Physicians, Heal Thyselves

Here's an idea -- if you've been treating Ebola patients in Africa and come back to NYC, lay low for 21 days. Don't doctors and public health officials have what non-experts like us consider common sense? -0- New report says...

How Mercury Triggered The Age of Autism

Conversation with the Authors of Plague

Autism Public Service Announcement

Canary Party Vaccine Court Video

A Glimpse into Autism

Meet Our Advertisers


Olmsted's Original UPI Series

  • The Age of Autism Tag

« Bachmann Was Right: Government Database Contains Reports of Mental Retardation as Vaccine Adverse Event | Main | Older Drug Reinvented for Autism »

AofA Science Summary: Do Childhood Mumps Protect Against Ovarian Cancer?

Science post image Mumps and ovarian cancer: modern interpretation of an historic association

Cancer Causes Control. Author manuscript; available in PMC 2011 August 1.
Published in final edited form as:
Cancer Causes Control. 2010 August; 21(8): 1193–1201.
Published online 2010 June 18. doi:  10.1007/s10552-010-9546-1

Background

Epidemiologic studies found childhood mumps might protect against ovarian cancer. To explain this association, we investigated whether mumps might engender immunity to ovarian cancer through antibodies against the cancer-associated antigen MUC1 abnormally expressed in the inflamed parotid gland.

Methods

Through various health agencies, we obtained sera from 161 cases with mumps parotitis. Sera were obtained from 194 healthy controls. We used an ELISA to measure anti-MUC1 antibodies and electro-chemiluminescence assays to measure MUC1 and CA 125. Log-transformed measurements were analyzed by t-tests, generalized linear models, and Pearson or Spearman correlations. We also conducted a meta-analysis of all published studies regarding mumps and ovarian cancer.

Results

Adjusting for assay batch, age, and sex, the level of anti-MUC1 antibodies was significantly higher in mumps cases compared to controls (p = 0.002). Free circulating levels of CA 125, but not MUC1, were also higher in cases (p = 0.02). From the meta-analysis, the pooled odds ratio estimate (and 95% CI) for the mumps and ovarian cancer association was 0.81 (0.68–0.96) (p = 0.01).

Conclusion

Mumps parotitis may lead to expression and immune recognition of a tumor-associated form of MUC1 and create effective immune surveillance of ovarian cancer cells that express this form of MUC1.

Read the full abstract at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951028/.

Comments

Feed You can follow this conversation by subscribing to the comment feed for this post.

I had mumps as a child and now I have stage 3 ovarian cancer. So I must be an exception.

Mumps, an anti-cancer vaccine? Kind of ironic that in vaccinating for mumps we may be "training" the immune system to avoid cancer-fighting training.

So having mumps around helps in preventing ovarian cancer
chicken poxs helps in preventing shingles.

Verify your Comment

Previewing your Comment

This is only a preview. Your comment has not yet been posted.

Working...
Your comment could not be posted. Error type:
Your comment has been saved. Comments are moderated and will not appear until approved by the author. Post another comment

The letters and numbers you entered did not match the image. Please try again.

As a final step before posting your comment, enter the letters and numbers you see in the image below. This prevents automated programs from posting comments.

Having trouble reading this image? View an alternate.

Working...

Post a comment

Comments are moderated, and will not appear until the author has approved them.

@AgeofAutism Tweets

follow me on Twitter

SPONSORS

  • HC Logo 2014
  • Canary final logo
  • VOR logo sidebar
  • Safeminds 2014 Logo
Age of Autism's Facebook Page