By Teresa Conrick
If you have been following this series (Part 1 and Part 2) on the connections of mercury, both environmental and pharmaceutical, I hope that it has become clear that many diseases appear to be sparked by exposure from both. Viruses, included as xenobiotics, may also be included, as mentioned in Part 3 here: " proteins in the intracellular signaling cascades that are activated by receptor tyrosines were initially isolated as oncogenes in cancer cells or tumor viruses." More specifically to measles, and for Megan and many of her autism peers, the additional regression, loss of language, fevers, rashes, GI disease, encephalopathy and seizures after the Measles, Mumps and Rubella vaccine, changed lives forever: here Tyrosine phosphorylation of measles virus nucleocapsid protein in persistently infected neuroblastoma cells
"The mechanisms governing the establishment and maintenance of a persistent MV infection in brain cells are still largely unknown. To understand the mechanisms underlying MV persistence in neuronal cells, a tissue culture model was studied.... We present data to show augmented protein tyrosine kinase activity in the persistently infected cells."
Is it possible Xenotropic murine leukemia virus-related virus ,XMRV, a virus first found in prostate cancer and now being linked to chronic fatigue syndrome/myalgic encephalomyelitis (ME) and autism, is also involved ? : "XMRV proteins are also homologous to proteins of the growth factor signalling networks (e.g. tyrosine kinases FLT3 and TYRO3) (Table 5) which are relevant to cancer-related growth (Fig 2)." Nature.com.
Since Meg's "estrogen behaviors" are such a drastic conversion of her usual self to a more "manic" state, I decided to look for a biological reason as to why it was happening: Protein Kinase C Inhibition in the Treatment of Mania A Double-blind, Placebo-Controlled Trial of Tamoxifen
"PROTEIN KINASE C (PKC) IS A family of enzymes that phosphorylate neurotransmitter receptors, intracellular signaling molecules, transcription factors, and cytoskeletal proteins......Several lines of evidence implicate abnormal PKC activity in bipolar disorder (BPD).... estrogens, which increase PKC activity in the brain, may exacerbate mania and increase risk of postpartum episodes of BPD." That quite possibly is what is happening in my daughter. Interestingly, Tamoxifen in addition to blocking estrogen, is also a tyrosine kinase blocker used in breast cancer. Again, not endorsing any medications or drugs here but do need to add that this one does have serious side effects : blood clots, strokes, uterine cancer, and cataracts. The fact that it can stop mania by blocking estrogen AND protein kinase seems very important in our puzzle pieces.
A true test of a theory is to see if it fits into the real puzzle and that made me think of Donald T. For many of us who have been on the biomedical road, looking at environmental and vaccine toxins as the trigger to much of the injury and subsequent medical symptoms that are children began to have, we knew about Donald as he was an original Dr. Leo Kanner patient in the 1943 paper, (HERE) . Dan Olmsted and Mark Blaxill went back in time investigating the use of mercury historically, and did the most comprehensive exploration of those Kanner patients, showing mercury as the very plausible roots to what we now see as an epidemic of cases. Donald is alive, doing well, and a testament that autism can be medically treated and arrested -- not unlike cancer. Here was a trailblazing article by Dan Olmsted when he first embarked on the journey looking into those original cases. Thanks to Ginger at Adventures in Autism, for reporting on it 6 years ago: The Age of Autism: Gold? (Adventures in Autism)
"Why would treatment with gold help someone with autism? ... That first autism patient, known as "Donald T.," is now 71 and lives in the small Mississippi town he grew up in. Diagnosed with autism at age 5, he had a life-threatening attack of juvenile arthritis at age 12, according to his brother; his temperature spiked uncontrollably, his joints stiffened and were extremely painful. He stopped eating.
"It looks like Don's getting ready to die," his father told a small-town physician after specialists failed to diagnose the ailment or find an effective treatment. That doctor suggested it might be juvenile arthritis, and after treatment with gold salts at a Memphis clinic, Donald's autism as well as his arthritis improved.
Injectable gold salts -- sodium aurothiomalate -- were used to treat arthritis because they have anti-inflammatory properties ..... "He had a miraculous response to the medicine," his brother told us at his Mississippi law office. "The pain in his joints went away. When he was finally released, the nervous condition he was formerly afflicted with was gone. The proclivity to excitability and extreme nervousness had all but cleared up." Donald also became "more sociable," he said."
--- A MIRACULOUS RESPONSE to the MEDICINE ---! Beautiful words in the world of immune issues, behavioral manifestations and autism. Let's take a look at where that may fit into this hypothesis: Effects of gold coordination complexes on neutrophil function are mediated via inhibition of protein kinase C
"Previous studies have shown that the gold compounds auranofin (AUR) and gold sodium thiomalate (GST) inhibit responses of various cells and tissues. ....we investigated the possibility that gold compounds might be interfering with signal transduction at this level. Enzymatic assays indicated that both gold compounds reduced the level of PKC (protein kinase C) activity... It is suggested that modulation of PKC represents a mechanism of action of gold coordination complexes at the cellular level."
Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study
"Gold(I) complexes containing N-heterocyclic carbene ligands were synthesized, characterized, and along with the antiarthritic drug, auranofin, tested as inhibitors of the cysteine-dependent protein tyrosine phosphatases, which are implicated in several disease states. These compounds exhibit potencies in the low micromolar range against the enzymes in vitro."
This though, has to be my favorite. I mentioned it briefly in Part 1 but it came up again when looking at gold salts, sodium aurothiomalate. It may be showing us both the poison and the antidote:
Mercuric chloride activates the Src-family protein tyrosine kinase, Hck in myelomonocytic cells , "Hck is a member of the Src-family of protein tyrosine kinases that appears to function in mature leukocytes to communicate a number of extracellular signals including various cytokines. In this study we show that the thiol-reactive heavy metal, mercuric chloride (HgCl2) induces rapid and robust activation of tyrosine phosphorylation within human myelomonocytic cells....Concomitant with the activation of Hck, there is a physical association of Hck with another cytoplasmic protein tyrosine kinase, Syk. The ability of HgCl2 to activate Src-family kinases such as Hck in hematopoietic cells may help explain why exposure to the heavy metal is associated with immune system dysfunction in rodents as well as humans."
Interesting, pertinent, and mentioned in the 50 references is number 43: Mechanism of inhibition of protein-tyrosine phosphatases by disodium aurothiomalate.
The Poison: "The administration of subtoxic levels of heavy metals such as mercuric chloride (HgCl2) is able to induce an autoimmune response that is similar to systemic lupus erythematosus in certain strains of mice and rats. In addition, there is a correlation with immune system dysfunction, including autoimmune disorders, in humans who have been accidentally exposed to mercuric compounds".
The Antidote: "Disodium aurothiomalate (AuTM) has been used successfully in the treatment of various autoimmune and inflammatory disorders....cellular effects of gold result from the inhibition of these important cell signaling molecules"
Mercuric Chloride needs some defining -1 ) Thimerosal, a mercury derivative composed of ethyl mercury chloride, or 2) Syphilis was frequently treated with mercuric chloride and more precisely, in discussing Donald T from Forest, Mississippi: 3 ). mercuric chloride - a white poisonous soluble crystalline sublimate of mercury; used as a pesticide or antiseptic or wood preservative. Wood...Forest....mercury preservative... takes us correctly to Dan and Mark's book - (HERE)
Round and round through the years and it may just turn out that autism and cancer share many factors. How horribly sad and wrong that the many ill children, like my daughter, have suffered while the history of autism research has allowed autism to remain a psychiatric disorder with first unloving parents of the 1940-1990's and then a new blame -- on the invisible, bad parent genes, when evidence-based research shows that autism, and its other adult versions of neurodegenerative disease (ALS, Alzheimer's, Parkinson's, Schizophrenia, etc), plus cancer and autoimmune diseases, have roots to the environmental, toxic, manmade chemicals, including those found in vaccines. Shame on so many who have allowed this to happen and to so many who CONTINUE to let the denial spin.
We have seen how autism and cancer have such similar components, from glutamate dysfunction to over-expression and altered protein tryosine kinase and phosphorylation. The use of gold salts helped Donald tremendously and again, I am not endorsing their use but to identify a point of origin. These diseases seem connected by not only a toxin, like mercury or a vaccine virus exposure, but are also connected by the DENIAL of that truth from too many who have a vested and often financial interest in that denial. Illnesses have become big business and "targeting" them with vaccines and then pills once chronic illness steps in has become as common as the nonsensical commercials for each. The list of side effects from vaccines and medications on those commercials describe a path to worse health consequences, comical back on Saturday Night Live, but in reality, a true tragedy to good health today. Unfortunately, there has been a trend for the Pharmaceutical Industry and Government to turn their back on seeing the cause/effect of disease and JUST looking for the business angle/financial gain of "herding immunity". Targeting the PTPome in human disease
"Protein tyrosine phosphatases (PTPs) play vital roles in numerous cellular processes and are implicated in a growing number of human diseases, ranging from cancer to cardiovascular, immunological, infectious, neurological and metabolic diseases. There are at least 107 genes in the human genome, collectively referred to as the human ‘PTPome’. Here the authors review the involvement of PTPs in human disease, discuss their potential as drug targets, and current efforts to develop PTP inhibitors for the treatment of human disease. Finally, the authors present their view of the future for PTPs as drug targets." (HERE)
Riluzole gives a patient with ALS a few months on a ventilator. Is that as good as it gets or can we STOP the majority of these diseases? Please join me in supporting The Canary Party, http://www.canaryparty.org/ because we have had enough! Also join me next in Part 5 for a look at medications, supplements and vitamins that seem related to these "targets."
Teresa Conrick is Contributing Editor for Age of Autism.