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Dr. Bradstreet, Nagalase, and the Viral Issue in Autism

JeffBradstreetBy Kent Heckenlively, Esq.

Although my daughter is not a patient of Dr. Jeff Bradstreet I've always had an enormous amount of respect for the good doctor.  I'll usually go on his website once or twice a month to find out what has most recently attracted his interest.  Often it seems we're looking at similar questions; which either means great minds think alike, or we suffer from some of the same delusions. 

I was intrigued by his October 11, 2011 entry, "An Update on Viral Issue in Autism" since it dovetailed with some of my own recent investigations.

In the past months Dr. Bradstreet has become interested in nagalese, which he describes as an enzyme "produced by cancer cells and viruses."  He thinks it unlikely that children with autism have undiagnosed cancers, and thus suspicion falls on a viral etiology.  Dr. Bradstreet writes, "Viruses make the nagalese enzyme as part of their attachment proteins.  It serves to get the virus into the cell and also decreases the body's immune reaction to the virus-thereby increasing the odds of viral survival."

Further on Dr. Bradstreet writes, "It is reasonable and likely that the nature of the immune dysfunction and the frequently observed autoimmune problems in autism are mediated by persistent, unresolved viral infections."  He claims to have tested approximately 400 children with autism for the viral marker, nagalese, and found that nearly 80% have significantly elevated levels.  He hopes to publish soon on this study and believes this information "is one of the most important developments in the clinical treatment of children on the spectrum that I have experienced in the last 15 years."

Dr. Bradstreet's article got my attention because of my daughter's own nagalese testing.  I had her tested back in May (when she'd endured three hospitalizations due to uncontrolled seizures) and her reading was 3.3 (reference range 0.35-0.95).  In desparation we tried the ketogenic diet (high fats and low carbs), and although there have been some rough patches since May we have avoided further hospitalizations.

And her stools normalized. 

Yes, I know all of you realize how important that is.  We're talking months and months of good stools.  Seizures down at least 80%.  So of course, your friendly neighborhood science teacher was interested in what her nagalese levels might be, so we did a retest in late September.  This time her reading was 1.7.  It was about a 50% drop, and while it's still abnormal, it is progress.  It makes me wonder if a low-carb diet starves viruses of an energy source.

There are critics of nagalese testing.  Dr. Enlander, a specialist in chronic fatigue syndrome/ME, another disease which may be viral in origin, doesn't believe the tests are sensitive enough to be of any value.  And he may be right.

Dr. Bradstreet also discusses a substance called GcMAF, which I don't have enough information about to make an informed judgment, and that after viral clearance, the possibility of using neuronal stem cells which can cross the blood-brain barrier.  I really can't comment on the advisability of either suggestion.

But if you are like me, still looking for that clue which might help your child join the ranks of the recovered, you might investigate nagalese. 

Kent Heceknlively is a Contributing Editor to Age of Autism

Comments

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jonney

The zyka virus , brasil , microcelopathy, autism, immune system, toxins, stresses, diet , psychoactives, glouten alchohol , ssris, glyphosate, plus virus= profund autism.
less factors equal=aspergers
even less= neurotypicals.
that is all.
retroviruses retroviruses retroviruses...now what did WE add to the mix?
zyka is not man made but it too is on the rise,
helped along by retroviruses?

Khadija

Hi I have 8 year boy with autism please help

Sophie Scholl

great article Kent - marvellous to have captured this given events over the summer .

Betty Bona

Thanks, Angus Files! It was a "must listen"!

Angus Files

David Noakes on.Autism,Cancer,pharma shut downs,Bradstreet etc A MUST LISTEN..


https://www.youtube.com/watch?v=mLWhNiT5Lwg

MMR RIP

Catherine Nichols Pogorzelski

Have you had your daughter tested for Ankylosing Spondylitis/HLAB-27 gene? I had back issues for years and no one knew why! Also, with AS , itis suspected that starches play a role in AS being worse, in some patients. I know I felt better when I was strictly vegan with no wheat/breads etc of any type!
I had thryoid disease, hyperactive, then ablation, but I still developed cancer and had it removed, last year, , along with left styloid bone (Eagle Syndrome) it was elongated and calcified, as thyroid has an affinity for the calcium of the body. Make sure to get nto only TSH cehced but Free T 3 and Free T 4 as well, check out Mary Shomon's FB group on THyroid disease as well as a FB Group called, Thryoid Sexy,a group run by Baywatch Babe, Gena Lee Nolin. I wish your family well!

Lou

My post directly below contains an error and it seems I have no way to correct it.

Here is the error.

do it Directly BEFORE a "vaccination", MMR coupled with as many other "vaccines" s possible, and 6 months LATER with no "vaccination" between.

Here is the correct text

Get a nagalase test Directly AFTER a "vaccination" and 6 months to a year LATER with no "vaccination" between get another Nagalase test. Compare test readings.

I have written a first cut at my Nagalase/GcMAF Protocol.

http://healthyprotocols.com/2_nagalase.htm


Lou

"Just think if everyone went to alternative practitioners instead of allopathic [my spell checker wants to call it pathological LOL] the trillions of dollars pharma would loose and everyone would be healthier for it, the costs worldwide for health care would plummet tomorrow, everyone would be able to get healthcare for what ever rare, occurrence came along."

They will kill millions before this happens. NAGALASE is a powerful immunosuppressant one of many contained in the "vaccinations". It appears to function much quicker than most. It is enabling MANY diseases besides Autism; Cancer for one. Many of the Autism associated diseases are also associated with NAGALASE. IMO NAGALASE is the real deal. GcMAF appears to neutralize NAGALASE. Too bad the criminals in Europe closed down down their production of GcMAF, as have we, indirectly the FDA has banned it for Autism. It is now very hard or impossible to get.

What to do:

o Get your Vitamin D levels up to at least 80ng/ml; get as much as you can from the sun.

o Find a way to get GcMAF; you may have call the Kenyan or his minions in "health care", your local newspaper or anyone you can think of personally and BITCH. Tell them or anyone who is interested in Autism, Cancer et al about NAGALASE or a NAGALASE producing substance is being added to "vaccinations".

o If you can find a place that has verified reliable NAGALASE tests do it Directly Before a "vaccination", MMR coupled with as many other "vaccines" s possible, and 6 months LATER with no "vaccination" between. If your "doctor" does not want your pin cushion child to "miss" a "scheduled" "vaccination" dismiss him or her as part of the problem.

o As always do not "vaccinate" for anything at any time and keep your children away from both drug pushers and "vaccination" pushers.

Yes folks we now have powerful evidence that they are DELIBERATELY adding Autism and other disease producing toxins to "vaccines". Good doctors, as opposed to the quacks injecting the NAGALASE, are being killed to COVER UP all this.

Here is an excellent article that completely covers this complex topic. It is complex because it was DESIGNED to be complex.

http://www.naturalnews.com/050553_Dr_Bradstreet_GcMAF_cancer_therapy.html

Angus Files

Anon I do agree with the brain washing desensitisation of the population but,I am not dociled by the death of Dr Bradstreet et-al the opposite to put it mildly. I don’t think nagalese is just as pharma,would have us all written off as another , crazy alternative “theory “ nagalese is a very well documented occurrence in cancers,never mind autism but then ,is autism a cancer? (I think it is) .

I cast my mind back to the great Pharma idol (he who should be worshipped ) of Pharma ,caught on camera talking about Merck vaccine scientist Dr. Maurice Hilleman admitted presence of SV40, AIDS and cancer viruses in vaccines…

“NaturalNews) One of the most prominent vaccine scientists in the history of the vaccine industry -- a Merck scientist -- made a recording where he openly admits that vaccines given to Americans were contaminated with leukemia and cancer viruses. In response, his colleagues (who are also recorded here) break out into laughter and seem to think it's hilarious. They then suggest that because these vaccines are first tested in Russia, they will help the U.S. win the Olympics because the Russian athletes will all be "loaded down with tumors." (Thus, they knew these vaccines caused cancer in humans.)”

Transcript
http://www.naturalnews.com/033584_dr_maurice_hilleman_sv40.html#

Video
https://www.youtube.com/results?search_query=maurice+hillieman+

Soo you see they f... knew what they were doing,MAURICE KNEW...Even the pharma paid puppet sock publications Pubmed et-al admit to nagalese …the telling point is ,you don’t find many studies, as the writer below points out some articles are written about then a sudden death of information.
http://www.ncbi.nlm.nih.gov/pubmed/16545013

Just think if everyone went to alternative practioners instead of allopathic the trillions of dollars pharma would loose and everyone would be healthier for it, the costs worldwide for health care would plummet tomorrow, everyone would be able to get healthcare for what ever rare, occurrence came along.
Dr Bradstreet et-al were starting to make a miniscule, impact on that road to recovery for everyone. I for one know that it wasn’t easy getting an appointment with Dr Bradstreet and the carpark at his clinic and other alternative practioners, in America are usually full to capacity ..says it all don’t you think?The comments below say it far better than I can RIP Dr Bradstreet, one extra star in the sky now.


MMR RIP

anon

discovery of the nagalase protein in the vaccine is what got him killed. how about.. people have gotten smart to the fact that vaccines cause autism, and so the pharma industry came out with this nagalase theory (made more credible by his murder) to make it look like a cover up and give us all hope that there is a cure for autism, when there is not. stories like this are being used to prevent rage and retribution by the public and keep us all docile and compliant longer. the big $ has all of their bases covered, and then some.

Jewels

I llike anything that doesnt come from a chemical cocktail as much as possible, Mercury is a chenmical those vaccinators put in us and our children.. Bradstreet knew what he was doing and he was getting somewhere too! Lets not let all his research go to waste and keep it going! Any pharma company or doctor pushing pills and other toxins at you needs to be looked at a little harder with a clearer vision of whats best..

Angus Files

https://www.youtube.com/watch?v=4AaAGYocbnk&feature=youtu.be

MMR RIP

Helios Chavarria

Some physicians are using low dose naltrexone to treat autism, it seems that with interesting results. You can go to Google and put “Low dose naltrexone autism”, or “LDN autism”.

Trevor

Doctor Bradstreet had just published a paper here:

http://www.la-press.com/initial-observations-of-elevated-alpha-n-acetylgalactosaminidase-activ-article-a3450-abstract

We are pleased to supply both Dr Bradstreet & Dr Nicola Antonucci with GcMAF who have treated over 1500 autistic children to date and are actively seeking other researchers to further the study already underway.

Please email me at info@gcmaf.eu - thank you.

With very best regards

Trevor

natasha

hi -I have a child on the autism spectrum and she tested positive for Lyme and multiple coinfections. after 3 years of treatment her symptoms are much better. I urge anyone with a child with autism to at least consider the possibility of lyme and get their child tested for it. there as a few labs with great sensitivity. we used igenex.

Diane

Hi
Has anyone tried MAF 314? Not sure if we should use Gcmaf or maf314 on our 5yr old, non verbal child.
Di

Katy

I am a biochemist and a researcher studying the links between inflammation and prostate cancer as well as some CNS pathologies. I have examined all the pertinent literature concerning both Nagalase and GcMAF and the papers stop at 2009 in PubMed. What happened? I also looked for commercially available antibodies against any form of Nagalase and found none (using the slang name and formal name). I have always believed that M2 macrophages are actually much more important as a target than lymphocytes in many pathological conditions and I would like to know the current scientific status of enzyme and substrate so I can decide whether or not to include these targets in my near-future plans. Papers stopping at 2009 scare me a bit although I've been known to publish late as well.

Steven Smith

i'd like to urge anyone who has an autistic child to seriously look at getting a nagalase test done. i was diagnosed just a few months ago at 31 and am going to my doctor to try to organise getting a blood sample sent to the lab in holland.

The simple fact is that a nagalase test will basically tell you if there is some kind of virus in your body. A high reading will indicate that there is and that it has seriously affected your immune system and your system isnt working proprly, so the virus can quite happily live inside you.

So for a very simple 50 -65 euros you can have a definite answer. If your levels are normal then at least you know the autism isnt caused by some kind of virus and that autism is really symptoms of having this virus living inside you.

If the test returns high levels then it is incredibly significant and there is a very real chance that the autism or severity of the autism is being caused by a virus. there is a very definite and single path of treatment to take.

I urge everyone with autistic people in their family (especially severe autism) to get the test done because you can learn a huge amount about what might or might not be the cause of autism for just 50-65 euros. It's better to learn something and open or close a path than to never know and just live with it your entire life.

If a nagalase test returns high levels then i suggest you then look to get a Vitamin D receptor gene type test. Right now it seems that 2 types of genes are high responders, but the rarest type of gene is a non responder. Tat is where we are just now, and the next step being worked on now is a way to bypass the non responsive gene or try to figure out some way of being able to treat everyone regardless of their gene type. But a Vit D recep test is another cheap way for you to know if the next step of treatment is likely to work, if the person has the rare gene type then it would seem right now that treatment wouldnt be effective.

if anyone with severe autism in their lives wold like any more info or help or support then please feel free to contact me angelesshc@gmail.com

i have autism and am going down this path myself, for the cost of a simple couple of test i will learn a huge amount about what is happening inside me, so a normal or high test result can be seen as a positive thing.

linda

I am perpetually trying to understand why scientists are not looking for novel viruses, perhaps retroviruses, in brain tissue of autism patients. They seem to look for known viruses but why not use deep sequencing techniques to look for new pathogens? There seems to be a consensus that this has viral etiology and that the immune system is dysfunctional. Perhaps I am being simplistic here, but why can't some people with finanacial means have this done?

Richard Karpinski

Nagalase and MAF 314

Fascinating information. Where did everybody get their Nagalase tests?
I want to use such a test as a screening test for the many causes of
high levels in serum. The one I know of costs about $65 and must be
ordered by a doctor.

The other source of Nagalase is pregnancy, I presume only after mother
and fetus share blood. Since cancer is created by a series of
aneuploid accidents after an initial wrong number of chromosomes, I
suspect that it's the fetal source gene that cancers use. I understand
that if you're HIV+, and gp120 is present, that serves as Nagalase on
its own.

I suspect that anything that emits Nagalase is protecting itself from
activated macrophages on the rampage looking for cells to consume with
active virus or the wrong chromosome complement such as a cancer cell
or a fetal cell or whatever makes gp120. I also suspect that cancers
that don't make Nagalase get eaten before they get big enough to get
noticed.

Professor Marco Ruggiero has created a probiotic yogurt, MAF 3 14,
which apparently makes people with a variety of ailments feel better
and have improved CD4 counts within weeks of starting consumption. He
had heard that milk contains some vitamin D binding protein, known as
either VDBP or Gc, and after 314 experiments found tasty yogurt
bacteria that converted some of the VDBP into macrophage activating
factor, MAF.

Ruggiero's recent report on MAF 314 at a conference in Italy is listed
among my many links. I have many more related links if anyone cares to
help annotate them to make the lists more useful. The only way I know
to get it is to take a $3500 course in maintaining properly balanced
yogurt and get 6 months worth of live yogurt starter material. I am
hoping to see MAF 314 spread widely by what I'm starting to call the
yogurt underground.

Serj

Thanks for the post, my question is if someone is positive in Negalase, what is the next step?
thanks.

Kent Heckenlively

Heather:

I used this lab in New Jersey. http://www.europeanlaboratory.nl/ Cost was $65.00.

All the best,
Kent.

Heather nichter

Can you share what test and by which lab company you used to determine Nagalese values?

Lisa B.

Thank you for sharing this information. I had never had this type of testing done but I will ask my sons DAN the next time we visit.

Maurine Meleck

Thanks. I find this very interesting. We are also doing the ketogenic diet and seeing much improvement with it.
Maurine

Teresa Conrick

Rituximab has been used with some good success in those with acute anti-NMDA Receptor Encephalitis in recovery from this increasing disease. Many have a cancer, a tumor or teratoma (paraneoplastic syndrome)yet this study stated not all do. The Rituximab seems to initiate - "B cell specific treatment."

Freitag, 24. September 2010, 12:30 - 14:30
Immunotherapy of anti-NMDA receptor encephalitis with rituximab – short report on a prospective one year follow-up
H. Schneider, A. Kotzian, U. Reuner, J. Schäfer, A. Vincent (Dresden; Oxford, UK)
Introduction: A new type of treatable encephalitis which predominantly affects young women has recently been described. The disorder is characterized by personality changes, seizures, dyskinesia and dysautonomia. Most patients have autoantibodies against NR1/NR2B subunits of the N-methyl-D-aspartate receptor (NMDAR), and in the majoritiy of patients a tumor, particularly an ovarian teratoma, can be detected.
Case report: We report about a female patient with clinical signs of limbic dysfunction and subacute onset of symptoms suggestive of NMDAR encephalitis. Anti-NMDAR-antibodies were detected in the patient and treatment with steroids and rituximab was initiated. The patient was followed-up for one year and showed complete remission of symptoms within 6 months. No ovarian teratoma or other tumor could be identified. CD19-positive B cells were completely suppressed by rituximab therapy. Serum levels of NMDAR-antibodies did not completely reflect the clinical course of the disease.
Summary: Our report proves the long-lasting clinical effect of B cell specific treatment with rituximab in a tumor-negative patient with NMDAR-encephalitis.

Jacey

Kent,
My son was on the Modified Atkins Diet for two and a half years. I just took him off this past summer. I put him on it for seizure, gut and mito issues. It was a dramatic diet and my son is now doing wonderful. Now your article has me curious as to other underlying issues. I'm going to research more. Thank you for your article. I appreciate your curiosity and willingness to inform us all.
Jacey

Judith Chinitz

This just came out today, Kent - thought you might be interested in it:
http://psychcentral.com/news/2011/10/20/potential-link-between-type-2-diabetes-and-autism/30542.html

Plus, I'm sure by now you've seen Dr. Buie and company's paper on carb metabolism issues in autism. By lowering carbohydrates in the diet, you're also radically changing gut flora. (The reason SCD works so well with so many kids.) Interesting that you saw a change in nagalase levels with the keto diet. You do have to wonder if there's any relationship.

Donna L.

Thanks so much for this, Kent. I so appreciate all your efforts to update - and give hope to - those of us whose kids are still really struggling, who are nowhere near recovery. Thank you!

Kent Heckenlively

To all of my wonderful readers:

Yes, we did the ketogenic diet under our neurologist's care.

I am somewhat familiar with GcMAF, but don't feel I have a good understanding yet of who it might help.

I'm also familiar with rituximab, and am waiting to see how it all shakes out before writing about it.

All the best,
Kent

KM

Kent here is a recent opinion paper which they also discuss low carbs and the role it may have. This is a different angle.

http://www.eurekalert.org/pub_releases/2011-10/ru-rpc101911.php

From a systems biology standpoint, these seem to be hitting or centering on Hubs and Nodes, the most connected and presumably most important proteins in cells. These tend to be the encoded by the genes mutated in major diseases like cancer.

David Taylor

Thank you for this report on Dr. Bradstreet.

Our son has been his patient since 2002 and has gone from a pale, non-verbal, self-stemming five-year-old with significant gut issues to an athletic 12-year-old in a classroom with "neuro-typical" children, on the honor roll, and something of a social butterfly.

We give credit to the courage of our son, of course, but his progress would not have been possible without the brilliant, hard work of Jeff Bradstreet. Talk to the families of any of his other patients and you will hear similar tales. It is hard to overstate the creative and positive difference this physician has made in the lives of our children.

Below is a link to a presentation on GcMAF that helps to explain some of the science behind the treatments and the role of nagalese that Dr. Bradstreet is pursuing. The presentation is by Dr. Kevin Bethel, Research Director at the IAT Cancer Clinic in Freeport, Bahamas.

Part 1: http://youtu.be/9o0J8dYfM3Q
Part 2: http://youtu.be/rkD2nni28Xs

Although you and Dr. Bradstreet mention this avenue of inquiry and treatment as a potential breakthrough for children on the spectrum, readers might be interested to know that GcMAF is increasingly seen as a potential breakthrough treatment for cancer and other immune diseases.

The research scientist most often credited with developing this line of inquiry is Dr. Yamamoto. Here is a PubMed entry from July 2008:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2510818/

Other PubMed entries on GcMAF can be found here:
http://www.ncbi.nlm.nih.gov/pmc/?term=gcmaf

I hope that AoA will continue to follow and report on Dr. Bradstreet's trials of GcMAF and the role of nagalese in causing the immune disorders of children on the spectrum.

csm888

My son and my nephew have received several doses of GcMAF this year. After this treatment I have seen such dramatic improvement in both boys that I believe we have found our magic bullet. My nephew's autism has improved to a point that I believe it would be only detectable a very experienced physician. My son is still receiving GcMAF but his language has improved dramatically.

Benedetta

My first link I gave is not working let me try to give it to you again.

http://www.pediatrics.ucsd.edu/news/pages/recurrentfeverresearch.aspx

Benedetta

Kent, I have thought the same thing about low carbs starving a lot of things including candida ablicans - yeast infections.

The Ketogenic diet is a rough diet, but it is only two years that you are suppose to stay on it, so good luck!

I am very curious though, if you did it yourself, or did you have professional help?

Jon Poling has his daughter on the 15 carb Atkin's diet and John Hopkins research says it works very well, also John Hopkins said that a glycemic diet of 30 carbs works too, but geeezze to figure out how much you can eat of a slow release cut steel oatmeal - not enough knowledge there.

Yesterday I read this from "Scientist News"

An anti-cancer drug could hold the key to treating chronic fatigue syndrome (CFS). Symptoms of the disease eased in 10 of 15 patients given rituximab, an anti-lymphoma drug.

Rituximab works by destroying white blood cells that make antibodies, called B cells. The results of the trial therefore suggest that these white blood cells might be involved in causing CFS – a disorder also known as myalgic encephalomyelitis (ME), and one that has so far defied explanation

Two words that stand out for my is lymphoma - lymph nodes, and B cells.

In Kawasakis disesase- is messed up with all of this too. There have been two studies released that link periodic fever disorder to Kawasakis. PFAPA (periodic or recurrent fever syndrome).

Which I and many parents have complained about for years. After the kids gets over the intial Kawasakis they have a fever once or twice a month that last about a week, but as the child gets older it slows down more and more (if you don't keep vaccinating). Many parents report that their kids had swollen lymph nodes some where in their bodies too. One of these studies says removing the tonsils "SOME TIMES" stops these recurring fevers.

My son had atypical Kawasakis - I never noticed if his tonisl were swollen though he always had a sore throat, so maybe it was???? However, he had more trouble with recurring fevers than my daughter who had very typical Kawasakis.

For my daughter it was her spleen.
The spleen swelled up to the point that a surgeon was called in - with the intention of removing it. Scary stuff, since a child who has had it's spleen removed seems to be okay, and then near death or dies a few years later.

The spleen and tonsils are large lymphoid organs that serve similar functions to lymph nodes, though the spleen filters blood cells rather than lymph.

It is also in the lymph nodes that the T cells sit around manufacturing lots of carbon copies of immune complexes brought to them by the B cells.
What if a child was lucky enough to have these problem T cells only in its tonsils. It may well make a difference in having them removed.

All this reminds me of amputated arms and legs in the past before there was pencillum, and cleaning wounds techniques.


http://www.pediatrics.ucsd.edu/news/pag ... earch.aspx

http://www.ncbi.nlm.nih.gov/pubmed/21220401

CT teacher

I have often wondered if any ASD kids were treated with COQ 10 and if they have had thorough screenings for endocrine disorders, especially thyroid and adrenal function. If I'm not mistaken, COQ10 improves cell metabolism and could be of benefit to them. At the same time, even a minor disturbance of the endocrine system can result in neurological symptoms. I don't know what the DAN protocol entails, but it might be worthwhile for parents to discuss COQ10 supplementation and endocrine screenings with them, as well as testing for B vitamin levels.

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