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Age of Autism Science Source: Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis?

Science post imageAutism Res. 2011 Aug 31. doi: 10.1002/aur.219. [Epub ahead of print]

Are thyroid hormone concentrations at birth associated with subsequent autism diagnosis?

Hoshiko S, Grether JK, Windham GC, Smith D, Fessel K.

Source

Environmental Health Investigations Branch, California Department of Public Health, Richmond, California. sumi.hoshiko@cdph.ca.gov.

Abstract

Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. We investigated whether thyroxine (T4) levels at birth are associated with subsequent ASD, using two existing California study groups in multivariate analysis. One study group included children born in the San Francisco Bay Area in 1994, with cases identified through the California Department of Developmental Services (DDS) and/or the Kaiser Permanente Medical Care Program of Northern California (244 cases, 266 controls); the other included children born in California in 1995, with cases identified through DDS (310 cases, 518 controls). Matched controls were selected from birth certificate records. This exploratory analysis suggested that infants with very low T4 (<3rd percentile) may have higher ASD risk, although results reached statistical significance only for the 1995 study group (1995: OR = 2.74 (95% CI 1.30-5.75; 1994: OR = 1.71 (95% CI 0.57-5.19). A variety of alternate analyses were conducted with available data, without further resolution of the difference between the two study groups. The results of our study indicate that further studies are warranted to investigate whether thyroid hormone perturbations play a role in the development of ASD by evaluating additional potential confounders and genotype or phenotype in larger studies. Autism Res 2011,4:xxx-xxx. © 2011 International Society for Autism Research, Wiley Periodicals, Inc.

Copyright © 2011, International Society for Autism Research, Wiley-Liss, Inc.

PMID:

21882364

[PubMed - as supplied by publisher]

Comments

Benedetta

"There has not been a comprehensive compilation of data regarding the epidemiology of all endocrine and metabolic disorders in the United States"

I thought the main job, function, purpose of CDC was to do epidemiology collection of reports?

Well now how come they have not?

Marytormey

Fluoridated water makes me vomit. I grew up in an area where the water was fluoridated. I was diagnosed with Hashimoto's after being forced to take Risperdal. I was told I would need to take thyroid med's for the rest of my life but I don't need them anymore.

Marie

That is interesting. Could Thimerosal in prenatal flu shots and rhogam shots begin the autoimmunity against the thyroid? My son has so many health problems -- ASD, GI problems, thyroid problems, failure to thrive, PANDAS, severe allergies. I don't see how the medical community cannot come together to figure out that these are all immune system problems. Vaccines are for the immune system -- can we put 2 and 2 together?

veritas

Thimerosal/mercury suppresses thyroid function and early vaccinations may produce autoimmunity against thyroid gland. Here is the link.

Patrick

From your article:
"Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression."

The environmental factor I was concerned about was the flu shot I received when I was pregnant in 1998 as my thyroid was injured subsequently and my son was injured. I looked up whether mercury effects the thyroid:
http://www.tuberose.com/Thyroid.html
This site states that deficiency of thyroid hormone may be due to impaired cellular conversion of T4 to T3 often caused by mercury toxicity.
It would make sense in our situation. I was diagnosed with hypothyroid within a year of giving birth and my son showed major symptoms after his second flu shot at age 4.

Lisa R

There was a talk at AutismOne about the thyroid connection.
http://www.autismone.org/content/thyroid-autism-connection-video
very interesting since I'm sure I passed it on to my kid and my mom passed the issue on to me.

DownWitTheSickness

Benedetta totally hit the nail on the head!

Benedetta

Another good study might be to have a little curosity as to why there are so many, so young, with a dysfunctional thyroid to begin with?

An autoimmune disease is it that slowly distroys it?
Brought on by what?
a tetanus shot that is also a sneaked in DPT shot instead to the adult population.

And what about regression autism? Hmmmm.

Well at least they finally doing some study on the thyroid, because it is has been linked a long time with autism. They are way behind in these studies at least 30 years behind.

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