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Science Summary: Paradigm Shift in Chemical Risk Assessment of Mercurial Compounds

Science post imageDose-response analysis indicating time-dependent neurotoxicity caused by organic and inorganic mercury-Implications for toxic effects in the developing brain.

Pletz J, et al. Toxicology. 2016.

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Abstract

A latency period preceding neurotoxicity is a common characteristic in the dose-response relationship induced by organic mercury. Latency periods have typically been observed with genotoxicants in carcinogenesis, with cancer being manifested a long time after the initiating event. These observations indicate that even a very small dose may cause extensive adverse effects later in life, so the toxicity of the genotoxic compound is dose and time-dependent. In children, methylmercury exposure during pregnancy (in utero) has been associated with delays in reaching developmental milestones (e.g., age at first walking) and decreases in intelligence, increasing in severity with increasing exposure. Ethylmercury exposure from thimerosal in some vaccines has been associated, in some studies, with autism and other neurological disorders in children. In this paper, we have examined whether dose-response data from in vitro and in vivo organic mercury toxicity studies fit the Druckrey-Küpfmüller equation c·t(n)=constant (c=exposure concentration, t=latency period), first established for genotoxic carcinogens, and whether or not irreversible effects are enhanced by time of exposure (n≥ 1), or else toxic effects are dose-dependent while time has only minor influence on the adverse outcome (n<1). The mode of action underlying time-dependent toxicity is irreversible binding to critical receptors causing adverse and cumulative effects. The results indicate that the Druckrey-Küpfmüller equation describes well the dose-response characteristics of organic mercury induced neurotoxic effects. This amounts to a paradigm shift in chemical risk assessment of mercurial compounds and highlights that it is vital to perform toxicity testing geared to investigate time-dependent effects.

Copyright © 2016. Published by Elsevier Ireland Ltd.

PMID

 26945727 [PubMed - as supplied by publisher]

Comments

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Not Relevent

You can expect a more un-biased science from Journals of Toxicology and Chemistry. The medical Journals are too tainted with politics and personal ego.

Birgit Calhoun

Wouldn't it be nice if the powers that be actually paid attention to this study? How about it Mr. Ian?

Patience (Eileen Nicole) Simon

In PubMed lookup the two articles below. Full text is available for the first paper, and the abstract for the second describes loss of speech understanding. Damage in the auditory pathway has been described in other reports of mercury and lead exposure, as well as herbicides pesticides, cancer drugs, and poisons that disrupt aerobic metabolism.

Most important is to learn how the brain is affected, in autism and other neurological disorders. How the brain is damaged by vaccine components, and other causes of autism, must be demanded as the focus of research.

[1] Nierenberg DW, et al. Delayed cerebellar disease and death after accidental exposure to dimethylmercury. N Engl J Med. 1998 Jun 4;338(23):1672-6.
[2] Musiek FE, Hanlon DP. Neuroaudiological effects in a case of fatal dimethylmercury poisoning. Ear Hear. 1999 Jun;20(3):271-5.

Angus Files

If we don't think out of the mainstream pharma,consumerism box, were all cancer cases waiting to happen,stop the pharma vaccines,stop the body sprays,stop the food that looks like food but isn't real food...

MMR RIP

Birgit Calhoun

Not ethyl mercury but di-methyl mercury. The toxicity delay is very similar.

Birgit Calhoun

The only thing I can say is: daaa! But thank you for having found this! My further comment is that this particular phenomenon should have caused anyone who knows anything about mercury to un-grandfather ethyl mercury a long time ago. I have mentioned Karen Wetterhahn in the past. She died nearly a year after having been exposed to a couple of lethal drops of that chemical. That case was described in the New England Journal of Medicine a number of years ago.

Jenny

Yes yes yes yes yes yes yes!!!

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