The Inflammation Highway: aka Autism
By Lisa Goes
"The one thing about my husband and I...we laugh...A lot. We find a way. We really do. Poop filled sleepless nights, injuries, missed appointments, clutter everywhere, missing paperwork...sometimes all you can do is laugh. But today, looking at the dark circles we've seen so many times under our children's eyes, seeing the suffering, the real genuine human suffering that we have worked for three years to alleviate...to see it reach these depths...there is no laughing today. There is sadness. Even the fight is gone. I should be sleeping, but I have to read up on one of our new remedies. Maybe this will be the one that touches his immune damage and regulates him? Maybe. Maybe, it will work for him like it has for THOUSANDS of other children. Maybe. I can't sleep when this could be it and I could be calling the next doctor tomorrow and we could have one less day of this. Plus, I already have an appointment to see a doctor tomorrow and I will need him to know that I know what I'm talking about. If there is one thing you learn as an autism parent it is that YOU MUST KNOW WHAT YOU ARE TALKING ABOUT WITH DOCTORS. You must learn to speak their language. If you don't you will get dismissed. Must read, now.
But, before I go, just need to let everyone know the women who work for us are angels from God. They were hurt today. Two of them. In their sweetest voices they kept repeating, "nice hands." And "time to get down monkey" when he climbed on the counter for the 27th time on their shift. He is 50 lbs now. Very fast and very strong. They get him. They see the real Noah in there, fighting like hell. He is mad. In fact, that's what he said in therapy today, "I'm MAD!" His therapists were thrilled. They were so excited to see him emote appropriately. I agree with them, it's encouraging. It's just that, he's mad he's sick. He's mad his head hurts all the time. He's mad his three year old brother can use the toliet and he cannot. He's mad that his body is rebelling against him and everything hurts. He's mad that in addition to not getting to go where everyone else goes and doing all the fun things other 5 year olds do, he also cannot EAT anything they do. It seems cruel doesn't it? It is.
Autism is the cruelest most malicious, devious, conniving, heinous disease. If you fear the chicken pox or diarrhea more you are in big, big trouble. Because I guarantee with the new schedule autism will come a knocking at your door. And it will get in. It finds a way. Sometimes it looks like OCD, sometimes it looks like ADHD, even arthritis. "That's nuts!", you say. Not really. It should all just be called autism. Because any time pharma causes inflammation they don't want you to find out about, they just make up a word for it. Autism. Asthma. ADD. Just made up words for inflammation. Off to read ABOUT AUTISM . It's a good one, you might want to check it out yourself... Much hope for all our beautiful children. xo lj "
Lisa Goes is Contributing Editor to Age of Autism.
Benedetta,
Laura Hayes just supplied the answer as to why female voices touch me so. They are all much more of gracious Mary and have to endure shedding of blood like our Savoir when life is given, or are aware that they may do so. It is more complex, but this is the core. Blood is life and death. One form is life, women almost always are this source.
“Labor of Love” by Andrew Peterson, sung by him and Jill Phillips, about Mary, mother of Jesus
https://www.youtube.com/watch?v=WIbXkofOxZM
Those who do carry weight with me.
Thank you Laura, a wonderful message.
Posted by: Visitor IH | December 09, 2024 at 06:29 PM
AI is better than average, but my last posting does not me it is prescient. Don't get cocky.
Posted by: Visitor Ih | December 09, 2024 at 04:56 PM
I serve after my father.
God Bless The USA (Cover)
https://www.youtube.com/watch?v=TqlOksRb9Sc
America has given us President Trump. He has our interests at heart.
Posted by: Visitor IH | December 08, 2024 at 03:24 PM
“But I know the rage that drives you. That impossible anger strangling the grief, until the memory of your loved ones is just poison in your veins. And one day you catch yourself wishing the person you loved had never existed, so you'd be spared your pain.”
― Christopher Nolan
Posted by: Visitor IH | November 30, 2024 at 09:26 AM
Oblivion
The outcome of human reasoning.
https://www.youtube.com/watch?v=PIzyNHmah6k
In my top 5.
Posted by: Visitor IH | November 23, 2024 at 02:41 PM
"They only see what they want to see."
Posted by: Visitor IH | November 23, 2024 at 02:17 PM
The first shall be last, and the last shall be first.
Posted by: Visitor IH | November 15, 2024 at 02:09 PM
Thank you for all your kindness Benedetta. You have been a source of blessing to me.
Posted by: Visitor IH | November 15, 2024 at 12:26 PM
Thankyou Visitor; that last article was very interesting
On the end there were suggestions of some things that might work.
We are reading Mid Western Doctor article on DMSO.
Seems to be working on a number of things for us.
Posted by: Benedetta | November 01, 2024 at 08:30 PM
Mast cells are involved in a large number and shows the histamine relation. The inflammation, histamine allergy, involvement has been a part of my understanding from the beginning of my study. Also wound healing and fibrin. This dysfunction covers so much it is too complex to explain to anyone not vested to learn very large amounts.
Mast Cells in Autism Spectrum Disorder—The Enigma to Be Solved?
https://pmc.ncbi.nlm.nih.gov/articles/PMC10932299/
Posted by: Visitor IH | November 01, 2024 at 01:18 PM
Yes histamines do in context. The term heterogenous has been applied to Autism and it is the case in discerning inflammation as well. I have discerned inflammation in our case and autism before it war entertained. It is/was a major factor in our case.
One reference affirming inflammation, but there are myriad.
Is autism caused by brain inflammation?
https://www.moleculera.com/autism-caused-by-brain-inflammation/
Tori Amos - "Smells Like Teen Spirit"
https://www.youtube.com/watch?v=vB2c7_vyBSM
Posted by: Visitor IH | October 30, 2024 at 01:24 PM
The song was from "Outlander" It is so pretty.
I never thought about the words so much, but they match what goes on with autism.
I would say that there is inflammation of their brains, and additional strep infections or even covid can cause inflammation levels to go higher, for those already with a tendency toward inflammation after the vaccines messed up their immune cells.
Dr. John Campbell did several podcast on mast cell activation syndrome after several of his guest mentioned that they had been diagnosed with that after a covid vaccine. Kyle Warner the mountain bike racer was one of them. He then interviewed a doctor Tina -- Peers I think was her name.
Histamines indicate high inflammation, don't they?
Posted by: Benedetta | October 27, 2024 at 08:36 PM
NLRP3 inflammasome-mitochondrion loop in autism spectrum disorder
Abstract
"Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted interests and repetitive behavior. To date, no single cause has been demonstrated but both genetic and environmental factors are believed to be involved in abnormal brain development. In recent years, immunological and mitochondrial dysfunctions acquired particular interest in the study of the molecular mechanisms underlying the pathophysiology of ASD. For this reason, our study focused on evaluating the mitochondrial component and activation of the NLRP3 inflammasome, a critical player of the innate immune system. The assembly of NLRP3 with ASC mediates activation of Caspase-1, which in turn, by proteolytic cleavage, activates Gasdermin D and the proinflammatory cytokines IL-1β/IL-18 with their subsequent secretion. Using primary fibroblasts of autistic and control patients we studied basal and stimulated conditions. Specifically, LPS and ATP were used to activate the NLRP3 inflammasome and MCC950 for its inhibition. In addition, FCCP was used as a mitochondrial stressor and MitoTEMPO as a scavenger of mitochondrial ROS. Our results showed a hyperactivation of NLRP3 inflammasome in ASDs, as evidenced by the co-localization of the two main components, NLRP3 and ASC, by the higher levels of ASC specks, oligomers and dimers and by the increased amounts of active Caspase-1 and IL-1β. In addition, increased mitochondrial superoxide anion and reduced mitochondrial membrane potential were detected in ASD cells. These data are in accordance with the abnormal mitochondrial morphology evidenced by transmission electron microscopy analysis. Interestingly, NLRP3 inflammasome inhibition with MCC950 improved mitochondrial parameters, while the use of MitoTEMPO, in addition to decrease mitochondrial ROS production, was able to prevent NLRP3 inflammasome activation suggesting for the first time an abnormal bidirectional crosstalk between mitochondria and NLRP3 inflammasome in ASD."
https://pubmed.ncbi.nlm.nih.gov/39433111/
Causal Metabolomic and Lipidomic Analysis of Circulating Plasma Metabolites in Autism: A Comprehensive Mendelian Randomization Study with Independent Cohort Validation
https://www.mdpi.com/2218-1989/14/10/557
Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches
https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2017.00034/full
Sing me a song of a lad that is gone,
Say, could that lad be I?
Merry of soul he sailed on a day
Over the sea to Skye.
Mull was astern, Rum on the port,
Eigg on the starboard bow;
Glory of youth glowed in his soul;
Where is that glory now?
Give me again all that was there,
Give me the sun that shone!
Give me the eyes, give me the soul,
Give me the lad that's gone!
3Billow and breeze, islands and seas,
Mountains of rain and sun,
All that was good, all that was fair,
All that was me is gone.
Posted by: Visitor IH | October 27, 2024 at 02:50 PM
Where truth may only be a consideration. If you have it it, that may not matter. Being is mostly learning to live accepting you can cannot say you have it.
Kansas - Dust in the Wind (Official Video) Dust has no motives.
https://www.youtube.com/watch?v=tH2w6Oxx0kQ
Posted by: Visitor IH | October 18, 2024 at 10:42 AM
Circulating MicroRNAs and Cytokines Associated with Celiac Disease
"Results: A significant dysregulation of these molecular players in patients with CD compared with healthy controls has been evidenced by results from this study. For instance, miR-155 was up-regulated, whereas miR-15b was significantly down-regulated in CD, illustrating their roles in immune responses and inflammation-mediated processes. Besides, there was an over-expression of IL-2 and an under-expression of IL-37 in patients with CD, indicating these biomolecules' role in immuno-dysregulation and inflammatory process underlying CD. In addition, a positive correlation between IL-2 and miRNA 155 expression levels was observed in patients with CD, suggesting that they could be involved together with other cytokines, showing the interplay between immune response pathways and inflammatory cascades during CD pathogenesis.
Conclusion: These molecular signature discoveries might result in new and revolutionary diagnostic modalities and molecular-targeted therapies for CD pathogenesis. When used with the scientific understanding of miRNAs and cytokines associated with CD pathophysiology, it creates a basis for personalized medicine based on the individualized molecular profile of all patients. This will undoubtedly increase the efficacy of CD treatment strategies. In brief, more research on molecular pathways' workings should be done to harness their potential in CD diagnosis and treatment."
https://pubmed.ncbi.nlm.nih.gov/39386332/
"Genetic Signature of a Healthy Lifestyle: New Horizons for Preventing Noncommunicable Chronic Diseases by Modulating MicroRNA-155
Abstract
The development and progression of several noncommunicable diseases (NCDs) are associated with microRNA (miR) 155 (miR-155) activation, which promotes inflammation and oxidative stress. In particular, miR-155 regulates nuclear transcription factor-kappa B (NF-κB) by silencing gene expression of proteins involved in NF-κB suppression, such as suppressor of cytokine signaling 1 (SOCS1) and SH-2 containing inositol 5' polyphosphate 1 (SHIP1), increases the production of reactive oxygen species, and suppresses gene expression of antioxidant enzymes through nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition. In this context, a healthy lifestyle based on a diet rich in nutrients and bioactive compounds as well as regular physical activity may modulate the activity of several miRs. Following this concept, studies involving nutrients, bioactive compounds, and physical activity have been developed to modulate miR-155 activation. This narrative review aims to discuss how a healthy lifestyle based on a diet rich in nutrients, bioactive compounds, and physical activity may modulate the miR-155 pathway and consequently prevent the development and progression of NCDs. Nutrients and bioactive compounds from food may act by inhibiting pathways that promote miR-155 activation such as NF-κB and promote activation of pathways that are associated with the downregulation of miR-155, such as Nrf2, and SOCS1 pathways. Regular physical activity also seems to influence miR-155 levels through an improvement in the immune system during muscle recovery. There is relevant evidence that shows a positive effect of nutrients, bioactive compounds, and physical activity with the modulation of miR-155, which can potentially provide benefits in the clinical setting in cases of NCDs."
https://pubmed.ncbi.nlm.nih.gov/39383044/
Neurodivergence Linked to Chronic Fatigue in Children
Neurodivergence is a term used by the self righteous. We are all this.
https://neurosciencenews.com/neurodivergence-chronic-fatigue-27498/
Study: Chronic Fatigue Twice as Likely Among Children with ADHD
https://www.additudemag.com/link-between-adhd-chronic-fatigue/
“The real question is: Can you get the sensitivity and specificity to the point where it’s useful clinically?” says Dan Arking, associate professor of genetic medicine at Johns Hopkins University in Baltimore, Maryland, who was not involved in the research.
The panel also contains many genes, making it too expensive for a diagnostic test, says Valerie Hu, professor of biochemistry and molecular biology at George Washington University in Washington, D.C., who was not involved in the study.
https://www.thetransmitter.org/spectrum/gene-levels-in-blood-forecast-autism-risk-in-toddlers/
Gene levels in blood forecast autism risk in toddlers
"Beyond its predictive potential, the profile implicates protein synthesis, immune response and inflammation in autism. It is “pulling out common, shared pathways that are disrupted,” Courchesne says."
https://www.thetransmitter.org/spectrum/gene-levels-in-blood-forecast-autism-risk-in-toddlers/
Posted by: visitor IH | October 14, 2024 at 05:21 PM
Everything I Do. The anthem of Jesus Christ. He did it all for the Father and us.
Bryan Adams - Everything I Do (Live At Wembley 1996)
https://www.youtube.com/watch?v=La0IJPt0t4Q
Posted by: visitor IH | September 23, 2024 at 05:25 PM
President Reagan's Interview with Tom Brokaw on January 17, 1989
https://www.youtube.com/watch?v=Py2U80qxvHw
Posted by: visitor IH | September 12, 2024 at 11:05 AM
“It is not good for the man to be alone"
Posted by: visitor IH | September 10, 2024 at 01:21 PM
The only area of strong disagreement I have with President Trump is in the burning of the American flag. I love what our country stands for and I can never see myself burning the flag, but is crucial you relent in this position. My father fought on Iwo Jima and was at the base of Mt. Suribachi
when the marines raised the flag. Please do not criminalize the right of America's citizens to protest their government. Protesting our government is what you represent. I strongly oppose criminalizing flag burning and I hope you will change your mind, for your sake and ours as Americans. I love what the American flag=means to me. Please choose liberty.
Home Free - God Bless the U.S.A. (featuring Lee Greenwood and The United States Air Force Band)
https://www.youtube.com/watch?v=SrMftm6Km3g
Thank you Prsident Trump.
Posted by: visitor IH | September 10, 2024 at 12:01 PM
Migraines are common in autistic adults, particularly women.
There many kinds of headaches, and migraine headaches are much more common among autistic adults (42%) than the general population (10%). As with the general population, females are three times more likely than males to experience migraines, so autistic females are especially prone to these types of headaches.
https://adult-autism.health.harvard.edu/resources/migraine-headaches/
Expression of miR-155 in monocytes of people with migraine: association with phenotype, disease severity and inflammatory profile
Results: miR-155 gene expression was higher in CM-MO group (2.68 ± 2.47 Relative Quantification - RQ) when compared to EM group (1.46 ± 0.85 RQ, p = 0.006) and HCs (0.44 ± 0.18 RQ, p = 0.001). In addition, miR-155 gene expression was higher in EM group when compared to HCs (p = 0.001). A multivariate analysis confirmed the difference between EM and CM-MO groups after correction for age, sex, smoking habit, preventive treatment, aura, presence of psychiatric or other pain conditions. We found higher gene expression of IL-1β, TNF-α, and lower gene expression of IL-10 in migraine participants when compared to HCs (p = 0.001 for all comparisons). TNF-α and IL-10 genes alterations were more prominent in CM-MO when compared to EM participants (p = 0.001). miR-155 positively correlated with IL-1β (p = 0.001) and TNF-α (p = 0.001) expression levels. Finally, in people with CM-MO, we described an up-regulated percentage of events in both M1 and M2 monocytic profiles.
Conclusions: Our study shows for the first time a specific profile of activation of miR-155 gene expression levels in monocytes of selected migraine subpopulations, more pronounced in subjects with CM-MO. Interestingly, mir-155 expression correlated with markers of activation of the inflammatory and immune systems. The CM-MO subpopulation showed a peculiar increase of both pro-inflammatory and anti-inflammatory monocytes which worths further investigation.
https://pubmed.ncbi.nlm.nih.gov/39187749/
My belief that the experts are slow has gone.
Posted by: visitor IH | September 09, 2024 at 03:24 PM
Don't Give up on Us
https://www.youtube.com/watch?v=RdTIFIvTf5M
I do love children and souls.
Posted by: visitor IH | September 08, 2024 at 05:31 PM
President Trump,
Sir, I have always respected you and read between the lines. In moments of seeming criticism I have seen you in the service of freedom and liberty. I salute your sacrifice and willingness to to endure death for your the courage of your beliefs. May God Bless you my President. As in Shogun when dear confidents would die in a cause to the greatest good I have sublimated my inner devotion to liberty to deflect assaults upon our Country, the beloved USA for which my father pledged his life, and your efforts to protect the citizens of this country and the cause of liberty. They just happen to intersect at the mental wellness of the children of our beloved country and Justice. God Bless You RFK, jr. God bless you Cheryl Hines. The holiness of what you have done will always shine.
I extol you as I did your forbearers.
https://www.hollywoodreporter.com/wp-content/uploads/2024/01/121623-CH47686_v1-Splash-2024.jpg?w=2000&h=1126&crop=1
Posted by: visitor IH | September 08, 2024 at 04:52 PM
"Nick; you probably like the female voice better, but for me
it is this: is better:"
So far from my understanding me and my and intended communication. I will cease to respond in providing perspective.
Posted by: visitor IH | September 06, 2024 at 03:12 PM
possibly 2011 or 12.
Those were pretty bad years.
Posted by: Benedetta | September 01, 2024 at 08:01 PM
Nick;
Every since I first heard it, it runs through my mind at least once a month if no more!
Strange that you should ask when I first heard it.
I was driving my husband to his once every three months pain clinic appointment cause he was on so much dope that he could no longer drive safety. Something he was always really good at, and liked to do. He had bought himself a brand new truck after all. We seem to always get involved in trends. I guess we are just trendy. So, the trend was to support the Sackler family, and Purdue pharmacy. After all it is not all that addictive, so they said. Dope makes a person crazy and he was getting kind of crazy. Then again maybe I was his crazy enabler and had lost all control. It is better now, but I am telling you Nick I did not need that in my life. I really resented this insult on top of insults.
Posted by: Benedetta | September 01, 2024 at 07:50 PM
Benedetta,
How many times have you heard Celo sing this and when did you first hear it?
Posted by: Visitor IH | September 01, 2024 at 05:54 PM
My taste might be better than yours. But, we can each appreciate what we are informed by.
Posted by: Visitor IH | September 01, 2024 at 05:41 PM
Lisa, I agree with you that autism is the most vicious, heinous, devious, horrible, devastating, life altering condition that can happen to any child. Our son was diagnosed at age 4 and it was like getting hit with a speeding train. I could not believe that my beautiful son was afflicted with this disastrous disorder and now that he is an adult I still can not accept his condition. I pray every day for research, research, research from pharmaceuticals and medical institutions to finally find the one or many possible miracle immune dysfunction or neurological drugs that will cure my son and the thousands of others suffering from this terrible diagnosis. Keep praying every day and never lose hope.
Posted by: Gayle | September 01, 2024 at 12:24 PM
Nick; you probably like the female voice better, but for me
it is this: is better:
https://www.youtube.com/watch?v=-N4jf6rtyuw
Posted by: Benedetta | September 01, 2024 at 11:16 AM
Gnarls Barkley - Crazy (Cover) by Daniela Andrade
https://www.youtube.com/watch?v=fzxag7U3Snk
Posted by: Visitor IH | August 30, 2024 at 03:17 PM
Knowing nearly enough or maybe not. Damn it all!
Posted by: Visitor IH | August 09, 2024 at 11:30 AM
12 Not that I have already obtained all this, or have already arrived at my goal, but I press on to take hold of that for which Christ Jesus took hold of me.
I Still Haven’t Found What I’m Looking For (U2 Cover) Peter Hollens feat. Home Free
"I have held the hand of a a devil. it was warm in the night, I was cold as a stone."
But' I still haven't found what I'm looking for.
https://www.youtube.com/watch?v=L6CE5IMX_7M
Posted by: Visitor IH | August 06, 2024 at 12:41 PM
Emma,
I am protective as my Lord instructed me. I hope you understand. My beloved, my lamb, is my charge.
Blessings to you in Christ.
Posted by: Visitor IH | August 06, 2024 at 11:16 AM
31 MILLION Excess Deaths: What caused them?
Good summary of CHD paper on this topic:
https://www.youtube.com/watch?v=rBkKBqpLjAk
Shocking Increase in U.S Child Mortality: What's Killing the Kids?
https://www.youtube.com/watch?v=NgzRz96rpbU
Posted by: Emmaphiladelphia | August 05, 2024 at 10:17 PM
I apologize for responding. You asked for Kim and I should have refrained.
Posted by: Visitor IH | August 05, 2024 at 01:42 PM
Emma asked:
"Kim, is there a way to access the original comments on this article from 2012?"
I am not Kim, but the only comments related to this thread are found by clicking the "newer" link at the bottom of each page until you get to the first page of comments. The first page is this;
https://www.ageofautism.com/2012/01/the-inflammation-highway-aka-autism/comments/page/9/#comments
Clicking "older" ate the bottom of that page and every page will bring you back to the most recent comment page linked below:
https://www.ageofautism.com/2012/01/the-inflammation-highway-aka-autism.html
If you knew this and are asking for something else please know I am not trying to condescend, but to be helpful.
Posted by: Visitor IH | August 04, 2024 at 03:43 PM
"Because any time pharma causes inflammation they don't want you to find out about, they just make up a word for it. Autism. Asthma. ADD. Just made up words for inflammation."
Kim, is there a way to access the original comments on this article from 2012?
Posted by: Emmaphiladelphia | August 03, 2024 at 12:12 AM
Patty Smyth - Sometimes Love Just Aint Enough (Cover) by Daniela Andrade
https://www.youtube.com/watch?v=1yZDAqgELCY
Posted by: Visitor IH | August 02, 2024 at 03:31 PM
So young to be a muse of mine , but is. A song my beloved would now sing to me if she could get there in song, so I do it for her. She does say it in ways only I understand and that is the same as the song.
Emily Linge - Treasure in My Heart
https://www.youtube.com/watch?v=5lDFwcOdNoY
Posted by: Visitor IH | July 06, 2024 at 10:37 PM
Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature
https://www.mdpi.com/2075-4426/14/6/641
Goodnight, Sweetheart by Sarah Vaughan
https://www.youtube.com/watch?v=go4DLBaQzM8
Posted by: Visitor IH | June 28, 2024 at 05:38 PM
Prevention of migraine with olmesartan in patients with hypertension/prehypertension
https://pubmed.ncbi.nlm.nih.gov/16618270/#:~:text=Patients%20were%20treated%20with%2010,the%20frequency%20of%20migraine%20attacks.
Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats
https://pubmed.ncbi.nlm.nih.gov/36398458/#:~:text=Thus%2C%20olmesartan%20treatment%20may%20slow,neurological%20disorders%20associated%20with%20MetS.
I have long ago commented on this Nucleus and systemic effect/immunity/inflammation.
A body–brain circuit that regulates body inflammatory responses
https://www.nature.com/articles/s41586-024-07469-y?error=cookies_not_supported&code=d45b9031-b3a8-4146-9e14-1596ecccfd6d
A body–brain circuit that regulates body inflammatory responses
PETULA CLARK REMEMBERS KAREN CARPENTER.
https://www.youtube.com/watch?v=EV-KPl9Y0JY
Petula Clark - While You See a Chance
https://www.youtube.com/watch?v=AEBe68d4HWM
Posted by: Visitor IH | June 27, 2024 at 03:52 PM
Existing high blood pressure drugs may prevent epilepsy, study finds
https://medicalxpress.com/news/2024-06-high-blood-pressure-drugs-epilepsy.html
Celiac Disease and Geographic Tongue
https://www.beyondceliac.org/celiac-disease/related-conditions/geographic-tongue/
One song a day.
Santana - Into The Night (Video) ft. Chad Kroeger
https://www.youtube.com/watch?v=fQ9nQNx0KEs
Posted by: Visitor IH | June 20, 2024 at 05:20 PM
Benedetta,
I am required to enter email to read the Mercola piece. I resist this demand and don't like this approach. I have read or watched the majority of Dr. Moulden's productions. A lot of truth, but for subsets and particulars in my view. I regard the work, and have alluded to strokes in my posts. But the total picture is much larger for most.
In the last post I mentioned https://www.youtube.com/watch?v=T8QmkDzD8Sk and this led to M. Jacksons https://www.youtube.com/watch?v=h_D3VFfhvs4.
Then I said: and this because of the relationship, but only of his talent. This related to M. Jacksons later creation. This the talent I meant to refer to in the following.
Charles Berthoud - Smooth Criminal (Official Music Video)
https://www.youtube.com/watch?v=ZUzy5EmXixg
Posted by: Visitor IH | June 17, 2024 at 05:58 PM
Nick;
Dr. Mercola had an article today written by the Midwestern Doctor. That is the name he writes under.
He said there were three ways that vaccine harms.
The third way he dwelled on the most and he called it zeta.
He says that vaccines with stuff like aluminum, or the spike proteins have a positive charge.
Positive charges causes clumping of the blood cells, starting with the capillaries right on up to the bigger veins and stuff.
Kawasaki is just that Thank you for the information on that.
He goes into all the little microstrokes that can be had, that effects not just the body, but every organ.
It was a good article. Let me link here for you.
https://articles.mercola.com/sites/articles/archive/2024/06/14/what-makes-vaccines-so-dangerous.aspx
Posted by: Benedetta | June 15, 2024 at 09:16 PM
I had negle4cted to post the other four genes related too Multiple Chemical Sensitivity from the last post. They are:
11 CYP3A5 Cytochrome P450 Family 3 Subfamily A Member 5 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
12 SOD2 Superoxide Dismutase 2 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
13 SLC6A4 Solute Carrier Family 6 Member 4 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
14 VIP Vasoactive Intestinal Peptide Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
Look at the Gene Card Entries of each of these genes.
The energy of the meaning of impulses of life flow can be grasped in a synchronous flow. I had found intuitive meaning between Astaire and Jacksons depictions in Smooth Criminal, but only recently had seen the phrase." "There was something about this kid that made you want to protect her - from life." 5:10-15 in the video.
https://www.youtube.com/watch?v=T8QmkDzD8Sk
and this because of the relationship, but only of his talent.
Posted by: Visitor IH | June 15, 2024 at 05:21 PM
I read this report when first released, but I have lost enthusiasm for trying to be relevant in the discussion. It is pleasing to see Cohen take such a direction in focus. My wife had/has astigmatism. A year after I started her on a regimen of biomedical intervention she went back to the eye doctor, who for the first time, commented with some surprise that her astigmatism had notably improved. That had not happened before. While vertigo is listed, and my wife deals with it, it did not become more of a problem until she was at a point I felt she had "recovered". At least recovered to the extent I believed possible. Celiac, in the report , is discounted as not of meaning after know family heritage of the condition, though I find that a prominent indicator or related element to other whet intolerance, in a subset. I have found gene ties with
Ehler-Danlos Syndrome with my wife. I have documented in this thread many of the conditions listed in the report as related to autism though one my wife has that is reported as involved for many is Reynaud's. My wife also had migraine, constipation, psoriasis, tinnitus, PMS, gastric reflux, a degree of urinary incontinence{mainly gone since intervention, chronic fatigue, some blurred vison with migraine. Another aspect for my wife was multiple chemical sensitivity. This is maybe still the most suspect condition in the medical community. It is real. I have also long ago posted that my wife's system was effected including all organs at some level.
Increased rates of chronic physical health conditions across all organ systems in autistic adolescents and adults
Several conditions remained significant after accounting for our demographic variables, alcohol use, smoking, BMI, and family history of the condition. These include: irritable bowel syndrome (IBS), gastric reflux, GI tract hernias, gallbladder disease, gallstones, chronic diarrhoea, chronic constipation, haemorrhoids, GI polyps, polycystic ovarian syndrome (females only), premenstrual tension (females only), endometriosis (females only), carpal tunnel syndrome, slipped discs, hypermobility (females only), Ehler-Danlos Syndrome (EDS) (females only), migraine, epilepsy (females only), syncope, vertigo, chronic fatigue syndrome, astigmatism, blurred vision, amblyopia, tinnitus, mouth ulcers, temporomandibular joint syndrome, urinary incontinence, iron deficiency anaemia, eczema, psoriasis, and acne. Autistic people had significantly higher risk of coeliac’s disease when adjusting for demographics, alcohol use, smoking, and BMI, but this finding became non-significant after accounting for family history.
https://molecularautism.biomedcentral.com/articles/10.1186/s13229-023-00565-2
I find the aspect of chemical and toxic contributions important, but they are not they are a part and not the whole cause or result.
Still I appreciate this report and it includes Reynaud's. I also links mast cells, allergies, xenobiotics, and possible drug intolerance to the mix
Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children
https://www.mdpi.com/2039-4713/14/1/22
Other related reading.
Multiple chemical sensitivity identified in some migraine patients
https://medicalxpress.com/news/2022-08-multiple-chemical-sensitivity-migraine-patients.html
Multiple Chemical Sensitivity
1 PON1 Paraoxonase 1 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
2 CYP2D6 Cytochrome P450 Family 2 Subfamily D Member 6 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
3 PON2 Paraoxonase 2 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
4 NAT2 N-Acetyltransferase 2 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
5 GSTM1 Glutathione S-Transferase Mu 1 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
6 CYP2C19 Cytochrome P450 Family 2 Subfamily C Member 19 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
7 GSTP1 Glutathione S-Transferase Pi 1 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
8 CCKBR Cholecystokinin B Receptor Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
9 CYP2C9 Cytochrome P450 Family 2 Subfamily C Member 9 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
10 MTHFR Methylenetetrahydrofolate Reductase Protein Coding
https://www.malacards.org/card/multiple_chemical_sensitivity#Genes_Related_wrapper
This anecdote is appropriate here I think:
From a board posting of a mother about her daughter.
"My daughter's results showed homozygous mutations in:
VDR Bsm
MTRR A66G
SOD2 A16V
Which I'm guessing means to supplement with Vitamins B12 and D??? I don't really know what else to do. What kind of doctor could help look at this stuff or is it all up to us.... (as usual).....
"And the heterozygous mutations were in:
COMT v158M
COMTH62H
MAO A R297R
MTHFR C677T
MTR A2756G
BHMT-04
BHMT-08
CYP1A2 164A>C
Cyp2C9*3 A1075C
CYP2D6 S486T
CYP2D6 2850C>T
GSTP1 I105V
NAT2 I114T
NAT2 K268R
Any opinions greatly appreciated...."
https://latitudes.org/forums/topic/20587-23-and-me-and-my-ds-mind-exploding-messily/
Allergic to the world: can medicine help people with severe intolerance to chemicals?
https://www.theguardian.com/lifeandstyle/2022/sep/20/allergic-to-the-world-multiple-chemical-sensitivity-mcs-can-medicine-help
Study: Higher chemical concentrations found in baby teeth of children with autism
https://news.uthscsa.edu/study-higher-chemical-concentrations-found-in-baby-teeth-of-children-with-autism/
Posted by: Visitor IH | June 14, 2024 at 11:19 AM
The simple leads to love, the complex leads to worship. God is love.
Lenny is going to be fine Benedetta. I appreciate your concern.
You may appreciate this report.
Serum NLRP3: A potential marker for identifying high-risk coronary arterial aneurysm in children with Kawasaki disease
https://pubmed.ncbi.nlm.nih.gov/38857561/
Call Me - Shinedown
https://www.youtube.com/watch?v=oNZjxRALKu0
Posted by: Visitor IH | June 12, 2024 at 11:48 AM
Is your brother doing okay?
Posted by: Benedetta | June 09, 2024 at 07:29 PM
My brother Lenny,
Politics is a lower tier. My brother knows love. It ain't over till it's over.
The spirit end has led me
.
https://www.youtube.com/watch?v=aKgAOhXwJhg
Posted by: Visitor IH | June 08, 2024 at 03:22 PM
"When the Rain Washes You Clean You'll Know"
Alison Krauss - When You Say Nothing At All
https://www.youtube.com/watch?v=1SCOimBo5tg
Posted by: Visitor IH | April 09, 2024 at 02:45 PM
God Moves In Mysterious Ways.
There are four things that are too mysterious for me to understand:
an eagle flying in the sky,
a snake moving on a rock,
a ship finding its way over the sea,
and a man and a woman falling in love.
we have come a ways, but the last one still puzzles me a bit.
Home Free - When A Man Loves A Woman
https://www.youtube.com/watch?v=-pygPmfGQvU
May the Lord Guide You Austin, I wish it were not so...all the best to all of Home Free.
Posted by: Visitor IH | April 03, 2024 at 05:48 PM
Thank you Nick.
That was a wonderful tribute to Easter, with the panoramic view of Russia I suppose. Easter sunrise and Till we meet again song.
Posted by: Benedetta | March 31, 2024 at 08:43 AM
For all the believers in need due to autism and for our fellow believers in Russia. Love to those who do not seek peace in Russia, God loves you.
Simon Khorolskiy – God Be with You
https://www.youtube.com/watch?v=ZGWOKT7Hfvs
Posted by: visitor IH | March 30, 2024 at 06:45 PM
We rest on Thee
1
We rest on Thee, our Shield and our Defender;
We go not forth alone against the foe;
Strong in Thy strength, safe in Thy keeping tender.
We rest on Thee, and in Thy Name we go.
2
Yea, in Thy Name, O Captain of salvation!
In Thy dear Name, all other names above;
Jesus our Righteousness, our sure Foundation,
Our Prince of glory and our King of love.
3
We go in faith, our own great weakness feeling,
And needing more each day Thy grace to know:
Yet from our hearts a song of triumph pealing;
We rest on Thee, and in Thy Name we go.
4
We rest on Thee, our Shield and our Defender:
Thine is the battle, Thine shall be the praise
When reigning in the Kingdom of Thy splendor;
Victors, we rest with Thee, through endless days.
God be with you Benedetta.
Posted by: Visitor IH | March 30, 2024 at 05:26 PM
Visitor Nick;
LadyHawke holds special memories. Thank you for sharing. .
Posted by: Benedetta | March 30, 2024 at 03:51 AM
Names of God - Give Me Jesus
https://www.youtube.com/watch?v=qedj7hANnmI
Posted by: Visitor IH | March 29, 2024 at 04:07 PM
Ladyhawke • I'll Stand By You • The Pretenders
https://www.youtube.com/watch?v=T8-SKY2bdtY
Posted by: Visitor IH | March 18, 2024 at 08:09 PM
Lady Gaga - Hold My Hand
https://www.youtube.com/watch?v=O2CIAKVTOrc
Posted by: Visitor IH | March 15, 2024 at 03:00 PM
From something with Frank to somewhere with Eva.
Eva Cassidy - Over The Rainbow
https://www.youtube.com/watch?v=2rd8VktT8xY
Posted by: Visitor IH | March 15, 2024 at 11:51 AM
All I am and have learned is laid at the feet of the Lord Jesus blessing his holy name for his love to me and his unspeakable grace and mercy. Praise the Lord God, Glory to God in the Highest!!!
In my life I say this with Love toward all. Autism may be challenge, but being without Jesus Christ is horrid. Thou shall Love the Lord thy God.. come unto Me the Lord says.
Bach - St Matthew Passion BWV 244 - Van Veldhoven | Netherlands Bach Society
https://www.youtube.com/watch?v=ZwVW1ttVhuQ
Posted by: Visitor IH | October 16, 2023 at 06:04 PM
Keep and never doubt your faith again. Congratulations. I rejoice with you .
Posted by: Benedetta | September 11, 2023 at 03:07 PM
I have returned fully to my faith and Lord. Anyone who has read my posts please forgive any sinful and loveless remarks I have uttered. The goodness of God have saved and preserved my spirit through all of this. I ask forgiveness for ay I have hurt or offended. May the gracious Love and Goodness of the Lord be with you. God is awesome and Amazing. I have only Jesus to thank.
Jesus is Lord.
For thine is the kingdom, The power, and the glory, For ever and ever. Amen.
Posted by: Visitor | September 11, 2023 at 10:35 AM
Please post my final song.
The sacrifice will make it all worthwhile. Praise the Lord Jesus, my savior, the light in the darkness.
Sarah McLachlan - Wintersong
https://www.youtube.com/watch?v=tuTWA6SBupY
Posted by: Visitor IH | June 27, 2023 at 09:23 AM
It is hard. I am sorry Nick.
Life is just so brief, even a long one the stretches into the 90s.
Posted by: Benedetta | June 24, 2023 at 11:01 PM
She's Gone
https://www.youtube.com/watch?v=JUkbC2ZrlHs
Its been 27 years, but the reality catches up to me from time in time.
The experience has given me understanding beyond imagination. I was not prepared.
Posted by: Visitor IH | June 24, 2023 at 06:06 PM
My precious wife was born in Canada and Gordon Lightfoot and Joni Mitchell are also Canadian. I learned a lot about the nation through my wife. She has been a dual citizen of the USA and Canada. I visited her in Canada while dating though she has no memory of it. I still honor Canadians because of this, I so loved the work of Gordon before I met her, but he helped form me. God speed Gordon. OH Canada. His passing has meaning to me.
Gordon Lightfoot - Saying Goodbye
https://www.youtube.com/watch?v=RsA7NlY1gtA
Posted by: Visitor IH | June 11, 2023 at 05:11 PM
Somewhere In Time (Main Theme)
https://www.youtube.com/watch?v=nzmprUUqryM
https://www.youtube.com/watch?v=MBDm9qWUFLQ
Posted by: Visitor IH | May 25, 2023 at 01:39 PM
"In sickness and in health"
Clint Black - When I Said I Do
https://www.youtube.com/watch?v=ZgalAdgEd-E
Posted by: Visitor IH | May 06, 2023 at 03:31 PM
Yeah, I saw that lightfoot died the other day at 80.
I always loved that song, great song!
Posted by: Benedetta | May 04, 2023 at 09:35 PM
Gordon Lightfoot - Wreck Of The Edmund Fitzgerald
https://www.youtube.com/watch?v=FuzTkGyxkYI
Posted by: Visitor | May 04, 2023 at 05:35 PM
Michael Pangilinan - How Am I Supposed To Live Without You
https://www.youtube.com/watch?v=eNanwOD94Uw
Posted by: Visitor IH | May 03, 2023 at 01:02 PM
The angels among us shining.
Collin Raye - She's With Me
https://www.youtube.com/watch?v=oj6GXVTAOiU
Posted by: Visitor IH | May 01, 2023 at 09:41 AM
Taylor Dayne - Love Will Lead You Back
https://www.youtube.com/watch?v=MO6xhLtfwW0
Posted by: Visitor IH | April 29, 2023 at 01:36 PM
Hi Benedetta,
I am fighting being taken over by the world. The song in discussion is beautiful to me, though I find earlier decades of songs more creative and beautiful to a great degree. The song we are discussing was released in: November 1971.
Here is another that just sweeps me into bliss.
Ambrosia - Biggest Part of Me
https://www.youtube.com/watch?v=bOm0Dq_kKNU
Posted by: Visitor IH | April 26, 2023 at 11:45 AM
Visitor what a beautiful song with such pretty lyrics! Thank you. I feel like poems, words put together so perfect today.
Interesting about urinary tract infections after DPT vaccines. Those are suppose to be rare in babies, but I noticed that they are not. I had one when I was very small and ended up in the hospital with it.
It began on a really wonderful day. Mother took my sister, I and my father to her university to watch her graduate with her four year degree. She was the first in our entire family.
We wore our pink laced, matching dresses. We got to play in a special play ground with swings and slides. I watched the whole class march down the side walk into the beautiful, Roman column building.
We sat really high up on bleachers as we watched and that was when I began to hurt.
Mother always wondered why? So now we have our answer.
If you live long enough, answers will come.
Posted by: Benedetta | April 25, 2023 at 11:18 AM
Al Green - Let's Stay Together
https://www.youtube.com/watch?v=XXx6RDzR6eM
Posted by: Visitor IH | April 24, 2023 at 08:29 PM
“‘“The Lord bless you
and keep you;
25 the Lord make his face shine on you
and be gracious to you;
26 the Lord turn his face toward you
and give you peace.”’
God is good. Love to all.
Posted by: Visitor IH | April 12, 2023 at 02:27 PM
An infant does not have to die from SIDS to have systemic developmental issues arise from an environmental insult while having a genetic predisposition to damage from said insult. The scenarios in these to reports describe effects that many who survive with Autism appear to have.
Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants
Abstract
"Chronic hypoxia, viral infections/bacterial toxins, inflammation states, biochemical disorders, and genetic abnormalities are the most likely trigger of sudden infant death syndrome (SIDS). Autopsy studies have shown increased pulmonary density of macrophages and markedly more eosinophils in the lungs accompanied by increased T and B lymphocytes. The elevated levels of immunoglobulins, about 20% more muscle in the pulmonary arteries, increased airway smooth muscle cells, and increased fetal hemoglobin and erythropoietin are evidence of chronic hypoxia before death. Other abnormal findings included mucosal immune stimulation of the tracheal wall, duodenal mucosa, and palatine tonsils, and circulating interferon. Low normal or higher blood levels of cortisol often with petechiae on intrathoracic organs, depleted maternal IgG antibodies to endotoxin core (EndoCAb) and early IgM EndoCAb triggered, partial deletions of the C4 gene, and frequent IL-10-592*A polymorphism in SIDS victims as well as possible hypoxia-induced decreased production of antiinflammatory, antiimmune, and antifibrotic cytokine IL-10, may be responsible for the excessive reactions to otherwise harmless infections. In SIDS infants, during chronic hypoxia and times of infection/inflammation, several proinflammatory cytokines are released in large quantities, sometimes also representing a potential source of tissue damage if their production is not sufficiently well controlled, eg, by pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP). These proinflammatory cytokines down-regulate gene expression of major cytochrome P-450 and/or other enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity, thus affecting metabolism of several endogenous lipophilic substances, such as steroids, lipid-soluble vitamins, prostaglandins, leukotrienes, thromboxanes, and exogenous substances. In SIDS victims, chronic hypoxia, TNF-alpha and other inflammatory cytokines, and arachidonic acid (AA) as well as n-3 polyunsaturated fatty acids (FA), stimulated and/or augmented superoxide generation by polymorphonuclear leukocytes, which contributed to tissue damage. Chronic hypoxia, increased amounts of nonheme iron in the liver and adrenals of these infants, enhanced activity of CYP2C9 regarded as the functional source of reactive oxygen species (ROS) in some endothelial cells, and nicotine accumulation in tissues also intensified production of ROS. These increased quantities of proinflammatory cytokines, ROS, AA, and nitric oxide (NO) also resulted in suppression of many CYP450 and other enzymes, eg, phosphoenolpyruvate carboxykinase (PEPCK), an enzyme important in the metabolism of FA during gluconeogenesis and glyceroneogenesis. PEPCK deficit found in SIDS infants (caused also by vitamin A deficiency) and eventually enhanced by PACAP lipolysis of adipocyte triglycerides resulted in an increased FA level in blood because of their impaired reesterification to triacylglycerol in adipocytes. In turn, the overproduction and release of FA into the blood of SIDS victims could lead to the metabolic syndrome and an early phase of type 2 diabetes. This is probably the reason for the secondary overexpression of the hepatic CYP2C8/9 content and activity reported in SIDS infants, which intensified AA metabolism. Pulmonary edema and petechial hemorrhages often present in SIDS victims may be the result of the vascular leak syndrome caused by IL-2 and IFN-alpha. Chronic hypoxia with the release of proinflammatory mediators IL-1alpha, IL-1beta and IL-6, and overloading of the cardiovascular and respiratory systems due to the narrowing airways and small pulmonary arteries of these children could also contribute to the development of these abnormalities. Moreover, chronic hypoxia of SIDS infants induced also production of hypoxia-inducible factor 1alpha (HIF-1alpha), which stimulated synthesis and release of different growth factors by vascular endothelial cells and intensified subclinical inflammatory reactions in the central nervous system, perhaps potentiated also by PACAP and VIP gene mutations. These processes could lead to the development of brainstem gliosis and disorders in the release of neuromediators important for physiologic sleep regulation. All these changes as well as eventual PACAP abnormalities could result in disturbed homeostatic control of the cardiovascular and respiratory responses of SIDS victims, which, combined with the nicotine effects and metabolic trauma, finally lead to death in these often genetically predisposed children."
https://pubmed.ncbi.nlm.nih.gov/15543094/
Urinary tract diseases revealed after DTP vaccination in infants and young children: cytokine irregularities and down-regulation of cytochrome P-450 enzymes induced by the vaccine may uncover latent diseases in genetically predisposed subjects
Abstract
"Prophylactic vaccinations may sometimes shorten the incubation period of some illnesses and/or convert a latent infection/inflammation into a clinically apparent disease. Cytokines play a major role in mediating the inflammatory process in various clinical entities and represent a potential source of tissue damage if their production is not sufficiently well controlled. It seems that irregularities in production of proinflammatory cytokines may be responsible for the abnormalities associated with full-blown clinical symptoms of various urinary tract diseases observed after DTP vaccination in 13 infants and young children hospitalized over the past 24 years. On admission, upper respiratory tract diseases, atopic dermatitis, and/or latent urinary tract infection/inflammation were found in these children. It is suggested that the whole-cell pertussis present in DTP vaccine, acting as an excessive stimulus in these patients, produced symptoms reminiscent of biologic responses to circulating proinflammatory monokines such as IL-1beta, TNF-alpha, and IL-6 because earlier it was reported that in vitro the whole-cell vaccine induced significantly more such cytokine production than did the acellular pertussis or diphtheria-tetanus-only vaccine. Analysis of the cellular immune disturbances previously reported in urinary tract infection/inflammation (increased serum and/or urinary IL-1alpha, IL-1 receptor antagonist, IL-6 and IL-8), steroid-sensitive nephrotic syndrome (increased IL-2, IFN-gamma, TNF-alpha, and decreased or increased IL-4, depending on the cells studied), and atopic dermatitis (decreased IFN-gamma and increased IL-4 production), may suggest that similar subclinical chronic cytokine-mediated abnormalities produced in the course of latent diseases revealed in our patients, combined with those caused by DTP vaccination stimulus, were responsible for the pathomechanism of these clinical entities. This speculation is in agreement with the reports on the long-lasting induction of cytokine release and down-regulation of hepatic cytochrome P-450 isoenzyme activities after administration of DTP vaccine to mice and may be supported by the fact that TH1 phenotype is associated with the up-regulation of intercellular adhesion molecule-1 and RANTES, whereas TH2 phenotype is associated with the up-regulation of the vascular cell adhesion molecule and P-selectin, which are key players in the migration into inflamed tissues and localization of lymphocytes and other allergic effector and inflammatory cells. Because several inflammatory cytokines down-regulate gene expression of major cytochrome P-450 and/or other enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity, thus affecting the metabolism of several endogenous lipophilic substances such as steroids, lipid-soluble vitamins, prostaglandins, leukotrienes, thromboxanes, and exogenous substances, their irregularities in the body may eventually lead to the flare of latent diseases in some predisposed subjects. Also, interleukin genetic polymorphisms, especially the constellation of TNF-alpha and IL-6 genetic variants, might predispose some infants with infection to a more than usually intense inflammatory response in the kidneys after vaccination. It seems that the aforementioned pathomechanism may also be responsible for some cases of sudden infant death syndrome, which is often preceded by infection/inflammation."
https://pubmed.ncbi.nlm.nih.gov/15356430/
Posted by: Visitor IH | April 06, 2023 at 09:23 AM
Benedetta,
We share things that manifest themselves in the unassuming mind. That has left us searching and trusting, while hoping. Trios IV and I appreciate you and wish you and I well. I do hope you are finding good in life as you do what is blessed and I feel you have done your best. I too find you thoughtful and a kindred spirit.
SINCE I have done my best, I do
Not fear the outcome; here I stand
Prepared for judgment when men view
The labor of my heart and hand.
If good, then happy I shall be,
If not, contented I'll abide,
And though the prize is not for me,
My joy shall be in having tried.
Since I have done my best, there is
No cause for me to sit and sigh,
Although the laurel wreath I miss,
My eyes shall smiling be and dry;
No vain excuses shall I make
For failing, and no vain regret,
But bravely judgment I shall take,
And say: 'A better man I've met.'
Since I have done my best, I'll go
Whenever God shall summon me,
Contented, for right well I know
However poor my record be
That, having nothing to regret,
No shame that I would seek to hide,
The Master's praises I shall get
For honest effort when I tried.
Edgar Albert Guest
Beneath Still Waters"
From 1979's 'Blue Kentucky Girl
https://youtu.be/TQ4jehpLCT0
Posted by: Visitor IH | March 19, 2023 at 03:35 PM
What a gorgeous piece of music! I’ve always loved the bass viol, it adds so much depth to music.
Posted by: Kate C | March 19, 2023 at 02:40 PM
Visitor:
I meant to respond to your thoughts on hypothalamus repair.
Mostly a thank you for your thoughtfulness .
2007 was a very, very busy time in my life , so I did not even know that Delp was dead! Great song though.
I swear I loved the new music coming out even up into 2007, but right now; nothing that is new on the radio seems appealing
Posted by: Benedetta | March 17, 2023 at 07:24 PM
I want to know are we...Boston - More Than A Feeling. The lead singer killed himself. Did he know something? I have always absolutely adored this song. What the hell are we?
Boston - More Than A Feeling
https://www.youtube.com/watch?v=zOILAZHf2pE
Posted by: Visitor IH | March 17, 2023 at 04:22 PM
Hi Kate C,
I'm glad you're glad.
Bach - Violin Concerto in E major BWV 1042 - Sato | Netherlands Bach Society
https://www.youtube.com/watch?v=QyZIU--9q88
Posted by: Visitor IH | March 16, 2023 at 04:45 PM
So glad to see you back posting articles. I will read this several times, but the findings on first reading are so interesting. Inflammation, inflammation, inflammation! Kate C
Posted by: Kate C | March 04, 2023 at 12:17 PM
Wrong address for second report in last post. Correct one is:
Understanding Brain Diseases: From Receptor Dysregulation to Neurodegeneration, Neuroinflammation and Memory Impairment
https://www.ingentaconnect.com/content/ben/cn/2023/00000021/00000002/art00003?crawler=true&mimetype=application/pdf
Posted by: Visitor IH | March 03, 2023 at 10:02 AM
Excellent report.
Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex
Significance
We present a comprehensive assessment of neuronal cell-type-specific gene expression and alternative splicing changes in ASD cortex, directly comparing RNA-seq results from bulk tissue with isolated neurons. We observe strong signatures of cell stress and neural-immune/inflammatory pathway activation present within ASD neurons—a signal that is typically attributed to astrocyte/microglial populations. Our findings also provide further evidence for the hypothesized imbalance of excitatory to inhibitory neuronal activity in the brains of individuals with ASD. Moreover, we find that the transcriptomic architecture of ASD interacts substantially with age, thus revealing windows of opportunity for treatments that target specific molecular pathology.
Abstract
Autism spectrum disorder (ASD) is a highly heterogeneous disorder, yet transcriptomic profiling of bulk brain tissue has identified substantial convergence among dysregulated genes and pathways in ASD. However, this approach lacks cell-specific resolution. We performed comprehensive transcriptomic analyses on bulk tissue and laser-capture microdissected (LCM) neurons from 59 postmortem human brains (27 ASD and 32 controls) in the superior temporal gyrus (STG) of individuals ranging from 2 to 73 years of age. In bulk tissue, synaptic signaling, heat shock protein-related pathways, and RNA splicing were significantly altered in ASD. There was age-dependent dysregulation of genes involved in gamma aminobutyric acid (GABA) (GAD1 and GAD2) and glutamate (SLC38A1) signaling pathways. In LCM neurons, AP-1-mediated neuroinflammation and insulin/IGF-1 signaling pathways were upregulated in ASD, while mitochondrial function, ribosome, and spliceosome components were downregulated. GABA synthesizing enzymes GAD1 and GAD2 were both downregulated in ASD neurons. Mechanistic modeling suggested a direct link between inflammation and ASD in neurons, and prioritized inflammation-associated genes for future study. Alterations in small nucleolar RNAs (snoRNAs) associated with splicing events suggested interplay between snoRNA dysregulation and splicing disruption in neurons of individuals with ASD. Our findings supported the fundamental hypothesis of altered neuronal communication in ASD, demonstrated that inflammation was elevated at least in part in ASD neurons, and may reveal windows of opportunity for biotherapeutics to target the trajectory of gene expression and clinical manifestation of ASD throughout the human lifespan....
Given mounting evidence suggesting potential mechanistic overlap between neurodevelopmental and neurodegenerative disorders, particularly with respect to genes involved in synapse and brain connectivity (24), we evaluated the overlap between our ASD findings with published results in Alzheimer’s disease (AD). Using results from Mount Sinai/JJ Peters VA Medical Center Brain Bank (MSBB) cohort (25), we demonstrated that the changes we detected in ASD were significantly overlapped with transcriptomic alterations observed in AD from the same brain region (Odds Ratio = 1.6, P = 1.9 × 10−8, SI Appendix, Fig. S8).
https://www.pnas.org/doi/10.1073/pnas.2206758120
This is also good.
Understanding Brain Diseases: From Receptor Dysregulation to Neurodegeneration, Neuroinflammation and Memory Impairment
file:///C:/Users/Nick/Downloads/002AC.pdf
Posted by: Visitor IH | March 03, 2023 at 09:51 AM
Last May I posted some the article "Recurrent UTIs linked to gut microbiome, chronic inflammation" and linked it. Here is a part of the article for the current purpose about butyrate and another article I am referencing about chronic fatigue. I have seen the linkage through my own study and wife's condition, but now it is being asserted by credentialed researchers. I had said my wife had chronic fatigue, leaky gut, and chronic urinary tract infections back in 96. These were a part of the picture.
Here is the piece I previously linked...
Recurrent UTIs linked to gut microbiome, chronic inflammation
"The real difference was in the makeup of their gut microbiomes. Patients with repeat infections showed decreased diversity of healthy gut microbial species, which could provide more opportunities for disease-causing species to gain a foothold and multiply. Notably, the microbiomes of women with recurrent UTIs were particularly scarce in bacteria that produce butyrate, a short-chain fatty acid with anti-inflammatory effects."
https://medicine.wustl.edu/news/recurrent-utis-linked-to-gut-microbiome-chronic-inflammation/
Now the one from the researcher I mentioned speaking about chronic fatigue and butyrate.
More Clues into ME/CFS Discovered in Gut Microbiome
"Of particular note, Williams team found that people with ME/CFS had abnormally low levels of several bacterial species, including Faecalibacterium prausnitzii (F. prausnitzii) and Eubacterium rectale. Both bacteria ferment non-digestible dietary fiber in the GI tract to produce a nutrient called butyrate. Intriguingly, Oh’s team also uncovered changes in several butyrate-producing microbial species, including F. prausnitzii.
Further detailed analyses in the Williams lab confirmed that the observed reduction in these bacteria was associated with reduced butyrate production in people with ME/CFS. That’s of special interest because butyrate serves as a primary energy source for cells that line the gut. Butyrate provides those cells with up to 70 percent of the energy they need, while supporting gut immunity.
Butyrate and other metabolites detected in the blood are important for regulating immune, metabolic, and endocrine functions throughout the body. That includes the amino acid tryptophan. The Oh team also found all ME/CFS participants had a reduction in gut microbes associated with breaking down tryptophan.
While butyrate-producing bacteria were found in smaller numbers, other microbes with links to autoimmune and inflammatory bowel diseases were increased. Williams’ group also reported an abundance of F. prausnitzii was inversely associated with fatigue severity in ME/CFS, further suggesting a possible link between changes in these gut bacteria and disease symptoms."
https://directorsblog.nih.gov/2023/02/14/more-clues-into-me-cfs-discovered-in-gut-microbiome/
One more for good measure.
9 Health Benefits Of Butyrate For Your Body And Gut
5. Plug a leaky gut
Your gut lining needs butyrate to stay healthy and function properly. It’s as simple as that.
The gut lining is an intestinal barrier. It selectively allows things like vitamins and minerals to leave the gut, enter the bloodstream, and travel to where they’re needed. Equally, it stops toxins, pathogens, and food compounds from entering the bloodstream and making you ill.
The process is called intestinal permeability by doctors and scientists. When the barrier is healthy, small holes called tight junctions relax, allowing water and nutrients to pass through.
Innocuous habits, like frequent snacking, stop these tight junctions from closing between meals, so bacteria and unwanted substances things can enter your bloodstream. This is leaky gut.photo_2019-05-13-15.17.17What is leaky gut and what’s my lifestyle got to do with it?
The butyrate produced by your gut microbes from the dietary fiber provides the fuel needed by the cells in your gut lining. By doing so, it preserves the integrity of your gut lining, preventing leaky gut from occurring.
https://atlasbiomed.com/blog/9-reasons-why-your-gut-needs-butyrate/
Posted by: Visitor IH | February 18, 2023 at 08:23 PM
I watched the half time show of the Supper Bowl last night and remembered 30 years ago when real talent was on stage, so sad.
Michael Jackson - Super Bowl XXVII 1993 Halftime Show
https://www.youtube.com/watch?v=EsopN7JKUVs
Posted by: Visitor | February 13, 2023 at 03:50 PM
As the shadow differs from the image the mind differs from the interpretation.
I think the following diagnosis and treatment came about in 2017 from the cited studies. it looks to some part to contain some fundamentals of the treatment I provided for my wife, but as I effected this treatment at 30 it was exponentially more difficult to understand and treat. It is such a blessing as she was caught so early in life. Nice to see professionals apply true treatment for some variations of this monstrous condition.
23-Month-Old Female with Regressive Autism
https://www.drkarafitzgerald.com/2017/08/30/23-month-old-female-with-regressive-autism/
I may have breeched my agreement as though two songs were linked, it was the same song. Have mercy please Kim. Bless you my sister. It will not happen again. Someone else is posting as "Visitor" at AoA as well. I have only posted twice since Christmas eve.
Intermezzo from Cavalleria Rusticana, Pietro Mascagni
https://www.youtube.com/watch?v=BIQ2D6AIys8
Posted by: Visitor | February 03, 2023 at 09:29 AM
Benedetta,
I have formulated some replies as to hypothalamic repair. I will say the wholistic approach in our case effected repair. I have found Doctors and researchers who give plausible pathology of repair, but I grow weary of speculation as an answer. I think of you regularly and will not respond to your query without a better grasp of the mechanism of repair. Though, a big step was taken when it was understood that certain neurons can be replaced or regenerated, which I felt had to be the case before it was accepted.
With the below I accentuate, feeling...or the lack thereof.
https://www.researchgate.net/figure/Non-conceptual-phenomenal-projection-The-sense-of-self-emerges-in-the-sphere-of-feeling_fig6_330320026#:~:text=The%20sense%20of%20self%20emerges%20in%20the%20sphere%20of%20feeling,Merleau%2DPonty%2C%201945).
Adele - Make You Feel My Love
https://www.youtube.com/watch?v=QVeubNxaBsg
... and the version I most appreciate.
Make You Feel My Love - Bob Dylan - Cover by Emily Linge
https://www.youtube.com/watch?v=qJu-_offsGI
Posted by: Visitor | February 01, 2023 at 10:27 AM
"Therefore let all the house of Israel know assuredly, that God hath made that same Jesus, whom ye have crucified, both Lord and Christ." Have mercy Lord.
God Bless us everyone. Merry Christmas
Posted by: Visitor | December 24, 2022 at 10:45 PM
NAD+ supplements
That would be found in dairy, milk and fish and such.
That leads me back to diet. and it all keeps changing.
And fasting is coming into play. We have fasted before, as far back as the mid 90s.
He is convinced by the studies that there should be
No processed foods for sure, and no vegetable oils. they now know for a fact that it causes INFLAMATION,!
I am reading the "Obesity Code" written by some kidney doctor and he has tons of studies and making heads and tails out of them too. He said diabetes lead to kidney problems and insulin too much was leading to diabetes 2
That too much INSULIN and too much cortisone hormones cause inflammation too. Those two hormones.
He talks about the hypothalamus and how lesions can cause obesity. On and on.
That calories , and calories out do not explain obesity. I am surprised.
Vinegar to my surprise stops insulin spikes. Two teaspoons in a drink right before or while eating carbohydrates.
I might have made a mistake of giving up whole milk, but not low fat and skim milk. Whole milk, a steak and especially whey may still cause insulin spikes but they also causes the stomach to produce hormones that cause satiety. That is a nice word.
There are all kinds of great nuggets in the book.
Can hypothalamus if injured be repaired?
Posted by: Benedetta | December 23, 2022 at 11:08 PM
(I Just) Died In Your Arms - Cutting Crew - Cover by Emily Linge
https://www.youtube.com/watch?v=lag6l-7S2GE
TRPM8 and body temperature effect neuron migration.
Posted by: Visitor | December 22, 2022 at 09:10 PM
Genomics and AI Spot Genetic Marker for Autism
"The Oak Ridge National Laboratory researchers discovered a significant site in the ACMSD (Aminocarboxymuconate Semialdehyde Decarboxylase) gene that is part of the kynurenine pathway and plays a role in the breakdown of tryptophan. According to the researchers, the ACMSD gene “lies at the nexus of numerous ASD-associated traits including neuroinflammation, sleep disorder, mitochondrial dysfunction, gastrointestinal abnormalities, and altered circadian rhythms.”
https://www.psychologytoday.com/us/blog/the-future-brain/202212/genomics-and-ai-spot-genetic-marker-autism
Not just in non verbal. Many conditions associated with ACMSD.
Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic
understanding of autism spectrum disorder
We then identify an SV in the GRIK2 gene that alters RNA splicing and a regulatory region of the ACMSD gene in the kynurenine pathway as significantly associated with a non-verbal ASD phenotype, supporting our hypothesis that these currently excluded loci can provide a clearer mechanistic understanding of ASD. Finally, we use an explainable artificial intelligence approach to define subgroups demonstrating their use in the context of precision medicine.
https://reader.elsevier.com/reader/sd/pii/S2666247722000677?token=103E941B5E7D00B27468DC43BA274FF39AE8CE3D0F5E6042A601F142CD12F56DB89F2C87F7ADD70DE643AA1742C822C9&originRegion=us-east-1&originCreation=20221210161548
The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People with ME/CFS are typically unable to carry out their routine activities. Key hallmarks of the disease are neurological and gastrointestinal impairments accompanied by pervasive malaise that is exacerbated after physical and/or mental activity. Currently, there is no validated cure of biomarker signature for this illness. Impaired tryptophan (TRYP) metabolism is thought to play significant role in the pathobiology of ME/CFS. TRYP is an important precursor for serotonin and the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD+). TRYP has been associated with the development of some parts of the brain responsible for behavioural functions. The main catabolic route for TRYP is the kynurenine pathway (KP). The KP produces NAD+ and several neuroactive metabolites with neuroprotective (i.e., kynurenic acid (KYNA)) and neurotoxic (i.e., quinolinic acid (QUIN)) activities. Hyperactivation of the KP, whether compensatory or a driving mechanism of degeneration can limit the availability of NAD+ and exacerbate the symptoms of ME/CFS. This review discusses the potential association of altered KP metabolism in ME/CFS. The review also evaluates the role of the patient’s gut microbiota on TRYP availability and KP activation. We propose that strategies aimed at raising the levels of NAD+ (e.g., using nicotinamide mononucleotide and nicotinamide riboside) may be a promising intervention to overcome symptoms of fatigue and to improve the quality of life in patients with ME/CFS. Future clinical trials should further assess the potential benefits of NAD+ supplements for reducing some of the clinical features of ME/CFS.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116917/
Posted by: Visitor | December 10, 2022 at 11:20 AM
The glory of love and the gift of ignorance meet.
Sometimes When We Touch. This is my reality.
https://www.youtube.com/watch?v=NhzzDaUizas
Love making an effort.
Posted by: Visitor | December 04, 2022 at 05:25 PM
ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21
https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00943-w
I give up.
Posted by: Visitor | December 01, 2022 at 03:08 PM
I am deeply indebted to all the scientists who have taught me and helped me in my understanding. Equally, if not more so, are the musicians who interpreted spirit into being. God bless you all. The spirit end has led me.
Posted by: Visitor | December 01, 2022 at 02:54 PM
Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD
"We find widespread transcriptomic changes across the cortex in ASD, exhibiting an anterior-to-posterior gradient, with the greatest differences in primary visual cortex, coincident with an attenuation of the typical transcriptomic differences between cortical regions."
"Notably, ETV4, which is known to have an important role in dendrite development, connectivity and plasticity and its expression—which is normally higher posteriorly (BA17) than anteriorly (BA4/6)—is significantly attenuated, diminishing this gradient in ASD16."
https://www.nature.com/articles/s41586-022-05377-7#Fig2
HIF dependent and independent transcriptional regulation of the human
PHD2 promoter
https://www.zora.uzh.ch/id/eprint/56116/1/Wollenick.pdf
Filmmaking and Cinematography Techniques: Blade Runner 2049
https://www.youtube.com/watch?v=lF5lmYgoYEM
Gata3 mir-155
Posted by: Visitor | November 09, 2022 at 05:30 PM
John Stone,
I have not been able to get up off the floor. If I can I will fight again. Blessings upon you.
Visitor
Posted by: Visitor | November 03, 2022 at 02:05 PM
The Lord God is my only hope.
Susan Ashton - Stand
https://www.youtube.com/watch?v=ElsOrzpD3mI
Posted by: Visitor | October 15, 2022 at 05:29 PM