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Autism One Announces Seizures Think Tank In May

Autism one THE AUTISM ONE 2009 CONFERENCE ANNOUNCES THE ELIAS TEMBENIS SEIZURES THINK TANK

Twenty of the world's leading minds come together in Chicago.

As the autism population ages, the incidence of seizures is increasingly reported.
Unfortunately, there is very little in the way of consensus as to causes or treatments. We know seizures present a danger. Elias Tembenis, who was recovering from autism, ultimately passed away while having a seizure. Autism One brings together leading experts to compare notes and research agendas, grow ideas, and find common ground that will provide paths and answers for parents on what treatments are best given each child’s unique biomedical background. Presentations and Q&A panel discussion for all conference attendees will follow on Sunday.

Among the participants at the think tank:

Rob Coben, PhD is the director and chief neuropsychologist of a private clinic in NY, which is also an affiliated research site with NYU's Brain Research Lab. Dr. Coben is board certified in EEG biofeedback and a diplomat of the QEEG Certification Board.

S. Hossein Fatemi, MD, PhD is a professor of psychiatry, adjunct professor of neuroscience, and adjunct professor of pharmacology. Dr. Fatemi authored GABAA Receptor Downregulation in Brains of Subjects with Autism and Expression of GABAB Receptors Is Altered in Brains  of Subjects with Autism.

Richard Frye, MD, PhD is an assistant professor, Department of Pediatrics, Division of Neurology, University of Texas-Houston Medical School. Dr. Frye completed his residency in pediatrics at the University of Miami, Jackson Memorial Hospital, and his residency in neurology at Children's Hospital Boston.

Paul Hardy, MD is a board certified neurologist with subspecialty training in behavioral neurology/neuropsychiatry. He has held teaching appointments at Harvard Medical School and Tufts University School of Medicine. A particular interest for him has been the recognition, evaluation, and treatment of developmentally disabled individuals with occult subclinical seizures.

Jeffrey Lewine, PhD is the executive director of the Alexian Brothers Center for Brain Research and the Illinois Magnetoencephalography Center. He received his doctorate in neuroscience from the University of Rochester where he was a member of the Center for Brain Research and the Center for Visual Science. At Los Alamos National Laboratory, he worked on the development of magnetoencephalography [MEG], then a new method for studying brain function.

Derrick MacFabe, MD is an assistant professor and director of the Kilee Patchell-Evans Autism Research Group, Departments of Psychology (Neuroscience) and Psychiatry (Division of Developmental Disabilities) at the Schulich School of Medicine and Dentistry, University of Western Ontario.

Jon Poling, MD, PhD is the medical director of the Athens Regional Medical Center Apheresis Unit, clinical assistant professor at the Medical College of Georgia, and a partner at Athens Neurological Associates. He is certified in MRI/CT interpretation by the American Society of Neuroimaging, is a diplomate of the American Association of Neuromuscular and Electrodiagnostic Medicine, and is board certified by the American Board of Psychiatry and Neurology.

Harry Schneider, MD is an associate research scientist, Functional MRI Research Center of Columbia University. He is in private practice at the Center for Medical and Brain Sciences in Plainview, NY.

Allan Sosin, MD is the founder and medical director of the Institute for Progressive Medicine. Dr. Sosin held the position of assistant medical director at The Institutes for the Achievement of Human Potential, a world-renowned facility for the treatment of brain injured children.

For extended bios and a complete listing of practitioners, please visit HERE.

Autism One thanks Prof. James Adams for moderating this event.

SUNDAY PRESENTATION SCHEDULE ON THIS TOPIC:

8:00 - 10:00 Dr. Paul Hardy; Dr. S.H. Fatemi; Dr. Allan Sosin
10:30-12:30 Dr. Richard Frye; Dr. Tappan Audhya; Dr. Derrick MacFabe
1:15 - 2:15 Dr. Rob Coben; Dr. Jeffrey Lewine
2:15 - 3:00 Panel Q & A 

For a complete main conference schedule, please visit http://www.autismone.org/schedules

Lee Silsby logo 09

The Treatment category is sponsored by Lee Silsby, the leader in quality compounded medications for autism.

Comments

Tom

This sounds very similar to what I had:(copy)

(
HOFFMAN, THOMAS P. RM.2l9 1329950 Jack Resnick,M.D.
Jack Strobel,M.D.
J. Fangman,M.D.

This is the 1st North Memorial Hospital admission for this 1 year old white male who was well until early this morning when he developed a fever and was given aspirin. He appeared to be well until 6:45 p.m., when he developed a left sided seizure and was rushed to the emergency room. He had some evidence of apnea and status epilepticus, was treated with IV Valium 1.5 mg. and had a temperature of 104. His seizures seem to be controlled on this medication, and he was brought to the floor. P

Past medical history revea1s measles, mumps, ruebella innoculations, 8 days prior to admission. There is no previous medical history of trauma, etc. He has had bilateral inguinal herniorrhaphy repairs at age 4 months. The patient'8 family history is important that the mother is on 4 anticonvulsant medications for seizure disorder.

Physical examination in the emergency room revealed tonic clonic movements of his left upper and lower extremities with twitching of his left side of this face and head.
He was thought to have a bulging fontanelle and a questionable stiff neck. Upon arrival
to the floor, I examined him and he had a perfectly normal physical examiuation except
for the neurological findings which was as follows; He had a full but not bulging
anterior fontanelle with a systolic bruit easily heard over tbe anterior fontanelle.
The sutures appeared normal. Be had a left sided hemiparesis which is probably
postictal and evidence of hyperreflexia of his left sided extremities. There were no evidence of upgoing toe signs. Be had deviation of both eyes to the right with
horizontal nystagmus to the right , and appeared to be having continual mild seizure
activity. A spinal fluid was performed which revealed crystallclear fluid and was sent
for the usual studies. IV was started and he was given IV Phenobarbitol and IV Ampicillin in case this should be a bacterial infection.
Impression; Most likely a viral encephalitis or a febrile convulsion. It is very possible that this child does have a post vaccination measles encephalitis, and if his spinal fluid shows cells, this should be studied carefully by sending cells and serum for viral studies to the state broad for measles.

Signed.
Jack Resn1ck,M.D./NMH/ms/7-16-73
..
Dr John Fangman
cc: Dr Muske

THOMAS P HOFFMAN '329950

DISCHARGE SUMMARY

ADMISSION
DISCHARGE
7/15/73
7/19/73
This one year old boy was admitted NMH on 7/15 and discharged on 7/19/73. He had been In good health until shortly before he was admitted when he was noted to have a fever and this was initially treated with aspirin. About two hours prior to admission, he developed a left sided seizure and was brought to the ER where he was then status epllepticus and he was given Valium 1.S mg. I. V. His temperature at that time was 104degrees, but had no further seizures with intravenous Valium.

Past history is summarized in admission note.

His initial laboratory studies included a hemoglobin of 11.3, white count of 9,8OO, 38 PMN'S and 60 lymphs. His Urinalysis was negative. He had 205 white cells in the spinal fluid. His spinal fluid protein was 26, his sugar 101. Spinal fluid culture
was sterile. His calcium was 8.5 and his BUN 187, but I. V. was running at that time.

Hospital course: There was rather progressive improvement with an immediate
post seizure Todd's hemiparesis, but this cleared 12 hours after admission. He was
quite irritable and fussy, but neurological examination did not reveal any focal findings.
His development, however, appeared to be somewhat delayed for his age. He is now
presently functioning around the 9-10 month level, his chronological age being 14 1/2
months.

The patient had an EEG and skull films. Skull films wer. normal. The EEG revealed
only some background changes with the background pattern being slower than one would expect for his age. This, however, may have been influenced somewhat by his previous
seizure 48 hours previously. He will be discharged on Phenobarbital because of the focal nature of the seizure, rather than a simple febrile seizure. He will be seen in two weeks for follow up examination and evaluation.

Signed,
John J Fangman,MD/NMH/CK/7-19-73

If It Smells Like ProQuad....

According to the Ohio Department of Health vaccine preventable diseases statistics, during 2006 there was a 434% increase in cases of Varicella seen that year over the previous four years combined then averaged.

From the year 2005 to 2006 Ohio Varicella cases climbed from 2021 to 8859 for a 339% increase.

The most likely difference in numbers relates to the introduction of Proquad, or infamously diabolical MMRV vaccine.

Dan Olmsted pointed out this vaccine carries ten times the quantity of live Varicella sealed for the prevention of spread in single disease vials.

Dr. Jon "I'd vaccine Hannah all over again, you bet" Poling will certainly consider his own child began her seizures in 2006?

Seizures and Proquad
http://www.fda.gov/cber/label/proquadLBinfo.htm

This is how Dr. Offit works. He claims to be the vaccine industry spokesperson, but when Merck biologics products act like good old fashioned infernal machines and blow up in his face he becomes Mr. Invisible.

Harold L Doherty

Thanks to Age of Autism for highlighting this important conference and thanks to Autism One for setting it up.

My son with autistic disorder has displayed seizure behavior and it is an issue that does not get enough attention.

passionlessDrone

Hello friends -

Our children are particarly predisposed to having seizures as a result of the upregulated generation of TNF-alpha in comparison to children without a diagnosis.

Take a look at this study, which is available in its entirity online:

Postnatal Inflammation Increases Seizure Susceptibility in Adult Rats

From the discussion section:

The most exciting finding of the present study is that a mild inflammatory response evoked by LPS during a critical period of development causes a long-lasting increase in hippocampal excitability in vitro, and enhanced seizure susceptibility to the convulsants LI-PILO, KA, and PTZ in vivo. The latter effect was observed over a range of mildly inflammatory doses of LPS and was only evident if administered during the second postnatal week (P7 and P14), and not before (P1) or after (P20) this time. Importantly, inactivation of the proinflammatory cytokine TNF with an intracerebroventricular TNF antibody blocked the long-term changes to seizure susceptibility induced by LPS, whereas intracerebroventricular administration of rrTNF alone mimicked the effect of LPS on seizure susceptibility. These novel results indicate that a single transient inflammatory episode during development can modify the brain through a TNF-dependant mechanism, making it more susceptible to generate seizures in adulthood.

Can anyone think of a way that our children have been having more single transiet inflammatory episodes during development than they used to a decade or two ago?

In any case, the key here is that our children have been shown again and again to generate exaggerated TNF-alpha responses in response to a variety of stimulants. For more, check out:

Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder.

Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders

Activation of the inflammatory response system in autism.

We also have two studies showing increased levels of tnf-alpha in the cns or brain of children with autism.

- pD

Seizures mom

There's no way I can make it to this, but I would love to be able to watch this somewhere later.

Jeanne

This is great news! Thanks for the heads-up!

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