Autism Speaks Co-Founders Suzanne and Bob Wright to Receive Honorary Degrees from the University of Massachusetts Medical School An honorary degree is a nod of approval for philanthropic efforts, and is feather in the Wright's caps, to add to the numerous magazine covers, international accolades and other kudos they have received.
We'd like to take this opportunity to confer an honorary degree from Age of Autism to the parents we met last month at Autism One. They won't get a fancy ceremony and a tasseled mortarboard, but they did gain usable medical knowledge for their children with autism by atttending sessions like:
Overview of Physiological Issues Underlying an Autism Spectrum Diagnosis - CME Program
Physiological research and observations are increasingly contradicting the conventional view that autism is a purely genetic and hardwired set of deficits. Systemic and brain metabolic and immune changes, regression, transient and persistent improvement, and remarkable brilliance even in some who can't talk, all suggest that "autism" may arise from an interacting web of physiological problems that create obstruction of function or obstruction of expression rather than deficient capability.
Metabolic Roles of Redox Regulation and Methylation: Part I: General Principles - CME Program
The ability to resist oxidation and to adapt to environmental stressors is fundamental to homeostasis, and sulfur metabolism provides the foundation for these abilities. Signaling molecules with the ability to change the redox state can exert a broad influence over cellular metabolism, including methylation-mediated epigenetic effects on gene transcription that can persist across the lifespan and even across generations. Conversely, environmental factors which interfere with redox signaling can disrupt its regulatory role, contributing to a number of disorders affecting almost every aspect of physiological function. This lecture will provide an overview of the metabolic and biochemical relationships that control the redox state of cells, including tissue-specific differences.
Richard C. Deth, PhD
Immune Dysregulation in Autism - CME Program
The immune system is intricately involved in brain development and its functional regulation. The brain’s intrinsic immune system modulates synaptic communication, and is equally important to defense from free radical damage and excitotoxicity. The GALT is 70% of the peripheral immune system and complex dysregulation of the gut immune system is well documented in a distinct autism subgroup. Additional evidence supports autoimmunity in pathogenesis of autism. This autoimmune process appears to overlap with streptococcal related cross-reactivity with basal ganglia (PANDAS). Autoantibodies are also noted to interfere with cerebral folate metabolism. These immunological aberrations will be defined. Appropriate diagnostic testing will be discussed with the intent of aiding the clinician in the workup and treatment.
James Jeffrey Bradstreet, MD, MD(H), FAAFP
What Do We Know About Gastrointestinal Disease in ASD's? Which Candidate Pharmaceuticals hold greatest promise for Future Research? - CME Program DVD
Gastrointestinal pathology is an exceedingly common comorbid condition in ASD's. This presentation will review the body of medical literature that addresses ASD's and GI disease with emphasis on the overlap between ASD associated inflammatory bowel disease and other IBD's.
Arthur Krigsman, MD
Neurological Abnormalities in Autism -- CME Program
Children with autism have been found to have many neurological abnormalities include differences in brain function, structure and connectivity, neurotransmitter and metabolic abnormalities and electrical disturbances in the brain including seizures. This talk will review some of the important aspects of these neurological abnormalities and their treatments.
Richard E. Frye, MD, PhD
Current State of Autism Biomedical Research
This presentation will summarize some of the recent advances in the biochemical understanding of autism and biomedical treatments for it. Topics include sulfation, oxidative stress, mitochondrial function, intestinal permeability, and more.
James B. Adams, PhD
The increasing rates of autism spectrum disorders cannot be fully explained by genetics or better diagnosis.This suggests that environmental factors play a role in the development of autism spectrum disorders. We will start with a overview of the scientific literature on the effects of various chemicals on neurological development. Then, tools and strategies will be presented to help you minimize your exposure to chemicals and electromagnetic fields and create a healthy home for your family.
Suruchi Chandra, MD
Integrating Stem Cells Into a Complete Biomedical Restoration Plan
So far, efforts to restore and maintain a healthy gut-brain-immune balance have yielded inconsistent results. The presumed pathogenic bacteria and yeast return, inflammation persists and symptoms come and go. Adipose derived stem cells can be harvested through minimally invasive techniques, and once implanted they seek out inflammation where they initiate immune regulation and repair. Plans to integrate stem cells into a comprehensive system of functional restoration will be discussed.
James Jeffrey Bradstreet, MD, MD(H), FAAFP
Update in Autism Associated enterocolitis: A window into the Evolution of Chronic Inflammatory Bowel Disease?
This lecture will review the clinical presentation of bowel inflammation in children with ASD's with emphasis on the signs and symptoms critical for early recognition. As with all diseases, the importance of early diagnosis and treatment cannot be overemphasized. Recent histologic and serologic data suggesting that ASD-associated enterocolitis may provide a window through which the evolution of chronic inflammatory bowel disease may be viewed will be presented.
Arthur Krigsman, MD
Global Alert: Environment Increases Autism Risk What You Can Do Now
An unprecedented global experiment is underway. Human activity is pushing ecological and biological boundaries beyond predictable limits. Accumulating evidence links ASD to synergistic effects of multiple, low levels, toxins at times of increased vulnerability. Using an integrative and functional medicine perspective Dr. Schwartz will review the scope of the problem and identify what can be done by:minimizing exposure, supporting detox pathways, optimizing diet, implementing biomed treatment.
Norm Schwartz, MD
Immunomodulation in ASDs
The role of gut flora, anti-oxidants and anti-inflammatories, and IVIG will be discussed in terms of restoring immune regulation and balance.The role of gut flora, anti-oxidants and anti-inflammatories, and IVIG will be discussed in terms of restoring immune regulation and balance.
Jane M. El-Dahr, MD, FAAP, FAAAAI
A Long Way to Tacitus
Autism associated gastrointestinal disease afflicts the majority of children with ASD's. They are treatable conditions and understanding their role in ASD's may provide important clues as to the origin of the autism epidemic. Thanks to the singular efforts of Mrs. Mina Yabnkova Eneva-Lambovsky, the Tokuda Hospital in Sofia opened their doors to these families and as a result, 11 children were evaluated by Dr. Arthur Krigsman, who demonstrated for the first time in Bulgaria the presence of gastrointestinal patholgy in ASD's and shared his experience and knowledge with the hospital administration and staff in a series of lectures. Mrs. Lambovsky will discuss how one passionate mother can effect a change in the way the medical community views ASD's. Dr. Krigsman will then summarize his findings in the 11 children evaluated at Tokuda Hospital.
Arthur Krigsman, MD
MENDING AUTISM: Repairing What's Broken
In this presentation, Dr. Kartzinel will explain some of the known broken biochemistry involved with Autism - because if we determine what is broken, then we can specifically target interventions that may greatly impact restoration of health. In addition, there will be a discussion on toxicity and its impact on oxidative stress, and inflammation and how this contributes to chronic illness. Finally, Dr. Kartzinel will present therapeutic interventions you can implement today! In this presentation, Dr. Kartzinel will explain some of the known broken biochemistry involved with Autism - because if we determine what is broken, then we can specifically target interventions that may greatly impact restoration of health. In addition, there will be a discussion on toxicity and its impact on oxidative stress, and inflammation and how this contributes to chronic illness. Finally, Dr. Kartzinel will present therapeutic interventions you can implement today!
Jerry J Kartzinel, MD FAAP
Glutathione's Role in Autism and Brain Injuries
What is glutathione? Learn about --Its functions and sources in the body --Why glutathione is the most important brain nutrient. --How glutathione is used to repair the blood brain barrier, grow new brain cells, and remove toxic metals. --Why glutathione is needed in seizures. --Glutathione, autism and mercury in the brain. --How to effectively deliver glutathione to the cells and raise liver glutathione production naturally.
Corinne Allen, PhD, MA, BA
Dental Care for Children on the Autism Spectrum
The dental care of patients with ASD presents many challenges. Examination may be difficult; medical conditions, including immune issues, may impact on the selection of restorative materials; and the patient's diet may present a trade-off between nutrition, medical complications, and tooth decay. Orthodontic care which requires excellent oral hygiene and patient compliance presents additional challenges. Dr.Cantor and his colleagues will address these issues and answer audience questions. The dental care of patients with ASD presents many challenges. Examination may be difficult; medical conditions, including immune issues, may impact on the selection of restorative materials; and the patient's diet may present a trade-off between nutrition, medical complications, and tooth decay. Orthodontic care which requires excellent oral hygiene and patient compliance presents additional challenges. Dr.Cantor and his colleagues will address these issues and answer audience questions.
Jeffrey S. Cantor, DDS
Michelle Feldner Lancaster, DDS
Pamela Johnson, DDS, MS
Patricia L. Gannon, DDS, MS
The Biosciences behind Autism: Explaining the Scientific Basis for Biomedical Interventions used for the Treatment of Autistic Spectrum Disorders
Fundamental basic medical sciences will be introduced and explained. This will include teaching some detailed biology (including cell biology), immunology and biochemistry, in order to provide parents and practitioners with a strong scientific foundation for understanding some of the exciting research that is unraveling in the field of autism research today. Some of the topics that will discussed include immune system regulation, dysregulation and dysfunction, antibodies and autoantibodies, opioid-like peptides, yeast and bacterial overgrowth, oxidative stress, methylation, and transsulfuration and how these topics relate to some of the latest biomedical research developments for the treatment of autism.
Lauren Underwood, PhD
Seizures in Autism Spectrum Disorders, An Overview
Dr. Hardy will discuss his extensive 30 year experience in evaluating and treating seizures in persons with autism. The general classification and the unique epidemiology of seizures in autism will be reviewed. Behavioral issues related to autism will be emphasized. Finally, treatments for epilepsy will be presented including nutriceutical as well as pharmaceutical therapies. The role of the ‘therapeutic trial’ will also be a focus of discussion with the risk of pharmaceutical treatment.
Paul Millard Hardy, MD
Remarkable Findings of Auto-antibodies: Testing and Treatment
New data shows that many children with autism and their parents produce auto-antibodies to a folate receptor which can lead to a condition called Cerebral Folate Deficiency (CFD). Multiple studies have shown CFD can cause autism, seizures, mitochondrial disease, motor abnormalities or other neurological problems. Dr. Rossignol will review recent studies and research on testing for these antibodies and innovative treatments that are typically covered by insurance. He will also discuss his current IRB approved study he is conducting with Dr. Richard Frye. Case studies treated by Dr. Rossignol over the last 9 months on newly diagnosed children, tough nut children and, surprisingly, their parents will be presented. This technique will potentially be invaluable for prevention, early intervention, and treatment of autism.
Daniel A. Rossignol, MD
Mitochondrial Disease and Autism - Bridging the Gap
Mitochondrial disorders alter the body’s ability to adequately convert food into the energy needed for bodily functions. These diseases, which affect up to 1 in 4,000 individuals, can result in widespread clinical problems. Many recent studies have linked autism spectrum disorder (ASD) to poor mitochondrial functioning. Understanding mitochondrial disorders, and evaluating their symptoms may help ASD families determine whether further testing may be important for their child.
Frances D. Kendall, MD
Understanding Your Child's Most Important Biochemical Pathways
This presentation will tell you about your child's most important central metabolic regulatory system. This is the springboard for understanding all else when planning your child's treatment and recovery plan with your healthcare professional. Decisions about intelligent supplementation and many other interventions hinge upon understanding some basic biochemical pathways, in general, and your child's unique situation, in particular.This presentation will tell you about your child's most important central metabolic regulatory system. This is the springboard for understanding all else when planning your child's treatment and recovery plan with your healthcare professional. Decisions about intelligent supplementation and many other interventions hinge upon understanding some basic biochemical pathways, in general, and your child's unique situation, in particular. Topics will include the critical role that methionine plays in our bodies and the importance of optimizing cysteine levels for the induction of glutathione formation. There will be time for your questions.
Nancy Mullan, MD