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Read This Now: Why Genes Explain Almost Nothing, Including Autism

Dnatoy3 Editor's note: We commend to your attention this definitive new post, "The Great DNA Deficit -- Are Genes for Disease a Mirage?" by Jonathan Latham and Allison Wilson, at the Bioscience Resource Project site. The authors do a superb job of pointing to the ultimate emptiness of gene research into the causes of disease. Beyond a few well-characterized single-gene disorders that were already known, billions of dollars of research has essentially led to one inescapable conclusion: Genes have little to do with disease, and environment has a lot to do with it. The implications, of course, powerfully apply to autism: "We can reiterate that according to the best available data, genetic predispositions (i.e. causes) have a negligible role in heart disease, cancer, stroke, autoimmune diseases, obesity, autism, Parkinson’s disease, depression, schizophrenia and many other common mental and physical illnesses that are the major killers in Western countries." 

Yet medical, scientific and media interests ignore the obvious: that the environment is where the clues and potential cures can be found. "Politicians like genetic determinism as a theory of disease because it substantially reduces their responsibility for people’s ill-health. By shifting blame towards individuals and their genetic ‘predispositions’ it greatly dilutes the pressure they may feel to regulate, ban, or tax harmful products and contaminants, courses of action that typically offend their business constituents. For a politician, therefore, spending tax dollars on medical genetics is an easy and even popular decision."

This article points clearly to a better way. Please read it now HERE

Comments

venus

It requires finding the antibody before you produce vaccine. Moreover, how to evaluate the change of the vaccine is a big question. I hope it http://www.creative-diagnostics.com/CommonTypeList_177.htm would be some help of you.

patrons99

@ eileen nicole simon -

There appears to be a convergence of thought occurring. There appear to be some distinct similarities between the signs and symptoms of snakebite victims, stroke victims, and vaccine-induced brain injuries. How qualitatively different is neurotoxic snake bite envenomation from vaccination? Suppose that the final common pathway to all disease, including all vaccine toxicity, was ischemic, hypoxic, anoxic injury, occuring throughout the body, with differing time scales.

“Partial third nerve palsy after Measles Mumps Rubella vaccination” on September 10, 2010.

http://www.biomedcentral.com/content/pdf/1824-7288-36-59.pdf

“Occular Motor Damage”

http://vactruth.com/wp-content/uploads/2010/03/polio-21.jpg

"In most cases lesions were observed within the colliculi and the third nerve nuclei."

Is this an infectious process or blood flow-related process? Aluminum salts are widely used flocculating agents in industry. It is entirely predictable that aluminum adjuvants in the vaccine schedules would be associated with sludging of blood flow and blood clots, sometimes subclinical or silent.

“Study clearly demonstrates that aluminum found in vaccines can cause neurologic damage”

http://vactruth.com/2009/09/21/study-clearly-demonstrates-that-aluminum-found-in-vaccines-can-cause-neurologic-damage/

“Occipital Infarction Revealed by Quadranopsia folowing Snakebite by Bothrops Lanceolatus”

http://www.ajtmh.org/cgi/reprint/73/3/583.pdf

“Cerebral vascular impairment after snakebite is rare. In a series of 309 snakebite patients, Mosquera and others reported cerebral vascular complications in eight (2.6%) patients, seven of a hemorrhagic nature and one of an ischemic nature.10"

“The prognosis was unfavorable in all eight patients: five died and three had serious neurologic sequelae.”

“Malayan Krait - Blue Krait - Highly Toxic Venom”

http://www.thailandsnakes.com/tag/malayan-blue-krait/

“Very toxic – even up to 16 times more so than the Naja kaouthia (cobras). Bungarus krait venom is neuro-toxic and attacks the human nervous system, shutting it down. Coma, brain death, and suffocation due to paralysis of the muscles necessary to breathe (diaphragm) are frequent causes of death.”

“A patient bitten by Bungarus candidus (Malayan krait) developed nausea, vomiting, weakness, and myalgia 30 minutes after being bitten. One hour later, ptosis and occulomotor palsies as well as tightness of his chest were noted. Respiratory failure requiring mechanical respiration appeared 8 hours after the bite and lasted for nearly 96 hours. “

http://archive.sajcc.org.za/1993%20Volume%209%20No%201/Articles/1.2%20A%20clinical%20approach%20to%20snakebite%20and%20rationale%20for%20the%20use%20of%20antivenom.pdf

“Bites presenting with neurological symptoms or signs should always be treated in a high care or intensive care unit. The cranial motor nerves are usually affected first with symptoms ot dysphagia, vertigo, nausea, sore throat, muscle pains, numbness and double vision. Ptosis follows, and evidence of bulbar dysfunction with hypersalivation and oculomotor weakness is seen. Tendon reflexes are reduced as muscular weakness progresses to paralysis and respiratory failure. The patient with severe anxiety may mimic neurotoxic envenomation.”


michael framson

Genetic research is the medical equivalent of financial derivatives. Billions of dollars going into worthless endeavors, that just perpetuate worthless endeavors which produce nothing of value except billions of dollars going into worthless endeavors which produce nothing.

The media keeps the American People blissfully ignorant, just the way the powers that be wants us.

Carol

When you search Google Scholar for "Navajo neuropathy" with "uranium," you come up with 8 articles, none of which are research articles. When you search Google Scholar for "Navajo neuropathy" without "uranium" (or "arsenic"), you get dozens of medical research articles.

In _Yellow Dirt_ by Judy Pasternak, the author discovers that Navajo neuropathy, which appeared in 1959, is one of those genetic diseases you pass on to your children when you drink water contaminated by uranium and arsenic. It's a good thing she's not a scientist or that would've gone completely over her head.

Paul

While I have been exploring some more of the X-files type ideas about DNA currently on my site, as someone who has authored a textbook chapter on the genomics of rare diseases this is an area where I might perhaps throw out some general comments.

First, yes there are clearly very serious and tragic genetically linked diseases. These are generally autosomal recessive and affect a key point in metabolism. Affected individuals generally die in childhood. I disagree that there are "only a few" of these diseases, there are dozens if not hundreds. However, they are generally rare to extremely rare sometimes affecting only a handful of patients in hundreds of millions.

Secondly, to add more complexity, there is not one single way that a gene "malfunctions." The gene has hundreds of base pairs anyone of which may have a novel, potentially deleterious change. If one goes to the site Online Menedellian Inheritance in Man (OMIN) it is found that even for very rare diseases, dozens or more different mutations have been cataloged, for even quite rare genetic diseases, though often one or two are predominant.

These changes may lead to a new three dimensional shape that leads to a complete loss of function or in other changes there may be some partial function still available, in general if there is even 5-10% genetic function available the "disease" is generally without clinical effect. Though, some have speculated, in NEJM I believe (will dig out the ref if necessary) that I believe a mild variant of Gaucher's disease with some function remaining may be responsible for some 5% of congestive heart failure cases. In some cases the enzymatic function of the aberrant protein remains completely intact but a changed configuration prevents it from getting shuttled to the proper orgnanelle where it would carry out its duties.

This is to say that even in serious genetic diseases where a single genetic defect affects a crucial metabolic pathway, things are complicated. If one considers multifactorial genetic effects, i.e. when it is claimed that these ten or twenty genes have been found to be tied to a disease one runs into the possibility of each of the genes acting upon the others. There is a combinatorial explosion of different combinations of different configurations (and varied mutations) of the ten or twenty genes which could easily run into the hundreds of thousands or millions. And we have not yet left the genome.

Adding in the local cellular environment, there are untold factors that effect the relative expression of various genes, vitamin D being one which has received some press recently. Others may affect various forms of post translational genetic expression. Moving on to the macro-environment of toxic and infectious exposures adds yet another level of complexity.

It is not surprising to me that for all but the most serious, monogenetic, interruptions of crucial, bottleneck physiologic processes there has been little predictive value from genetic analysis.

As regards autism, despite the frequent press on possible genetic links, it clearly can not be primarily a genetic disease. The prevalence has increased ten fold or more inside of a generation or two - the genome hasn't been reshuffled enough within such a short time for genetics to account for such a massive increase in prevalence, (though certainly genetics plays a role in susceptibility). It is epidemiologically consistent with an infectious or toxic exposure.

Paul

Paul Maher, MD
http://healthjournalclub.blogspot.com/

patrons99

Dr Simon - my visit to your website makes me seriously believe that we might, at some point, consider replacing the "A"-word with vaccine-related "hypoxic brain injury". Personally, I don't believe that ASD is the only vaccine-related brain injury. I'm also of the strong opinion that brain injuries are not the only vaccine-related injuries in humans. Consider also vaccine-related injuries to the heart, lungs, gut, kidneys, and pancreas.

The focus of your research makes perfect sense. The answers that we seek will be found by studying the effect of vaccines on blood flow - perfusion. Areas of the brain which require the greatest blood flow, i.e. perfusion, would be the most vulnerable. End capillary, watershed distributions throughout the body are the most vulnerable to ischemic injury.

“Dr. Andrew Moulden (Interview): What You Were Never Told About Vaccines” on July 21, 2009.

http://www.cafemom.com/journals/read/1501736/Dr_Andrew_Moulden_Interview_What_You_Were_Never_Told_About_Vaccines

“The brain (and other organ systems) do not have blood flow receptors. There are only blood pressure receptors. Accordingly, when flow is diminished, there are no signals to the body that something is wrong when pressure remains adequate. This all plays out at the microscopic level, sometimes at the angstrom level – we have no microscopes to see this live within the human body.”

“When an infant dies of “sudden infant death” or “no cause of death” after vaccination, the actual cause of death is impaired blood flow, in this case to the microscopic, watershed, end-capillary vessels in the brain stem controlling the central drive for respiration. The impaired blood flow has to be bilateral. This causes a cessation of breathing. Cardio respiratory arrest ensues in a perfectly healthy human. Coroners will not find cause of death as the cause of death “no microscopic capillary blood flow” in life is also present for us all in death – no blood flow.”

“We do not need to vaccinate for all the pathogens on earth, since all pathogens are inducing disease and death and disability via a singular common set of mechanism. It is these mechanism that need to be addressed on an as needed basis. This is now do -able it always was. Louis Pasteur’s germ theory was just that – a theory. His contemporaries, Dr Antoine Bechamp and Dr Rudolph Virchow were closer to the truth as to the cause of disease. Remarkably, this means that much of what we are doing in western medicine is wrong – we have been practicing medicine in a state of confusing cause and effect and causing more harm, globally, than good…for over 200 years!”

“Yes, however, vaccines are not addressing the common cause of disease and disorder in human physiology. It is not the germs causing disease and death and chronic illness, it is the bodies common, generic, non-specific immune response and electrostatic instability of blood flow that is causing disease, and many states of autoimmunity, including multiple sclerosis, and much much more.”

“I have quantified and expanded standard neurological and clinical neuropsychological tools of brain function and assessment. In essence, I have “digitized” the neurological and neuropsychological physical neurological exams across neurodevelopment using contemporary image enhancement software constrained to functional localization in the brain relative to end vascular, watershed territories – “the end of the road” for varied brain blood vessel areas. All of my tools and techniques are non-invasive.”

patrons99

“There is no such thing as an acquired genetic epidemic. The epidemic is an acquired phenomenon, from environmental factors, for which I can now conclusively show, vaccinations are the mass culprit for most of this.” -- Andrew Moulden on July 21, 2009

Jen

I went to bed late- so angry at an article someone wrote in our paper about how all the new CCSVI theory ( re MS) was "hyped- up" and should basically not be given any attention at all. Then the reporter called some probably useless gene study done in mice, "ground breaking." so frustrating!! I'm going to look up who sponsors his radio show. He also is (surprise) completely in love with the genetic theory for autism and loves to discredit anything about vaccine concerns.

Eileen Nicole Simon

Hunting for disturbed gene loci on chromosomes to try to explain a spectrum of behavioral disorders is silly. Autistic behaviors are observed as part of many different medical disorders. Phenylketonuria (PKU) is one such disorder, and was understood as a genetic disorder in 1934, long before the structure of DNA was known. PKU results from a defective enzyme that produces abnormal metabolites that are toxic to the brain. Several other genetic metabolic disorders have since been found that are also associated with autistic behaviors (e.g. adenylosuccinase deficiency).

What loci in the brain are affected in these genetic disorders? This is the question to ask. I will continue to propose the auditory system as a "final common pathway" in the brain, until someone can provide evidence to the contrary.

Genetics is interesting. If not obsessed with autism, I might have picked a topic in nucleic acid biochemistry for my doctoral dissertation. Then my focus would have been sub-microscopic mechanisms for transcription of DNA segments to messenger- and transport RNAs, and mitochondrial DNA and electron transport enzymes of aerobic metabolism would have been most interesting.

References on request, or look around on my website, conradsimon.org.

Becky H-A

Per Tara
"However, when ONE twin has a diagnosis of autism, the other is over 90% likely to be somewhere on the autism spectrum. That's NINETY percent - higher than for almost any other disorder."

Heart disease, cancer, even schizophrenia all occur a lot later in life than autism, which usually manifests itself in the first 3 years (well, my son didn't regress until after his 4th mercury flu shot at 3yr 2mo, but I digress). Identical twins sharing the womb and the pediatrician well baby visits and the nursery, and the same food source (mom or formula), etc have a much more controlled identical environment than identical twins who have grown to teenagers in different classrooms, with different friends, food likes, hobbies, sports, etc or to adults living in differnt locations with different professions.The fact that after years and lots of money they can't definitely find an autism snp, gene, profile associated with even 10% of autistics, yet identical twins share 90% correspondence for autism expression strongly suggest that early environmental exposures , and toxic burdens carried over from the mother, are at play and without these exposures there is not gene or mutation that would have made the twins autistic.

My guess is, the later an environmentally triggered disease typically manifests, the less concordance you will see between identical twins because their environments have changed.

I'm lucky my other twin is a girl, her estrogen (and low testostorne) probably played a role in not being so affected by the first flu I got while pregnant just 3 weeks before my twins were born, as well as their flu shots at age 1 and 3. While her genetic composition may make her less susceptible than her brother, her biochemistry certain had a lot to do with not joining the fate of her twin.

patrons99

"What Really is DNA?" by Paul Maher, MD, MPH on September 19, 2010.

http://healthjournalclub.blogspot.com/2010/12/what-really-is-dna.html

http://healthjournalclub.blogspot.com/2010/12/what-really-is-dna-part-ii.html#more

"There is of course still the 90% of DNA that does not code for proteins, we don't know what it does, if anything. So being not understood, scientists rather arrogantly term it, "junk DNA," leftover garbage from evolutionary dead-ends and random viral infections."

Paul Jaep

The Genetic Cause. Myth
Faulty genes in the population are apparent ..how genes are switched on and off how they interact is the key to health ..Infection very effectively highjacks the process.
please read my site , my research reveals that autism is an infectious disease..

http://www.yeast-candida-infections-uk.co.uk/autism-is-increasing-exponentially

L Land

Simply, Great!
Merry Christmas!

Tara Marshall

What's not mentioned, when they discuss heart disease, schizophrenia, and etc. as opposed to autism, is the identical twin studies. There are many. In heart disease and schizophrenia, identical twins have an only 30% rate of sharing the diagnosis.

However, when ONE twin has a diagnosis of autism, the other is over 90% likely to be somewhere on the autism spectrum. That's NINETY percent - higher than for almost any other disorder.

That said, there are identical twins where one is severely affected, unable to communicate, and in diapers... and the other has a mild case of Asperger's and is likely to grow up to be a computer engineer.

The research in this area has shown that when identical twins share more of their environment in the womb and beyond - such as when they share a placenta - they are more likely to be similar in functioning. If they don't share a placenta, they are more likely to be disimilar in functional level.

Autism is a matter of both genetics and environment. Actually do your reading.

patrons99

Searching for gene susceptibility factors in autism is a complete waste of time and money. Autism is not genetic. Autism is iatrogenic. The vaccine schedules are the susceptibility factor that we ALL share. Dietary deficiencies exacerbate our susceptibility.

It’s neither disease-causing germs nor medical genetics that cause disease. It’s our internal environment that causes disease. A dysfunctional, deficient, polluted, toxic environment, often referred to as “the terrain” - causes disease. The vaccine schedules act as a portal for disease. Increasingly, the vaccine schedules use the vaccinated public as vectors of disease.

“Synoptic Overview: Issues in Immunization Theory and Practice” by Raymond Obomsawin on November, 2009.

http://www.theoneclickgroup.co.uk/documents/vaccines/Synopsis%20of%20Immunization%20Issues-1.pdf

“The Center for Vaccine Research in Pittsburgh, Pennsylvania confirms that “Vaccine induced enhancement of infection and disease has been reported for a number of viral pathogens.” The production of antiviral antibodies can fail to inactivate infectivity and actually “enhance” the entry of certain viruses (including Coxsackie virus; Respiratory Syncytial virus; Rabies virus; Influenza A virus; Epstein -Barr virus and Herpes Simplex virus) into target cells and increase infectivity and worsen disease symptoms. Whether antibodies neutralize or worsen viral infection depends on a number of factors, including virus strain and dose, host cell–antibody combination, and the concentration and class of the antibody. Takada A. and Kawaoka Y.; Antibody-dependent enhancement of viral infection: molecular mechanisms and in vivo implications; Reviews in Medical Virology; No. 13; 2003; pp. 387-398. “

patrons99

Wonderful article! The authors conclude that it’s the environment that causes disease. Pasteur was wrong. The Terrain is everything! This is one more large crack in Pasteur’s Germ Theory, the foundation upon which so much of Western medicine is based, including vaccine "madness".

Lorene Amet

There is a growing concern within those using Genome Wide Association Studies (GWAS) to research various human diseases, that there is an insufficient characterization and understanding of the genetic changes that have been identified (reported for example cancer, various psychiatric conditions etc, http://www.wikigenes.org/e/pub/e/84.html).

The term of Post-GWAS has been coined to include further evaluations of the changes identified, whether they relate for example, to Single Nucleotide Polymorphism (SNP) or Copy Number Variant (CNV) , as we have seen reported unconvincingly in autism. It has been proposed that additional functional studies should be conducted with for example, the in vitro characterization of human tissues or the establishment of in vivo models of disease development. However, models are generally limited to study one variant at a time, and given that no consensus variant has been found in autism, this approach is not currently technically very feasible.

We must stress that a genetic change is not necessarily associated with any phenotype, that changes can take place anywhere, not solely within the gene but also in other, and sometimes very distant regions away from the gene being regulated (many of these regulatory domains have not been identified), that the changes can be tissue-specific and developmental-stage specific. Furthermore, there is a strong likelihood that most complex diseases involve several genes concomitantly. More importantly still, there are yet other changes that can affect the expression of genes that will not be identified through SNP or CNV analyses, e.g. promoter methylation, histone tail modification, altered expression of non-coding RNAs (that can associate with chromatin modifying complexes), as well as epigenetic; these processes respond to the action of environmental modifiers.

In my opinion, we do not currently have the resolution and technologies to search for gene susceptibility factors in autism. We should instead focus on identify suitable animal models and screen for the environmental factors that have the potential to tip the balance toward autism. Equally, studying in details, in vitro various affected tissues should be greatly informative. Monitoring behaviourally and molecularly the affected children during their development, whether or not they follow an intervention should also reveal a lot of very valuable information. These studies would require a lot less funding that the genetic research that has so far very inconclusively been conducted.

Bob Moffitt

Last paragraph of "Why Genes Explain Almost Nothing" ..

"While individual effort has a place, many positive lifestyle and social changes require the cooperation of the state. Nevertheless, most governments cooperate far more, for example, with their food industries than with those who wish to eat a healthy diet. The laying to rest of genetic determinism for disease, however, provides an opportunity to shift this cynical political calculus. It raises the stakes by confronting policy-makers as never before with the fact that they have every opportunity, through promoting food labeling, taxing junk food, or funding unbiased research, to help their electorates make enormously positive lifestyle choices. And, when their constituents realise that current policies are robbing every one of them of perhaps whole decades of healthy living, these citizens might start to apply the necessary political pressure."

While this paragraph speaks of "government" cooperating with "food industires" .. it could just as easily read of our "government cooperating with vaccine industries".

Hopefully, the day will SOON arrive when politicians will be held accountable by the electorate for having supported current vaccine policies that were eventually proven to have "robbed every one of them perhaps whole decades of healthy living".

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