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Mitochondrial Dysfunction and Autism Found in Study

Mitochondria Managing Editor's Note: How many of your kids see a mitochondrial specialist? We do.  Mitochondria are known as "the powerhouses of the cell." Imagine if the system is broken or injured and the body can not create energy to fuel the organs, muscles and BRAIN?  KS

From Reuters Health:

By Frederik Joelving

NEW YORK | Tue Nov 30, 2010 5:15pm EST

NEW YORK (Reuters Health) - Most of the kids tested in a small autism study turned out to have problems with energy production in their cells, scientists said Tuesday.

Enzymes in the energy-producing 'power plants,' or mitochondria, in their blood cells were only about a third as effective as in kids of the same age without autism.

The work adds to research hinting that damage to the mitochondria may sometimes play a role in the little-understood disorder. But it doesn't prove it.

"This is a snapshot of these children," said researcher Cecilia Giulivi of the University of California, Davis. "I don't know if it is the cause or the consequence of autism."

Autism spectrum disorders range from mild Asperger's Syndrome to severe mental retardation and social disability, and there is no cure or good treatment.

While autism has been on the rise for decades, its causes continue to elude researchers. Their best bet is that it's related to both genetic and environmental factors.

A few reports have suggested a link between autism and mitochondria gone awry.

In 2007, for instance, the U.S. vaccine court settled the case of Georgia girl Hannah Poling, who had developed autistic symptoms after receiving several vaccines over a short period of time.

While the link between vaccines and autism has been widely discredited, in Poling's case the court found the shots had worsened an underlying mitochondrial disease, which affects less than 20 in 100,000, according to some studies.

Autism is much more common, affecting about one in 100 kids, but some of its symptoms overlap with mitochondrial disease, said Giulivi.

"So we wanted to check if the majority of autistic children had mitochondrial dysfunction," she told Reuters Health.

With her colleagues, she compared mitochondrial activity and DNA between 10 California toddlers with autism and 10 without.

One autistic child met the criteria for mitochondrial disease, and most had some biochemical sign that their mitochondria weren't running at full speed. They also had some extra mitochondrial DNA, suggesting that the mitochondria were trying to make up for their lost productivity.

That could be important because the brain is one of the biggest energy hogs in the body....

Read the fulll article HERE.

 

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Please review this study "Medication induced
mitochondrial damage".It gives an egzample
how many (mostly used for mental illness)medications causing mitochondrial damage.
The FDA does not ask companies to check their product against the mitochondria.
I think we will have a major health disaster
in a few years.This paper came out in 2008.

Dr Andrew Cutler (ALA Chelation) offered several references to Mercury Poisoning causing mitochondrial disorder in a Yahoo group earlier this week.

It appears ALA Chelation removes the source of the cause and these disorders should be resolving themselves?

Perhaps the MITO COCKTAILS so often referenced are able to 'jump start' the mitochondria and benefit affected kids?

Concerned Mom;
I've been there too, trying to get help from a so called intellectual giant who can barely stand ordinary people let alone someone who is in their eyes even less!

Apparently we all have! I steamed with rage to hear what Estepp had to say about trying to get a referral to a DAN doctor from her son's pediatrician.

What was even worse these intellectual giants don't mind saying some really ugly, hurtful things in from of my child. And believe me - he understands.

I have come out of the doctor's office driving all the way home with my son in complete - utter silence (not because he cannot talk because he can, but because his feelings are so hurt!)

I would not want to be them come judgement day.


"And the pharmaceutical industry and medical system want to make it all sound so complicated so that they can continue to blame our children's inherited DNA instead of the actual cause which is plain old POISON."

Along the lines of Autism Grandma's observation I just quoted, that's exactly the reaction I got from a pediatric neurologist in Boston I took my son to see when we thought he might be having seizures. At the time, my son had severe anxiety issues, receptive and expressive language difficulties, OCD, and he was excessively fidgety (couldn't sit still, had to get up and walk around, touch everything in the office, etc.). The doctor took one look at my son and his look of disgust which he could barely conceal made my heart and stomach collide in my chest. Against my better judgment (because I wanted to take my son and run as fast as we could), I let this 'doctor' do something akin to a field sobriety test to check my son's reflexes and responses. He had to repeat the directions to my language-impaired son and became so impatient, his look of disgust now not concealed at all, he actually said to my son in a raised, annoyed voice, "Stop being so silly!" I knew right then and there he saw my son as nothing but a collection of broken pieces haphazardly fashioned into a defective organism for which no cause or cure exists. It's just the way my son was made and I really had no business asking questions or seeking help for it. That's what these a**holes really think and that's how they treat our kids. The good news is that that sorry excuse for a pediatric neurologist was wrong... my son is about 90 percent recovered and getting better every day. So he, and the rest of the "it's the DNA, Stupid!" crowd can stick their blame and disgust where the sun don't shine and spin on it.

Autism Grandma speaks the truth.

Not surprised at all.

I have CFS.
I am XMRV positive.
I have mitochondrial dysfunction as measured by the Acumen ATP Profile.
Suspect a couple of my relatives might have Aspergers.

A few other things to check for in a ASD child is Lyme disease and PANDAS if they have had a lot of strep infections (even years ago) or sudden new OCD issues.

Both can take months of antibiotics to clear out the problem.

and then remove those from an endless checklist...

As someone who has researched the effects of toxic exposures and toxic overloads due to my own chemical injury over 20 years ago, from my own point of view "this ain't exactly rocket science". Basically, when the body is POISONED by toxins, the gamut of damages runs from the cellular level up to the end organ damage. The detoxification system collapses due to being depleted of critical nutrients from the toxic overload. Methyl B12, Glutathione, Magnesium, Niacin, and other nutrients are not available to detoxify, thus resulting in additional toxic overload.

In the case of the intestines, when the crucial intestinal flora is wiped out by toxins, including antibiotics and steroid medications, the digestive tract cannot digest foods sufficiently resulting in malabsorption of protein, fat and nutrients, which then results in a "leaky gut" [intestinal lining becomes permeable] and therefore undigested food toxins leak into the bloodstream creating another toxic overload.

These toxins produce mitochondrial DNA damages and also take up residence in the cells, with some toxins more stubborn to remove than others, especially heavy metals. The toxins stored in the cells prevent the cells from functioning properly and also interfere with nutrient uptake into the cells.

Good God, it's a miracle that any cells can function at all in this condition, and another miracle of Divine Creation that human beings can even remain alive. Thankfully, God has created many nutrients that can assist the human body to recover from these damages and even regenerate new cells. But all of this requires alot of careful attention so as not to re-circulate poisons stored in cells back into the system to create further damages.

It's sure a heck of alot more complicated to remove the toxins and reverse the damages, than it would have been if the toxins were not introduced into the body to begin with. How easy it was for the doctors to just inject toxins directly into our childrens body leaving us with the barren landscape of an atomic explosion to deal with.

Yes, it's a very complicated situation to address the many toxic injuries and remove the toxins from the cells, but it doesn't take a rocket scientist to understand the simple fact that toxins poison the cells in the body thus resulting in cellular malfunctioning, "mitochondrial Dysfunction" and damaged DNA, which then results in autism,and many other diseases including cancer.

I am grateful to be alive after so many serious health issues caused by toxic poisoning, and I am grateful to have reversed much of the damage caused in the last 20 years, and I am grateful to be a two time cancer survivor thanks to natural therapies created by God and NOT manmade toxic chemo and radiation....

However, it sure as hell would have been a whole lot easier if every cell in my body was not poisoned in the first place, and I can say the same for my grandson who was poisoned by 27 doses of vaccines given within 6 months.

No, it doesn't take a rocket scientist to understand all this, but medical doctors with an 8 year Harvard education can't even figure out that "an ounce of prevention is worth a pound of cure"... Most of them don't WANT to know that they are systematically poisoning our children, and they have big house payments to make so they are not about to stop vaccinating and they are going to continue prescribing toxic drugs.

And the pharmaceutical industry and medical system want to make it all sound so complicated so that they can continue to blame our children's inherited DNA instead of the actual cause which is plain old POISON.

hi Benedetta,

no, we haven't done this mito test although I'd like to have my son tested. You could probably email the company to inquire more about the test.

I've read about OXPHOS through this excellent mitoaction article here:

"Has your child with autistic symptoms been properly screened for a subset of mitochondrial disorders known as OXPHOS?"
http://www.mitoaction.org/files/AutismFile36_AlyssaDavi[1].pdf

It's useful to remember that Rett syndrome, which causes severe ASD-like condition to emerge after a period of apparently normal development, in some ways resembles mitochondrial disorders. Rett syndrome is caused by mutations in the MECP2 gene, which encodes a protein that profoundly affects neurodevelopment by regulating the expression of many other genes—and affects mitochondria. Although mutations within the MECP2 are rare in ASD, expression of this regulatory gene is commonly altered and the levels of the MECP2 gene product are commonly aberrant in ASD. Thus the mitochondrial defects observed in this study may well be a consequence of the abnormal expression of this critical regulatory gene in ASD rather a cause of ASD.

Oh dear I have one more thing to say:

It took a DAMN VACCINE TO CAUSE THIS ILLNESS IN ALL THREE OF MY FAMILY MEMBERS TO APPEAR.

Sarah:
So this new test; have you had it done?
If so is it just a blood test or does it still require cutting a piece of muscle from the shoulder and leg?

New dynamics Dignostic Company: is this the only place in the United States, way out in California? If so that is a bit far to send blood or even muscle samples that have to be very - very fresh from the EASTERN Part of the US?

And does this mitochondria test just say you have it, or does it zero into exactly what part of the Krebs Cycle is screwed up?

As far as I can read many of the kids that have this mitochondria dysfunction that comes from vaccines, are like my husband and Hannah Poling: it is called Oxidation Phosphorylation, and the Krebs cycle is messing up on the complex I and complex III.

I'm pretty sure I read an article within the past year or so, too, about a large portion of pharmaceuticals that have ended up "in the bin" and not making it to market due have corresponding "mitochondrial" issues that are only now being recognized. It wasn't being examined as part of the clinical trials, but they feel a large portion of them may be resurrected under this new light. So if you think all the mito research is just because of autism, it may be more about getting old, halfway researched drug into the market quickly.

There's a company called Medomics that has developed a Mito diagnostic test. Here's more info:

Medomics Mito test:

http://www.medomics.com/MitoDx

Watch Gwynnie's story:

http://www.youtube.com/watch?v=k8KQhDy3Z3E


New Test Helps Detect Mitochondrial Disease

http://www.medomics.com/sites/default/files/docs/news/MEDomics%20KTLA%20Jan%2029,%202010.pdf

"Funding for the study was provided by a UC Davis MIND Institute Pilot Research Grant, the National Institute of Environmental Health Sciences (NIEHS), the U.S. Environmental Protection Agency and Autism Speaks."
http://www.autismspeaks.org/press/jama_mitochondria_autism.php

Who was that last one? The Great Satan who wastes all our money on genetic stuff and shouldn't be supported under any circumstances? Hmmmmm...

It's like Ground Hog Day anymore. The same stuff keeps coming up. Yes, mercury/thimerosal causes mito dysfunction and autism. Just admit it already. Oh yeah, they already have at Simpsonwood.

There is no doubt that my family has a mitochondria disfunction.

The question is: What is causing it?

Is it a vaccine (yes that is what started it all) So what is in the vaccine. Is it mercury, is it aluminium, is it a virus, is it our own immune system that has been turned on.

Why us and not everybody if that is the case. Is it because we already have an overload of mercury, a virus, organic phosphates, pesticides to begine with?

OR


Is it genetic; some kind of DNA mutations that just have not been recognized - YET?
My husband was tested for those KNOWN genetic causing mitochondria dysfunctions and none was found. It was listed as acquired by one of the 50 mitocondrial experts the very main one that help begin these studies way back in the early 90's.

If it is genetic - once again - why is the incidence of autism increasing? If it is genetic then why is the result (autism) of mitochondrial defects increasing?

And I am not sure that everybody else but our family is getting away with it.

What is this obesity epidemic in the United States?

How many times do we see thin people eating everything and then someone says he has a great metabolism.

Well is not metabolism and mitochondrial disfunction pretty much the same thing?

The news article from Science Daily below reports that "1 in 200 individuals harbor mitochonrial DNA mutations that may lead to diease" so the fact that UC Davis MIND Institute scientists found mito dysfunction in our kids makes sense.

A letter to President Obama signed by over 50 Mitochondrial experts states that mitochindrial dysfunction is "at the core of many common diseases and chronic conditions".

If they look at the mitochondrial DNA in our kids, they'll probably see small otherwise hidden defects. I surmise too much stress on these weakened areas would trigger a mitochondrial dysfunction, energy depletion and autistic regression.


Large Reservoir Of Mitochondrial DNA Mutations Identified In Humans

http://www.sciencedaily.com/releases/2008/08/080811200144.htm

Letter to President Obama signed by over 50 Mitochondrial Experts:

http://www.solacenutrition.com/reading-room/mitochondrial-disease/mitochondrial-research-letter.html

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