Wakefield's Science Proven Valid Again In New Study That Replicates Findings

Read the full study, Clinical presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic spectrum Disorder and Chronic Gastrointestinal symptoms at Autism Insights . View a .pdf HERE.

Arthur Krigsman 1, Marvin Boris 2, Alan Goldblatt 3 and Carol Stott 4

Abstract

Background: Children with developmental disorders experience chronic gastrointestinal symptoms.

Aims:To examine the nature of these gastrointestinal symptoms and histologic findings in children with autism spectrum/developmental disorders and ileocolonic disease.

Methods:
Chart review. 143 autism spectrum/developmental disorder patients, with chronic gastrointestinal symptoms, undergoing diagnostic ileocolonoscopy.

Results: Diarrhea was present in 78%, abdominal pain in 59% and constipation in 36%. Ileal and/or colonic lymphonodular hyperplasia (LNH), defined as the presence of an increased number of enlarged lymphoid follicles, often with hyperactive germinal centers, was
present in 73.2%. Terminal ileum LNH presented visually in 67% and histologically in 73%. Colonic LNH was multifocal and presented histologically in 32%. Ileal and/or colonic inflammation presented in 74%, consisting primarily of active or chronic colitis (69%). Ileal
inflammation presented in 35%. Presence of LNH significantly predicted mucosal inflammation.

Patients with ileal and/or colonic LNH had lower mean/median age than those without; patients with ileal and/or colonic inflammation had lower mean/median age than those
without. There was a significant association between ileo and/or colonic inflammation or LNH, and onset of developmental disorder; plateaued or regressive onset conferred greater risk than early onset.

Conclusions: Patients with autism or related disorders exhibiting chronic gastrointestinal symptoms demonstrate ileal or colonic inflammation upon light microscopic examination of biopsy tissue. Further work is needed to determine whether resolution of histopathology
with appropriate therapy is accompanied by GI symptomatic and cognitive/behavioral improvement.

Keywords:ASD ileitis, colitis, lymphonodular hyperplasia

1 Assistant professor of pediatrics, New York University school of Medicine Director of Gastroenterology services, Thoughtful House Center for Children, 3001 Bee Caves Rd, Austin, Texas, 78746, UsA.

2 Associate Clinical professor of pediatrics, New York University school of Medicine, 550 1st Ave., New York, NY 10016, UsA.

3 Adjunct professor Touro College, 27-33 West 23rd st, New York, NY 10010, UsA.

4Thoughtful House Center for Children, 3001 Bee Caves Rd,
Austin, Texas, 78746, UsA.

Autism Insights 2010:2 1–11

This article is available from http://www.la-press.com.
© the author(s), publisher and licensee Libertas Academica Ltd.
This is an open access article. Unrestricted commercial use is permitted provided the original work is properly cited.

 

Comments

[Greg]

The media here in Australia continue to ‘bash’ Dr Wakefield and anyone who disagrees with the vaccine mantra. Yet another article today in the Daily Telegraph.

Jo Thornley – Anti-vaccine zeal akin to my belief in Santa Claus ….

http://www.dailytelegraph.com.au/news/opinion/anti-vaccine-zeal-akin-to-my-belief-in-santa-claus/story-e6frezz0-1225984596970

We readily accept that harm/deaths on our roads and toddlers drowning in backyard pools as horrible tragedies and rightly so . The consensus is that even one death is one too many. Yet when it comes to the injuries and death caused by vaccination we are supposed to readily accept the collateral damage as a worthwhile sacrifice for the good of the rest of us. OK as long as its not your kid hey Jo!

[Jewel]

This study confirms what we all knew, that there are GI issues common with Autism. It does NOT make any claims about cause and it doesn't say anything about vaccinations And yet you want to call it 'proof' that Wakefield wasn't a liar and a con. Good grief.

[lissi]

there wont be any independent studies done to back wakefield's findings up or to continue his vaccinated vs unvaccinated studies because WHOLE COUNTRIES WILL GO BROKE after compensating all the people they have damaged thru the use of vaccines when they get proof that vaccines damage, and damage BADLY. It will never happen. The only way we can stop this happening to more people is to KEEP SCREAMING until so many people decline vaccines that they are no longer profitable. It is happening, more and more people are waking up and are beginning to question.

[Eric]

Did anyone actually read past the first 3 words? Look at the method - as an analogy, it would be like saying I got 143 people with brown hair and a cold and studied their symptoms and then made the leap to say colds cause brown hair (which the authors of the study didn't do). The idea here was just to get an idea of the prevalence of symptoms in kids with both ASD and gastrointestinal problems and then to suggest studying treating those symptoms to see if there would be an improvement in ASD behaviors (which the study didn't do). READ, the speak.

[Mairead Hilliard]

Has anyone looked at the huge increase in IBD in young people i.e. Crohn's disease
and Ulcerative colitis in the Western World
since mass vaccination began with the MMR vaccine 1994?

100.000 children/ young adults under the age of 18 in he USA diagnosed with IBD according to Crohn's & Colitis Foundation
USA.

Irish Colitis & Crohn's Support.

[Jen in TX]

"Would society be pushing back so hard if the measles lesions were external rather than internal, impossible to ignore?"

I don't recall reading anywhere in this study that these findings were "measles lesions."

[nhokkanen]

The truth is hidden inside these sick, hurting children, where only scopes and biopsies can find it.

Would society be pushing back so hard if the measles lesions were external rather than internal, impossible to ignore?

[Jack]

Good idea Garbo. Two copies in the mail to GIs now. 1260 to go.

[Garbo]

Pictures don't lie, and neither did Dr. Wakefield. More of this please. If every ped gastro person out there were made aware, they could be looking for and corroborating this with photographic evidence too. Then maybe they can all get together and check the biopsies for viruses, retroviruses, etc. According to HealthGrades, there are 1262 practicing pediatric gastroenterologists in the U.S. It shouldn't be that hard to mount an educational camapaign for them.

[Elucidatus]

Its about time someone else replicated his findings! I am surprised this was not done sooner. All they need now is to replicated 1,000 times more so that the courts will at least look at the results.