Can't belive this happened.. OMG!!!!

The Hans Zimmer Interview

https://www.youtube.com/watch?v=TbeevzNmU1g

Not a messgage for most, but a few may have encountered a similar social dilmna. This is for especially
a selct few within my family. I have tried my best to speak truth. There is nothing more dificult.

Beyond Justice To Mercy

https://www.youtube.com/watch?v=c1NzHlo1-1U

Nick you are a good researcher, get on here and see what you can find out about Devarjaye Daniels, and the toxin that caused his brain cancer. See if there is any information out there on what it was, or what they think it was, or if the virus was found in his cancer?

The last submission was crap. I have tried, but it has overwhlmed me. I wished to be more than I am.

EVERY TIME YOU GO AWAY . PAUL YOUNG

https://www.youtube.com/watch?v=hUKBuAkr4Lg

From: Being Libertarian

Jd Vance- "Europe doesn’t have free speech anymore."

Europe- "You can’t say that here."

“Freedom” by Alice Cooper

https://youtu.be/mL1kQQbhmY8

I do not know what control is.

Till I Gain Control Again Alison Krauss

https://www.youtube.com/watch?v=PPexiProLhs

Scientists discover mitochondria's role in shaping memory circuits

Scientists discover mitochondria's role in shaping memory circuits
by Virginia Tech

Research led by Shannon Farris, an assistant professor at the Fralin Biomedical Research Institute at VTC, found a mitochondrial mechanism that helps explain how CA2 neurons, like those highlighted here, function in mice. The research has implications in better understanding memory and social recognition. Credit: Shannon Farris/Virginia Tech
Virginia Tech neuroscientists have uncovered a mitochondrial process that supports the brain cells critical for learning, memory, and social recognition.

Led by Shannon Farris, assistant professor at the Fralin Biomedical Research Institute at VTC, the research in mouse models examines the hippocampal CA2 region, a specialized area in the brain's memory center essential for social recognition memory.

Published this week in Scientific Reports, the study reveals the critical role of the mitochondrial calcium uniporter (MCU), a protein that regulates calcium flow into mitochondria, in enabling neurons to strengthen connections. This process, known as synaptic plasticity, is fundamental to cognitive function and adaptive learning.

"Our findings highlight a distinct mitochondrial mechanism that helps explain how CA2 neurons function, which may contribute to its role in social cognition and its vulnerability in certain neurological disorders," Farris said.

A unique role for the CA2 region in social memory
The hippocampal CA2 region is a small but critical hub for social recognition—the ability to remember and distinguish individuals. Unlike neighboring hippocampal regions, CA2 neurons resist certain forms of synaptic plasticity, raising intriguing questions about their specialized function.

Farris and her team discovered that mitochondria in CA2 neurons are not uniform. Instead, their structure and function vary depending on their location within the neuron. Mitochondria in the farthest reaches of the dendrites of neurons—at the outermost synaptic input connections—are highly specialized and depend heavily on MCU to control their activity.

To explore this, the researchers deleted the MCU gene in CA2 neurons of genetically engineered mice. This caused a disruption in plasticity at the outermost synapses, while those closer to the cell body were unaffected.

"This suggests that mitochondrial diversity isn't just a biological quirk," said Farris. "It's a fundamental feature that allows different parts of the same neuron to function in distinct ways."

Potential implications for Alzheimer's, autism spectrum disorder
Mitochondrial dysfunction is increasingly recognized as a major contributor to neurological disorders such as Alzheimer's disease, autism, schizophrenia, and depression.

Synapses need a lot of energy to stay connected and process information. When mitochondria don't work properly, it can disrupt the functional capacity of these cell-cell communications channels, leading to problems with thinking and memory.

It is known that the most distal outermost synapses are among the first synaptic connections affected in Alzheimer's disease. The findings suggest that MCU's function in CA2 neurons may contribute to this initial weakness, offering potential insight into why this circuit is particularly susceptible to neurodegeneration.

Shannon Farris, assistant professor at the Fralin Biomedical Research Institute at VTC, led a team that recently published research in Scientific Reports examining a specialized area in the brain's memory center essential for social recognition memory. Credit: Clayton Metz/Virginia Tech
"Understanding why mitochondria in CA2 neurons are different—and how they fail—could help us design therapies to protect or restore function in specific brain regions," Farris said.

Beyond Alzheimer's, the study raises broader questions about how mitochondrial diversity might influence other neurological disorders. The ability of neurons to fine-tune mitochondrial properties could be a critical factor in understanding autism, where CA2 dysfunction could be linked to the known social deficits that occur in this spectrum.

Decoding mitochondrial function in neural circuits
This study advances understanding of mitochondrial biology and overcomes a technical hurdle in assessing mitochondria in dense and diverse brain tissues, the researchers said.

Using electron microscopy and artificial intelligence to unbiasedly identify only the dendritic mitochondria within the densely packed synaptic layer, Farris's team mapped mitochondrial structure in CA2 neuron dendrites at high spatial resolution with extreme precision over millimeter expanses of tissue. The analysis revealed that MCU-deficient mitochondria were smaller and more fragmented, a structural shift that may underlie their impaired ability to support synaptic function.

More broadly, the study challenges the long-held assumption that mitochondria work the same way throughout all parts of the neuron. Instead, neurons may actively modify mitochondrial properties to optimize function at specific synapses, a concept that could reshape our understanding of neural energy regulation and plasticity.

https://medicalxpress.com/news/2025-02-scientists-mitochondria-role-memory-circuits.html

Guide Me to Thee

https://www.youtube.com/watch?v=cggJaQXts00

Condensed underestanding is lack of understanding, in other words. In other words..

Alan O'Day - Undercover Angel

https://www.youtube.com/watch?v=01PSf4Bokic

“I don't know if mama was right, that we each have a destiny, or if if was Lt Dan, that we are all just floating around, accidental, like on a breeze, but I think... I think... maybe... it's both happening at the same time.”

Thanks Emma,

The Three Degrees - When Will I See You Again (Official Audio)

https://www.youtube.com/watch?v=5OpuZzsPBhQ

I have done everthing to bring her back. Broken is apt.

Megan Woods - The Truth (Official Music Video)

https://www.youtube.com/watch?v=85I6HI2E4AA

Bless you my brothers and sisters. Those who tarry.

My father who served our country and our Lord died February 6, 2013. I went to see him in the hospital on February 3 just after midnight and slipped in the hospital parking lot on black ice and broke my ankle and tore all the tendons around the ankle and was in the emergency room of that same hospital. I had a very brief meeting with him on that morning that I don't much recall, but did not get to speak to him hardly at all and did not remember what did take place as any of it as I was on Dilaudid.

He thought things about my wife and family that were not so and I wanted to explain things to him, but I ran out of time. There are too many tragedies for one life in my world. I was in hospital in Louisville, KY awakening from surgery on my ankle when they told me my dear father had died.

Mike + The Mechanics - The Living Years

https://www.youtube.com/watch?v=5hr64MxYpgk

I wonder what God is doing with me.

Thank you Visitor; that is a very touching allegory especially for the Chirstmas season.

AI is better than average, but my last posting does not me it is prescient. Don't get cocky.

“But I know the rage that drives you. That impossible anger strangling the grief, until the memory of your loved ones is just poison in your veins. And one day you catch yourself wishing the person you loved had never existed, so you'd be spared your pain.”

― Christopher Nolan

"They only see what they want to see."

Thank you for all your kindness Benedetta. You have been a source of blessing to me.

Mast cells are involved in a large number and shows the histamine relation. The inflammation, histamine allergy, involvement has been a part of my understanding from the beginning of my study. Also wound healing and fibrin. This dysfunction covers so much it is too complex to explain to anyone not vested to learn very large amounts.

Mast Cells in Autism Spectrum Disorder—The Enigma to Be Solved?

https://pmc.ncbi.nlm.nih.gov/articles/PMC10932299/

The song was from "Outlander" It is so pretty.
I never thought about the words so much, but they match what goes on with autism.

I would say that there is inflammation of their brains, and additional strep infections or even covid can cause inflammation levels to go higher, for those already with a tendency toward inflammation after the vaccines messed up their immune cells.

Dr. John Campbell did several podcast on mast cell activation syndrome after several of his guest mentioned that they had been diagnosed with that after a covid vaccine. Kyle Warner the mountain bike racer was one of them. He then interviewed a doctor Tina -- Peers I think was her name.

Histamines indicate high inflammation, don't they?

Where truth may only be a consideration. If you have it it, that may not matter. Being is mostly learning to live accepting you can cannot say you have it.

Kansas - Dust in the Wind (Official Video) Dust has no motives.

https://www.youtube.com/watch?v=tH2w6Oxx0kQ

Everything I Do. The anthem of Jesus Christ. He did it all for the Father and us.

Bryan Adams - Everything I Do (Live At Wembley 1996)

https://www.youtube.com/watch?v=La0IJPt0t4Q

“It is not good for the man to be alone"

Migraines are common in autistic adults, particularly women.

There many kinds of headaches, and migraine headaches are much more common among autistic adults (42%) than the general population (10%). As with the general population, females are three times more likely than males to experience migraines, so autistic females are especially prone to these types of headaches.

https://adult-autism.health.harvard.edu/resources/migraine-headaches/

Expression of miR-155 in monocytes of people with migraine: association with phenotype, disease severity and inflammatory profile

Results: miR-155 gene expression was higher in CM-MO group (2.68 ± 2.47 Relative Quantification - RQ) when compared to EM group (1.46 ± 0.85 RQ, p = 0.006) and HCs (0.44 ± 0.18 RQ, p = 0.001). In addition, miR-155 gene expression was higher in EM group when compared to HCs (p = 0.001). A multivariate analysis confirmed the difference between EM and CM-MO groups after correction for age, sex, smoking habit, preventive treatment, aura, presence of psychiatric or other pain conditions. We found higher gene expression of IL-1β, TNF-α, and lower gene expression of IL-10 in migraine participants when compared to HCs (p = 0.001 for all comparisons). TNF-α and IL-10 genes alterations were more prominent in CM-MO when compared to EM participants (p = 0.001). miR-155 positively correlated with IL-1β (p = 0.001) and TNF-α (p = 0.001) expression levels. Finally, in people with CM-MO, we described an up-regulated percentage of events in both M1 and M2 monocytic profiles.

Conclusions: Our study shows for the first time a specific profile of activation of miR-155 gene expression levels in monocytes of selected migraine subpopulations, more pronounced in subjects with CM-MO. Interestingly, mir-155 expression correlated with markers of activation of the inflammatory and immune systems. The CM-MO subpopulation showed a peculiar increase of both pro-inflammatory and anti-inflammatory monocytes which worths further investigation.

https://pubmed.ncbi.nlm.nih.gov/39187749/

My belief that the experts are slow has gone.

President Trump,
Sir, I have always respected you and read between the lines. In moments of seeming criticism I have seen you in the service of freedom and liberty. I salute your sacrifice and willingness to to endure death for your the courage of your beliefs. May God Bless you my President. As in Shogun when dear confidents would die in a cause to the greatest good I have sublimated my inner devotion to liberty to deflect assaults upon our Country, the beloved USA for which my father pledged his life, and your efforts to protect the citizens of this country and the cause of liberty. They just happen to intersect at the mental wellness of the children of our beloved country and Justice. God Bless You RFK, jr. God bless you Cheryl Hines. The holiness of what you have done will always shine.

I extol you as I did your forbearers.

https://www.hollywoodreporter.com/wp-content/uploads/2024/01/121623-CH47686_v1-Splash-2024.jpg?w=2000&h=1126&crop=1

possibly 2011 or 12.
Those were pretty bad years.

Benedetta,

How many times have you heard Celo sing this and when did you first hear it?

Lisa, I agree with you that autism is the most vicious, heinous, devious, horrible, devastating, life altering condition that can happen to any child. Our son was diagnosed at age 4 and it was like getting hit with a speeding train. I could not believe that my beautiful son was afflicted with this disastrous disorder and now that he is an adult I still can not accept his condition. I pray every day for research, research, research from pharmaceuticals and medical institutions to finally find the one or many possible miracle immune dysfunction or neurological drugs that will cure my son and the thousands of others suffering from this terrible diagnosis. Keep praying every day and never lose hope.

Gnarls Barkley - Crazy (Cover) by Daniela Andrade

https://www.youtube.com/watch?v=fzxag7U3Snk

12 Not that I have already obtained all this, or have already arrived at my goal, but I press on to take hold of that for which Christ Jesus took hold of me.

I Still Haven’t Found What I’m Looking For (U2 Cover) Peter Hollens feat. Home Free

"I have held the hand of a a devil. it was warm in the night, I was cold as a stone."
But' I still haven't found what I'm looking for.

https://www.youtube.com/watch?v=L6CE5IMX_7M

31 MILLION Excess Deaths: What caused them?

Good summary of CHD paper on this topic:
https://www.youtube.com/watch?v=rBkKBqpLjAk

Shocking Increase in U.S Child Mortality: What's Killing the Kids?
https://www.youtube.com/watch?v=NgzRz96rpbU

Emma asked:

"Kim, is there a way to access the original comments on this article from 2012?"

I am not Kim, but the only comments related to this thread are found by clicking the "newer" link at the bottom of each page until you get to the first page of comments. The first page is this;

https://www.ageofautism.com/2012/01/the-inflammation-highway-aka-autism/comments/page/9/#comments

Clicking "older" ate the bottom of that page and every page will bring you back to the most recent comment page linked below:

https://www.ageofautism.com/2012/01/the-inflammation-highway-aka-autism.html

If you knew this and are asking for something else please know I am not trying to condescend, but to be helpful.

Patty Smyth - Sometimes Love Just Aint Enough (Cover) by Daniela Andrade

https://www.youtube.com/watch?v=1yZDAqgELCY

Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature

https://www.mdpi.com/2075-4426/14/6/641

Goodnight, Sweetheart by Sarah Vaughan

https://www.youtube.com/watch?v=go4DLBaQzM8

Existing high blood pressure drugs may prevent epilepsy, study finds

https://medicalxpress.com/news/2024-06-high-blood-pressure-drugs-epilepsy.html

Celiac Disease and Geographic Tongue

https://www.beyondceliac.org/celiac-disease/related-conditions/geographic-tongue/

One song a day.

Santana - Into The Night (Video) ft. Chad Kroeger

https://www.youtube.com/watch?v=fQ9nQNx0KEs

Nick;
Dr. Mercola had an article today written by the Midwestern Doctor. That is the name he writes under.

He said there were three ways that vaccine harms.
The third way he dwelled on the most and he called it zeta.

He says that vaccines with stuff like aluminum, or the spike proteins have a positive charge.
Positive charges causes clumping of the blood cells, starting with the capillaries right on up to the bigger veins and stuff.

Kawasaki is just that Thank you for the information on that.

He goes into all the little microstrokes that can be had, that effects not just the body, but every organ.

It was a good article. Let me link here for you.

https://articles.mercola.com/sites/articles/archive/2024/06/14/what-makes-vaccines-so-dangerous.aspx

I read this report when first released, but I have lost enthusiasm for trying to be relevant in the discussion. It is pleasing to see Cohen take such a direction in focus. My wife had/has astigmatism. A year after I started her on a regimen of biomedical intervention she went back to the eye doctor, who for the first time, commented with some surprise that her astigmatism had notably improved. That had not happened before. While vertigo is listed, and my wife deals with it, it did not become more of a problem until she was at a point I felt she had "recovered". At least recovered to the extent I believed possible. Celiac, in the report , is discounted as not of meaning after know family heritage of the condition, though I find that a prominent indicator or related element to other whet intolerance, in a subset. I have found gene ties with
Ehler-Danlos Syndrome with my wife. I have documented in this thread many of the conditions listed in the report as related to autism though one my wife has that is reported as involved for many is Reynaud's. My wife also had migraine, constipation, psoriasis, tinnitus, PMS, gastric reflux, a degree of urinary incontinence{mainly gone since intervention, chronic fatigue, some blurred vison with migraine. Another aspect for my wife was multiple chemical sensitivity. This is maybe still the most suspect condition in the medical community. It is real. I have also long ago posted that my wife's system was effected including all organs at some level.

Increased rates of chronic physical health conditions across all organ systems in autistic adolescents and adults

Several conditions remained significant after accounting for our demographic variables, alcohol use, smoking, BMI, and family history of the condition. These include: irritable bowel syndrome (IBS), gastric reflux, GI tract hernias, gallbladder disease, gallstones, chronic diarrhoea, chronic constipation, haemorrhoids, GI polyps, polycystic ovarian syndrome (females only), premenstrual tension (females only), endometriosis (females only), carpal tunnel syndrome, slipped discs, hypermobility (females only), Ehler-Danlos Syndrome (EDS) (females only), migraine, epilepsy (females only), syncope, vertigo, chronic fatigue syndrome, astigmatism, blurred vision, amblyopia, tinnitus, mouth ulcers, temporomandibular joint syndrome, urinary incontinence, iron deficiency anaemia, eczema, psoriasis, and acne. Autistic people had significantly higher risk of coeliac’s disease when adjusting for demographics, alcohol use, smoking, and BMI, but this finding became non-significant after accounting for family history.

https://molecularautism.biomedcentral.com/articles/10.1186/s13229-023-00565-2

I find the aspect of chemical and toxic contributions important, but they are not they are a part and not the whole cause or result.

Still I appreciate this report and it includes Reynaud's. I also links mast cells, allergies, xenobiotics, and possible drug intolerance to the mix

Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children

https://www.mdpi.com/2039-4713/14/1/22

Other related reading.

Multiple chemical sensitivity identified in some migraine patients

https://medicalxpress.com/news/2022-08-multiple-chemical-sensitivity-migraine-patients.html

Multiple Chemical Sensitivity

1 PON1 Paraoxonase 1 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
2 CYP2D6 Cytochrome P450 Family 2 Subfamily D Member 6 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
3 PON2 Paraoxonase 2 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
4 NAT2 N-Acetyltransferase 2 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
5 GSTM1 Glutathione S-Transferase Mu 1 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
6 CYP2C19 Cytochrome P450 Family 2 Subfamily C Member 19 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
7 GSTP1 Glutathione S-Transferase Pi 1 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
8 CCKBR Cholecystokinin B Receptor Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
9 CYP2C9 Cytochrome P450 Family 2 Subfamily C Member 9 Protein Coding
DISEASES inferred14
GeneCards Inferred via: (sections)
10 MTHFR Methylenetetrahydrofolate Reductase Protein Coding

https://www.malacards.org/card/multiple_chemical_sensitivity#Genes_Related_wrapper

This anecdote is appropriate here I think:
From a board posting of a mother about her daughter.

"My daughter's results showed homozygous mutations in:

VDR Bsm

MTRR A66G

SOD2 A16V

Which I'm guessing means to supplement with Vitamins B12 and D??? I don't really know what else to do. What kind of doctor could help look at this stuff or is it all up to us.... (as usual).....

"And the heterozygous mutations were in:

COMT v158M

COMTH62H

MAO A R297R

MTHFR C677T

MTR A2756G

BHMT-04

BHMT-08

CYP1A2 164A>C

Cyp2C9*3 A1075C

CYP2D6 S486T

CYP2D6 2850C>T

GSTP1 I105V

NAT2 I114T

NAT2 K268R

Any opinions greatly appreciated...."

https://latitudes.org/forums/topic/20587-23-and-me-and-my-ds-mind-exploding-messily/

Allergic to the world: can medicine help people with severe intolerance to chemicals?

https://www.theguardian.com/lifeandstyle/2022/sep/20/allergic-to-the-world-multiple-chemical-sensitivity-mcs-can-medicine-help

Study: Higher chemical concentrations found in baby teeth of children with autism

https://news.uthscsa.edu/study-higher-chemical-concentrations-found-in-baby-teeth-of-children-with-autism/

Is your brother doing okay?

"When the Rain Washes You Clean You'll Know"

Alison Krauss - When You Say Nothing At All

https://www.youtube.com/watch?v=1SCOimBo5tg

Thank you Nick.
That was a wonderful tribute to Easter, with the panoramic view of Russia I suppose. Easter sunrise and Till we meet again song.

We rest on Thee

1
We rest on Thee, our Shield and our Defender;
We go not forth alone against the foe;
Strong in Thy strength, safe in Thy keeping tender.
We rest on Thee, and in Thy Name we go.
2
Yea, in Thy Name, O Captain of salvation!
In Thy dear Name, all other names above;
Jesus our Righteousness, our sure Foundation,
Our Prince of glory and our King of love.
3
We go in faith, our own great weakness feeling,
And needing more each day Thy grace to know:
Yet from our hearts a song of triumph pealing;
We rest on Thee, and in Thy Name we go.
4
We rest on Thee, our Shield and our Defender:
Thine is the battle, Thine shall be the praise
When reigning in the Kingdom of Thy splendor;
Victors, we rest with Thee, through endless days.

God be with you Benedetta.

Names of God - Give Me Jesus

https://www.youtube.com/watch?v=qedj7hANnmI

Lady Gaga - Hold My Hand

https://www.youtube.com/watch?v=O2CIAKVTOrc

All I am and have learned is laid at the feet of the Lord Jesus blessing his holy name for his love to me and his unspeakable grace and mercy. Praise the Lord God, Glory to God in the Highest!!!

In my life I say this with Love toward all. Autism may be challenge, but being without Jesus Christ is horrid. Thou shall Love the Lord thy God.. come unto Me the Lord says.

Bach - St Matthew Passion BWV 244 - Van Veldhoven | Netherlands Bach Society

https://www.youtube.com/watch?v=ZwVW1ttVhuQ

I have returned fully to my faith and Lord. Anyone who has read my posts please forgive any sinful and loveless remarks I have uttered. The goodness of God have saved and preserved my spirit through all of this. I ask forgiveness for ay I have hurt or offended. May the gracious Love and Goodness of the Lord be with you. God is awesome and Amazing. I have only Jesus to thank.

Jesus is Lord.

For thine is the kingdom, The power, and the glory, For ever and ever. Amen.

It is hard. I am sorry Nick.
Life is just so brief, even a long one the stretches into the 90s.

My precious wife was born in Canada and Gordon Lightfoot and Joni Mitchell are also Canadian. I learned a lot about the nation through my wife. She has been a dual citizen of the USA and Canada. I visited her in Canada while dating though she has no memory of it. I still honor Canadians because of this, I so loved the work of Gordon before I met her, but he helped form me. God speed Gordon. OH Canada. His passing has meaning to me.

Gordon Lightfoot - Saying Goodbye

https://www.youtube.com/watch?v=RsA7NlY1gtA

"In sickness and in health"

Clint Black - When I Said I Do

https://www.youtube.com/watch?v=ZgalAdgEd-E

Gordon Lightfoot - Wreck Of The Edmund Fitzgerald

https://www.youtube.com/watch?v=FuzTkGyxkYI