What Would Woodward Do? An Autism Analogy.
James Ottar Grundvig Reviews Callous Disregard by Dr. Andrew Wakefield

"Test" for Autism Measuring Gut Microbes?

Gut-population-1233311 Read the full article in the UK's Telegraph. We ask the question, what is altering the "gut" microbes in these infants? And didn't a certain British doctor ask similar questions, relating autism with GI disease and lose his medical license? We hope this leads to more promising research into the brain/gut/autism connection.

Diagnosis of autism has always been difficult and often the condition remains unrecognised until too late for treatment to have a maximum effect.

But now researchers at Imperial College London have discovered a potential way of spotting the disorder in children as young as six months old.

That would mean that intensive behavioural and social treatment could begin before the disease has caused any permanent psychological damage.

Professor Jeremy Nicholson, the author of the study, said: "Children with autism have very unusual gut microbes which we can test for before the full blown symptoms of the disease come through.

"If that is the case then it might become a preventable disease." Read the full article in the UK's Telegraph.

Comments

Nick

NMDA Receptor - kynurenic acid - glutamatergic signaling

http://www.ncbi.nlm.nih.gov/pubmed/18655201

Nick

Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1−/− mice

http://journals.cambridge.org/action/displayAbstract;jsessionid=80E6F3C23AAC8ACC3A173EFB6DBA3EB4.tomcat1?fromPage=online&aid=7550432

http://en.wikipedia.org/wiki/Sensorimotor_rhythm

"It is an oscillatory idle rhythm of synchronized electromagnetic brain activity. It appears in spindles in recordings of EEG, MEG, and ECoG over the sensorimotor cortex. For most individuals, the frequency of the SMR is in the range of 12 to 15 Hz."
"Neurofeedback training can be used to gain control over the SMR activity. Neurofeedback practitioners believe - and have produced experimental evidence to back up their claims[3] - that this feedback enables the subject to learn the regulation of their own SMR. People with learning disabilities,[4] ADHD,[5] epilepsy,[6] and autism[7] may benefit from an increase in SMR activity via neurofeedback."

Nick

AJW?

http://bloodjournal.hematologylibrary.org/cgi/content/full/108/13/4118

http://jvi.asm.org/cgi/content/abstract/79/12/7768

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0F-484N5VV-3T&_user=10&_coverDate=07%2F31%2F1994&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1361847545&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=bb87fd55c54e244d0c9b6b131de1d774

Nick

More on the nicotinic acid/niacin connection and tryptophan.

http://moodinflame.eu/consortium/
"In the MOODINFLAME project, the research group will (1) carry out basic and translational in vitro (glial and neuronal cultures) and in vivo studies (gestational stress or prenatal stress in mice) on the immune system and tryptophan metabolism related pathophysiology; additionally, on new therapeutic and preventive approaches using inhibitors of enzymes of the tryptophan/kynurenine metabolism, (2) participate in the standardization of tryptophan pathway biomarker analyses and the validation of these markers in clinical and experimental samples, (3) participate in multicentre clinical data and sample collection for biomarker studies in the consortium, and (4) coordinate a phase II clinical study on anti-inflammatory cyclooxygenase-2 therapy. Our centre will collaborate also with other non-EU collaborators from the University of New South Wales, Australia and the University of Illinois, United States of America".

Kynurenine - http://en.wikipedia.org/wiki/Kynurenine
"L-Kynurenine [(S)-kynurenine] is a metabolite of the amino acid L-tryptophan used in the production of niacin."

Benedetta

Allison,
No, I did not notice that untill you pointed it out. I was too amazed that they came out with this GI stuff perion - on the heels of the GMC/Deer/Dr. Wakefield injustice stuff.

I thought that was the end of it all- science had spoken - and in Deer's words it is just
"con sa pay shon" in his British accent. and then Nick,jenny, and Burns made me have to do a little thinking which is a very useless thing for me to do. Never the less Nick thanks for the last link.

Nick

Benedetta,
You wrote:
"Clostridia is a bacteria found in the soil and the cause of tetanus."

There a number of strains of clostridia and while some are found in the soil they some are in the body. Tetanus is cause bu one particular starin of clostridia. If you are interested you might go thorugh the linked articles at the link below. The things they address are interelated from my viewpoint. They tie into the things that we are talking about here.

http://curemyth1.org/forum7/3525-2.html

Allison

Anyone else notice that they said they could start diagnosing as early as 6 months of age when the study used kids 3 -9 years of age? They are guessing they will find it at 6 months, all of the children tested were already diagnosed with autism. They could have developed the abnormalities later.

I know others have pointed out this, but the fact that they are not talking about treating the kids that are already sick with this knowledge, or early medical intervention, they are supposedly only using this information for early detection for behavioral therapy??HUH? Absurd!

Nick

Benedetta,
It may be that something is happening in the biochemistry that is producing the same effect as 3-Acetylpyridine. I does seem silly to think this could be produced in the body, but I don't rule anything out. Working from the extreme backwards sometimes helps me look at these things in what I feel is a more associative way.

Nick

My key board is losing some key function esp the "u". I can spell compound.

Nick

Jenny,
Your links are related to some of what I am talking about and very good, thanks. I have know about ketosis way before I started looking at Ramona's situation. She was and is not diabetic and was not actively limiting carbs when her breath had the odor. It may be that the meatbolic factors themselve simply made her have ketosis, but at the time with her clostridia and yeast problems I started wondering if there culd have been another channel for the ketone formation or at least this type of ordor on the breath. I had correlated her improvements with the clostridia and yeast reduction before I ahd any understanding as to why. Dr. Shaw's work gave insight into this, but had not, at least in 96-97, specified any explantion for how the chemicals effected could end up effecting the brain.
Ramona had/has an unusaual condition I believe which shares some of the biological problems that apparently effect some autistic children.Since Shaw found this compond in some autistics and schizophrenics I surmised that a compond synergistic effect altered her brain in just the way to make her the way she was. This link may not contain ino that has been esablished with a lot of clinical testing, but is bears out things that I saw in Ramona, althogh she was not just or even properly schizophrenic.

http://webcache.googleusercontent.com/search?q=cache:ZnSQXsw8ZukJ:findarticles.com/p/articles/mi_m0ISW/is_2001_April/ai_72297183/+acetone+odor+breath+autism&cd=26&hl=en&ct=clnk&gl=us

"Over the past 50 years, orthomolecular psychiatrists have identified four biochemical conditions that underlie schizophrenic behavior: very high blood histamine levels (histadelia), very low blood histamine levels (histapenia), excess urinary kryptopyrole (pyroluria), and cerebral allergies to foods, chemicals, or airborne substances. Each biotype is associated with a set of symptoms. Histadelia, for example, is linked to deep depression and suicidal compulsions while histapenia tends to manifest with paranoia and hallucinations. Pyroluria, which is an inherited tendency, tends to bring on depression, tension, and irritability. Physical symptoms include headaches, sensitivity to cold, and a sweet acetone breath and body odor. People who excrete excess kryptopyrole in their urine (and not all pyrolurics are schizophrenic) find that their symptoms increase when they are under stress. Kryptopyrole binds with B6 and then zinc, which depletes the body of these nutrients associated with stress resistance. Cerebral allergies, the fourth condition, tend to cause radical mood shifts, erratic thought processes, and fatigue. Other physical conditions such as blood sugar irregularities, heavy metal toxicity, endocrine and organic brain disorders, and candida can also produce schizophrenic-type symptoms. Neurotransmitter imbalances are also common. As Edelman points out, a person may suffer from several of these conditions at the same time."

Benedetta

Jenny that was helpful.
Thanks!

Jenny Allan

http://www.ncbi.nlm.nih.gov/pubmed/11339861

http://facta.junis.ni.ac.rs/mab/mab200603/mab200603-01.pdf
Two more research papers. The second one is extremely long and technical. I suggest just reading the section on the right hand side of page 128 beginning:-
‘Metabolic disturbances'
'Bacterial flora of fecal type in the small intestine results in metabolic disturbances, the most frequent of which are fat and B12 vitamin absorption
disturbances.’

Jenny Allan

Nick, Benedetta and others. I'm not sure if this has been highlighted before on this web site, but it seems to be quite relevant and is not too technical.

http://www.autismrecoverytreatment.com/autism-treatment-%E2%80%93-clostridia-regression/

Benedetta

Nick;
I looked at your 3 Acetylpyridine link it is interesting. But am unsure what it all meant. It interferes with B3 uptake in the body esp with those animals that are low on it to begin with??? The dogs with blacktongue died from it.

I looked up a little more on it. http://www.jbc.org/content/157/2/455.full.pdf

Mice given 3- Acetylpryridine that had low amounts of niacin developed red mouths --and a rash??? Maybe that is Kawasaki's??? and maybe I am too tired, and silly to be trying to make sense of it.

We all here would love to know what is messing up the krebs cycle. Dr. Wakefield says that B12 is high in autistic children's blood which indicates their guts absorb it but the cells are not.

Benedetta

Nick;
ketosis is a good thing for brain injuries. That is what the ancients did when they starved epileptics. That is what the Ketogenic diet back in the 30's did. That is what the modified Atkin's diet does today. After two years being in ketosis an epileptic could come off the diet and seizures would not come back. It was a cure for 39 Percent of the epileptics.

Your wife's eyes dilated - My daughter's eyes are dilated a lot. She had a psychotic episode the beginning of May. Oh, a surprise out of the blue! Yes, for mother's day she showed me she was a surgent and operated on her hand! We spent the night in the hospital and since she works as a psych nurse, she dignosed herself as bipolar. All the medical people are going along with it. She is on Lamcital a seizure medicine also for bipolar too.
So far I can get no one to listen to me that perhaps seeing a nuerologist might be a good idea!

I looked up all the nicotinic acid, niacin, nicotine. I think some research shows that niacin and nicotine are similiar molecules and the body will use nicotine in place of niacin. A lot of people with mental problems smoke. I am not sure if it is just always getting into trouble or if there is a need in the nicotine they crave, like replacing a need for B3 with a more reactive nicotine.
Clostridia is a bacteria found in the soil and the cause of tetanus. My husband had a seizure at age 28 after numerous tetanus shots and then suffered terrible muscle pain to this day when he received yet another tetanus shot at age 34. He is dignosed with acquired mitochondria disorder

I am sorry I cannot talk organic chemistry with you, I am too shallow.

ElizaCassandra

From "across the pond":- Nick, I don't have the necessary medical/scientific background to directly help you but ..... many ASD children come from families with strong medical histories of auto-immune disorders including diabetes where ketosis is involved (the production of ketones by the body). I was unable to breastfeed as I wished - my later NT son thrived on formula but his later ASD twin sister reacted badly, as in severe bowel colic two hours after every feed. Was this a significant precursor to her later diagnosis? (no answer expected). N.B. I still date her regression to within a month after her MMR when she lost many acquired abilities.

Nick

Autism Glutathione Levels Low In Some Autistics-Why?
Abstract
We have examined the integrity of J774 cell nitric oxide (NO) production and glutathione maintenance, whilst NADPH supply was compromised by inhibition of the pentose pathway with 6-aminonicotinamide. In resting cells 6-phosphogluconate accumulation began after 4 h and glutathione depletion after 24 h of 6-aminonicotinamide treatment. Cellular activation by lipopolysaccharide/interferon-λ decreased glutathione by ∼50% and synchronous 6-aminonicotinamide treatment exacerbated this to 31.2% of control (P<0.05). In activated cells production was inhibited by 60% with 6-aminonicotinamide (P<0.01), and superoxide production by 50% (P<0.01) in zymosan-activated cells. NADPH production via the pentose pathway is therefore important to sustain macrophage NO production whilst maintaining protective levels of glutathione.

http://linkinghub.elsevier.com/retrieve/pii/S0014579398009594

http://endo.endojournals.org/cgi/content/abstract/141/7/2429

http://en.wikipedia.org/wiki/Phosphoinositide_3-kinase

http://www.ncbi.nlm.nih.gov/pubmed/16439036

I am still trying to find out about 3-Acetylpyridine as it seems somehow related to the nicotinic acid and the acetone/ketone smell my wife's breath used to have.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196513/?page=1

Jenny Allan

Nick says:-
'it is deeply saddening to read all the demeaning and ignorant statements from those who are the "experts" and then the piling on from all the masses of lay people who are psychologically vested in venerating there pronouncements without any understanding on their own part of the research or the implications.'

I think we all know exactly who you are talking about Nick!! But hey! Give yourself some credit!! In this world there are NO 'experts' only a certain amount of expertise which amounts to nothing without experience. You and lots of others who post here are doing very well in giving the pseudo experts and snake oil salesmen and women a run for their money!!

Nick

Jenny Allan wrote:"Perhaps AT LAST our research scientists will be allowed to carry out some REAL researches into what ails our children and the causes."

Wouldn' it be wonderful if the great ability of the collective of science would get focused on these matters? I am so worn out from all of it. If what I continue to find were not so "fascinating" I would have stopped trying to understand more long ago and counted myself fortunate to have learned enough to deal with the problems without having a more detailed understanding of the disease states involved and the causes. But, it is deeply saddening to read all the demeaning and ignorant statements from those who are the "experts" and then the piling on from all the masses of lay people who are psychologically vested in venerating there pronouncements without any understanding on their own part of the research or the implications. I have been let know indirectly, but clearly that I am not "peer reviewed". If by chance you don't know how I why and how I began looking into all of this you could read the posts at the link below. The story I posted is mainly still fundementally what I see as involved in my wife, and related to other neurlogical based mental disease. I have a different view on a few points mentioned in the notebook foreword posted there, but I don't revise it as it could become confusing. One example is now I believe the pupil dilation is from the compounds related to the clostrida not the gluten peptides. I am now trying to see if 3-Acetylpyridine is somehow being produced from gut organisms.

http://curemyth1.org/forum7/3525.html

Jenny Allan

Nick- I am fascinated by what you say about clostridia in the gut. I am a hospital acquired Clostridium difficile survivor and have ended up with a bowel condition very similar to my 'Wakefield babe' Grandson. In common with him I have pain, discomfort and food and alcohol intolerances. We BOTH take the same prescribed laxatives!!

My searches also uncovered some research which indicated a link between clostridia in the ileum and B12 deficiency. There is a huge amount of further medical research required to increase our understanding about the dynamics of gut flora and metabolic interactions, in particular any cumulative neurological effects.

The above research appears to indicate the tacit acceptance of the medical establishment, previously in complete denial, that there IS a link between autism and bowel disorders. Perhaps AT LAST our research scientists will be allowed to carry out some REAL researches into what ails our children and the causes. Denials are NOT science!!

Nick

Benedetta,
It seems reasonable that many neurlogic problems overlap in aspects of causes and treatment. Your concept of an isomer that could target the problem may not be without some hope.

http://www.prnewswire.com/news-releases/envivo-initiates-phase-iib-alzheimers-disease-trial-for-evp-6124-93405394.html

Nick

Dan Burns and Nick;
What does this mean?
Does this mean that they are going to use nicotinic acid and tryptophan to make a isomer of B12 that can be absorbed by a person with acquired mitochondrial disorder?

Benedetta wrote:
"Or does this mean that we should scramble around and find more nicotitic acid and tryptophan supplements?

Something better happen soon or it is going to be too late for my family. I feel we are entering the end stage of two of my three. It seems my aspie is the most healthy right now????"

I suspect it will not be as simple as introducing a compond to fix the problem. It takes time to reverse some of the dysregulation that has happened in a persons system. In addition, I hope I am wrong here, but there are certain types of damgage to receptors that supposedly make it hard t6o return to normal function.
I can not answer if there is a substance that will provide substantial improvement quikly. I do think that there are certain bacteria and viruses causing a great deal of the problem esp Clostridia. Candida's involvement is being underappreciated and dismissed as an opportunistic infection. B12 may help , but clearly is not a cure even with supplementing other amino acids or vitamins. My experience is you have to hit a number of fronts overtime to reverse the problems in many of those ammenable to biomedical treatment. Some have responded quickly though from what I have read. I am going to see if I can understand any new ways to approach the problem this nicotinic/acetylcholine avenue may reveal. As it stands it only points out what many of us have known about the gut issues and ecology. Sorry I don't have more to offer, but the apporach I took with my wife has done wonder though she still has inflamatory issues form certain bacteria and likely viruses. I am glad to say that we, that is my wife and I, are trying a new approach to try to deal with these remaing issues.

Schoolteacher in NYC

Apparently the new unspoken message from the medical establishment is that scientists are free to rip off the work of Wakefield et. al. and come to the same conclusions provided they don't mention the MMR, and they can have all the credit, glory and profits.

It is too late for them to whitewash history. The internet will insure that the real story is out there and that the right man gets his due.

Benedetta

Dan Burns and Nick;
What does this mean?
Does this mean that they are going to use nicotinic acid and tryptophan to make a isomer of B12 that can be absorbed by a person with acquired mitochondrial disorder?

Or does this mean that we should scramble around and find more nicotitic acid and tryptophan supplements?

Something better happen soon or it is going to be too late for my family. I feel we are entering the end stage of two of my three. It seems my aspie is the most healthy right now????

A Friend


Others have pointed it out but I was just rolling on the floor after reading the beginning of this article. A few sentences into the article:

"They have found that children with autism spectrum disorder (ASD) also suffer from disorders in their gut and that this can be detected with a simple urine test.

That would mean that intensive behavioural and social treatment could begin before the disease has caused any permanent psychological damage".

So, they go from children have disorders in their gut that can be detected with a urine test (clearly a medical concern)... to, send in the behavioral and social treatment experts.... OMG... No wonder we are in such bad shape.

Dan E. Burns

The abtract: "Autism is an early onset developmental disorder with a severe life-long impact on behavior and social functioning that has associated metabolic abnormalities. The urinary metabolic phenotypes of individuals (age range=3−9 years old) diagnosed with autism using the DSM-IV-TR criteria (n = 39; male = 35; female = 4), together with their nonautistic siblings (n = 28; male = 14; female = 14) and age-matched healthy volunteers (n = 34, male = 17; female = 17) have been characterized for the first time using 1H NMR spectroscopy and pattern recognition methods. Novel findings associated with alterations in nicotinic acid metabolism within autistic individuals showing increased urinary excretion of N-methyl-2-pyridone-5-carboxamide, N-methyl nicotinic acid, and N-methyl nicotinamide indicate a perturbation in the tryptophan−nicotinic acid metabolic pathway. Multivariate statistical analysis indicated urinary patterns of the free amino acids, glutamate and taurine were significantly different between groups with the autistic children showing higher levels of urinary taurine and a lower level of urinary glutamate, indicating perturbation in sulfur and amino acid metabolism in these children. Additionally, metabolic phenotype (metabotype) differences were observed between autistic and control children, which were associated with perturbations in the relative patterns of urinary mammalian-microbial cometabolites including dimethylamine, hippurate, and phenyacetylglutamine. These biochemical changes are consistent with some of the known abnormalities of gut microbiota found in autistic individuals and the associated gastrointestinal dysfunction and may be of value in monitoring the success of therapeutic interventions." See the full article at http://pubs.acs.org/doi/abs/10.1021/pr901188e

Jenny Allan

Absolutely Amanda!! This was one of Wakefield's findings. Professor O'Leary, in Ireland identified this as vaccine derived measles virus using DNA markers.
For me one of the saddest and most evil days in medicine was watching a very frightened O'Leary being interviewed in a very hostile manner on TV. His research, like Wakefield's was later 'discredited'. The GMC's 'show trial' of Wakefield et al attempted to make out that the biopsy samples from the children, used for this research, was obtained 'unethically' although colonoscopies and lumber punctures are normal clinical procedures, necessary to diagnose gut lesions and abnormalities or meningitis infections.

Amanda Blinn

Could one of the gut microbes be LIVE MEASLES?

jen

I'm with you Cynthia, why is the Imperial College in London not standing up for Wakefield?? The GMC will have to be eating their words in a matter of weeks. I can't believe the crap they put him through and yet garbage autism prevalence studies such as Fombonnes' and Thorsens' get the green light. It is infuriating and such a double standard!! What a joke.

jen

just came back from the vet to get our dog's bordatella vaccine and expressed my concerns re. too many vaccinations and the vet blew me away by saying that they have now gone to spacing out the shots more than in the recent past. She flat out said she feels they had been overdoing it. Even in her own practice from 10 years ago she preferred a more conservative approach to this current "throw everything at them, they'll be fine (and if they're not that's o.k. too)" approach. I told her I wish the peds would also be acting more cautiously. I can dream...

Cynthia Cournoyer

Um. I think I've just entered the twighlight zone!

So Dr. Wakefield looked at autistic children and saw GI disorders, got his article retracted and stripped of his medical license.

OK ..... So the Imperial College London says, "They have found that children with autism spectrum disorder (ASD) also suffer from disorders in their gut."

OK ...... So Dr. Wakefield said that, gee we should study this further, and then Imperial College London says "We recognize that more work needs to be carried out in this area."

I feel really weird right now, do you?

Jeff C.

This is almost like having a time machine. Things we all have long known to be true from our own observations and studying the DAN protocol are trumpeted in the media years later as revelations. If only my son’s OAT and stool samples gave me future Super Bowl winners and stock picks it might make his treatment more affordable.

I’m grateful the truth is getting out, but also angry as I’m sure the hard work of ARI, Dr. Wakefield, and our DAN doctors will be swept completely under the rug. Following that will be patents by the pharmaceutical industry and required prescriptions for items we now easily access as supplements. We need to mobilize to ensure that doesn’t happen.

Kristina

I wish I had known about probiotics when my youngest was a baby. She had diarrhea, colic, and speech delay. She was never vaccinated, not even hepatitis B, never had antibiotics, Tylenol, or any medication. I didn't have any amalgam fillings, and never ate fish. She was exclusively breastfed. Years later, I found out she had been born with Lyme disease, and the diarrhea and speech delay and colic began to make sense. I know she would have been autistic if I had vaccinated her, so I will always be grateful to the strangers on the internet who first got me researching vaccines.

Because her body was not assaulted with anything other than Lyme, she was able to grow out of her speech delay on her own, and was totally caught up by age 3 1/2, before we discovered the gestational Lyme disease. We got her tested after I found out I had it.

Nick

I meant to poit out a couple of things in the last post.
Scopolamine - "Physiology
Scopolamine acts as a competitive antagonist at muscarinic acetylcholine receptors, specifically M1 receptors; it is thus classified as an anticholinergic, anti-muscarinic drug." Wiki

Pharmacology
Anticholinergics are classified according to the receptors that are affected:

"Antimuscarinic agents operate on the muscarinic acetylcholine receptors. The majority of anticholinergic drugs are antimuscarinics.
Antinicotinic agents operate on the nicotinic acetylcholine receptors. The majority of these are non-depolarising skeletal muscle relaxants for surgical use, along with a few of the depolarising agents and drugs of other categories structurally related to curare." wiki

Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction . Being ionotropic receptors, nAChRs are directly linked to an ion channel and do not make use of a second messenger as metabotropic receptors do.[1]

Like the other type of acetylcholine receptors - muscarinic acetylcholine receptors (mAChRs) - the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). However, whereas muscarinic receptors are also activated by muscarine, nicotinic receptors are also opened by nicotine. Hence, the name "nicotinic".

Nick

I wish I had an intricate understanding of chemistry/biochemistry. Specifically I would like to know the funtional difference in the body of similarly named chemicals. I am trying to learn what differs between
S)-3-hydroxy-2-phenyl-propionic acid, found in Scopolamine, and 3-(3-hydroxyphenyl)-3-hydroxypropionic acid found by Shaw in the urine of patients with autism and schizophrenia. I am suspecting that the improper breakdown of gluten and casien that is proposed to end up as opiate type peptides in the blood of some with autism and other neurological conditions and mixed with 3-(3-hydroxyphenyl)-3-hydroxypropionic acid ends up producing the type of effect produced by Scopolamine and morphine given to women in childbirth years ago. Imagine a continuous, but possibly varying, influx of this chemical and these peptides from the gut along with the immune/inflamatory brain problems{cytokines} and the feedback involved in the nervous and immunochemistry of those with these conditions. Then consider all the immune, metabolic, and endocrine disruption in varying degrees. The 3-(3-hydroxyphenyl)-3-hydroxypropionic acid might be present in those in the very first months of life and present with autism earliest due to the gut bacteria and other who regress may have this conditon subclinically and then escalted into a pathological state by the triggers or mixtures of triggers of vaccination, other infection, druges{esp. tylenol at vaccination} and the commencment of ingestion cows gluten/many grains esp. wheat and cows milk/dairy. The regressive types are more likely to have the dietary problems. The chronic digestive/gut problems have now taken hold for many.
Others may possibly have the bacterial out put of the chemical that produces nurological anf biochemical effects without the problematic got of dietary issues. The bacteria in these people may produce moe of the chemcal without the peptides in the blood or immune/inflamatory effects. The would acount for those who say diet helped or did not or why candida proliferates or does not.

Scopolamine - http://en.wikipedia.org/wiki/Scopolamine
"Ophthalmic
The drug is used in eye drops to induce mydriasis (pupillary dilation) and cycloplegia (paralysis of the eye focusing muscle), primarily in the treatment of eye disorders that benefit from its prolonged effect, e.g. uveitis, iritis, iridocyclitis, etc.

Memory research
Because of its anticholinergic effects, scopolamine has been shown to prevent the activation of medial temporal lobe structures for novel stimuli during spatial memory tasks.

It has also been shown to impair memory in humans to mimic the cognitive deficits found in Alzheimer's Dementia."

Shaw - Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia.

http://www.ncbi.nlm.nih.gov/pubmed/20423563

Benedetta

Deb;
No colic was not mentioned in the article, you are right. But in my mind gut microbes, gut, infant all add up to colic.

If you ever had an infant with colic there is no doubt (well in my mind anyway) that it is the gut that hurts them. They cry and cry and cry no matter what you do. They draw up their legs againest their chest. They shake with pain or at least I think so. If you hold them a certain way with their belly up againest you they hush for a little while. They sleep better if you prop them up in a carrier (almost like acid reflux problem). The ped gave us a stomach medicine called Bental - a stomach medicine and it did work but since he was so little they gave this sparingly.Probiotics???? i doubt my kids peds knew there was any other microbe except things like strep, and stuff the vaccines took care of.

Every watch that show that comes on every once in a while about Tippman "Brain man"
his mother said he had really bad colic - it is funny to hear her tell about it. Then he had a big bad seizure. No mention of a vaccine and I often wondered if they left out that part in the show.

Mary

And just how is "behavorial and social therapy" supposed to help with a medical illness that has its roots in the gut? It seems to me that, as always, the powers that be are doing everything they can to avoid classifying autism as a medical illness amenable to treatment. Can you imagine "behavorial and social therapy" for diabetes? Asthma? Biochemical markers mandate a biomedical approach. Probiotics make a lot more sense here than ABA.

Adriana

I can't help worrying that these researchers will be trying to raid what they *think* is Dr. Wakefield's tomb (they missed the memo that he's far from dead), all the better to start peddling bandaid pharmaceuticals to children with autism markers even earlier in infancy without ever acknowledging cause. Hopefully those who did this recent study are actually trying to keep a good idea alive and it was the press coverage the cuts out the contributions of the Lancet study team.

In any case, many of the industry-embedded researchers who've been seen attacking Dr. Wakefield in the press recently are on the pharma gravy train because of the enormous rise in inflammatory bowel disease and Crohn's among children and young adults especially. For example, Karel Geboes, a favorite Deer quotee, may be researching vaccine and bandaid anti-inflammatories for Crohn's for Scherring Plough, Abbott Labs and UCB Pharma; Tom MacDonald, also quoted in the recent Slate hit piece on Dr. Wakefield, may be investigating the use of protease for IBD for GSK. Ingvar Bjarnason said of Dr. Wakefield "once a crook, always a crook"-- but himself promoted Vioxx for IBD ( http://tinyurl.com/29wvqtn ).

In other words, more and more jackels have picked up the scent of IBD as a marketing opportunity. But I think the real answers are still going to come from the vaccine injury researchers.

ObjectiveAutismDad

This test could be very useful: take a large group of kids and test them every 3 months and see what changes after each round of vaccines.

Stagmom

The science is on the side of safety, despite the best attempts of THE OTHERS to use studies that have been massaged more often than Charlie Sheen....

Jack

Wow, the paper really tries to tie in all the high notes: oxidative stress, sulfur metabolism probelms (tylenol issues), gut dysbiosis (antibiotic use issues). They certainly seem to know what is going on. Hard to square this paper with the notion that "science has spoken" and we're just a bunch of whack-jobs.

THIS paper is what's going on in science, whether or not the media wants to take note.

Deb

Um, I must have missed a step, was colic mentioned in the article? I don't remember seeing "psychological damage" mentioned either? For us, my son didn't have colic, or apparent vaccine reactions and was diagnosed at age 2. Either way, we have gut issues. I hope this spurs further research and that they realize they may be looking at a subgroup rather than an entire population.

Christina S.

My daughter had colic for 4 mths or so and got better until her vaccines at 14 mths. old and 20-30 minutes later her pupils of her eyes dialated off and on and was acting nuerologically odd, she progressively got worse with her overall health, sick every month with either ear infections or sinus infections, antibiotics didn't seem to help much, was diagnosed with autism at 18 mths old.

Jenny Allan
we shall overcome

Benedetta,

My son had colic for the first couple months since he was born. We gave him probiotics and the colic went away in a couple days. One of those simple and safe cures no pediatrician knows or wants to know about.

SarahS

Our son had colic too, and reflux.
What I find interesting is if there is an actual lab test they can use to diagnose autism, does that not mean it will be reclassified as it should be - as a medical disease, rather than in the DSM? That would have huge implications for insurance provision of services too I would think, I mean, then it's on a par with other diseases such as crohns, cancer etc.

I do love the way they say they could provide services before developmental problems occur. Sure, in a perfect world we could, but how many people are having trouble getting services for their children now, years after damage has been done?
I just don't see there being enough provision or the mentality of the so-called medical profession to prevent damage, or even put in work now when the child is young enough to give them the best possible chance as an adult.

Mary

What a weirdly worded article. What is psychological damage? Is that brain damage from mercury?

What could be messing up their guts. Gee, I don't know - maybe MERCURY and ANTIBIOTICS. Throw in some tylenol and wham you made autism.

mlhall

Interesting, my oldest had colic and reactions to the DTAP (we stopped after these) and has Autism. My six month has not had any vaccine's or colic. He is the most easy going baby and yet we will have to wait to see how he does.

Benedetta

My sister born back in 1948 had colic and cried day and night. She did not have autism, she was above average, great fine motor skills, cheerleader.

However my son had colic for four long months. It was bad. Then he got over it and was just the most smiling pleasant baby. He walked at only nine monts old, said lots of words beginning at 6 months.
He was having problems with the DPT shot but it took three to give him a stroke.

I have heard that kids that have colic are more prone toward not just autism but also adverse reactions to vaccines.

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