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Autism and the Microbiome: Will Fecal Transplants Be the Next “AWAKENINGS?

MicrobiomeBy Teresa Conrick

Awakenings 
is a 1990 American drama film based on Oliver Sacks' 1973 memoir of the same title. It tells the true story of British neurologist Oliver Sacks, fictionalized as American Malcolm Sayer (portrayed by Robin Williams), who, in 1969, discovered beneficial effects of the drug L-Dopa. He administered it to catatonic patients who survived the 1917–28 epidemic of encephalitis lethargica. Leonard Lowe (played by Robert De Niro) and the rest of the patients were awakened after decades of catatonia and have to deal with a new life in a new time.

I have a very ill daughter who is diagnosed with AUTISM.  Megan also has a seizure disorder and an Awakeningsautoimmune diagnosis.  More and more research is pointing to the MICROBIOME as the key to health and disease. Since witnessing Megan regress into autism after vaccination, we have been on a journey to restore health and functioning to her brain and body, thus the similarity to Awakenings. I have gathered much research showing that both MERCURY   and VACCINES  can alter the MICROBIOME and that is a big concern with parents.

The studies on the microbiome are fascinating and may be showing us the potential of vastly IMPROVING symptoms and possibly even a CURE for those diagnosed with Autism. Now some of you may be asking why putting a disgusting thing like feces into someone would help in anything, but especially in Autism. Let’s look at what the research shows.

Altered Bacteria Shows Microbiome is Big Part of Autism

“Gut–brain link grabs neuroscientists - Idea that intestinal bacteria affect mental health gains ground.”

Similarly, a 2013 study from Mazmanian’s lab found that a mouse model with some features of autism had much lower levels of a common gut bacterium called Bacteroides fragilis than did normal mice3. The animals were also stressed, antisocial and had gastrointestinal symptoms often seen in autism. Feeding B. fragilis to the mice reversed the symptoms. The group also found that the mice with these symptoms had higher levels of a bacterial metabolite called 4-ethylphenylsulphate (4EPS) in their blood, and that injecting that chemical into normal mice caused the same behavioural problems.

Potential involvement of gut microbes in ASD  etiology has been speculated for more than a decade. Many pathogenic gram-negative bacteria contain lipopolysaccharide (LPS) in their cell walls, which can cause damage in various tissues including the brain [11]. LPS-induced inflammation in the brain increases permeability of the blood-brain barrier and facilitates an accumulation of high levels of mercury in cerebrum, which may aggravate ASD symptoms [6]. A test in rats showed that prenatal LPS exposure decreased levels of glutathione [12], which is an important antioxidant involved in heavy metal detoxification in the brain. The down-regulated synthesis of glutathione may increase the vulnerability of children to ASD and other neurologic disorders, such as Friedreich’s Ataxia [13]. Indeed, a recent pyrosequencing analysis showed that gram-negative bacteria, Desulfovibrio and Bacteroides vulgatus, were detected at higher levels in autistic children [14]. On the other hand, Clostridium, a gram positive bacterium, has also been widely studied in the context of ASD [15], [16] because it produces exotoxins and propionate. In a study on rats which was recently reported, propionate worsened ASD-like behavior [17]. In addition, Clostridium difficile produces p-cresol, which can cause depletion of glutathione [18]. Vancomycin and ampicillin, antibiotics targeting cell wall damage, significantly affect the physiology and structure of gut microbiota; especially on gram-positive bacteria such as Clostridium difficile [19]. One study showed that in a small scale clinical setting, vancomycin treatment resulted in temporary improvement of autistic symptoms in children with late-onset autism [20].

And more evidence of high levels of abnormal bacteria in Autism:            

Autism spectrum disorder (ASD) is a neurodevelopmental disorder where there is evidence of gastrointestinal (GI) disturbance in many affected individuals. Several studies have demonstrated an altered GI microbiota in children with ASD compared with controls [1-4]. Recently, Williams et al.[5] reported a significantly higher prevalence of Sutterella spp. in biopsies taken from the GI tract of ASD children with GI disturbance compared to controls with GI disturbance. Bacteria of the genus Sutterella have been identified in canine and human feces [6,7]. Sutterella wadsworthensis is noteworthy as it has been associated with some GI infections in humans [8]….. In summary, we show further evidence of changes in the gut microbiota of children with ASD, now demonstrating that fecal abundances of Sutterella and R. torques are altered…

“Studies implicate gut bacteria in autism” 

Autism, with its constellation of behavioral and cognitive symptoms, might seem to be all in the brain. But intriguing new studies suggest that some aspects of the disorder might originate in the gut.

For decades, doctors have heard anecdotal reports that children with autism have frequent gastrointestinal problems, suffering from bloating, abdominal pain, constipation, diarrhea and more.

The latest research, conducted over the past several years, probes the controversial possibility that whatever is amiss in the gut is not just a symptom of autism, but one of the causes. The work is an offshoot of mounting scientific interest in the human microbiome, the stew of bacteria that make their homes in our gastrointestinal tracts.

A new study, published 31 January in the Proceedings of the National Academy of Sciences, suggests that these microbial residents may direct brain development, ultimately shaping behavior1….A 2006 study revealed, for instance, that 70 percent of children with autism suffer from gastrointestinal problems, compared with only 28 percent of typically developing children2.

Armed with these findings, researchers began to explore whether changes in gut bacteria, rather than being mere symptoms of autism, contribute to the disorder. Anecdotal evidence suggested that might be the case — parents often reported that their children's behavior seemed to get worse when their gut symptoms were exacerbated.

………. The fecal biota of children with ASDs consistently contained different Clostridium species    than that of healthy children, as well as a statistically significant increase in clostridial species overall. The siblings of the children with ASDs exhibited intermediate levels of Clostridium species, suggesting that environmental factors and genetics may affect gut populations of these species. The researchers point out that Clostridium species produce not only enterotoxins that lead to GI problems but also neurotoxins, which they hypothesize could lead to characteristic signs of ASDs.

FMT for Non-GI Disease Encouraged by the amazing success of FMT in treating GI illness   - there is new research being done on treating non-GI diseases as well. Encouraging results have been reported in treating chronic fatigue syndrome, obesity, autism, and autoimmune diseases with FMT.

Improving the Microbiome Decreases Disease - What About Autism?

The research has been extremely positive concerning HUGE changes in the microbiome when Clostridium Difficile (C. diff.) has been treated via Fecal Transplant.  Since Autism has a significant connection to numerous and abnormally high bacteria, including Clostridia, Fecal Transplants are on the radar:

•  “Gut Feelings: Why Fecal Transplants are Gaining Ground

 Disrupting the bodies’ internal ecosystem may do more than create a hospitable environment for C. diff. As scientists look more closely at microbiome management, hopes are high that the cure for all sorts of chronic conditions—even depression, obesity, and autism—might be tied to improving the health of our gut with a substance we are taught from childhood to shun in polite conversation. Studies are beginning to show benefits in the management of other incurable inflammatory bowel diseases such as colitis and Crohn’s disease. Positive results have also been observed in the treatment of diabetes. “There are many conditions that will likely benefit from fecal transplant,” says Sonia Michail, a pediatric gastroenterologist.

•  Medicine’s Dirty Secret: Fecal Transplants Are the Next Big Thing in Health Care”  

At least a dozen trials are now investigating whether fecal transplants can help treat some form of inflammatory bowel disease, be it Crohn’s disease or ulcerative colitis. Another is looking into Type 2 diabetes, and one is even using lean donors to test fecal transplants on patients with metabolic syndrome. Researchers say it won’t be long before they’re joined by studies investigating whether the therapy might aid diseases like multiple sclerosis and autism.

•  “Fecal transplants dramatically improve C. difficile in kids” 

"But with ongoing inflammatory conditions, you have to do the transplant more frequently for more-modest results. There is also tremendous interest in fecal microbiota transplantation for obesity, about which we're excited but wary. We are also interested in treating abdominal symptoms in kids with autism.

•  “Fecal transplant policy and legislation”   World J Gastroenterol 2015 January 7; 21(1): 6-11

Substantial connections have also been identified between gastrointestinal health, gut microbiota, and certain neurodegenerative and neurodevelopmental disorders and those involving mood and thought[34]. The discussion surrounding autism is particularly interesting. A variety of observations linking autism to the gut microflora, such as disease onset often correlating with antimicrobial administration; increased levels of particular Clostridium species found in stool samples of autistic individuals; and the alleviation of autistic symptoms following oral vancomycin, have all supported the expansion of the traditional model of the brain-gut axis to a brain-gut-microbiota axis. Such data further allude to the vast therapeutic role of FMT (Fecal microbiota transplantation)  [34-36].

The Future – Factors to Consider, Hurdles, and Hope

•  Although standards are necessary with regard to any procedure, it is important to refrain from establishing excessive and disparate suggestions, which can have harmful consequences for patients. Guidelines are thought to be evidence-based, reliable, and precise -and therefore unbiased - but they are inherently biased in unique ways. Most guidelines are consensus reports, and as such, are influenced by authors’ convictions and their connections to external parties, including pharmaceuticals.   

•  They found the children with autism had different types of gut bacteria, and had less diversity in the numbers of different species of these bacteria, than kids without autism… The next step is to try and see if changing the populations of gut bacteria affects symptoms. “We will try fecal transplants to children with autism,” Kang said. “We will try to administer fecal material from healthy people to children with autism.”  That will require permission from several groups, including the Food and Drug Administration…….. 

•  Reduced microbiota diversity associated with C. difficile infection is reported in humans [49]-[51] and mice [52], [53]. This finding was confirmed in our study with multiple post-FMT samples collected up to one year after the procedure. Compared to healthy donors the fecal microbiota diversity of RCDI patients was reduced, as shown by rarefaction analysis of OTU counts (Fig. 2). Microbiota diversity increased significantly in post-FMT patient samples, as demonstrated by Shannon diversity index calculations… These results suggest that FMT restores the reduced microbiota diversity associated with RCDI. Furthermore, diversity increases immediately after FMT and remains stable over time.

•  HBOT [Hyperbaric Oxygen Therapy] has been used to decrease the amount of abnormal bacteria in the gut and therefore can function as an antibiotic [104]. In animal studies, HBOT was effective in reducing intestinal bacterial counts after bacteria overgrowth in the distal ileum associated with bile duct ligation [105]. It also shows bactericidal activity against many pathogenic bacteria, including Pseudomonas [106] Salmonella and Proteus, Staphylococcus [107], Mycobacterium tuberculosis [108], and anaerobic bacteria such as Clostridia [109]. Based on the fact that oxygen-dependent killing of Staphyloccus aureus by phagocytic leukocytes has been shown to increase by HBOT in animals [110], and that HBOT has also been shown to inhibit the growth of some yeast [111] and to possess virucidal activity against some enveloped viruses [112], HBOT might lead to an improvement in the dysbiosis found in some autistic patients by reducing counts of abnormal pathogens

•  Synthetic Poop Made in the Lab  Allen-Vercoe, who is a professor in Guelph's Department of Molecular and Cellular Biology, made her synthetic poop from purified intestinal bacteria grown in a piece of lab equipment that she and her team nicknamed the "Robo-gut".  Robo-gut essentially mimics the environment of the gut so as to produce a "super-probiotic" mix of the friendly bacteria that exist in the large intestine of healthy humans. For their proof of principle study, the researchers tested the synthetic stool on two patients with chronic C. difficile infections that were failing to respond to several rounds of antibiotics. Both patients were free of symptoms within three days of treatment, and both still tested negative for C. difficile six months later…. Allen-Vercoe hopes her synthetic poop idea can also be used to treat other gastrointestinal problems, such as inflammatory bowel disease, obesity and even autism by replacing abnormal gut microbial ecosystems with healthier versions.

•  “The Michael J. Fox Foundation For Parkinson’s Research - Gut Check on Parkinson’s: New Findings on Bacteria Levels, December 08, 2014” 

Filip Scheperjans, MD, PhD, and colleagues from the University of Helsinki, Finland examined the intestinal contents of 72 people with Parkinson’s and 72 without PD. Their research, funded by MJFF and published recently in Movement Disorders, revealed that people with Parkinson’s had lower levels of a certain bacterium and that concentrations of another bacterium varied among subgroups of those with PD with differing motor symptoms.

…..In Dr. Scheperjans’ study, the bacteria Prevotella was present at lower levels in the guts of people with Parkinson’s disease. This bacterium aids in the creation of the vitamins thiamine and folate and the maintenance of an intestinal barrier protecting against environmental toxins. This finding may therefore have implications not only for diagnosis but also for dietary adjustments or vitamin supplementation for management of PD in the future.

In people with Parkinson’s with more severe postural instability and gait difficulty, as opposed to tremor, the bacterium Enterobacteria was present at higher levels. The reasons for this association were not clear.

Studying Intestinal Bacteria Will Advance Understanding of Parkinson’s

Deciphering information from the gut could lead to earlier and more definitive diagnosis, a better understanding of how Parkinson’s progresses, and ways to separate the populations of people with differing symptoms of PD.

If researchers determine that there are specific and consistent differences in the gut, bacteria may serve as biomarkers — objective measurements to diagnose or track PD. As the gut is much more accessible than the brain and can be analyzed through stool samples, a bacterial biomarker is an attractive prospect. 

…..Additionally, we don’t know why people with Parkinson’s disease show such varied motor symptoms (gait problems versus tremor, for example) or who will get which. Bacterial differences may allow us to separate the subtypes of Parkinson’s… 

I added that last part about the Michael J. Fox Foundation as I find it pertinent and remarkable.  They are now also seeing the significance of the MICROBIOME in the development of Parkinson’s.  They are looking at bacteria and certain symptoms as their research showed it:

“Another interesting finding was that, within the PD group, abundance of Enterobacteriaceae bacteria was related to the severity of postural instability and gait difficulty (PIGD). So there was a connection between gut microbiota and the motor symptoms of our patients. Our study is the first to demonstrate alterations of microbiome composition in neurodegenerative disease. With respect to previous research it is interesting to note that reduced abundance of Prevotellaceae has been reported also in children with autism spectrum disorder and type 1 diabetes.”  

If Michael J. Fox wants to include anymore research on AUTISM, I am all for it as we need as much help as possible, plus I personally think his passion and commitment are incredible.  YEARS of wasted TIME and MONEY has kept the AUTISM EPIDEMIC rolling along. Looking at components of the microbiome as biomarkers of symptoms is brilliant and may help us see why Autism is a SPECTRUM. It may also help support the need for Fecal Transplants as well as prevention of Autism by promoting healthy microbiomes prenatally, and in infancy and childhood.

As far as hope –“ Unlike the genome, which is relatively fixed, a person's microbiome is changeable over a lifetime — and perhaps even daily.”   Also -“brain disorders, including anxiety, depression and autism, may be treated through the gut, which is a much easier target for drug delivery than the brain.” Well, that may be true and POOP may end up being the best “drug” of all.

Teresa Conrick is Contributing Editor for Age of Autism.

Comments

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kathy

Anyone know physicians familiar with FMT for kids with autism in Southern California? Anyone with experience having done FMT willing to share?

Joseph W. Motacek

Using a blender to prepare the sample is an outdated and faulty approach. After all, 90 % of the bacteria being transplanted are anaerobic, thus using a blender would kill most of them by incorporating air throughout the sample.

Proper screening of a donor should also include avoidance of any psychological issues.
Athletes tend to have more diverse microbiomes.

PSmom

Can we get anywhere.
All talk
autism could be cured with a series of FT, or corrective bacteria pills. This should be given at clinics & the pills should be at specialists offices by now. It is an inability for breakdown sugar into glucose, then the brain starves & we all know what causes that in the first place, but oh no, we can't say that!
When is anyone going to do something about it ...this conversation started 4 years ago. Autism out-numbers all other childhood diseases combined.....just talk talk talk
Age of Autism, AutismONE Why don't you actually do SOMETHING about this

peter

Just stumbled across a documentary about this on Dutch TV and it's quite plausible. I googled further and found this website, very little is known about this. I've heard bits here and there regarding the gut and autism and it makes sense but the relationship between brain and rest of body is looking to be much more integrated than we were taught. If you think about the brain being the first organ to get what you ingest after digestion and the bowel being the last part. There has to be more connections between the two than we were aware of.

Joseph W. Motacek


Hi,
I just wanted to share my success story using a home FMT to treat my IBS-D. You can read more about it here :
http://www.ibsgroup.org/forums/topic/243081-i-recently-fixed-my-ibs-d-its-gone/

I have read about the connection between Autism and the Human Microbiome. I have long suspected that an FMT would help to alleviate symptoms of Autism.

Special note : Dr. Glen Taylor of Taymount Clinic, Hartforshire, recently gave a patient with MS an FMT. He reports "the patient is now walking on his own, and with confidence". Very impressive in my opinion.

Benedetta

Wow Jenny - you are thinking light speeds and asking great questions.

Great questions!

Jenny

https://www.ncbi.nlm.nih.gov/pubmed/25046162

"Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota."

http://www.vitamindcouncil.org/blog/study-shows-daily-high-dose-supplementation-of-vitamin-d-improves-symptoms-associated-with-sickle-cell-disease/?mc_cid=9627bad00f&mc_eid=bc136d26f6
(sickle cell causing damage from oxygen problem)

Are heavy metals excreted through the gut changing the microbiome and decreasing oxygen levels in the gut and body, thereby further changing the diversity of the body's biome to one that no longer provides the nutrient bi-products that the body needs. Maybe food itself was never enough. And maybe the amount of food matters not as much as availability of certain bacteria in the gut to maximize the bioavailability of what foods go in. And how does the microbiome affect the capability of blood to carry oxygen to the rest of the body. How much oxygen does the newly found
brain lymph vessel system need to survive, if any? Does myelin use oxygen? Do heavy metals bind oxygen making it unavailable to bacteria that need it in the gut? Do heavy metals bind oxygen making it unavailable to the brain?

Benedetta

National Geographics had an article that were along the lines of gut microbiota. They were going in and looking at this tribe and a few others, plus studying the Inuit too.

They were of course focusing only on diet and trying to figure out what really did our ancestors eat, looking at these people

They decided that the primitive diet did not always have meat as the hunters were not always successful That the hunteres was only half of the hunters - gatherers -- taht the women gathered plenty of grains, berries, starchy tubers.

That it was not meat that caused our big brains but the fact that we cooked it and made nutrients more available. That microbes were mostly there because of what we decided to eat. And that our problem today was - nutrients were just too available by the way we process it

Sounds reasonable. Except they are missing so much of the equation.

Wrless1

I heard an NPR Science Friday report about a remote tribe in Brazil that had a more varied micro biome than in our Western Culture. It seems that they would have been the perfect source for fecal transplant material. But what this article doesn't mention, and what I heard in the radio report was that researchers are accessing this village by helicopter (the only means) and vaccinating this tribe. They didn't say that this tribe, who has been completely separated from the rest of civilization, is suffering from mumps, measles, whooping cough, and our other diseases. But in vaccinating them they are surely altering this fabulous micro biome.
http://www.npr.org/blogs/goatsandsoda/2015/04/21/400393756/how-modern-life-depletes-our-gut-microbes

Jenny

Here's one article I am just adoring right now. My mind is doing flips over it!

http://endomune.com/blog/probiotics-may-boost-the-benefits-of-the-flu-shot/

Is it possible to get rid of adjuvents in vaccines completely with a combo approach?

Also, here is a interesting comprehensive article on probiotics from Beth Israel Deaconess Medical, I found it under a Sickle Cell search I did. http://medicalcityhospital.com/your-health/condition_detail.dot?id=11561

Looks like the list of symptoms stemming from sickle cell are strangely familiar looking. All due to red blood cells not being able to carry oxygen around the body. Considering Elaine Nicole Simon's research into results of oxygen deprivation, and a post once on this site having to do with sticky blood in a child with autism (could that result in lack of oxygen being bio-available in the body), and how some of the autism biomed solutions could result in improved oxygen, and vaccines making people faint (gardesil & others) and bacteria being both aerobic and anaerobic, and how sickle cell is most common in the African American population, which also is most prone to damage from the MMR, I think the tie-ins are important somehow. Part of me wonders if an African American boy (boys have fluctuating testosterone levels during youth) with an allele for sickle cell may be at higher risk from damage from the MMR. And would parasites in the body decrease oxygen levels somehow, or use it for themselves to the body's detriment?

Benedetta

http://www.scientificamerican.com/article/among-trillions-of-microbes-in-the-gut-a-few-are-special/

Again the same article that talks about the importance of clostrida goes on to say that Clostrida - C diff loosens the intestinal barries, but the other clostridial clusters do just the opposite—they keep the gut barrier tight and healthy, and they soothe the immune system.

The article goes on to link lack of clostrida clusters to peanut allergies: Earlier this year Cathryn Nagler, an immunologist at the UNIVERSITY of Chicago, knocked out the clostridial bacteria with antibiotics and then fed the animals peanut protein. Without those microbes and their corresponding Tregs present, the protein leaked through the GUT barrier into circulation, prompting the rodent version of a food allergy. She could prevent the sensitization just by introducing those clostridial bacteria.

So, perhaps all along; a lot of this can be linked to the tetanus vaccine? That tying in the tetanus vaccine with the whooping cough toxoid made it even more potent?

In the end James Cherry, Colleen Boyle, Tom Insel and a host of others can just claim they had no idea even though so many wept and cried and told them. In the end it will be God and history will be left to judge them.

Benedetta

http://www.scientificamerican.com/article/mental-health-may-depend-on-creatures-in-the-gut/

Diet may soon be a treatment for mental illness.

Benedetta

What will they quiet it down with?

Perhaps a low carb/hig fat diet.

If you read the other article that was in Scientific America - about microbes and mental health they say that perhaps mental health will some day be treated by special diets.

Although there are plenty of pharma drugs out there that do quiet the immune system - all the heart burn meds for one - and I am pretty sure my son's seizure meds.

While it is probably shrinking his brain.

Speaking of such - in the third aritcle put out by Scientific American - it said that mice born germ free had reduced sized hearts - and other organs.

Jeannette Bishop

Benedetta,

Some are talking about rebooting or shutting down the immune system to restore gut health?!? (of course with no theorizing about the possible role of the most deliberate immune system manipulation we engage in)

Will they then tell patients who undergo this procedure that they need to take or retake all the infant/kiddie vaccines (making the current schedule sound like it's kid's stuff) ... like with some cancer therapies that involved wiping the immune system?

Teresa Conrick

Thanks, Benedetta.

It is key that we are on the path but it is still so new but YES-- this would be an idea that needs MUCH more research. The recipe is here-- somewhere.

"To overcome the inertia, Sonnenburg foresees treating the host and the microbiota simultaneously. The idea has not been tested, but he imagines clearing out the microbiota, perhaps with antibiotics, followed by immunosuppressants to quiet the patient's immune system and allow healing. Only then might the new community of microbes stick and successfully recalibrate THE IMMUNE SYSTEM.

Benedetta

http://www.scientificamerican.com/article/among-trillions-of-microbes-in-the-gut-a-few-are-special/

This article says scientists have found that there are speicial ones missing and they are part of the family of clostidium types

Tetanus or lock jaw is a type of clostridium.

But of course no mention of the vaccine - only we are not eating enough fiber and we are too clean.

But I am sorry: it also says:


Several years ago Max Nieuwdorp, a gastroenterologist at the Academic Medical Center in Amsterdam, transplanted microbes from lean donors to patients recently diagnosed with metabolic syndrome, a cluster of symptoms that often predicts type 2 DIABETES. The recipients saw improvements in insulin sensitivity and an enrichment of their microbiota, including among those clostridial species. But six months after the transplant the patients had relapsed, metabolic improvements had faded and their microbes had reverted to their original states.

To Sonnenburg, this outcome suggests that the dance between human host and microbial community has considerable momentum. Removing the “diseased” ecosystem and installing a new one may not overcome the inertia. The GUT immune system may simply mold the new community in the image of the old. That may explain why fecal transplants, which effectively vanquish C. difficile–associated diarrhea, have so far failed to treat inflammatory bowel disease. The former is caused by a single opportunist; the latter may be driven by an out-of-whack ecosystem and our response to the microbial derangement.

To overcome the inertia, Sonnenburg foresees treating the host and the microbiota simultaneously. The idea has not been tested, but he imagines clearing out the microbiota, perhaps with antibiotics, followed by immunosuppressants to quiet the patient's immune system and allow healing. Only then might the new community of microbes stick and successfully recalibrate THE IMMUNE SYSTEM.

______________________________

I hope that is what it is, and not that the tetanus shot has not only caused our immune system to watch out for lockjaw but also what we need to have good health.

Jill

Yes, where would you find a healthy donor? Very interesting. Thank you for the great information. Would love to hear on-going research or anecdotal experiences from anyone involved with this. Thank you again!

Benedetta

Autism Go Away;
Yeah, what would be a healthy donor. My Dad all his life seemed like a very healthy man if you looked at all he did - constant little work horse. But he had allergies . He may have been a healthy donor untill he had a bunch of flu shots.

He has the type of Parkinson that affects his gait and causes rigidity but not any shaking of his hands or head.

He was a cattle farmer and a factory worker. Nothing pleased him more than to save a calf if the cow got into distress. HE would put his arm up a cow to his shoulder, and turn a calf - so if anyone should have the right type of Prevotella which presents in low levels of those with Parkinson?? Maybe though he has high levels of Enterobacteria - which are Shigella, Salmonella, Eschericha coli, Klebsiella, shigella and Yersina pestis - is that last one the black death?

Teresa I worry we are going to get excited about this and find that our GI track has had iscemia damage from small blood vessels - I traced back what Michael J Fox Feed Blog said. There is plaque build up around the nerves of the GI track before the symptoms of Parkinson shows up - and then these plaques finally go to the brain.

Dr Wakefield said years ago that shortening the GI track caused certain microbes to grow and he seem to indicate there was nothing that could be done about it.

I so hope it can be changed - I am thrilled that the C diff fecal transplants is working so I should not be a Debbie Downer.

If we all lived close together we should all chip in and buy a HBOT. Get that oxygen to some of those enterobacteraceae whih is a large family of bugs.

Was there any one type of enterobacter they found, Yet?

ron@jgi

Very interesting ! The gut connection with autism. For all of you who suffer with serious gastro-intestinal health disorders of every level imaginable, I urge you to check out the work of Dr Frank Jackson at Jacksongi.com . The research on Prebiotics and how they are the key to maximizing your healthy gut efforts. Nothing could be easier to give your system the boost it needs. Really would be interested to hear about any research being done regarding autism and prebiotics, if any.

Becky Accetta

Martha, my son had a paralyzed bowel for many years. He could not even pass gas. He is in recovery with a near flat abdomen (not bloated anymore) and attends public school every day. Send me a friend request on FB if you would like my help. I would love to help your son.

AutismGoAway

Thank you for this article. Any studies or anecdotal evidence withASD kids? Success stories? How does one decide what constitutes a healthy donor? Also, why are all the good strains in your article not found in probiotics? WHy does the feces have to be done? Why can't they just isolate the bacteria and give those?

nhokkanen

Fascinating that one clinical trial "is even using lean donors to test fecal transplants on patients with metabolic syndrome."

Many of us likely saw the articles last month about a woman who became obese after receiving a fecal transplant from an overweight donor.

Who knows what the beneficial possibilities might be? Fighter pilots, skydivers and formula race car drivers might find themselves asked to donate....

Denise Anderstrom Douglass

Thank you for having the courage to publish this. I've been following the issue for a while, but this article has it all, and in language you don't have to necessarily have a medical degree of some kind to understand. My mother had Parkinson's; my grandson has Autism with bowel issues, one of my adult children has IBS. Thank you! I will be forwarding this article.

Martha

Well, I have a son age 41 with paralyzed bowels. He was making progress with training when younger but an institution stopped the training and caused him to have such a severe impaction his bowels never functioned again. The bowel muscles are paralyzed.
He just had an outburst and landed in the hospital and subsequently he had another impaction.

I hope we find out some answers. I wish the doctors could also learn from our adults and what happened to them. I hope we can stop people with IDD and autism from being so affected.

We have a method to help but small things like medication increases can make a big difference.

JP Sand

Apparently, written records show that fecal matter has been used in the treatment of disease throughout the history of medicine. In 4th century China, stool transplantation was used to treat food poisoning and diarrhea; in the 16th century, an influential herbalist named Li Shizhen treated abdominal diseases using remedies that contained fresh, dried, or fermented stool. In the 20th century, during World War II, German soldiers confirmed that a Bedouin remedy - the consumption of fresh camel dung - was an effective treatment for bacterial dysentery. Moreover, contemporary veterinary medicine still uses parallel processes, that date back to at least the 16th century, to treat disorders among ruminating (cut-chewing) animals: "transfaunation" involves the transfer of micro-organisms from the stomach of healthy donor animals to those of sick animals.

The National Institutes of Health established the Human Microbiome Project in 2008. Since then, the information base on human fecal matter transplants (FMT) has expanded considerably and it is good to see that this ancient procedure has finally received validation from the modern medical establishment. However, it would be highly unfortunate if this life-saving practice gets tied up in bureaucratic red tape and monopolized by corporate medical interests.

The public needs to be aware that there is ample current research from mainstream, peer-reviewed medical literature which assures us that FMT is a safe and simple procedure that can be done at home by any responsible lay person. Donor selection is a process that is best addressed by a commonsensical health assessment of the prospective donor who should be free of infectious diseases and chronic diseases including metabolic syndrome. Suffice to say, it has been shown that fecal transplantation DOES NOT require the services of medical personnel; nor does it require sophisticated equipment -- a standard blender appliance and an enema bag will suffice. Please see the following references for specific details.

1) News article from MedPage Today: "Endo Type: DIY Fecal Transplant" (http://www.medpagetoday.com/Endocrinology/GeneralEndocrinology/45141). This article has a link to a 30 minute YouTube video by Michael Hurst: "DIY Fecal Transplants to Cure Yourself of Digestive Disease" (https://www.youtube.com/watch?v=WEMnRC22oOs).

2) Research paper from the medical journal Clinical Gastroenterology and Hepatology: "Success of Self-Administered Home Fecal Transplantation for Chronic Clostridium Difficile Infection" (http://www.cghjournal.org/article/S1542-3565%2810%2900069-8/fulltext).

3) News article overview from Medical News Today: "Fecal Matters: Treating Infection with Stool Transplants" (http://www.medicalnewstoday.com/articles/289613.php).

Hope this helps. Best to all.

CD

Years ago I was lucky enough to hear Dr. Lawrence Brandt speak on fecal transplants for refractory C. Diff colitis patients. It was such a radical idea at the time. Now I regularly see patients seeking this therapy when conventional medicine fails them. However the regulatory process makes it difficult and expensive to perform, so many people resort to DIY transplants. The challenge is finding a healthy donor.
I also wish there would be more motivation to research transplants in children with autism and other autoimmune conditions. I'm so fascinated by the emerging research on the microbiome and I always enjoy your articles Teresa. Thank you for a fascinating read.

BTW if anyone is curious, here are the DIY instructions for transplant:
http://thepowerofpoop.com/epatients/fecal-transplant-instructions/

Who is William Thompson ?

The BBC (the Brainwash, Bribery & Corruption corporation)
ran an article on fecal transplants on their premier news show "Newsnight" just 2 weeks ago .
I couldnt believe - nearly fell off the chair .

Fecal Transplants are definitely going mainstream .

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