine at Weill Cornell Medicine and a nephrologist at NewYork-Presbyterian/Weill Cornell Medical Center.

Dr. John Lee
Dr. John Lee
The research suggests that the gut microbiota – the unique bacterial population of the digestive system – may be capable of “seeding” the urinary tract with infectious organisms. The research also suggests that new treatments for UTIs may be found in strategies that alter the balance of gut bacteria toward so-called “good” organisms.

The study identifies gut bacterial profiles associated with the risk of developing UTIs. Previous research detected the association at the time of infection, but stopped short of identifying the microbial characteristics believed to precede the UTI.

Lee and his team, including first author Matthew Magruder, a student at Weill Cornell Medical College, investigated the link by collecting fecal and urine samples from 168 kidney transplant recipients over a three-month period, quantifying the specific amount and types of bacteria using state-of-the-art sequencing technology.

Kidney transplant recipients were chosen as study subjects because their anti-rejection medications diminish the activity of the body’s immune system to reduce the likelihood that it will be rejected as a “foreign” organ. The diminished immune response increases the risk for UTIs and other infections.

The researchers discovered that when a disease-causing bacterium, or pathogen, exceeded 1% in these patients’ feces, it significantly increased the chance that they would go on to develop urinary infections caused by the same pathogen.

E. coli accounted for the majority of the UTIs in their subjects.

“While we were excited to see this association between the gut microbiota and development of UTI, we wanted to explore this connection at a deeper level to see whether the origin of the UTI is likely from the gut,” said Lee, who is a named inventor on a patent application focused on detecting cell-free DNA in biological samples.

After further sequencing the bacterial DNA in each transplant patient’s fecal and urine specimens, the investigators found enough similarity to conclude that the gut bacteria were likely the source of infections.

The findings have implications that reach beyond this immunosuppressed population. UTI is one of the world’s most common infections, and accounts for more than 10 million doctor visits each year in the United States alone.

Altering the gut microbiota may someday offer a promising new source of adjunct UTI treatments, particularly for recurrent cases, Lee said. The leading gut-altering techniques today use probiotics (live bacteria introduced via food or supplements) and fecal microbiota transplant (the transfer of gut bacteria from one individual to another) to establish a healthier balance of microorganisms.

The team is now planning follow-up studies to further establish the link between gut microbiota and UTIs.

https://news.cornell.edu/stories/2020/02/study-infectious-gut-bacteria-may-predict-uti-risk


Visitor

Speaking magnesium and migraines I would mention Hyperemesis Gravidarum along with Autism as showing relation to its deficiency. This is mice, but I am guessing it translates a lot.

Dietary magnesium deficiency induces the expression of neuroinflammation-related genes in mouse brain

Abstract
"Aims: Dietary Mg2+ deficiency (MgD) impairs hippocampus-dependent memory in mice; however, the molecular mechanisms underlying MgD-induced memory impairments are unclear. Here, we investigated the molecular signatures in the hippocampus of MgD mice by analyzing the hippocampal transcriptome.

Methods: We performed RNA-sequencing of the hippocampal transcriptome of MgD mice. We used gene ontology analyses and quantitative real-time PCR to validate the RNA-sequencing results.

Results: mRNAs for neuroinflammation-related genes were upregulated in the hippocampus and cortex of MgD mice.

Conclusion: MgD induces neuroinflammation in the mouse brain, including the hippocampus and cortex. Our findings suggest that MgD-induced neuroinflammation triggers the impairments of hippocampus-dependent memory."

INTRODUCTION
"Magnesium (Mg2+) is an essential mineral for maintaining normal cellular functions by functioning as a cofactor in more than 300 enzymatic reactions.1-3 Mg2+ deficiency (MgD) disturbs the homeostasis of numerous biological processes, causing chronic and acute diseases such as metabolic syndrome,4 type 2 diabetes,5 and hypertension.6 Importantly, Mg2+ is required for the voltage‐dependent blockade of N‐methyl‐D‐aspartate‐type glutamate receptors, thereby controlling their opening,7-9 and also contributes to synaptic plasticity such as long‐term potentiation.

Consistently, Mg has been shown to play an important role in learning and memory. Increasing brain Mg2+ concentration improves learning ability, working memory, and short‐ and long‐term memory in rats,10 while MgD impairs fear memory formation.11, 12 We previously investigated the effects of MgD on brain function and found that MgD diet‐fed mice have deficits in hippocampus‐dependent memories such as contextual fear, spatial, and social recognition memories, while they have normal amygdala‐ and insular cortex‐dependent conditioned taste aversion memory, locomotor activity, and emotional behaviors.13 Conversely, MgD mice have normal spine density and morphology of hippocampal neurons. Thus, previous studies have shown that MgD impairs hippocampus‐dependent memory without affecting hippocampal neuron morphology.13 However, the molecular mechanisms underlying the impairments of hippocampus‐dependent memory by MgD remain unclear. In this study, we analyzed the hippocampal transcriptome in MgD mice to identify the molecular signatures of MgD‐induced deficits of hippocampus‐dependent memory performance in mice."

https://onlinelibrary.wiley.com/doi/10.1002/npr2.12167

Visitor

I few posts back when I posted info and the link to "Mimicking a chronic immune response changes the brain" I meant to add the link to the report below as it shows association between Il-17.

The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis

Abstract
"Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17, the major effector cytokine in the pathogenesis of psoriatic disease, along with the rationale for targeting the IL-17 cytokine family (IL-17A, IL-17F, and IL-17 receptor A) in the treatment of psoriasis and psoriatic arthritis. Emerging evidence indicates that major sources of IL-17A in patients with psoriatic disease are mast cells, γδ T cells, αβ T cells, and innate lymphoid cells in lesional skin and synovial fluid. Within the skin and joints, IL-17A acts on cellular targets, including keratinocytes, neutrophils, endothelial cells, fibroblasts, osteoclasts, chondrocytes, and osteoblasts, to stimulate production of various antimicrobial peptides, chemokines, and proinflammatory and proliferative cytokines, which, in turn, promote tissue inflammation and bone remodeling. The critical importance of the IL-23/IL-17A axis to the pathogenesis of psoriatic disease has resulted in many new biologic treatments targeting these cytokines. These biologics dramatically improve skin and joint symptoms in patients with moderate-to-severe psoriasis and psoriatic arthritis."

https://pubmed.ncbi.nlm.nih.gov/30109481/

Visitor

My wife has Raynaud's, psoriasis, hypothyroidism, some early hair thinning., arthritis. She used to have a lot of migraines until I treated her.

Saw this when it came out. I have waited for them to verify these matters.

Pregnant mother's immunity tied to behavioral, emotional challenges for kids with autism

"The researchers measured the children's autism severity and assessed a set of behavioral and emotional problems such as aggression and anxiety. They also measured the children's development and cognitive functioning.

The study found that around 27% of the mothers had immune conditions during their pregnancy. Of these mothers, 64% reported a history of asthma, the most common immune condition. Other frequent conditions included Hashimoto's thyroiditis (hypothyroidism), Raynaud's disease (blood circulation disease), alopecia (hair loss), psoriasis (skin disease) and rheumatoid arthritis (joint tissue inflammation)."

https://www.sciencedaily.com/releases/2020/08/200814163307.htm

A refrain here.

Developing a Deeper Understanding of Autism: Connecting Knowledge through Literature Mining

"Other immune abnormalities possibly linked to autism are familial autoimmunity, maternal transfer of autoantibodies from the mother to child during pregnancy, production of antibodies against brain tissue in autistic patients, lower levels of normal immunoglobulins, and elevation of some cytokines [5]. Besides immune dysfunctions there are other epigenetic mechanisms potentially linked to autism such as increased level of oxidative stress, mitochondrial dysfunction, and excitotoxicity [2, 3]....

A powerful idea for investigating yet to be explored relationships between biomedical concepts was proposed by Swanson [7]. If there is a relationship between A and B reported in the literature on A, and a relationship between B and C in literature on C, then the concept B, might reveal interesting connections across previously disjoint contexts A and C. Swanson found many relationships, unknown at the time, for example, connecting Raynaud’s syndrome with fish oil, and migraine headaches with magnesium deficiency [7]."

https://www.hindawi.com/journals/aurt/2011/307152/

benedetta

Wow Grace; I had not thought of that.

It could well be mercury fillings.

I hurt a tooth falling down hard on my butt some years back. I think the fall killed that tooth. It has been breaking off pieces ever since. So, I did get a big filling in two years ago, and that filling came out back this past September. The night it came out, I must have really grinded my teeth in my sleep really bad. I woke up the next morning with the most painful muscles in my jaw that morning and was spitting out pieces of my porcelain crown that chipped off. Soon after the tips of my upper, good ear that had no problems begin to form psoriasis.

You might be right!

Grace Green

I often had eczema behind the ears in my teen years. Did this follow the fitting of new mercury fillings? Possibly, but too long ago to make the connection now.
After having several mercury fillings removed by an incompetent dentist who washed the debris down my throat, I had eczema progressively down my body until it disappeared off the end of my hands and feet!
I had numbness of the mouth for years when eating certain foods - completely cured after removal of last mercury fillings.
So many more things. I decided a few days ago that all chronic illnesses are due to poisoning. Then I watched the witness statement of Dr. Robert Young and heard him say the same thing!

benedetta

We they have a lot of things for psoriasis, Ointments, steroids, sunshine, light therapy in the winter.

Some time or another if you have an orange you kept too long in the refrig or out in our garage in a bag, and it gets a lot of blue mold on it, pour some apple cider over it and watch like magic that mold disappear. Better than peroxide, or alcohol or bleach.

Apple cider on and in my ears is working pretty good.

I have been putting it on every night, it is helping.
I think the steroid mask the symptoms. Yes, I got something kind of creme that cost 100 dollars that clears it up for months at a time. Well it did for a while and then that did not work eventually.
Hydrogen peroxide seems to work, but using it night after night can hurt your skin. Apple cider does not.

I think it is Canadensis. Why my immune system is not taking better care of it; I don't know. Better now that I gave up gluten. Better that I do low carb.

I do know that when I upped my thyroid medicine to a higher level ( cause I had some extra pills and it was against the doctor's orders, it went away too) What they consider to low to high on thyroid is a really wide range by the way.

I see that a lot of people are taking apple cider - drinking it with water for yeast infections.

Is it an immune problem of not fighting off fungus, or a endocrine problem of not enough energy to fight off fungus? Maybe just an allergic reaction to a common body fungus?

It cannot be that simple as being a fungus problem though. I mean; we have big phrama, and psoriasis research societies; and if it was a fungus they would have told us.

So much lying and trickery now a days, we are all dazed and confused.

But it can go into arthritis.

Visitor

Benedetta ,
The report I posted that you refer to does point to T cell;s issuing IL-17 from the gut. I have come across, or attempted to determine, why psoriasis may occur in a particular area. My wife has a small amount on her scalp that you haver to look for because her hair covers it. Se also has, and I have mentioned in this thread, Geographic tongue which is thought to be a form of psoriasis. With her food reactivity the food contact with her oral area seems intuitive. Food effects beyond her mouth though.

The book you cite sounds very interesting, be sure to share any valuable things you find. The mouth metal and microbe connection also seems intuitive, also in the gut.

Though beyond well psoriasis IL-17 and mir-155 are inflammatory players though both can have inverse effects under certain conditions. I mentioned psoriasis in previous posts in this thread. Here some of the links I have previously posted.

MiR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis.

https://www.ncbi.nlm.nih.gov/pubmed/28402921

Immune Mediated Conditions in Autism Spectrum Disorders

"Psoriasis occurred more than twice as often in cases than in controls "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414798/

The codependence of angiogenesis and chronic inflammation.

"Angiogenesis is the growth of new blood vessels from existing ones. It is an important aspect of new tissue development, growth, and tissue repair. It is also a component of many diseases including cancer, blindness, and chronic inflammation such as rheumatoid arthritis (RA) and psoriasis. There is considerable evidence to suggest that angiogenesis and chronic inflammation are codependent; recent studies have begun to reveal the nature of this link, which involves both augmentation of cellular infiltration and proliferation and overlapping roles of regulatory growth factors and cytokines."

http://www.fasebj.org/content/11/6/457

Copper Toxicity

"It causes joint pain and arthritis, digestive problems, irritable bowel, overgrowth of candida albicans, breathing difficulties including asthma, and chronic skin problems which can range from acne to psoriasis."

http://www.tvernonlac.com/copper-toxicity.html

Mycoplasma

A wide spectrum of rheumatic conditions are linked to MP as a co-factor,

"Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), Arthritis Asthma, Arterial sclerosis, Atypical pneumonia, Bronchitis, Cardiovascular diseases, CFS/CFIDS, Crohn’s diseases, COPD, fibromyalgia syndrome (FMS), Interstitial cystitis, Leukemia, Lymphoma, Lupus (SLE), Multiple sclerosis (MS), Pelvic inflammatory disease (PID), Psoriasis, Scleroderma, Solid (&lung) cancers, Sjogren’s syndrome,."

http://www.ra-infection-connection.com/Mpneumoniae.htm

REG3A molecule may lead to new treatments for psoriasis, wound-healing

"An international team of scientists led by principal investigator Richard L. Gallo, MD, PhD, professor of medicine and chief of UC San Diego's Division of Dermatology, analyzed skin biopsies of patients with and without psoriasis, as well as the skin of mice with psoriasis and with wounds on their backs. They discovered that a molecule called regenerating islet-derived protein 3-alpha (REG3A) is highly expressed in skin cells during psoriasis and wound-healing, but not under normal skin conditions.

In tests on mice, researchers found that inhibiting REG3A slowed wound-healing but cleared up psoriasis, which is commonly characterized by patches of inflammation and white, scaly skin.

The scientists also noted that REG3A acts in concert with interleukin-17 (IL-17), an immune system protein involved in the signaling cascade which prompts skin cells to multiply in excess numbers. "IL-17 binds to receptors on skin cells and causes REG3A to be expressed,"

{my note: REG3A is a gut factor in Autism and maybe elsewhere}

http://www.news-medical.net/news/20120622/REG3A-molecule-may-lead-to-new-treatments-for-psoriasis-wound-healing.aspx

benedetta

I see that Psoriasis foods to avoid is like everything.

How come I only got it on my ears?

T cells is going to the gut to make this interleukin 17. Is that a clue happening in the gut before spreading to all the body.

Nick, I have been reading Maready "Crooked"
It kind of circles back around to metals and microbes.

All of the mercury and silver fillings out of my teeth, including lifting the caps as well, well sometimes money is an issue

Visitor

I have failed the Lord in so many ways. He has never failed me once.

Jesus is Lord. Blessed Mary, mother of our Lord.

https://www.youtube.com/watch?v=Yiw6EfrHDhg

Our God never lets go.

https://www.youtube.com/watch?v=C0nM3_lhBWo

May God bless each of the autism family.

Visitor


Mimicking a chronic immune response changes the brain

"Researchers led by Professor Yosuke Takei and Assistant Professor Tetsuya Sasaki at the University of Tsukuba in Japan have been studying an important cytokine called interleukin (IL)-17A. Their recent study shows that chronic increases in the levels of IL-17A circulating in mouse blood can reduce the microglia activity in one part of the brain's hippocampus. This might explain why it's related to several neurological diseases.

The researchers focused on IL-17A because it is known to be involved in neurological autoimmune disorders as well as disorders of the mind. "In addition to being linked to multiple sclerosis," explains Sasaki, "recent reports show that IL-17A is also a factor in Alzheimer's disease, schizophrenia, and autism spectrum disorder." To study how chronically high levels of IL-17A can affect the brain, the team used their knowledge of how IL-17A is made naturally in the body.

The researchers focused on immune cells called helper T-cells. Helper T-cells come in many varieties, each one making its own cytokine, and each one created from a generic helper T-cell. "Our strategy," says Sasaki, "was to induce more generic helper T-cells to become the kind that produce IL-17A." With more of these helper T-cells, called Th17, the mutant mice did indeed produce more IL-17A in the gut, which spread throughout the body in the blood.

IL-17A is known to interact with two kinds of glial cells in the nervous system, astrocytes and microglia. The researchers found that chronically high IL-17A led to reduced activity and density of microglia in one region of the hippocampus, a part of the brain that is needed for learning and forming memories. In contrast, astrocytes in the brain did not differ between the mutant and control mice. Thus, there was reason to believe that chronic IL-17A inflammation would affect cognition, specifically memory. Surprisingly, spatial memory seemed to be just as good in the mutant mice as in the control mice.

"These mutant mice can be used in future studies as a model for chronic IL-17A-related inflammation," says Takei. "Further neuronal and behavioral testing will help us begin to understand IL-17A's role in a range of debilitating neurological disorders."

https://www.sciencedaily.com/releases/2021/02/210217151057.htm

Inflammation and Psoriasis in the two links below.

https://www.healthline.com/health/psoriasis/facts-about-inflammation#systemic-inflammation

https://www.healthline.com/health/psoriasis/food-triggers-for-psoriasis

Visitor

"Scary times; and always has been frustrating time to try to warn." More truth.
"Is anybody listening?

Benedetta

I am so sorry Nick. Scary times; and always has been frustrating time to try to warn.

Now we know how Cassandra was so cursed.

Visitor

For the record my family to this day had dismissed and disparaged everything I told them. They can take this up with God. I was totally abandoned by them. I made the overtures to create a bond and it has been mainly artificial from my end though I had hoped for a real relationship. It I am spitting into the wind, so be it. I have tried to be honest and real. Dirt in my face is all I have received.

Visitor

A diamond necklace played the pawn
Hand in hand some drummed along, oh
To a handsome man and baton
A blind class aristocracy
Back through the opera glass you see
The pit and the pendulum drawn
Columinated ruins domino

Canvass the town and brush the backdrop
Are you sleeping?

Hung velvet overtaken me
Dim chandelier awaken me
To a song dissolved in the dawn
The music hall a costly bow
The music all is lost for now
To a muted trumpeter swan
Columinated ruins domino

Canvass the town and brush the backdrop
Are you sleeping, Brother John?

Dove nested towers the hour was
Strike the street quicksilver moon
Carriage across the fog
Two-Step to lamp lights cellar tune
The laughs come hard in Auld Lang Syne

The glass was raised, the fired rose
The fullness of the wine, the dim last toasting
While at port adieu or die

A choke of grief heart hardened I
Beyond belief a broken man too tough to cry

Surf's up
Aboard a tidal wave
Come about hard and join
The young and often spring you gave
I heard the word
Wonderful thing
A children's song

Child, child, child, child, child
A child is the father of the man
Child, child, child, child, child
A child is the father of the man
A children's song
Have you listened as they played
Their song is love
And the children know the way
That's why the child is the father to the man
Child, child, child, child, child
Child, child, child, child, child
Na na na na na na na na
Child, child, child, child, child
That's why the child is the father to the man
Child, child, child, child, child

Visitor

For me is is intensely sad ...not say. God speed Teresa.

Visitor

For me is is intensely say because Teresa has such a tremendous grasp of the issues. We could have been fiends or at least acquaintances. I hold no animus. Pain and desperation restrain even the most loving. I burn no bridges and cherish grace.

Visitor

I posted the studio elemental version of Dreams in early March of this year. I would almost never simply post as version of a song but this is a nearly complete capture of all the energy of the song. It is jazz in flight. Bravo! I wonder how diverse is her talent.

https://www.youtube.com/watch?v=V1LhC1zGouc

Visitor

I am on a journey too, but know why. I also now mainly understand what directed my sweetheart. It does not change my illusions.

Kentucky is where I began as did my other and this journey. Running to or from. She was nothing like those who have a context. Neurodiversity is awful in concept for my wife and those like her lost in biologicals malice and damage.

I have shared some of my journey in context. My search of looking for something.

Kentucky rain - Barb Jungr

https://www.youtube.com/watch?v=SJxVQVoG_5I

Visitor

So it is fight, flight, or freeze. To a world or away, from a world or away, or frozen in thought or frozen in motion or else in a journey. Flap your hands or rock to escape the unknown. Uncertainty or pain causes these reactions. The glimpses of uninformed effort of knowing. The trip is for the addicted or the lost. The context is moving and shifts as the focus changes. One needs to, or is arrested by change, but has no notion of why. This probably makes no sense to anyone. I believe it to be valid for the effected.

I have long been around cattle. I concur.
The heterogeneity means this is generally the case.

Genetic link between cattle temperament and autism in humans

https://www.sciencedaily.com/releases/2020/08/200827102148.htm

https://www.youtube.com/watch?v=qeMFqkcPYcg&list=RDqeMFqkcPYcg&index=2

Visitor

Gabapentin effective in Hyperemesis Gravidarum in early pregnancy, finds study

https://medicaldialogues.in/obstetrics-gynaecology/news/gabapentin-effective-in-hyperemesis-gravidarum-in-early-pregnancy-finds-study-71163

The following is not new information but relates to the 1st report. It is not a coincidence that the medication has been useful in autism and seizures and now found to be helpful in many cases of hyperemesis-gravidarum. Inthis thread you can find my connecting the conditions.

Study finds altered brain chemistry in people with autism
Neuroscientists link autism to reduced activity of key neurotransmitter in human brain.

https://news.mit.edu/2015/altered-brain-chemistry-autism-1217

Benedetta

Visitor Nick;
I am very sorry for the loss of your mother.

Inflammation Highway in the end looks like it is going to be the way our bodies handles aluminum don't it?

Does it seem that way to you?

Visitor

My mother, the smartest and the best. Went home 2007 , I love you mother.

Visitor

My last post was a bit facetious. the reasons maybe only views accepted by me, but some one followed my presentations of understanding and ignored me. when proclaiming their elements. A virtuoso for me is Pentatonix's performance. I have found I know how to burn bridges. This speaks to me more than "Disturbed's" version. I would have given on God had I not seen worship in my fellow creatures as I do in the members of Pentatonix.

"Yet he has not left himself without testimony: He has shown kindness by giving you rain from heaven and crops in their seasons; he provides you with plenty of food and fills your hearts with joy."

https://www.youtube.com/watch?v=gdVjVtpr55M

One that keeps me holding on.. I miss my mother.

https://www.youtube.com/watch?v=8THtJ5T4u_E

Visitor

Teresa please reconsider your decision. Your contributions ae immerses. For the love of God please reconsider and continue writing for AoA!

Visitor

I do very much like "Disturbed's" version.

I have been in a mental blender for may years and don't find my faith has me on the heavenly side of the sea above creation. I am holding on, but can't really explain the faith I still have as the science challenges severely. Some surely is actually doing the holding.
I come back to that simple blessed place when I go alone in my thoughts to long

Sea of glass brings many visions and states of mind. This song reminds me of home. {only the lambs will appreciate this adoration}

https://www.youtube.com/watch?v=opscb36ltco

Benedetta

Nick;

PENTATONIX: is great in everything that they do. But Disturbed did "Sound of Silence" best:

I have seen people, my best friends that have bound and prayed to the neon God they had made, in the last few years that hurts my heart.


https://www.bing.com/search?q=sound+of+silence+by+disturbed&cvid=7a2ba59e33384553a948726d7aa68c58&pglt=43&FORM=ANNTA1&PC=U531

Benedetta

And speaking of beast, the seven headed beast produced another beast that came out of the earth (like all those metals that medicine and other industries have used on the human body, that is harming people --- like aluminum -- that is causing "Inflammation Highway")

Benedetta

Visitor;
You are one of the Glass Sea, mingled with fire; that stood up against the dark sea that produced the seven headed beast (one head with a mortal wound and yet lived) - that has to represent the medical institutions, for sure. The Glass sea will defeat the beast.

Be of good spirit Visitor, for God delights in you. He gave visions to John that wrote Revelations about you and those like you that loves the truth, and hates lies It is people like you that questions everything and fooled by little. For you are one of the Glass sea mixed with fire!

Visitor

Music has been one of my best teachers. One in four male to female autistic.

https://www.youtube.com/watch?v=gdVjVtpr55M

Visitor

Business Insider was quoted by Cia. in posits on AoA. I am going to give her the benefit of the doubt as to why she vouched for their information.. They have proven to be a lying source of information.

Anti-maskers are the new anti-vaxxers

https://www.businessinsider.com/anti-maskers-are-new-anti-vaxxers-threatening-public-health-coronavirus-2020-7

It is a miniscule amount of people that connect the two notions, but they are aware of who knows the score. They seek to squash any realization of truth. Cia quoted this vile group Business Insider. . Business Insider be cursed. Wake up Cia.

Anti-maskers are the new anti-vaxxers. These peolple arte the defintiojn of evil,

https://www.businessinsider.com/anti-maskers-are-new-anti-vaxxers-threatening-public-health-coronavirus-2020-7
They are only aware of this because of their control agenda. They are evil.

Visitor

I am a very simple man whom God has loved. Please forgive my ignorance and swearing. Love to you Kim and Benedetta. Susan Welch is such a kind spirit.

https://www.youtube.com/watch?v=Ix6Yr9FYFeA

susan welch

Visitor, thanks for the video links. They were both appropriate and enjoyable.

Sorry you appear to be feeling so 'down'. You are right about the powerful, but we have the truth.

Hang in there.

Visitor

from one small voice that has linked to the ":Atlantic", let me me state without qualification the Atlantic is a rag publication that deserves no respect and should be seen as a scumbag piece of journalism. I am ashamed to have ever linked one article of their putrid verbosity.

Visitor

People without autism.

https://www.youtube.com/watch?v=gdVjVtpr55M

Visitor

No money , No status, just truth. It will matter little.

https://www.youtube.com/watch?v=Ilybv2ZKOto

Visitor

II am only one, but I have innocently investigated it all. There is no meaning. Chaos rules. You can find effect continuously. When you seek to the end it all means shit. There is no meaning and I wished there was. The strongest rule. The ,most selfish rule.

Visitor

The ACE2/Angiotensin, Rage TLR's and other aspects including HMGB1. This makes you think about latent viral expression in some with Autism and aspects o vascular effects in vascular constriction and dementia and also in Kawasaki's. Hypoxia diminishes antiviral immune responses. It seems to be a microcosm of how a vaccine may mediate a damaging inflammatory state in those predisposed and Covid may be doing this some with particular states of ACE2, maybe down regulated ACE2. II on't attempt to re-state all that is spoken about in this thread regarding these matters, but it is there.


HMGB1: A Possible Crucial Therapeutic Target for COVID-19?

High mobility group box-1 (HMGB1) is a chromatin-linked, nonhistomic, small protein with cytokine activity that has nuclear, cytosolic, and extracellular actions. It binds to chromosomal DNA but also to Toll-like receptor 3 (TLR3), TLR4, and the receptor for advanced glycation end products (RAGE) that activates nuclear factor (NF)-κB (Fig. 1a), which mediate the upregulation of leukocyte adhesion molecules as well as the production of proinflammatory cytokines and angiogenic factors that promote inflammation. HMGB1 was initially known as alarmin and is a well-recognized damage-associated molecular pattern (DAMP) protein.

Fig. 1.
a HMGB1 shows both intracellular and extracellular effects. By binding to TLR2, TLR4, and RAGE, it activates NF-κB which leads to the production of proinflammatory cytokines that have local and systemic effects. b HMGB1 is increased both locally and in the circulation in conditions like obesity, cystic fibrosis, and polycystic ovary, and, whenever insulin resistance occurs, it is produced by adipose tissue and the immune system. CFTR malfunction causes an increase in HMGB1, besides other changes such as inflammation and increased autophagy.

https://www.karger.com/Article/FullText/508291

In our case my wife had re-occurring bronchial infections which were often viral. These declined progressively with many treatments along with eventually Olmesartan, which does numerous things in cell and immune system.

Doctor offers coronavirus protection advice

"Antihypertensives, a class called ARBs (angiotensin receptor blockers), which are normally used to reduce blood pressure and protect kidney function. ARBs increase ACE-2 activity and have been proposed as a treatment to promote healing of the lung in corona virus pneumonia. A recent study from China demonstrated through indirect measures that ACE-2 function declines with viral load and severity of COVID-19 pneumonia. For people already taking blood pressure medication, the inclusion of an ARB may improve the response to COVID-19 infection. The Federal government is sponsoring a trial of the ARB losartan for amelioration of COVID-19. However, the ARB that most enhances ACE-2 levels in humans is olmesartan (Benicar). Of all the ARBs, olmesartan has the greatest impact on immune function. "

https://www.fox5ny.com/news/doctor-offers-coronavirus-protection-advice

Visitor

On the topic of measles and atopic dermatitis there are conflicting reports, but this one suggests a timing that does associate with the start of measles virus vaccines. Again, many with autism don't show AD, but the terrain of their skin still may reflect aberrant function.

Atopic dermatitis is increased following vaccination for measles, mumps and rubella or measles infection.
"Abstract
The prevalence of atopic dermatitis increased markedly in the period 1960s to the 1990s. Earlier findings indicate that infections acquired in early life enhance or suppress the expression of atopic disease as a result of a change in immune reactivity. Our objectives were to examine the association between measles, mumps and rubella vaccination, measles infection and the risk of atopic dermatitis. A random sample of 9,744 children were followed up from birth to 3-15 years. Their parents responded to a questionnaire including highly structured questions on atopic dermatitis, measles, mumps and rubella vaccination and measles infection. Information on parental educational level was obtained from Statistics Denmark. The cumulative incidence of atopic dermatitis at age 14 was 19.7%. The confounder adjusted incidence ratio of atopic dermatitis among measles, mumps and rubella vaccinated children versus children not subjected to measles, mumps and rubella vaccination and measles infection was 1.86 (95% CI 1.25-2.79); the incidence ratio for measles-infected children was similar. The incidence of atopic dermatitis increased after measles, mumps and rubella vaccination and measles infection, which is surprising in view of the hygiene hypothesis. We suggest further study of the possible short-term and long-term effects of virus and bacteria on the immune responses and expression of atopic disease."

https://www.ncbi.nlm.nih.gov/pubmed/14690341

COVID-19 may be tied to rare syndrome in children, UK doctors warn

Also, I know AoA is aware of this news, but given the detoxification and inflammatory effecting the systems of many with autism and the viral associations it is interesting to read the elements that they describe the condition with. {Toxic shock- Kawasaki's...fits with factors of this thread}

"The alert noted that these cases showed symptoms similar to those found in two rare conditions: toxic shock syndrome and Kawasaki disease. Toxic shock syndrome is a life-threatening condition that's caused by toxins produced by certain types of bacteria; Kawasaki disease is a childhood illness that causes inflammation in blood vessel walls, and in serious cases can cause heart damage."

https://www.livescience.com/covid-19-kids-rare-inflammatory-syndrome.html

Visitor

Not too far back in this thread you will find information on ccr4/ccl17 and findings relating it to autism and showing effects in the brain. I am still working on this and how this could be related to atopic dermatitis which is much higher in those with autism. CCl17 is also related to "Dress Syndrome" and shows hypersensitivity. This possibly could be a trigger after MMR though I have not begun looking as to how this keratinocyte/skin reaction might communicate or effect the same factors in the brain. In the hypersensitive this could conceivably be a trigger and though many more may get atopic dermatitis without having autism there may be a correlation to study as to the age or degree one has the Atopic condition. There are many questions that could prove to abolish this theory, and MMR might only effect a subset in sparking regression or developmental effects or ADHD with or without Atopic Dermatitis. The first masles vaccine did not come till 1963 I have read, but certain flu vaccine among others began in wWorld Wae 2.
The first paragraph might show a timing relationship with Autism.

TARC and CTACK;
Two Pivotal Chemokines in
Atopic Dermatitis
Christian Vestergaard
"The incidence of atopic dermatitis has been rising in the wes
tern countries since World War II (2), a fact which has been
ascribed to better living conditions and the western lifestyle
(3, 4) although it seems to have levelled out during the 90’s
(5). Atopic dermatitis affects between 15% and 20% of all
Danish children (6, 7) however; the number varies with a li
fetime prevalence between 13% and 37% (8). In a Norwegian
study 13% of the population under the age of 20 was affected
by atopic dermatitis, whereas only 2% of the population over
the age of 20 was affected (9). In 60% of the cases the onset of the disease is in the first year of life
and in 85% of the cases before the age 5 years (10)."

"Infections also play a role in the pathogenesis of atopic
dermatitis. In a recent study it was shown that children who
were subjected to the measles, mumbs and rubella vaccination
or measles infectionhad a significantly higher risk of developing atopi dermatitis
ping atopic dermatitis than children who were not vaccinated or had had measles."

https://www.medicaljournals.se/forum/articles/12/Supplement%2014/Suppl14.pdf

Visitor

I t does not matter what i post anymore than the one reading this can be understood by another. I have understood another. That is of note..

Now here I go again, I see the crystal visions
I keep my visions to myself, it's only me
Who wants to wrap around your dreams and,
Have you any dreams you'd like to sell?
Dreams of loneliness,
Like a heartbeat, drives you mad
In the stillness of remembering, what you had,
And what you lost and what you had and what you lost

https://www.youtube.com/watch?v=6ZShvtyeUpk

I keep my visions to myself. I have shared the science the reality would never be believed thoug I have alluded to it.

Visitor

"You have done so very much on all of this, it is staggering piece of work"
After over a hundred thousand studies I am a puddle.
Nihilism. or Faith. I have not fared well in the milieu. over the last 23 years. I have been focused like a laser and am totally taxed in my ability at every turn. The vacillation between the two is a bit unhealthy.{understatement}. I want a n end point, but it just keeps unfolding. What is a post without a song?

https://www.youtube.com/watch?v=Vol9dZ-t93s

Visitor

Isaiah 9:6-7 ESV
For to us a child is born, to us a son is given; and the government shall be upon his shoulder, and his name shall be called Wonderful Counselor, Mighty God, Everlasting Father, Prince of Peace. Of the increase of his government and of peace there will be no end, on the throne of David and over his kingdom, to establish it and to uphold it with justice and with righteousness from this time forth and forevermore. The zeal of the Lord of hosts will do this.

So at his second coming he will be in control of government. No more humans just out for themselves, but instead really working for the good of us all. That is the future of mankind.

It is True - So Be It

Benedetta

Nick;
Your last study you shared toward the end was about intestinal mucosal . After my son's third DPT reaction about a week later -- he filled his diaper with mucous, so I know what that looks like and now I know maybe why. Thanks.

Advent last Sunday and I was looking for a verse to share with my family about "Hope" That is the theme of the first Sunday of December.

Isaiah 9:6-7 ESV
For to us a child is born, to us a son is given; and the government shall be upon his shoulder, and his name shall be called Wonderful Counselor, Mighty God, Everlasting Father, Prince of Peace. Of the increase of his government and of peace there will be no end, on the throne of David and over his kingdom, to establish it and to uphold it with justice and with righteousness from this time forth and forevermore. The zeal of the Lord of hosts will do this.

So at his second coming he will be in control of government. No more humans just out for themselves, but instead really working for the good of us all. That is the future of mankind.

Visitor

Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease.

Abstract

Kawasaki disease (KD) is a systemic febrile syndrome during childhood that is characterized by coronary arteritis. The etiopathogenesis of KD remains to be elucidated. NLRP3 inflammasome is a large multiprotein complex that plays a key role in IL-1β-driven sterile inflammatory diseases. In the present study, we investigated the role of NLRP3 inflammasome in a murine model of KD induced by Candida albicans water-soluble fraction (CAWS) and found that NLRP3 inflammasome is required for the development of CAWS-induced vasculitis. CAWS administration induced IL-1β production, caspase-1 activation, leukocyte infiltration, and fibrotic changes in the aortic root and coronary arteries, which were significantly inhibited by a deficiency of IL-1β, NLRP3, and ASC. In vitro experiments showed that among cardiac resident cells, macrophages, but not endothelial cells or fibroblasts, expressed Dectin-2, but did not produce IL-1β in response to CAWS. In contrast, CAWS induced caspase-1 activation and IL-1β production in bone marrow-derived dendritic cells (BMDCs), which were inhibited by a specific caspase-1 inhibitor and a deficiency of NLRP3, ASC, and caspase-1. CAWS induced NLRP3 and pro-IL-1β expression through a Dectin-2/Syk/JNK/NF-κB pathway, and caspase-1 activation and cleavage of pro-IL-1β through Dectin-2/Syk/JNK-mediated mitochondrial ROS generation, indicating that CAWS induces the priming and activation of NLRP3 inflammasome in BMDCs. These findings provide new insights into the pathogenesis of KD vasculitis, and suggest that NLRP3 inflammasome may be a potential therapeutic target for KD.

https://www.ncbi.nlm.nih.gov/pubmed/31836541

miR-155 Regulates claudin1 Expression in Humans With Intestinal Mucosa Dysfunction After Brain Injury.

Abstract

Patients with craniocerebral trauma often have intestinal mucosal dysfunction, and the claudin1 protein plays an important role in intestinal mucosal function. Our previous work has shown that the expression of microRNA-155 (miR-155) in the peripheral blood of patients with craniocerebral trauma is decreased. Animal experiments also suggest that the expression of miR-155 is increased in the intestinal mucosa of mice with brain injury and the expression of claudin1 is decreased. We recruited 56 samples (35 patients with traumatic brain injury [TBI] and 21 patients without history of head trauma) to detect the expression of miR-155 on claudin1 regulation by quantitative polymerase chain reaction, reverse transcriptase polymerase chain reaction, and so on. We also used the receiver operating characteristic curve (ROC) to further evaluate the diagnostic value of the 2 biomarkers. From the results, we found that the expression level of miR-155 and claudin1 in the case group was lower than that in the control group. Human miR-155 (Hsa-miR-155) may positively regulate intestinal mucosal function by inhibiting the expression of claudin1, leading to intestinal mucosal barrier dysfunction. Combining the ROC curve data, the results further prove that miR-155 and claudin1 might be the new clinical diagnostic markers and treatment targets for the intestinal mucosal barrier dysfunction after TBI.

https://www.ncbi.nlm.nih.gov/pubmed/31810510

Trying to be cute with the bless you and ___ a couple of post back relating to some want to abuse you from "Sweet Dreams", but I was not in a right frame of mind to make any intelligent remarks at that time. Sorry.

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