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Part 3--Regressive Autism---a New Hypothesis to End an Enigma?

Hypothesis
Read Part 1 and Part 2 of this series.                                                          

By Bill Welsh

“First of all they ignore you,
 then they ridicule you
 then they fight you
and then you win"

Ghandi.

It is important to remind readers that this series of articles is based on a ‘hypothesis’---a theory. It was made clear in the first episode that this is not a criticism of any earlier hypotheses. So please read the 3 episodes in as neutral a manner as you can, then discuss.

I will summarise the two previous articles and respond to some of the interesting points raised.

It is proposed that the role of auditory processing disruption should be given closer consideration as a material factor in the development of autistic symptoms. It is also proposed that a vaccine contaminant, namely Mycoplasma fermentans, an undesirable by- product of the cell-line technology used in some vaccine manufacturing processes, may be directly responsible for many of the symptoms commonly seen in regressive autistic children. This would include not only auditory processing problems but also chronic gastritis.  (It has been claimed elsewhere that 6% of commercial vaccines are contaminated). Mycoplasma’s opportunistic nature and affinity to the cilia, the hair like structures that extend from nearly all mammalian cells including the cilia containing areas of the inner ear, G.I tract, the eyes’ photoreceptors, and central nervous system would explain a great deal of what is articulated by parents when describing their child’s regression.

 Mycoplasma fermentans is a bacterial pathogen and if it were proved to be in the cells of regressive autistic children the source of the contamination would be difficult to disprove, in my (naive?) view.

In response:

To answer ‘Not an MD’: I mentioned herbal treatments and I can recommend the book “Healing Lyme Disease Co-infections” by Stephen Harrod Buhner. It contains comprehensive (but somewhat harrowing) information on mycoplasmas and includes a rather complex herbal treatment protocol. I have discussed my theory with the author and he says “This makes a lot of sense to me”.

If you start researching mycoplasmas you will find that most research has centred on Mycoplasma pneumonia because of its association with the respiratory system, we can learn from this.

 

I also mentioned there is a treatment currently in clinical development and I can confirm I have been in contact with the company involved. Trials are taking place in Australia, using sheep. I have been in touch with the lead scientist.

 No, I have not yet spoken to the sheep!

Important note: Mycoplasma is not visible to the naked eye, mycoplasma detection is difficult, sometimes impossible when using traditional microbiological techniques. Qualitative Polymerase Chain Reaction (PCR) is necessary to identify the presence of mycoplasma.

Mycoplasmas can also be very hard to culture in the laboratory and are often missed as pathogenic causes of diseases for this reason.

More in response:

To answer Sarah: It is the CATS study (California Autism Twins Study),   Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism. Arch Gen Psychiatry. Published online july 4, 2011. Doi:10.1001/archgenpsychiatry.2011.76

To answer Seonaid:  ‘Mycoplasma infection often results in middle ear infections’.

To answer Eindeker: my article contained the following; “Interestingly, a search of the literature on veterinary vaccines reveals the serious concern that pathogenic  mycoplasmas, specifically Mycoplasma Fermentans, have generated over many years which may highlight poor ‘quality control’ and a lack of sufficient care in the manufacturing process”.

To answer Jenny: Chronic gastritis can be caused by mycoplasma, in fact I noticed in the scientific literature that none other than Professor John Walker Smith has been a co-author of a prospective study on that very subject.

To answer Barbara and Kathy: It was not suggested that this is restricted to ‘one vaccine’. It was hypothesised that contamination by Mycoplasma Fermentans may be a feature of the cell line technology used in the vaccine manufacturing process.

The vaccine manufacturing process is convoluted and frankly a potentially unclean procedure. Any vaccine can become contaminated during the process but the prospect increases when the vaccine is a multiple vaccine. The likelihood increases further when the vaccine is a live virus vaccine, and even more so when the vaccine is a multiple live virus vaccine.  MMR is more likely to become contaminated than any other vaccine on the current UK childhood vaccine schedule, not just three times more likely, but many times more likely. (Hence the increase in autism?)

To answer Millie: You are quite correct. From your personal perspective this hypothesis is ‘garbage’. From the perspective of many others on the autism spectrum this hypothesis could be very significant.

To answer Greg: No, I am not saying vaccines are safe, but I am saying they would be safer without contamination with a bacterial pathogen.

To answer Carol: My litigation list is incomplete but at least 6 children had batch D1433. Autism and bowel problems the result.

With regard to the issue of ‘testing’ to establish whether or not Mycoplasma fermentans is present in a patient, (and to prove or disprove this hypothesis), that is more problematic.

In truth, this will require a properly conducted and funded research initiative. I am urgently exploring this aspect with others. A research project could be set up immediately by, say, a government body, but one danger is that the government body would have an interest in the outcome and may skew the results by for example testing the wrong children.

Nothing is ever straightforward where our children are concerned, is it?

I hope I have answered all the questions.

I am aware that pinpointing just one bacterial pathogen as the possible cause of regressive autism will seem simplistic to many but Mycoplasma fermentans ticks all the right boxes:

1) Associated with bowel disease.

2) Associated with problems of the auditory canal.

3) Difficult to detect.

4) Able to cross the blood/brain barrier.

5) Opportunistic.

6) Associated with vaccines. In fact I am hypothesising that it has actually been injected directly into the bloodstream of our children.

Bill Welsh.

Bill Welsh is the founder and former Honorary President of Autism Treatment Trust, Edinburgh, Scotland.

This abridged hypothesis outlines the putative involvement of the pathogen mycoplasma fermentans as a potential aetiological agent and that vaccination is one likely conduit for this covert pathogen and a cause of the symptoms commonly seen in regressive autistic children. It is an abbreviated version of the scientific paper: Mycoplasma Fermentans and deciliation as a precursor to Regressive Autism.(copyright Bill Welsh).

Comments

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Eindeker says (to Bill Welsh):-
"I'd respectfully suggest Bill that your hypothesis needs a little more fact rather than speculation"

With 'respect' Eindekker, hypotheses ARE mostly about 'speculation', usually based on observations. In order to 'prove' a hypothesis it is necessary to carry out carefully controlled research studies.

As Bill's response demonstrates, your troll like post seems designed to 'change the subject', diverting us to a load of unrelated stuff about antibiotic sensitivity. Bill's main hypothesis is about VACCINE CONTAMINATION possibly causing harm, including autism. Getting hard 'facts' about this is virtually impossible without the cooperation of world governments, the WHO, and the vaccine manufacturers.

I'm not holding my breath!!

Eindeker,
What is it about this excerpt from the hypothesis you do not understand
“Interestingly, a search of the literature on veterinary vaccines reveals the serious concern that pathogenic mycoplasmas, specifically Mycoplasma Fermentans, have generated over many years which may highlight poor ‘quality control’ and a lack of sufficient care in the manufacturing process”.
Bill

Bill that's just plain wrong about antibiotic sensitivity of M fermentans, there's several classes of antibiotic that this organism is sensitive to: macrolides, tetracyclines, etc etc http://jmm.sgmjournals.org/content/42/6/421.full.pdf These do not target the cell wall and so the organism remains sensitive, see also http://www.ncbi.nlm.nih.gov/pmc/articles/PMC192419/ and of course no vaccine is "injected directly into the bloodstream"
Mycoplasma spp are normal commensal organisms, they can become pathogens in immunocompromised situations eg AIDS http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/mycoplasma-spp-eng.php
I'd respectfully suggest Bill that your hypothesis needs a little more fact rather than speculation

Bill, thank you for the quote from Gandhi. Also, thank you again for pointing out infection as a cause of injury to the auditory system. Prenatal rubella infection has long been associated with auditory system defects. This needs to be better researched.

I continue to try to point out the vulnerability of the auditory system. Blood flow and metabolism are higher in nuclei of the brainstem auditory pathway than any other area of the brain (Sokoloff et al. J. Neurochem 1977; 28:897-916). This seems difficult to understand, but the auditory sense appears to have evolved as an alerting mechanism for visual attention. Beyond alerting, the auditory system has evolved as an active “information seeking system” (Angelo R. Otolaryngol Clin North Am. 1985;18:285-303). Language is at the pinnacle of information seeking capabilities.

Language distinguishes the human species, and reflects evolution of specialized association circuits in the brain. These have been identified as the auditory receptive area of the temporal lobes (Wernicke) and Broca’s area in the frontal lobe. These language areas are not fully developed at birth. Maturation continues for 3 to 5 years after birth, and under guidance of trophic neurotransmitters produced in brainstem auditory nuclei (Friauf & Lohmann. Cell Tissue Res. 1999;297:187-95).

Nuclei of the auditory system are vulnerable to injury from myriad toxic substances like mercury, lead, methyl bromide, carbonyl sulfide, chemotherapy medications, “recreational” substances (including alcohol), the nerve gas Soman, and likely many more chemicals that should be better tested before employed as medicines, like metronidazole (Flagyl). Sadly Teresa Conrick’s daughter was given this substance for GI parasitic infection.

Asphyxia of 6 to 8 minutes at birth causes prominent damage in nuclei of the brainstem auditory pathway (Windle, Scientific American, Oct 1969). This was shown in research with monkeys. There are a few reports of auditory system injury in human infants revived from asphyxia. Note that this is different from cerebral palsy, which is caused by prolonged partial insufficiency of oxygen (Myers RE, Am J Obstet Gynecol. 1972;112:246-76).

Many different mechanisms lead to injury, sometimes hemorrhagic, sometimes ischemic. The poison pyrithiamine displaces vitamin B1 (thiamine) on enzymes of aerobic metabolism (Troncoso et al. Arch Neurol. 1981;38:350-4). It is not simple. They may claim there is no evidence of harm from vaccines, but where is the evidence of safety? Research on neurotoxicity must be demanded.

Ted,
None of the current anti-biotics is 100% successful against Mycoplasma fermentans due to its lack of a cell wall. There is one AB, specifically for mycoplasma in advanced development. We must be patient.

Angus,
Our children are indeed different but that may be because of the opportunistic nature of this pathogen which, having been injected into the blood may alight where it prefers eg, gut, auditory canal, GI tract, synovial tissues etc.

Rae,
Donald W Scott is new to me but I will seek out his work.

Please note, my scientific paper is now available at:

http://homepage.ntlworld.com/albiggar/Bill%20Welsh.html

Bill

The late Canadian researcher Donald W. Scott called mycoplasma fermentans "the linking pathogen in neurosystemic diseases." Often dismissed as a crank for lack of an MD or a chemistry doctorate, he was nothing of the kind: his education was in the field of science librarianship and he made superb use of it. It's not necessary to accept all his theories to be convinced that the fermentans could well play a role in at least some cases of autism.

Thanks for the information Bill it all helps. As we all know no child is the same and each would have a different response ..no silver bullet on Autism that's the story.But any break through only to glad to read about it ..food for thought ..Thanks Bill

MMR RIP

Maybe that is why turmeric helps people with brain inflammation because it purifies their blood. Glad to be in a company that produces this along with electrolyzed reduced water!!!

"It has been estimated that at least 11 to 15% of U.S. laboratory cell cultures are contaminated with mycoplasma. [13] A Corning study showed that half of U.S. scientists did not test for mycoplasma contamination in their cell cultures. The study also stated that, in former Czechoslovakia, 100% of cell cultures that were not routinely tested were contaminated while only 2% of those routinely tested were contaminated (study page 6). Since the U.S. contamination rate was based on a study of companies that routinely checked for mycoplasma, the actual contamination rate may be higher. European contamination rates are higher and that of other countries are higher still (up to 80% of Japanese cell cultures).[14] About 1% of published Gene Expression Omnibus data may have been compromised.[15][16] Several antibiotic based formulation of anti-mycoplasma reagents have been developed over the years."[17]

Years ago my then five year old autistic son was treated for a throat infection with erythromycin. During the 7-10 days he was on erythromycin, he had some improvement in speech, saying a few words instead of his usual mutism. Erythromycin has some activity versus mycoplasma. Coincidence?

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